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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32956

FusionGeneSummary for SDF2_ARHGAP44

check button Fusion gene summary
Fusion gene informationFusion gene name: SDF2_ARHGAP44
Fusion gene ID: 32956
HgeneTgene
Gene symbol

SDF2

ARHGAP44

Gene ID

6388

9912

Gene namestromal cell derived factor 2Rho GTPase activating protein 44
Synonyms-NPC-A-10|RICH2
Cytomap

17q11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionstromal cell-derived factor 2SDF-2rho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2
Modification date2018052320180523
UniProtAcc

Q99470

Q17R89

Ensembl transtripts involved in fusion geneENST00000247020, ENST00000592250, 
ENST00000379672, ENST00000340825, 
ENST00000262444, ENST00000578087, 
Fusion gene scores* DoF score4 X 3 X 2=244 X 4 X 4=64
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDF2 [Title/Abstract] AND ARHGAP44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-93-8067-01ASDF2chr17

26989064

-ARHGAP44chr17

12832246

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000247020ENST00000379672SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
intron-3CDSENST00000247020ENST00000340825SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
intron-3CDSENST00000247020ENST00000262444SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
intron-intronENST00000247020ENST00000578087SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
5UTR-3CDSENST00000592250ENST00000379672SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
5UTR-3CDSENST00000592250ENST00000340825SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
5UTR-3CDSENST00000592250ENST00000262444SDF2chr17

26989064

-ARHGAP44chr17

12832246

+
5UTR-intronENST00000592250ENST00000578087SDF2chr17

26989064

-ARHGAP44chr17

12832246

+

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FusionProtFeatures for SDF2_ARHGAP44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDF2

Q99470

ARHGAP44

Q17R89

GTPase-activating protein (GAP) that stimulates theGTPase activity of Rho-type GTPases. Thereby, controls Rho-typeGTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomalrecycling protein which, in association with SHANK3, is involvedin synaptic plasticity. Promotes GRIA1 exocytosis from recyclingendosomes and spine morphological changes associated to long-termpotentiation. {ECO:0000269|PubMed:11431473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDF2_ARHGAP44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDF2_ARHGAP44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDF2DMWD, HNRNPD, EGFR, PVRL3, DNAJB11, C11orf54, HSPB2, ALS2, PSG1, HSPA5, PTPRO, UBCARHGAP44HN1, CDC42, RAC1, TRIP10, TIPRL, ARHGAP17, FNBP1L, SH3BP1, SH3KBP1, CD2AP, CASP5, PPP3CC, WDTC1, VPS26A, SLC9A3R2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDF2_ARHGAP44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDF2_ARHGAP44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource