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Fusion gene ID: 32976 |
FusionGeneSummary for SDHA_NBAS |
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Fusion gene information | Fusion gene name: SDHA_NBAS | Fusion gene ID: 32976 | Hgene | Tgene | Gene symbol | SDHA | NBAS | Gene ID | 6389 | 51594 |
Gene name | succinate dehydrogenase complex flavoprotein subunit A | neuroblastoma amplified sequence | |
Synonyms | CMD1GG|FP|PGL5|SDH1|SDH2|SDHF | ILFS2|NAG|SOPH | |
Cytomap | 5p15.33 | 2p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialflavoprotein subunit of complex IIsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp) | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P31040 | A2RRP1 | |
Ensembl transtripts involved in fusion gene | ENST00000264932, ENST00000504309, ENST00000510361, ENST00000507522, | ENST00000441750, ENST00000281513, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 8 X 9 X 3=216 |
# samples | 5 | 9 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SDHA [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SDHA | GO:0006105 | succinate metabolic process | 7550341 |
Hgene | SDHA | GO:0022904 | respiratory electron transport chain | 7550341 |
Hgene | SDHA | GO:0055114 | oxidation-reduction process | 7550341 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG490462 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000264932 | ENST00000441750 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000264932 | ENST00000281513 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000504309 | ENST00000441750 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000504309 | ENST00000281513 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000510361 | ENST00000441750 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000510361 | ENST00000281513 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000507522 | ENST00000441750 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
intron-intron | ENST00000507522 | ENST00000281513 | SDHA | chr5 | 238273 | + | NBAS | chr2 | 15647766 | - |
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FusionProtFeatures for SDHA_NBAS |
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Hgene | Tgene |
SDHA | NBAS |
Flavoprotein (FP) subunit of succinate dehydrogenase(SDH) that is involved in complex II of the mitochondrial electrontransport chain and is responsible for transferring electrons fromsuccinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act asa tumor suppressor (PubMed:20484225).{ECO:0000269|PubMed:20484225, ECO:0000305|PubMed:24781757}. | Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SDHA_NBAS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SDHA_NBAS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SDHA_NBAS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SDHA | P31040 | DB09270 | Ubidecarenone | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for SDHA_NBAS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SDHA | C0023264 | Leigh Disease | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | SDHA | C1855008 | Mitochondrial Complex II Deficiency | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | SDHA | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | SDHA | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | SDHA | C3279992 | PARAGANGLIOMAS 5 | 1 | UNIPROT |
Tgene | NBAS | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | NBAS | C3541319 | SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY | 1 | ORPHANET;UNIPROT |
Tgene | NBAS | C3809651 | INFANTILE LIVER FAILURE SYNDROME 2 | 1 | ORPHANET;UNIPROT |