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Fusion gene ID: 32971 |
FusionGeneSummary for SDHAF2_RIN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SDHAF2_RIN1 | Fusion gene ID: 32971 | Hgene | Tgene | Gene symbol | SDHAF2 | RIN1 | Gene ID | 54949 | 9610 |
| Gene name | succinate dehydrogenase complex assembly factor 2 | Ras and Rab interactor 1 | |
| Synonyms | C11orf79|PGL2|SDH5 | - | |
| Cytomap | 11q12.2 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | succinate dehydrogenase assembly factor 2, mitochondrialSDH assembly factor 2hSDH5succinate dehydrogenase subunit 5, mitochondrial | ras and Rab interactor 1ras inhibitor 1ras inhibitor JC99ras inhibitor RIN1ras interaction/interference protein 1 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q9NX18 | Q13671 | |
| Ensembl transtripts involved in fusion gene | ENST00000301761, ENST00000542074, ENST00000537782, ENST00000543265, ENST00000534878, | ENST00000311320, ENST00000424433, ENST00000530056, ENST00000524804, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SDHAF2 [Title/Abstract] AND RIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A06N-01A | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| TCGA | LD | BRCA | TCGA-A8-A06N-01A | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301761 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000301761 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000301761 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000301761 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-intron | ENST00000542074 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000537782 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-intron | ENST00000543265 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000534878 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000301761 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000542074 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000537782 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000543265 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000534878 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
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FusionProtFeatures for SDHAF2_RIN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SDHAF2 | RIN1 |
| Plays an essential role in the assembly of succinatedehydrogenase (SDH), an enzyme complex (also referred to asrespiratory complex II) that is a component of both thetricarboxylic acid (TCA) cycle and the mitochondrial electrontransport chain, and which couples the oxidation of succinate tofumarate with the reduction of ubiquinone (coenzyme Q) toubiquinol. Required for flavinylation (covalent attachment of FAD)of the flavoprotein subunit SDHA of the SDH catalytic dimer.{ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}. | Ras effector protein, which may serve as an inhibitorymodulator of neuronal plasticity in aversive memory formation. Canaffect Ras signaling at different levels. First, by competing withRAF1 protein for binding to activated Ras. Second, by enhancingsignaling from ABL1 and ABL2, which regulate cytoskeletalremodeling. Third, by activating RAB5A, possibly by functioning asa guanine nucleotide exchange factor (GEF) for RAB5A, byexchanging bound GDP for free GTP, and facilitating Ras-activatedreceptor endocytosis. {ECO:0000269|PubMed:15886098,ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RIN1 | chr11:61205585 | chr11:66101129 | ENST00000311320 | - | 6 | 10 | 624_706 | 530 | 784 | Domain | Ras-associating |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RIN1 | chr11:61205585 | chr11:66101129 | ENST00000311320 | - | 6 | 10 | 259_268 | 530 | 784 | Compositional bias | Note=Pro-rich |
| Tgene | RIN1 | chr11:61205585 | chr11:66101129 | ENST00000311320 | - | 6 | 10 | 456_598 | 530 | 784 | Domain | VPS9 |
| Tgene | RIN1 | chr11:61205585 | chr11:66101129 | ENST00000311320 | - | 6 | 10 | 69_163 | 530 | 784 | Domain | SH2 |
| Tgene | RIN1 | chr11:61205585 | chr11:66101129 | ENST00000311320 | - | 6 | 10 | 294_727 | 530 | 784 | Region | Note=Ras and 14-3-3 protein binding region |
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FusionGeneSequence for SDHAF2_RIN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_377aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYK EQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_304aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLQG >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_377aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYK EQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_377aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYK EQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_304aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLQG >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_377aa MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFA KEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLA LLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYK EQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_1131nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAG GAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCT GAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGG GATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCT >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_912nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTCCAGGGG AACCAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAGGGTCATTCGGGGCGGGAGACCCTGAGCCTGCTGAG >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_1131nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAG GAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCT GAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGG GATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCT >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_1131nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAG GAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCT GAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGG GATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCT >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_912nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTCCAGGGG AACCAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAGGGTCATTCGGGGCGGGAGACCCTGAGCCTGCTGAG >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_1131nt ATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCA TTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGAT GAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCT AAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTAC TGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTG GAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCC CTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGC CTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCC CCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAG GAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCT GAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGG GATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_1419nt CGTGGTCGGCTGGCCGGGCGGCTAGGAGTTCCCGGAAGTGCCCGCGCAGCCGGTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAG TGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACA GAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCA AAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGC ACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTACTGGGCCACAGGGGAGG GCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGT CGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGG GTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACT GCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTG CCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAGGAGCAGGGCTACCACC GCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCTGAGACCCAGGGGGCTG TGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGGGATGCTGGGGTCAAAG CCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCTGCTCAGCCAGGGGAAC CAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAGGGTCATTCGGGGCGGGAGACCCTGAGCCTGCTGAGAAA TCCTTTTAGCGCCAGCAAGCCCCACCCAGGGCCCTGTCCTGTGTCTGCCACCACCTTTGTCTGATACTTGTTTCCAGGGAAGCTGGGGGA >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_1114nt CGTGGTCGGCTGGCCGGGCGGCTAGGAGTTCCCGGAAGTGCCCGCGCAGCCGGTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAG TGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACA GAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCA AAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGC ACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTACTGGGCCACAGGGGAGG GCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGT CGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGG GTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACT GCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTG CCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTCCAGGGGAACCAGAGGCAGAGGG AAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAGGGTCATTCGGGGCGGGAGACCCTGAGCCTGCTGAGAAATCCTTTTAGCGCC AGCAAGCCCCACCCAGGGCCCTGTCCTGTGTCTGCCACCACCTTTGTCTGATACTTGTTTCCAGGGAAGCTGGGGGAACTGCCACATCTG >In-frame_SDHAF2_ENST00000301761_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_1258nt CGTGGTCGGCTGGCCGGGCGGCTAGGAGTTCCCGGAAGTGCCCGCGCAGCCGGTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAG TGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTCTCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACA GAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCCTCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCA AAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTGCATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGC ACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAGTAATGACTGGGATATTTACTACTGGGCCACAGGGGAGG GCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTGTGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGT CGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGACCAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGG GTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCTCAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACT GCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCACCTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTG CCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACACTTTTGGCCTCTTCCTGTACAAGGAGCAGGGCTACCACC GCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGTCTACCGCCGGGCGGAGTGGCCTGAGACCCAGGGGGCTG TGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGAGCAAGGGTGCCAGGGAGATGGGGATGCTGGGGTCAAAG CCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCAGGGTCAAGCCCAGGAAGGCCCTGCTCAGCCAGGGGAAC >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000311320_chr11_66101129_-_1367nt GTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTC TCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCC TCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTG CATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAG TAATGACTGGGATATTTACTACTGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTG TGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGAC CAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCT CAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCAC CTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACAC TTTTGGCCTCTTCCTGTACAAGGAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGT CTACCGCCGGGCGGAGTGGCCTGAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGA GCAAGGGTGCCAGGGAGATGGGGATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCA GGGTCAAGCCCAGGAAGGCCCTGCTCAGCCAGGGGAACCAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAG GGTCATTCGGGGCGGGAGACCCTGAGCCTGCTGAGAAATCCTTTTAGCGCCAGCAAGCCCCACCCAGGGCCCTGTCCTGTGTCTGCCACC ACCTTTGTCTGATACTTGTTTCCAGGGAAGCTGGGGGAACTGCCACATCTGAGGAACTGGAATAAAGATGAGGGGGCTTCGGGGGCCCCC >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000424433_chr11_66101129_-_1062nt GTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTC TCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCC TCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTG CATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAG TAATGACTGGGATATTTACTACTGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTG TGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGAC CAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCT CAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCAC CTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACAC TTTTGGCCTCTTCCTCCAGGGGAACCAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAGGGTCATTCGGGGC GGGAGACCCTGAGCCTGCTGAGAAATCCTTTTAGCGCCAGCAAGCCCCACCCAGGGCCCTGTCCTGTGTCTGCCACCACCTTTGTCTGAT >In-frame_SDHAF2_ENST00000537782_chr11_61205585_+_RIN1_ENST00000530056_chr11_66101129_-_1206nt GTTTCCGGTGCAGGTGGGGAAAATGGCGGTGTCTACAGTGTTCTCGACTTCGTCGCTGATGCTTGCTCTGTCAAGGCACAGCCTATTGTC TCCTTTGCTCAGTGTGACATCATTCAGACGCTTCTACAGAGGTGACAGCCCAACAGATTCCCAAAAGGACATGATTGAAATCCCTTTGCC TCCATGGCAGGAGAGAACTGATGAATCCATAGAAACCAAAAGAGCCCGCCTGCTCTATGAGAGCAGAAAGAGGGGAATGTTGGAAAACTG CATTCTTCTTAGTCTTTTTGCTAAAGAACATCTGCAGCACATGACAGAAAAGCAGCTGAACCTCTATGACCGCCTGATTAACGAGCCTAG TAATGACTGGGATATTTACTACTGGGCCACAGGGGAGGGCGCGGGTGCCGACGAGTTCCTGCCTCTGCTGAGCCTCGTCTTGGCCCACTG TGACCTTCCTGAGCTGCTGCTGGAGGCCGAGTACATGTCGGAGCTGCTGGAGCCCAGCCTGCTTACTGGAGAGGGTGGCTACTACCTGAC CAGCCTCTCTGCCAGCCTGGCCCTGCTGAGTGGCCTGGGTCAGGCCCACACCCTCCCACTGAGCCCCGTGCAGGAGCTACGGCGCTCCCT CAGCCTCTGGGAGCAGCGCCGCCTGCCTGCCACCCACTGCTTCCAGCACCTCCTCCGAGTAGCCTATCAGGATCCCAGCAGTGGCTGCAC CTCCAAGACCCTGGCCGTGCCCCCAGAAGCCTCGATTGCCACCCTGAACCAGCTCTGTGCCACCAAGTTCCGAGTGACCCAGCCCAACAC TTTTGGCCTCTTCCTGTACAAGGAGCAGGGCTACCACCGCCTGCCCCCTGGGGCCCTGGCCCACAGGCTGCCCACCACTGGCTACCTCGT CTACCGCCGGGCGGAGTGGCCTGAGACCCAGGGGGCTGTGACAGAGGAGGAGGGCAGTGGGCAGTCAGAGGCAAGAAGCAGAGGGGAGGA GCAAGGGTGCCAGGGAGATGGGGATGCTGGGGTCAAAGCCAGCCCCAGGGACATTCGGGAACAGTCTGAGACAACTGCTGAAGGGGGCCA GGGTCAAGCCCAGGAAGGCCCTGCTCAGCCAGGGGAACCAGAGGCAGAGGGAAGCCGGGCAGCAGAGGAGTAGCTTGAAGTGGCCAGAAG |
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FusionGenePPI for SDHAF2_RIN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SDHAF2 | IMMT, CCDC90B, EEF1A1, IKBKAP, RBM12, CTTN, OXCT1, COA7, VCL, UQCRFS1, UBXN7, CCNB1, PLAUR, PCMT1, SH3BGRL, SUMO2, SUCLG2, ABCA2, CTNNA2, HSPA8, HSPA9, RRM2, SDHA, SLC1A5, CORO2A, KLHDC2, NOL8, SSX2IP, CWF19L2, TRIM25 | RIN1 | HRAS, RAB5A, RAB5B, RALGDS, MLLT4, RRAS2, STAM2, EGFR, SMAD2, ERBB2, ERBB3, ABL2, CALCOCO2, LZTS2, ANKS1B, COMT, ZWINT, KRAS, ANKS1A, NRAS, RRAS, YWHAZ, ISCA1, YWHAE, YWHAG, YWHAH, ABL1, RAP2B, DPP8, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SDHAF2_RIN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SDHAF2_RIN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SDHAF2 | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
| Hgene | SDHAF2 | C1866552 | PARAGANGLIOMAS 2 (disorder) | 1 | CTD_human;UNIPROT |
| Tgene | RIN1 | C0025202 | melanoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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