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Fusion gene ID: 33 |
FusionGeneSummary for AAK1_KCMF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AAK1_KCMF1 | Fusion gene ID: 33 | Hgene | Tgene | Gene symbol | AAK1 | KCMF1 | Gene ID | 22848 | 56888 |
| Gene name | AP2 associated kinase 1 | potassium channel modulatory factor 1 | |
| Synonyms | - | DEBT91|FIGC|PCMF|ZZZ1 | |
| Cytomap | 2p13.3 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP2-associated protein kinase 1adaptor-associated kinase 1 | E3 ubiquitin-protein ligase KCMF1FGF-induced in gastric cancerFGF-induced ubiquitin-protein ligase in gastric cancersRING-type E3 ubiquitin transferase KCMF1ZZ-type zinc finger-containing protein 1differentially expressed in branching tubulogenesis 9 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q2M2I8 | Q9P0J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000409068, ENST00000409085, ENST00000406297, ENST00000470281, | ENST00000409785, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 5 X 5 X 3=75 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AAK1 [Title/Abstract] AND KCMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AAK1 | GO:0006468 | protein phosphorylation | 17494869|18657069 |
| Hgene | AAK1 | GO:0032880 | regulation of protein localization | 18657069 |
| Hgene | AAK1 | GO:0045747 | positive regulation of Notch signaling pathway | 21464124 |
| Hgene | AAK1 | GO:0050821 | protein stabilization | 21464124 |
| Hgene | AAK1 | GO:2000369 | regulation of clathrin-dependent endocytosis | 18657069 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-7744-01A | AAK1 | chr2 | 69870010 | - | KCMF1 | chr2 | 85255012 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409068 | ENST00000409785 | AAK1 | chr2 | 69870010 | - | KCMF1 | chr2 | 85255012 | + |
| In-frame | ENST00000409085 | ENST00000409785 | AAK1 | chr2 | 69870010 | - | KCMF1 | chr2 | 85255012 | + |
| In-frame | ENST00000406297 | ENST00000409785 | AAK1 | chr2 | 69870010 | - | KCMF1 | chr2 | 85255012 | + |
| intron-3CDS | ENST00000470281 | ENST00000409785 | AAK1 | chr2 | 69870010 | - | KCMF1 | chr2 | 85255012 | + |
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FusionProtFeatures for AAK1_KCMF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AAK1 | KCMF1 |
| Regulates clathrin-mediated endocytosis byphosphorylating the AP2M1/mu2 subunit of the adaptor proteincomplex 2 (AP-2) which ensures high affinity binding of AP-2 tocargo membrane proteins during the initial stages of endocytosis.Isoform 1 and isoform 2 display similar levels of kinase activitytowards AP2M1. Regulates phosphorylation of other AP-2 subunits aswell as AP-2 localization and AP-2-mediated internalization ofligand complexes. Phosphorylates NUMB and regulates its cellularlocalization, promoting NUMB localization to endosomes. Binds toand stabilizes the activated form of NOTCH1, increases itslocalization in endosomes and regulates its transcriptionalactivity. {ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124}. | Has intrinsic E3 ubiquitin ligase activity and promotesubiquitination. {ECO:0000269|PubMed:15581609}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AAK1 | chr2:69870010 | chr2:85255012 | ENST00000406297 | - | 2 | 18 | 12_42 | 54 | 864 | Compositional bias | Note=Gly-rich |
| Hgene | AAK1 | chr2:69870010 | chr2:85255012 | ENST00000409085 | - | 2 | 22 | 12_42 | 54 | 962 | Compositional bias | Note=Gly-rich |
| Tgene | >KCMF1 | chr2:69870010 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 225_257 | 5 | 382 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >KCMF1 | chr2:69870010 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 333_336 | 5 | 382 | Compositional bias | Note=Poly-Ser |
| Tgene | >KCMF1 | chr2:69870010 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 376_380 | 5 | 382 | Compositional bias | Note=Poly-Pro |
| Tgene | >KCMF1 | chr2:69870010 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 3_50 | 5 | 382 | Zinc finger | ZZ-type |
| Tgene | >KCMF1 | chr2:69870010 | chr2:85255012 | ENST00000409785 | + | 0 | 7 | 78_101 | 5 | 382 | Zinc finger | C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000406297 | - | 2 | 18 | 397_614 | 54 | 864 | Compositional bias | Note=Gln-rich |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000406297 | - | 2 | 18 | 658_663 | 54 | 864 | Compositional bias | Note=Poly-Ala |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000409085 | - | 2 | 22 | 397_614 | 54 | 962 | Compositional bias | Note=Gln-rich |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000409085 | - | 2 | 22 | 658_663 | 54 | 962 | Compositional bias | Note=Poly-Ala |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000406297 | - | 2 | 18 | 46_315 | 54 | 864 | Domain | Protein kinase |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000409085 | - | 2 | 22 | 46_315 | 54 | 962 | Domain | Protein kinase |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000406297 | - | 2 | 18 | 52_60 | 54 | 864 | Nucleotide binding | ATP |
| Hgene | >AAK1 | chr2:69870010 | chr2:85255012 | ENST00000409085 | - | 2 | 22 | 52_60 | 54 | 962 | Nucleotide binding | ATP |
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FusionGeneSequence for AAK1_KCMF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES >In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES >In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_431aa MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGA TTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAH LTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSG PSASQLQQLQMQLQLERQHAQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPKMSETERQSMES |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT >In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT >In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_1293nt ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCA TGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCA ACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCT GTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACAT GCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCAT CTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTA GGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGC AATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGC CCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCA CGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGC AGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGC GAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGG GGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AAK1_ENST00000409068_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7670nt CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG TCACAGTGGACGAGGTGTTGGCGGAAGGTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTT GCTACGATTACGATCTTTGTGCATCTTGTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAA CAAGGGTAGATTTTGATTTATACTATGGTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGG GCTATACGGAGACATCTCTTCAAGAACATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTAC CTGGAGGCGATCCTAATCATGTCACGGATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTG GTGTTCGACATGTACGTAGAATGTTTCACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTT CTACTGGTGGACTTTCTTCTTCTCAGAGTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTAT CAGGAGTGAGACGTTCTGCAGGAGGACAGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAG AACGGCAGCATGCCCAGGCAGCACGGCAACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAA TCACACAATCCACAGCAACAACCAACATAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGA ATGATCCTAAAATGTCTGAAACGGAGCGCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCA CTTTAGTGCGTGAAGAGAGCTCATCCTCAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGC CTTTAGATGTTGCTTTAGAAAACCTAAATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATT CGCAGACAATGTCCTCTGTGCTGTATTTGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTC ACTCTTGTTACATTGTGTACATTCAAAAGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTA AATGTAGGTAGCAGTGCAGGGGTGATCTCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGG AAAATTGAAATCTCTAATGAAGCTGCTGTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATG AGGTTTTTTGCAGCGTGCATGAGTTTTAGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCC CAAAGCTTTCCCAAACATTATTCAATGGTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCT ACGCACAAAGCCAGCTCTGCAGTGGAATCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTC ATCTTGCCTGTGTGGAGCTCAGCCTGTCTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCC TTTGTGTGCCCTAAAAACAAATCCTGTTCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATG TTTTATTCAGGTGTAGATGAATTTCATTTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATT CTCAATCATATTTTGCATTATTTATGTATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCA GATTTGTCAGTATATTACAACCAAATTCTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTT TTAATTGAATCATGCCACCTATATGCCTATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTG GAAGGGCCGGGTTATTTTTTATTTCCTGTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGT TGGGAGGGCAGTTTTTGGAATGTAAATTTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCA TGTCTCGTTCCAGTTCTCTTTTCTCTGAGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTC CGTTTCTTCAACATGACAAGCATACAGACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACC AAAAAAGAAGTCACCCTACATGTCTGAAAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTT TTCTTTAGTTCTGTAATGGATAATGTTTAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCA TTTTTTTTCATTTGGTTGTTGAGAAGTTTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCA ATAAAGCATTTTCAAGACTGTTGACCACTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAAT CCAGTATTTTTTTTCTTTTTATGCTAAACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTA TATGTACTTTCCCTTTTCTGCACAAATTCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATT CAGAGCAGTTTAATTTAGATGATCACTTTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTA ATTATTTTTTACCAGATATTTTACAAATACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATA TCAATATAAAAATATATTCAAGCCCTTGAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTG AATAAAAATTAATTGCAAAGACTTTGATGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCA GATCCTGAATTTTGAGAATTTTTTGTTTCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTT CCTGTTTAGAAATCATTTAAATCTTTCCCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTC CTTGTATGGCTGCAATCATAAGACAGAATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAA AAAATCCACAGAAGTAGAACCTAGGTTTGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCT CCCTGTGGCCCCCAGAGAAATGAAGTAGGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCC ACCCCCCATTTTCCCTCTCAATATTAGAAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGT CTGTGGGCCACAGTTAAAAGAACGGGTAACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCT CACTGCAAATATTAACGCTTTATATATTTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAA GTGGGTTGGGGGGTAGAAGGAGAATACTAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAG TGTTCAGTACCAATATTAAGTCTACTGTAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGA ATGGGTGCTAAAAGCTCTTAACAGTTTTGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCA CAGTTTAAGGGGCACATGCAATATTGGTTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCA CTTTGCGAGGCCGAGGCGGGTGGATCACGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACA AAAAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAG GTTGCAGTGAGCTGAGATCACGCCGCCATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACAC TAGGTACGAAATTATCCCAGAATTATACGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAA CTAGACACTAAAACAGTTCTCTCCTTGAGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATC TCATCTCATTTCAGCCTCAACAGTAATTGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCA GTCTGCAGACTTTCAGGTTGTGACGATGTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAG CCAAATTCAAGTGACTGTTTTTCTGAATAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTC TAATTCGTACTCTTGCCTCTTGGTTTCTGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAAC CCTGCAGCAGACCTCGAATAAAATGTGACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCG TCTCAGAGAAGTTGATCCTGAACCTCCACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATC ACAAAGGAGAATGCTCTCAAGTCCTCATGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTT AAGTCTGACTGTCCCAGGTAACTTTACTTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATG TGGGGCCGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTG GCCAAGATGGTGAAACCCCATCTCTACTAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGC TGAGGCAGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGA CTCTCCTCAAAACAAAAAAAAAAGAAAGAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGAT GTTTCTCTTCAAGGAGGCCTTTACTAACCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTT GGCTCCTCTGTCTATAGAAACCATCAGTTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAA CATTATTTACCAACTGCGATTTTTACAGACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAA AGGTCATCAAGCCGGTTGCGTTTGGTCAGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGA CAGCATTTGGAATCTGCCTCACACATAAGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATG GAGTCCCAGCTCTCTCTCCTTGTATATAAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAA GATTCTATAATACTCCTGTATTGGCAAGTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATG GATTCTTACCCCCTAGTCATGAAAGCTATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAG ACACTAGTTTCCCCATAAAAGTCCATTTTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACC ATGTGTGCTGACCACTCACGATTCAGACTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAG GCTCCGAGACTAATTTGTACTGAACCCTTGATATAGATTACCTTTTATAACATCACCACCTGTCATGAAGCTTATCTGTTTTCTGATTTG >In-frame_AAK1_ENST00000409085_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7733nt GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG GTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTT GTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATG GTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAAC ATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGG ATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTC ACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGA GTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGAC AGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGC AACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACA TAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGC GCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCT CAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAA ATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCGCAGACAATGTCCTCTGTGCTGTATT TGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCACTCTTGTTACATTGTGTACATTCAAA AGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAATGTAGGTAGCAGTGCAGGGGTGATC TCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAAAATTGAAATCTCTAATGAAGCTGCT GTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAGGTTTTTTGCAGCGTGCATGAGTTTT AGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCAAAGCTTTCCCAAACATTATTCAATG GTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTACGCACAAAGCCAGCTCTGCAGTGGAA TCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCATCTTGCCTGTGTGGAGCTCAGCCTGT CTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTTTGTGTGCCCTAAAAACAAATCCTGT TCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTTTTATTCAGGTGTAGATGAATTTCAT TTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCTCAATCATATTTTGCATTATTTATGT ATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGATTTGTCAGTATATTACAACCAAATT CTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTTAATTGAATCATGCCACCTATATGCC TATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGAAGGGCCGGGTTATTTTTTATTTCCT GTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTGGGAGGGCAGTTTTTGGAATGTAAAT TTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATGTCTCGTTCCAGTTCTCTTTTCTCTG AGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCGTTTCTTCAACATGACAAGCATACAG ACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAAAAAAGAAGTCACCCTACATGTCTGA AAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTTCTTTAGTTCTGTAATGGATAATGTT TAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATTTTTTTTCATTTGGTTGTTGAGAAGT TTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAATAAAGCATTTTCAAGACTGTTGACCA CTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCCAGTATTTTTTTTCTTTTTATGCTAA ACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATATGTACTTTCCCTTTTCTGCACAAAT TCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCAGAGCAGTTTAATTTAGATGATCACT TTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAATTATTTTTTACCAGATATTTTACAAA TACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATCAATATAAAAATATATTCAAGCCCTT GAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAATAAAAATTAATTGCAAAGACTTTGA TGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGATCCTGAATTTTGAGAATTTTTTGTT TCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCCTGTTTAGAAATCATTTAAATCTTTC CCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCTTGTATGGCTGCAATCATAAGACAGA ATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAAAATCCACAGAAGTAGAACCTAGGTT TGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCCCTGTGGCCCCCAGAGAAATGAAGTA GGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCACCCCCCATTTTCCCTCTCAATATTAG AAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCTGTGGGCCACAGTTAAAAGAACGGGT AACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCACTGCAAATATTAACGCTTTATATAT TTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGTGGGTTGGGGGGTAGAAGGAGAATAC TAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTGTTCAGTACCAATATTAAGTCTACTG TAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAATGGGTGCTAAAAGCTCTTAACAGTTT TGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACAGTTTAAGGGGCACATGCAATATTGG TTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCGGGTGGATCA CGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAAAAGTTAGCTGGGCATGGTGGCAGGC ACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCGCC ATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTAGGTACGAAATTATCCCAGAATTATA CGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACTAGACACTAAAACAGTTCTCTCCTTG AGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTCATCTCATTTCAGCCTCAACAGTAAT TGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGTCTGCAGACTTTCAGGTTGTGACGAT GTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCCAAATTCAAGTGACTGTTTTTCTGAA TAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTAATTCGTACTCTTGCCTCTTGGTTTC TGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCCTGCAGCAGACCTCGAATAAAATGTG ACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTCTCAGAGAAGTTGATCCTGAACCTCC ACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCACAAAGGAGAATGCTCTCAAGTCCTCA TGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAAGTCTGACTGTCCCAGGTAACTTTAC TTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTGGGGCCGGGTGTGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTAC TAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG AGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACTCTCCTCAAAACAAAAAAAAAAGAAA GAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGTTTCTCTTCAAGGAGGCCTTTACTAA CCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGGCTCCTCTGTCTATAGAAACCATCAG TTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACATTATTTACCAACTGCGATTTTTACA GACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAGGTCATCAAGCCGGTTGCGTTTGGTC AGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACAGCATTTGGAATCTGCCTCACACATA AGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGAGTCCCAGCTCTCTCTCCTTGTATAT AAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGATTCTATAATACTCCTGTATTGGCAA GTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGATTCTTACCCCCTAGTCATGAAAGCT ATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGACACTAGTTTCCCCATAAAAGTCCATT TTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCATGTGTGCTGACCACTCACGATTCAGA CTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGCTCCGAGACTAATTTGTACTGAACCC >In-frame_AAK1_ENST00000406297_chr2_69870010_-_KCMF1_ENST00000409785_chr2_85255012_+_7733nt GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG GTGTCAGCTGTGATGCATGTTTAAAAGGAAATTTTCGAGGTCGCAGATATAAGTGTTTAATTTGCTACGATTACGATCTTTGTGCATCTT GTTATGAAAGTGGTGCAACAACAACAAGGCATACAACTGACCACCCAATGCAGTGCATATTAACAAGGGTAGATTTTGATTTATACTATG GTGGGGAAGCTTTCTCTGTAGAGCAGCCACAGTCTTTTACTTGTCCCTATTGTGGAAAAATGGGCTATACGGAGACATCTCTTCAAGAAC ATGTTACTTCTGAACATGCAGAAACATCAACAGAAGTGATTTGTCCAATATGTGCAGCGTTACCTGGAGGCGATCCTAATCATGTCACGG ATGACTTTGCAGCTCATCTTACACTTGAACACAGAGCCCCTAGAGATTTAGATGAATCGAGTGGTGTTCGACATGTACGTAGAATGTTTC ACCCTGGCCGGGGATTAGGAGGTCCTCGTGCTCGTAGATCAAACATGCACTTTACTAGCAGTTCTACTGGTGGACTTTCTTCTTCTCAGA GTTCATATTCTCCAAGCAATAGGGAAGCCATGGATCCTATAGCTGAGCTTTTATCTCAGTTATCAGGAGTGAGACGTTCTGCAGGAGGAC AGCTTAATTCCTCTGGCCCTTCCGCTTCTCAGTTACAACAACTGCAGATGCAGCTGCAGCTAGAACGGCAGCATGCCCAGGCAGCACGGC AACAACTGGAGACCGCACGCAACGCAACCCGGCGTACTAACACAAGCAGTGTCACCACTACAATCACACAATCCACAGCAACAACCAACA TAGCTAATACAGAAAGCAGTCAGCAGACTCTACAGAATTCCCAGTTTCTTTTAACAAGGTTGAATGATCCTAAAATGTCTGAAACGGAGC GCCAGTCCATGGAAAGCGAGCGTGCAGACCGCAGCCTGTTTGTCCAAGAGCTCCTTCTGTCCACTTTAGTGCGTGAAGAGAGCTCATCCT CAGATGAGGATGATCGGGGGGAGATGGCAGATTTTGGTGCTATGGGCTGTGTAGATATTATGCCTTTAGATGTTGCTTTAGAAAACCTAA ATTTAAAAGAGAGTAATAAAGGAAATGAGCCTCCACCACCTCCTCTTTGATGACATCCCAATTCGCAGACAATGTCCTCTGTGCTGTATT TGCCAATGAAAGTGGACAACAACTATCTTGGGTTTGTTTGGTGATTGTAATTTCAGGTCTGTCACTCTTGTTACATTGTGTACATTCAAA AGGAAGAGAGAAAATATATATGATAATCATTTCCACTTAACTAATTTTTACTTCTAGCAGGTAAATGTAGGTAGCAGTGCAGGGGTGATC TCTGCTTCCTGTACCTTGACATGCAAAAGGCTCTCCTAATACTCCACATTCAAACTGAAGAGGAAAATTGAAATCTCTAATGAAGCTGCT GTGTGTATTTATGAATATTAATGAATAAAAACTGCTTGGATGGTTTACCTTAACTACTGCATGAGGTTTTTTGCAGCGTGCATGAGTTTT AGTGACCTTGTTATTTAAGAAGTTAAATACAAGGAGTAAAACTTAAAAAAAAAATACAAAGCCCAAAGCTTTCCCAAACATTATTCAATG GTTACACGACGAAGTAGCTTTTGAATAATGTCTGCCTGAATCACCTTTCTTTGTGTGCCTCCTACGCACAAAGCCAGCTCTGCAGTGGAA TCTGGGGATTATAGCCGGGTGTGGCACTCCGCCCTGTGTGACTGTCCTGTCGCCCTGTTAGTCATCTTGCCTGTGTGGAGCTCAGCCTGT CTCTTTAACTCATCTGTAGAAGACACACCAGTAAAGCTACTGTTGGAATCTGCTGCAGGGGCCTTTGTGTGCCCTAAAAACAAATCCTGT TCATGTTTGTTTAAAGTTTTTACTTTTTGTGGTTGTTTAAAATTTTTTCAATTGTTAAATATGTTTTATTCAGGTGTAGATGAATTTCAT TTATTGACTGTTCAACAGAGTTAACCTGAATTATGTTGTCTTTGTTTTTAAAAATCTCACATTCTCAATCATATTTTGCATTATTTATGT ATTTGCTTTGTAGTTTGCTGAGACAGATCAGTATCAGGGGAGCTTTGAGGATTTGCCTTCCCAGATTTGTCAGTATATTACAACCAAATT CTTAATGCTAATTTTAGCACCTTTTATTTATTGGGTTTTTTCTGGCATAAAAAGTAAAGCCTTTTAATTGAATCATGCCACCTATATGCC TATATTATTAATCCTATGTGTAAAAAAAATGTACAGCTTTTTTTGGGTTTGTTTTGGGGTTTGGAAGGGCCGGGTTATTTTTTATTTCCT GTTTCAGTTTTTGTGCATAGACTTTCACAATAGCTCCAAGGCAGGGACAGCGGGTTTGGGGGTTGGGAGGGCAGTTTTTGGAATGTAAAT TTAGGACTTTTAAAAAGGTGCGCACAGCTTCTGATAAATTTATAACTAGACTTAACCTAATCATGTCTCGTTCCAGTTCTCTTTTCTCTG AGCCCTTTTCAAAGTCTCCTCTCTTTCTCCTGTCATCCTTTTCCTTTCCTGTCCGTGTATCTCCGTTTCTTCAACATGACAAGCATACAG ACTTGAACACCCCTCCGGTGTTCTTCCGAGAACTGTGAAGTCCATGTTCATCCAAATGTAACCAAAAAAGAAGTCACCCTACATGTCTGA AAAACTGTTGCTTCTCCTCTGAAACTTCAAACTCCAACGATTTCCAAATACAATAGCTTTGTTTTCTTTAGTTCTGTAATGGATAATGTT TAAAGGAAAACTTTACACCAGGCTTCTGGTTACACTAGAAGTCAAGCCCATTAGGGATTTTCATTTTTTTTCATTTGGTTGTTGAGAAGT TTCAAAAATCAGTTTTCAAGCTGTGGTCTTTCAAACACATCTGCACATAAGTCACACATTTCAATAAAGCATTTTCAAGACTGTTGACCA CTTGAATTTCTTTGGTGTTAGTGGATTAACCTAACCATTACTCTGAGATTTTATATCTCTAATCCAGTATTTTTTTTCTTTTTATGCTAA ACATGGGAGATCCTGGTTTTGTGTGAATGCATTATTTTGGATGTGAGAAATAAATGCCAATTATATGTACTTTCCCTTTTCTGCACAAAT TCTGGGAAAATGTAAAAGCCTTCATTTTTTAACATGGTTTTAGGGAACAACTGTAAGTCCATTCAGAGCAGTTTAATTTAGATGATCACT TTTAACACTGCAGAAGACCTAAGGAGTCATAAGATTCCATCTCATGTAGAATACTGTATATTAATTATTTTTTACCAGATATTTTACAAA TACCTCACCTCATCCTGTATGTAATCAATAATGTATTATTTTAGGGTAGAACGACACAGAATATCAATATAAAAATATATTCAAGCCCTT GAAATTCTTGTGTCCTTTTTCTTTAGTTTCTGAATGAAAATCTTATTACTGGATGTACTATTGAATAAAAATTAATTGCAAAGACTTTGA TGGAGACAAAATCAAAATATACCACTGTTTATTTTGGCAGCACCTTCAAATTTCTAAGGACCAGATCCTGAATTTTGAGAATTTTTTGTT TCGTTGAGTTTTGAGTGTCTAGGATATAAGTTTATAAATGTTCTACAGTGCTTGTCTTTACTTCCTGTTTAGAAATCATTTAAATCTTTC CCCTCGAGGTGCTCTGGAAGAAGTTTAATTTCAGCTCTGAACAAGTAGAAATAACTGTGCTTCCTTGTATGGCTGCAATCATAAGACAGA ATTTCTGTGGTTGGCTACCGTGAAATCTTTGTATTTATATTGCATTGTTTTGTTAAAAAAAAAAAAATCCACAGAAGTAGAACCTAGGTT TGCTACTAACAAAGTAGTGGATTCTTATAATTAGGCTCAGGTAAAGTAAGAGAAAACTTCTCTCCCTGTGGCCCCCAGAGAAATGAAGTA GGATAGCAGATTACACTATTAGAAATAATAGACGTAACAAAAAAAATCCAGCCCATTATCCCCACCCCCCATTTTCCCTCTCAATATTAG AAATTTCAATAATATGCTGACAGATTTTCAAAGGTCACCAAGGCTTTTGTGTTTTTTTCCGGTCTGTGGGCCACAGTTAAAAGAACGGGT AACAGGTTCAGAGTTCTCTTGATACGTCCAAGCCTTAGTTTCCAGGAAAAAAGCTAGGCTCCTCACTGCAAATATTAACGCTTTATATAT TTACTCCATGGATGTTGGGGTAAGCACATATATCAATAGTTCATAGCTCTAGTTAAGGACAAAGTGGGTTGGGGGGTAGAAGGAGAATAC TAGAGAGGTTACGGTAGCAGGTGGCTGCAGAAAAGAATCTTTTGAATGGGATTCCTGTAACAGTGTTCAGTACCAATATTAAGTCTACTG TAAGTGGGGTCTGATATGGCTTACTGATACAGGCATGTGTAAAAAACTAAGTGTGATGGAGGAATGGGTGCTAAAAGCTCTTAACAGTTT TGTAGAGAAGCCCTGCAGCCGTGTTTACTATATATGACATGCCTGTTTCTTAGTTTGCATGCACAGTTTAAGGGGCACATGCAATATTGG TTTCATGTGCAGTAAAAATTAAAACACGGCTGAGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGCGAGGCCGAGGCGGGTGGATCA CGAGGTCGAGTTTGAGACCATTTTGGCCAGCATAGTGAAACCCCATCTCTACTAAAAAATACAAAAAGTTAGCTGGGCATGGTGGCAGGC ACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCGCC ATTGCACTCCAGCCCGGGCGACGGTGCAAGACTCTGTCTCAAAAAAAAAAAAAATTAAAACACTAGGTACGAAATTATCCCAGAATTATA CGCGAAAGTTGGTGTTCATGCTGGAAAACAGTTACGGTTATCTGTGCTCTTTCTAAAGCTCAACTAGACACTAAAACAGTTCTCTCCTTG AGACCGGAAGTGGGATGGGGGTGGGCAGGTGGAAGGGAAGAGGCTGGGGAGGAGCCTCTCATCTCATCTCATTTCAGCCTCAACAGTAAT TGAAACCCTATGCCTGGCCTGGAGTGGGTAGAGGTTAGGGTTAGAGTGCAGGATGGAGCAGCAGTCTGCAGACTTTCAGGTTGTGACGAT GTCATGAAATTCTGTGCTATTAAACATGGCTATGTCTGAGTCAGTCATTACGGTATTCCAAAGCCAAATTCAAGTGACTGTTTTTCTGAA TAGTATAAAAATCTAATTCCCTGTGCTTATCGGCTTCAACTGTGCTTACACAACGTTTGTTTCTAATTCGTACTCTTGCCTCTTGGTTTC TGTAGTTTTTCAACCCATTTCTGTCAGTGTTCTATAAATGCATACATTCGTTATTTAAGGAACCCTGCAGCAGACCTCGAATAAAATGTG ACTTGATGTTTGTTGCCACTTCCTCAACTTGGTTAGCAAATTCAAGTTTTGAAAGACGATTCGTCTCAGAGAAGTTGATCCTGAACCTCC ACGTCACATTTTAGTCGGTTGCTATTAGGTGGGTAATGCCTAATAACATGGGTTCCTCAAATCACAAAGGAGAATGCTCTCAAGTCCTCA TGTTAACTTTAGTAAGTCAGTTAACTTTACAGCAACTAAAGAGATCAATTAAAAAGAACCCTTAAGTCTGACTGTCCCAGGTAACTTTAC TTGCTGTACAGATAGTGCACAGATATGGATGAGGGCTGCACATGGCTGATTTGAAAACCCATGTGGGGCCGGGTGTGGTGGCTCACGCCT GTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACGAGGTTAGTTCAGGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTAC TAAAAATACGAAAATTAGCTGGGCTTGGTGGCAGATGCCTGTAATTCCTGCTACTCGGGAGGCTGAGGCAGAGAATTGCTTGAACCCGGG AGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACACAGTGAGACTCTCCTCAAAACAAAAAAAAAAGAAA GAAAACCCATGTGGGCCGCATGTGCACAGCCTGGGGCTGCTTTCCACAGGCCTGGATAATGATGTTTCTCTTCAAGGAGGCCTTTACTAA CCACAGGGAACCTAGCATCTGACTGTGTCCTTGGCAGACAGTGCATGTAGCCTGTAGAATGTTGGCTCCTCTGTCTATAGAAACCATCAG TTCGCTGCTCTCTCATTCATACATACTTTTTGAGTTCCCAGTAGGTACGAAGCTTTGTCTAAACATTATTTACCAACTGCGATTTTTACA GACTTCCCCTGTAAGAATTTTCTAAAAGAGCCTTTCTCCCTTACACAATTGAAACGTTTTCAAAGGTCATCAAGCCGGTTGCGTTTGGTC AGTCACGTGACCAATCAGAGCTGGTGAGTGAGCTGCTCCCTTAAATCTACCAAATTAGACTGACAGCATTTGGAATCTGCCTCACACATA AGAGATCCATATTCATTTAATAGTGAAGCCAGCCCAGAAGCATCCTCTTCTGTAAGCTGGATGGAGTCCCAGCTCTCTCTCCTTGTATAT AAGGAGACCACACCCTGTATATAAGGTTTTCTTGAGGTAGATGCAGCAATATTCCTGGGGTAAGATTCTATAATACTCCTGTATTGGCAA GTGGACTGGACCAACAGACACAGGCCTCAGCCACTGTCGCTAGGGACTGAAGGAGAGTTCATGGATTCTTACCCCCTAGTCATGAAAGCT ATTCTGGCCAGCCTTGAATCCATTTAATTTTGCCCACGAGAACCTTTCATGACAATTAACAAGACACTAGTTTCCCCATAAAAGTCCATT TTTAAATATATAGTATGCTAATTAGCAGTGTCTGTTGAATTGCCCTATCGGATAGCAGCCACCATGTGTGCTGACCACTCACGATTCAGA CTTACCTTGGAAAATATCACACTGACGATACAGTACTTTAGAATAAATTGCATATTGTATCAGGCTCCGAGACTAATTTGTACTGAACCC |
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FusionGenePPI for AAK1_KCMF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AAK1 | AP2M1, ATP13A2, APP, AP2A1, AP2B1, NTRK1, DYNLT1, XPO1, CLTB, CLTC, GAK, HSPA5, GTSE1, ANLN, CDH1, AP2S1, REPS1, RUNDC3A, RALBP1, PLEC, PPIP5K2, SEC24B, CCDC88A, EYA4, UBE2D2, LUZP1, URGCP, NUP88, DVL3, QSER1, WNK1 | KCMF1 | GRK5, VCP, SOX2, BYSL, EIF3L, FLNC, HDLBP, HERC1, IKBKG, PNO1, PSMC1, PSMC5, PSMD11, PSMD12, PSMD13, PSMD3, PSMD7, PSMD8, RPS13, TJP2, TXNL1, UBR4, UCHL5, WDR26, WIBG, KCMF1, UBE2D2, UBC, FIGF, TFDP3, ABHD10, SARS2, IDH2, CEP85, NIPSNAP3A, MRS2, TESPA1, POGLUT1, EDA, CHIA, CD96, CST9, RASSF9, RASSF10, UBE2A, UBE2B, NIPSNAP1, SSBP1, ACOT9, NUP188, OGT, NUP93, NUP214, PRCP, QARS, HSPB1, KRAS, MED20, XPO1, POU5F1, A1BG, FSTL4, C15orf27, VWA5A, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AAK1_KCMF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AAK1_KCMF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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