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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 33

FusionGeneSummary for AAK1_KCMF1

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1_KCMF1
Fusion gene ID: 33
HgeneTgene
Gene symbol

AAK1

KCMF1

Gene ID

22848

56888

Gene nameAP2 associated kinase 1potassium channel modulatory factor 1
Synonyms-DEBT91|FIGC|PCMF|ZZZ1
Cytomap

2p13.3

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionAP2-associated protein kinase 1adaptor-associated kinase 1E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9
Modification date2018052320180519
UniProtAcc

Q2M2I8

Q9P0J7

Ensembl transtripts involved in fusion geneENST00000409068, ENST00000409085, 
ENST00000406297, ENST00000470281, 
ENST00000409785, 
Fusion gene scores* DoF score9 X 6 X 7=3785 X 5 X 3=75
# samples 97
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AAK1 [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAAK1

GO:0006468

protein phosphorylation

17494869|18657069

HgeneAAK1

GO:0032880

regulation of protein localization

18657069

HgeneAAK1

GO:0045747

positive regulation of Notch signaling pathway

21464124

HgeneAAK1

GO:0050821

protein stabilization

21464124

HgeneAAK1

GO:2000369

regulation of clathrin-dependent endocytosis

18657069


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7744-01AAAK1chr2

69870010

-KCMF1chr2

85255012

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409068ENST00000409785AAK1chr2

69870010

-KCMF1chr2

85255012

+
In-frameENST00000409085ENST00000409785AAK1chr2

69870010

-KCMF1chr2

85255012

+
In-frameENST00000406297ENST00000409785AAK1chr2

69870010

-KCMF1chr2

85255012

+
intron-3CDSENST00000470281ENST00000409785AAK1chr2

69870010

-KCMF1chr2

85255012

+

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FusionProtFeatures for AAK1_KCMF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAK1

Q2M2I8

KCMF1

Q9P0J7

Regulates clathrin-mediated endocytosis byphosphorylating the AP2M1/mu2 subunit of the adaptor proteincomplex 2 (AP-2) which ensures high affinity binding of AP-2 tocargo membrane proteins during the initial stages of endocytosis.Isoform 1 and isoform 2 display similar levels of kinase activitytowards AP2M1. Regulates phosphorylation of other AP-2 subunits aswell as AP-2 localization and AP-2-mediated internalization ofligand complexes. Phosphorylates NUMB and regulates its cellularlocalization, promoting NUMB localization to endosomes. Binds toand stabilizes the activated form of NOTCH1, increases itslocalization in endosomes and regulates its transcriptionalactivity. {ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124}. Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870010chr2:85255012ENST00000406297-21812_4254864Compositional biasNote=Gly-rich
HgeneAAK1chr2:69870010chr2:85255012ENST00000409085-22212_4254962Compositional biasNote=Gly-rich
TgeneKCMF1chr2:69870010chr2:85255012ENST00000409785+07225_2575382Coiled coilOntology_term=ECO:0000255
TgeneKCMF1chr2:69870010chr2:85255012ENST00000409785+07333_3365382Compositional biasNote=Poly-Ser
TgeneKCMF1chr2:69870010chr2:85255012ENST00000409785+07376_3805382Compositional biasNote=Poly-Pro
TgeneKCMF1chr2:69870010chr2:85255012ENST00000409785+073_505382Zinc fingerZZ-type
TgeneKCMF1chr2:69870010chr2:85255012ENST00000409785+0778_1015382Zinc fingerC2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69870010chr2:85255012ENST00000406297-218397_61454864Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr2:85255012ENST00000406297-218658_66354864Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr2:85255012ENST00000409085-222397_61454962Compositional biasNote=Gln-rich
HgeneAAK1chr2:69870010chr2:85255012ENST00000409085-222658_66354962Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69870010chr2:85255012ENST00000406297-21846_31554864DomainProtein kinase
HgeneAAK1chr2:69870010chr2:85255012ENST00000409085-22246_31554962DomainProtein kinase
HgeneAAK1chr2:69870010chr2:85255012ENST00000406297-21852_6054864Nucleotide bindingATP
HgeneAAK1chr2:69870010chr2:85255012ENST00000409085-22252_6054962Nucleotide bindingATP


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FusionGeneSequence for AAK1_KCMF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA
TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH
LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG
PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES

>In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA
TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH
LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG
PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES

>In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA
TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH
LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG
PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA
TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA
ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT
GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT
GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT
CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA
GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC
AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC
CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA
CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC
AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC
GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG
GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT

>In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA
TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA
ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT
GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT
GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT
CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA
GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC
AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC
CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA
CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC
AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC
GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG
GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT

>In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA
TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA
ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT
GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT
GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT
CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA
GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC
AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC
CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA
CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC
AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC
GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG
GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7670nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTT
GCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAA
CAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGG
GCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTAC
CTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTG
GTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTT
CTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTAT
CAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAG
AACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAA
TCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGA
ATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCA
CTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGC
CTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATT
CGCAGACAATGTCCTCTGTGCTGTATTTGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTC
ACTCTTGTTACATTGTGTACATTCAAAAGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTA
AATGTAGGTAGCAGTGCAGGGGTGATCTCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGG
AAAATTGAAATCTCTAATGAAGCTGCTGTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATG
AGGTTTTTTGCAGCGTGCATGAGTTTTAGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCC
CAAAGCTTTCCCAAACATTATTCAATGGTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCT
ACGCACAAAGCCAGCTCTGCAGTGGAATCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTC
ATCTTGCCTGTGTGGAGCTCAGCCTGTCTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCC
TTTGTGTGCCCTAAAAACAAATCCTGTTCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATG
TTTTATTCAGGTGTAGATGAATTTCATTTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATT
CTCAATCATATTTTGCATTATTTATGTATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCA
GATTTGTCAGTATATTACAACCAAATTCTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTT
TTAATTGAATCATGCCACCTATATGCCTATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTG
GAAGGGCCGGGTTATTTTTTATTTCCTGTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGT
TGGGAGGGCAGTTTTTGGAATGTAAATTTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCA
TGTCTCGTTCCAGTTCTCTTTTCTCTGAGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTC
CGTTTCTTCAACATGACAAGCATACAGACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACC
AAAAAAGAAGTCACCCTACATGTCTGAAAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTT
TTCTTTAGTTCTGTAATGGATAATGTTTAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCA
TTTTTTTTCATTTGGTTGTTGAGAAGTTTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCA
ATAAAGCATTTTCAAGACTGTTGACCACTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAAT
CCAGTATTTTTTTTCTTTTTATGCTAAACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTA
TATGTACTTTCCCTTTTCTGCACAAATTCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATT
CAGAGCAGTTTAATTTAGATGATCACTTTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTA
ATTATTTTTTACCAGATATTTTACAAATACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATA
TCAATATAAAAATATATTCAAGCCCTTGAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTG
AATAAAAATTAATTGCAAAGACTTTGATGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCA
GATCCTGAATTTTGAGAATTTTTTGTTTCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTT
CCTGTTTAGAAATCATTTAAATCTTTCCCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTC
CTTGTATGGCTGCAATCATAAGACAGAATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAA
AAAATCCACAGAAGTAGAACCTAGGTTTGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCT
CCCTGTGGCCCCCAGAGAAATGAAGTAGGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCC
ACCCCCCATTTTCCCTCTCAATATTAGAAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGT
CTGTGGGCCACAGTTAAAAGAACGGGTAACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCT
CACTGCAAATATTAACGCTTTATATATTTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAA
GTGGGTTGGGGGGTAGAAGGAGAATACTAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAG
TGTTCAGTACCAATATTAAGTCTACTGTAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGA
ATGGGTGCTAAAAGCTCTTAACAGTTTTGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCA
CAGTTTAAGGGGCACATGCAATATTGGTTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGCGAGGCCGAGGCGGGTGGATCACGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACA
AAAAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAG
GTTGCAGTGAGCTGAGATCACGCCGCCATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACAC
TAGGTACGAAATTATCCCAGAATTATACGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAA
CTAGACACTAAAACAGTTCTCTCCTTGAGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATC
TCATCTCATTTCAGCCTCAACAGTAATTGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCA
GTCTGCAGACTTTCAGGTTGTGACGATGTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAG
CCAAATTCAAGTGACTGTTTTTCTGAATAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTC
TAATTCGTACTCTTGCCTCTTGGTTTCTGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAAC
CCTGCAGCAGACCTCGAATAAAATGTGACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCG
TCTCAGAGAAGTTGATCCTGAACCTCCACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATC
ACAAAGGAGAATGCTCTCAAGTCCTCATGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTT
AAGTCTGACTGTCCCAGGTAACTTTACTTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATG
TGGGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTG
GCCAAGATGGTGAAACCCCATCTCTACTAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGC
TGAGGCAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGA
CTCTCCTCAAAACAAAAAAAAAAGAAAGAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGAT
GTTTCTCTTCAAGGAGGCCTTTACTAACCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTT
GGCTCCTCTGTCTATAGAAACCATCAGTTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAA
CATTATTTACCAACTGCGATTTTTACAGACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAA
AGGTCATCAAGCCGGTTGCGTTTGGTCAGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGA
CAGCATTTGGAATCTGCCTCACACATAAGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATG
GAGTCCCAGCTCTCTCTCCTTGTATATAAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAA
GATTCTATAATACTCCTGTATTGGCAAGTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATG
GATTCTTACCCCCTAGTCATGAAAGCTATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAG
ACACTAGTTTCCCCATAAAAGTCCATTTTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACC
ATGTGTGCTGACCACTCACGATTCAGACTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAG
GCTCCGAGACTAATTTGTACTGAACCCTTGATATAGATTACCTTTTATAACATCACCACCTGTCATGAAGCTTATCTGTTTTCTGATTTG

