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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32976

FusionGeneSummary for SDHA_NBAS

check button Fusion gene summary
Fusion gene informationFusion gene name: SDHA_NBAS
Fusion gene ID: 32976
HgeneTgene
Gene symbol

SDHA

NBAS

Gene ID

6389

51594

Gene namesuccinate dehydrogenase complex flavoprotein subunit Aneuroblastoma amplified sequence
SynonymsCMD1GG|FP|PGL5|SDH1|SDH2|SDHFILFS2|NAG|SOPH
Cytomap

5p15.33

2p24.3

Type of geneprotein-codingprotein-coding
Descriptionsuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialflavoprotein subunit of complex IIsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein
Modification date2018052320180519
UniProtAcc

P31040

A2RRP1

Ensembl transtripts involved in fusion geneENST00000264932, ENST00000504309, 
ENST00000510361, ENST00000507522, 
ENST00000441750, ENST00000281513, 
Fusion gene scores* DoF score5 X 5 X 4=1008 X 9 X 3=216
# samples 59
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDHA [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSDHA

GO:0006105

succinate metabolic process

7550341

HgeneSDHA

GO:0022904

respiratory electron transport chain

7550341

HgeneSDHA

GO:0055114

oxidation-reduction process

7550341


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG490462SDHAchr5

238273

+NBASchr2

15647766

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264932ENST00000441750SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000264932ENST00000281513SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000504309ENST00000441750SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000504309ENST00000281513SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000510361ENST00000441750SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000510361ENST00000281513SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000507522ENST00000441750SDHAchr5

238273

+NBASchr2

15647766

-
intron-intronENST00000507522ENST00000281513SDHAchr5

238273

+NBASchr2

15647766

-

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FusionProtFeatures for SDHA_NBAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDHA

P31040

NBAS

A2RRP1

Flavoprotein (FP) subunit of succinate dehydrogenase(SDH) that is involved in complex II of the mitochondrial electrontransport chain and is responsible for transferring electrons fromsuccinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act asa tumor suppressor (PubMed:20484225).{ECO:0000269|PubMed:20484225, ECO:0000305|PubMed:24781757}. Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDHA_NBAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDHA_NBAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDHA_NBAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSDHAP31040DB09270UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SDHA_NBAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDHAC0023264Leigh Disease3CTD_human;ORPHANET;UNIPROT
HgeneSDHAC1855008Mitochondrial Complex II Deficiency2CTD_human;ORPHANET;UNIPROT
HgeneSDHAC0029408Degenerative polyarthritis1CTD_human
HgeneSDHAC0036341Schizophrenia1PSYGENET
HgeneSDHAC3279992PARAGANGLIOMAS 51UNIPROT
TgeneNBASC0038356Stomach Neoplasms1CTD_human
TgeneNBASC3541319SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY1ORPHANET;UNIPROT
TgeneNBASC3809651INFANTILE LIVER FAILURE SYNDROME 21ORPHANET;UNIPROT