>In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7733nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTT
GTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATG
GTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAAC
ATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGG
ATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTC
ACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGA
GTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGAC
AGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGC
AACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACA
TAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGC
GCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCT
CAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAA
ATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCGCAGACAATGTCCTCTGTGCTGTATT
TGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCACTCTTGTTACATTGTGTACATTCAAA
AGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAATGTAGGTAGCAGTGCAGGGGTGATC
TCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAAAATTGAAATCTCTAATGAAGCTGCT
GTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAGGTTTTTTGCAGCGTGCATGAGTTTT
AGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCAAAGCTTTCCCAAACATTATTCAATG
GTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTACGCACAAAGCCAGCTCTGCAGTGGAA
TCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCATCTTGCCTGTGTGGAGCTCAGCCTGT
CTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTTTGTGTGCCCTAAAAACAAATCCTGT
TCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTTTTATTCAGGTGTAGATGAATTTCAT
TTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCTCAATCATATTTTGCATTATTTATGT
ATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGATTTGTCAGTATATTACAACCAAATT
CTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTTAATTGAATCATGCCACCTATATGCC
TATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGAAGGGCCGGGTTATTTTTTATTTCCT
GTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTGGGAGGGCAGTTTTTGGAATGTAAAT
TTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATGTCTCGTTCCAGTTCTCTTTTCTCTG
AGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCGTTTCTTCAACATGACAAGCATACAG
ACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAAAAAAGAAGTCACCCTACATGTCTGA
AAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTTCTTTAGTTCTGTAATGGATAATGTT
TAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATTTTTTTTCATTTGGTTGTTGAGAAGT
TTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAATAAAGCATTTTCAAGACTGTTGACCA
CTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCCAGTATTTTTTTTCTTTTTATGCTAA
ACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATATGTACTTTCCCTTTTCTGCACAAAT
TCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCAGAGCAGTTTAATTTAGATGATCACT
TTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAATTATTTTTTACCAGATATTTTACAAA
TACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATCAATATAAAAATATATTCAAGCCCTT
GAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAATAAAAATTAATTGCAAAGACTTTGA
TGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGATCCTGAATTTTGAGAATTTTTTGTT
TCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCCTGTTTAGAAATCATTTAAATCTTTC
CCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCTTGTATGGCTGCAATCATAAGACAGA
ATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAAAATCCACAGAAGTAGAACCTAGGTT
TGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCCCTGTGGCCCCCAGAGAAATGAAGTA
GGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCACCCCCCATTTTCCCTCTCAATATTAG
AAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCTGTGGGCCACAGTTAAAAGAACGGGT
AACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCACTGCAAATATTAACGCTTTATATAT
TTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGTGGGTTGGGGGGTAGAAGGAGAATAC
TAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTGTTCAGTACCAATATTAAGTCTACTG
TAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAATGGGTGCTAAAAGCTCTTAACAGTTT
TGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACAGTTTAAGGGGCACATGCAATATTGG
TTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCGGGTGGATCA
CGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAAAAGTTAGCTGGGCATGGTGGCAGGC
ACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCGCC
ATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTAGGTACGAAATTATCCCAGAATTATA
CGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACTAGACACTAAAACAGTTCTCTCCTTG
AGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTCATCTCATTTCAGCCTCAACAGTAAT
TGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGTCTGCAGACTTTCAGGTTGTGACGAT
GTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCCAAATTCAAGTGACTGTTTTTCTGAA
TAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTAATTCGTACTCTTGCCTCTTGGTTTC
TGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCCTGCAGCAGACCTCGAATAAAATGTG
ACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTCTCAGAGAAGTTGATCCTGAACCTCC
ACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCACAAAGGAGAATGCTCTCAAGTCCTCA
TGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAAGTCTGACTGTCCCAGGTAACTTTAC
TTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTGGGGCCGGGTGTGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTAC
TAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG
AGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACTCTCCTCAAAACAAAAAAAAAAGAAA
GAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGTTTCTCTTCAAGGAGGCCTTTACTAA
CCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGGCTCCTCTGTCTATAGAAACCATCAG
TTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACATTATTTACCAACTGCGATTTTTACA
GACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAGGTCATCAAGCCGGTTGCGTTTGGTC
AGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACAGCATTTGGAATCTGCCTCACACATA
AGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGAGTCCCAGCTCTCTCTCCTTGTATAT
AAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGATTCTATAATACTCCTGTATTGGCAA
GTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGATTCTTACCCCCTAGTCATGAAAGCT
ATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGACACTAGTTTCCCCATAAAAGTCCATT
TTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCATGTGTGCTGACCACTCACGATTCAGA
CTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGCTCCGAGACTAATTTGTACTGAACCC

>In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7733nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTT
GTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATG
GTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAAC
ATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGG
ATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTC
ACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGA
GTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGAC
AGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGC
AACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACA
TAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGC
GCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCT
CAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAA
ATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCGCAGACAATGTCCTCTGTGCTGTATT
TGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCACTCTTGTTACATTGTGTACATTCAAA
AGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAATGTAGGTAGCAGTGCAGGGGTGATC
TCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAAAATTGAAATCTCTAATGAAGCTGCT
GTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAGGTTTTTTGCAGCGTGCATGAGTTTT
AGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCAAAGCTTTCCCAAACATTATTCAATG
GTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTACGCACAAAGCCAGCTCTGCAGTGGAA
TCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCATCTTGCCTGTGTGGAGCTCAGCCTGT
CTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTTTGTGTGCCCTAAAAACAAATCCTGT
TCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTTTTATTCAGGTGTAGATGAATTTCAT
TTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCTCAATCATATTTTGCATTATTTATGT
ATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGATTTGTCAGTATATTACAACCAAATT
CTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTTAATTGAATCATGCCACCTATATGCC
TATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGAAGGGCCGGGTTATTTTTTATTTCCT
GTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTGGGAGGGCAGTTTTTGGAATGTAAAT
TTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATGTCTCGTTCCAGTTCTCTTTTCTCTG
AGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCGTTTCTTCAACATGACAAGCATACAG
ACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAAAAAAGAAGTCACCCTACATGTCTGA
AAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTTCTTTAGTTCTGTAATGGATAATGTT
TAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATTTTTTTTCATTTGGTTGTTGAGAAGT
TTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAATAAAGCATTTTCAAGACTGTTGACCA
CTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCCAGTATTTTTTTTCTTTTTATGCTAA
ACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATATGTACTTTCCCTTTTCTGCACAAAT
TCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCAGAGCAGTTTAATTTAGATGATCACT
TTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAATTATTTTTTACCAGATATTTTACAAA
TACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATCAATATAAAAATATATTCAAGCCCTT
GAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAATAAAAATTAATTGCAAAGACTTTGA
TGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGATCCTGAATTTTGAGAATTTTTTGTT
TCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCCTGTTTAGAAATCATTTAAATCTTTC
CCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCTTGTATGGCTGCAATCATAAGACAGA
ATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAAAATCCACAGAAGTAGAACCTAGGTT
TGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCCCTGTGGCCCCCAGAGAAATGAAGTA
GGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCACCCCCCATTTTCCCTCTCAATATTAG
AAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCTGTGGGCCACAGTTAAAAGAACGGGT
AACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCACTGCAAATATTAACGCTTTATATAT
TTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGTGGGTTGGGGGGTAGAAGGAGAATAC
TAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTGTTCAGTACCAATATTAAGTCTACTG
TAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAATGGGTGCTAAAAGCTCTTAACAGTTT
TGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACAGTTTAAGGGGCACATGCAATATTGG
TTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCGGGTGGATCA
CGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAAAAGTTAGCTGGGCATGGTGGCAGGC
ACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCGCC
ATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTAGGTACGAAATTATCCCAGAATTATA
CGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACTAGACACTAAAACAGTTCTCTCCTTG
AGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTCATCTCATTTCAGCCTCAACAGTAAT
TGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGTCTGCAGACTTTCAGGTTGTGACGAT
GTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCCAAATTCAAGTGACTGTTTTTCTGAA
TAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTAATTCGTACTCTTGCCTCTTGGTTTC
TGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCCTGCAGCAGACCTCGAATAAAATGTG
ACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTCTCAGAGAAGTTGATCCTGAACCTCC
ACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCACAAAGGAGAATGCTCTCAAGTCCTCA
TGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAAGTCTGACTGTCCCAGGTAACTTTAC
TTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTGGGGCCGGGTGTGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTAC
TAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG
AGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACTCTCCTCAAAACAAAAAAAAAAGAAA
GAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGTTTCTCTTCAAGGAGGCCTTTACTAA
CCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGGCTCCTCTGTCTATAGAAACCATCAG
TTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACATTATTTACCAACTGCGATTTTTACA
GACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAGGTCATCAAGCCGGTTGCGTTTGGTC
AGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACAGCATTTGGAATCTGCCTCACACATA
AGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGAGTCCCAGCTCTCTCTCCTTGTATAT
AAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGATTCTATAATACTCCTGTATTGGCAA
GTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGATTCTTACCCCCTAGTCATGAAAGCT
ATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGACACTAGTTTCCCCATAAAAGTCCATT
TTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCATGTGTGCTGACCACTCACGATTCAGA
CTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGCTCCGAGACTAATTTGTACTGAACCC


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FusionGenePPI for AAK1_KCMF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AAK1AP2M1, ATP13A2, APP, AP2A1, AP2B1, NTRK1, DYNLT1, XPO1, CLTB, CLTC, GAK, HSPA5, GTSE1, ANLN, CDH1, AP2S1, REPS1, RUNDC3A, RALBP1, PLEC, PPIP5K2, SEC24B, CCDC88A, EYA4, UBE2D2, LUZP1, URGCP, NUP88, DVL3, QSER1, WNK1KCMF1GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AAK1_KCMF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AAK1_KCMF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource