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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 3293

FusionGeneSummary for ATP1A1_CSN2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1A1_CSN2
Fusion gene ID: 3293
HgeneTgene
Gene symbol

ATP1A1

CSN2

Gene ID

480

9318

Gene nameATPase Na+/K+ transporting subunit alpha 4COP9 signalosome subunit 2
SynonymsATP1A1|ATP1AL2ALIEN|CSN2|SGN2|TRIP15
Cytomap

1q23.2

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase suCOP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15
Modification date2018052320180523
UniProtAcc

P05023

P05814

Ensembl transtripts involved in fusion geneENST00000295598, ENST00000537345, 
ENST00000369496, ENST00000491156, 
ENST00000353151, 
Fusion gene scores* DoF score15 X 20 X 7=210014 X 11 X 2=308
# samples 253
** MAII scorelog2(25/2100*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/308*10)=-3.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP1A1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

HgeneATP1A1

GO:0030641

regulation of cellular pH

12112599

TgeneCSN2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A1KO-01AATP1A1chr1

116931334

+CSN2chr4

70823366

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295598ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
In-frameENST00000537345ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
In-frameENST00000369496ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-
intron-3CDSENST00000491156ENST00000353151ATP1A1chr1

116931334

+CSN2chr4

70823366

-

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FusionProtFeatures for ATP1A1_CSN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A1

P05023

CSN2

P05814

Important role in determination of the surfaceproperties of the casein micelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+12382_84-841024RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+12382_84-89993RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+12382_84-1211024RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+1231007_1023-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123109_131-841024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123153_288-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123309_320-841024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123339_772-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+1236_87-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123793_802-841024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123824_843-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123867_918-841024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123939_951-841024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123971_985-841024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+1231007_1023-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123109_131-89993Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123153_288-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123309_320-89993Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123339_772-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+1236_87-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123793_802-89993Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123824_843-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123867_918-89993Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123939_951-89993Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123971_985-89993Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+1231007_1023-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123109_131-1211024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123153_288-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123309_320-1211024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123339_772-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+1236_87-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123793_802-1211024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123824_843-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123867_918-1211024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123939_951-1211024Topological domainCytoplasmic
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123971_985-1211024Topological domainExtracellular
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123132_152-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123289_308-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123321_338-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123773_792-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123803_823-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123844_866-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+12388_108-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123919_938-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123952_970-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000295598+123986_1006-841024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123132_152-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123289_308-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123321_338-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123773_792-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123803_823-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123844_866-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+12388_108-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123919_938-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123952_970-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000369496+123986_1006-89993TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123132_152-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123289_308-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123321_338-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123773_792-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123803_823-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123844_866-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+12388_108-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123919_938-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123952_970-1211024TransmembraneHelical
HgeneATP1A1chr1:116931334chr4:70823366ENST00000537345+123986_1006-1211024TransmembraneHelical


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FusionGeneSequence for ATP1A1_CSN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATP1A1_ENST00000295598_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_212aa
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWI
KFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI

>In-frame_ATP1A1_ENST00000537345_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_212aa
MAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWI
KFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI

>In-frame_ATP1A1_ENST00000369496_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_181aa
MDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAAT
EEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATP1A1_ENST00000295598_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_636nt
ATGGGGAAGGGGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGG
GACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC
CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATC
AAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT
ACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAA
GAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATA
AATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGC

>In-frame_ATP1A1_ENST00000537345_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_636nt
ATGGCCTTTAAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGG
GACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC
CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATC
AAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT
ACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAA
GAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATA
AATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGC

>In-frame_ATP1A1_ENST00000369496_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_543nt
ATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGG
GGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAG
TTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACA
GAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAA
GCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAAT
GCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATP1A1_ENST00000295598_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_3033nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTC
AGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACT
TAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGG
TCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGAT
TGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCT
ATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCC
TCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGG
AGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCTGCAAGGATGAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACA
GCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAGCCTGCTGTGGTGCTGCC
TGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCCTTAAATCTCCAAC
GATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGCCCTTGATGCAGCA
GGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGCCTATCCCCCAGCA
AGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCC
TGTGACTCAGCCACTTGCCCCAGTTCATAACCCCATTAGTGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTATTTTTGGAATCTAT
TACAGAATACAAGGTAAATTTTCACATTTAAAATGTACACATTTTCAAAATTTCCTCCTTTTAATCTTTACAGATGGTAACATATCTTTA
TATATGATATATCTTTAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGTAATTTGTTAATGATAAGTATATGTT
TAAAATTATTATAAAGTATAATACATACAAAAATATTTATAATGTGTATGTTGATTCTAAAGAATGATAATAAAATAAATGCCATATACC
CACCAACCACTTTAAAAATTAAACATTGATAAAGTCAATATATTTTCTAGGATATGCATGCATTTTTAAACTCATAATTAATTTCTAGAA
TACAGACTAAATACATAATGATATTACTAATGGTATATCTGTTTTCAACAAGTACACATTGGTGGGAACATTTCCAGGTTGGGAACTATG
ATCCTCTTATTTCCAAGGTGGATATGGTAATGAAAAGGTGTATACGGCTGGTAAAAAAACCTATGTAAAATTTGTCCCATATTGCCTTTA
TTCCCATATGGACAACACAAAATCCTGTATTTCATTAAATTACATTTATGGTGATATGTTTACCCAATTATAATTTTCAATTGCTTTGTG
TACCAATGAATTGTTTGGAGTCACATAAAATATTTCTAAAATCAAATTTAAACAAAAAAATTGATGTCTCTTGAAAGACTCAAGAGACTA
TCTTCTCCCAAGGGAAGGAATGTAAGAATTTGGCCGGTGTTAAATTACTTCCTGAGATTAGCCACAAATTAAGACTGATTTTCTTTTTCA
TCAAACCAAAACAAAACAAAAATAAACCTTGGAATTGTCCCTCTAAGTCTTTTTAAACTGATCTCTTTTCACTGTATGAAAACAATTTGG
TCTACTATTGGCACAACTGTGTTGAAAAGTAAATTCTCTCTGAAGACCAAAGTGTACAGCTACAGCTATCCAGGCAATTCAGGAAAATGT
TAAAAAAAGTGTTTCTGAAATATCCAAACATTGATTTCACTTTGGCCTGTGGAGTTACCCATGAAGTGAGTGGATTAAAATTTTTCAACA
AACAGTTTACTCATTTTTCTTCGCATGACTCAAGATACTTTCTTAACCAAAATAAGTGAAATATTTTCTCCTCTCTTTTTACTCATTTAT
CATTGTCTAAAAGAGAGAAATGAATTCATTATGAATGGCAATTATAGCTTAATCAAGGACTCAAAGATTCTTTTTCCTTCTTTCCAGGAT
GAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAA

>In-frame_ATP1A1_ENST00000537345_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_3033nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTC
AGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACT
TAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGG
TCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGAT
TGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCT
ATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCC
TCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGG
AGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCTGCAAGGATGAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACA
GCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAGCCTGCTGTGGTGCTGCC
TGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCCTTAAATCTCCAAC
GATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGCCCTTGATGCAGCA
GGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGCCTATCCCCCAGCA
AGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCC
TGTGACTCAGCCACTTGCCCCAGTTCATAACCCCATTAGTGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTATTTTTGGAATCTAT
TACAGAATACAAGGTAAATTTTCACATTTAAAATGTACACATTTTCAAAATTTCCTCCTTTTAATCTTTACAGATGGTAACATATCTTTA
TATATGATATATCTTTAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGTAATTTGTTAATGATAAGTATATGTT
TAAAATTATTATAAAGTATAATACATACAAAAATATTTATAATGTGTATGTTGATTCTAAAGAATGATAATAAAATAAATGCCATATACC
CACCAACCACTTTAAAAATTAAACATTGATAAAGTCAATATATTTTCTAGGATATGCATGCATTTTTAAACTCATAATTAATTTCTAGAA
TACAGACTAAATACATAATGATATTACTAATGGTATATCTGTTTTCAACAAGTACACATTGGTGGGAACATTTCCAGGTTGGGAACTATG
ATCCTCTTATTTCCAAGGTGGATATGGTAATGAAAAGGTGTATACGGCTGGTAAAAAAACCTATGTAAAATTTGTCCCATATTGCCTTTA
TTCCCATATGGACAACACAAAATCCTGTATTTCATTAAATTACATTTATGGTGATATGTTTACCCAATTATAATTTTCAATTGCTTTGTG
TACCAATGAATTGTTTGGAGTCACATAAAATATTTCTAAAATCAAATTTAAACAAAAAAATTGATGTCTCTTGAAAGACTCAAGAGACTA
TCTTCTCCCAAGGGAAGGAATGTAAGAATTTGGCCGGTGTTAAATTACTTCCTGAGATTAGCCACAAATTAAGACTGATTTTCTTTTTCA
TCAAACCAAAACAAAACAAAAATAAACCTTGGAATTGTCCCTCTAAGTCTTTTTAAACTGATCTCTTTTCACTGTATGAAAACAATTTGG
TCTACTATTGGCACAACTGTGTTGAAAAGTAAATTCTCTCTGAAGACCAAAGTGTACAGCTACAGCTATCCAGGCAATTCAGGAAAATGT
TAAAAAAAGTGTTTCTGAAATATCCAAACATTGATTTCACTTTGGCCTGTGGAGTTACCCATGAAGTGAGTGGATTAAAATTTTTCAACA
AACAGTTTACTCATTTTTCTTCGCATGACTCAAGATACTTTCTTAACCAAAATAAGTGAAATATTTTCTCCTCTCTTTTTACTCATTTAT
CATTGTCTAAAAGAGAGAAATGAATTCATTATGAATGGCAATTATAGCTTAATCAAGGACTCAAAGATTCTTTTTCCTTCTTTCCAGGAT
GAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAA

>In-frame_ATP1A1_ENST00000369496_chr1_116931334_+_CSN2_ENST00000353151_chr4_70823366_-_3033nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTC
AGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACT
TAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGG
TCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGAT
TGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCT
ATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCC
TCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGG
AGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCTGCAAGGATGAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACA
GCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAAAACATTCTGCCTCTTGCTCAGCCTGCTGTGGTGCTGCC
TGTCCCTCAGCCTGAAATAATGGAAGTCCCTAAAGCTAAAGACACTGTCTACACTAAGGGCAGAGTGATGCCTGTCCTTAAATCTCCAAC
GATACCCTTTTTTGACCCTCAAATCCCAAAACTCACTGATCTTGAAAATCTGCATCTTCCTCTGCCTCTGCTCCAGCCCTTGATGCAGCA
GGTCCCTCAGCCTATTCCTCAGACTCTTGCACTTCCCCCTCAGCCCCTGTGGTCTGTTCCTCAGCCCAAAGTCCTGCCTATCCCCCAGCA
AGTGGTGCCCTACCCTCAGAGAGCTGTGCCTGTTCAAGCCCTTCTGCTCAACCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCC
TGTGACTCAGCCACTTGCCCCAGTTCATAACCCCATTAGTGTCTAAGAAGATTTCAAAGTTAATTTTCCCTCCTTATTTTTGGAATCTAT
TACAGAATACAAGGTAAATTTTCACATTTAAAATGTACACATTTTCAAAATTTCCTCCTTTTAATCTTTACAGATGGTAACATATCTTTA
TATATGATATATCTTTAGCAGAAAGTTGAGAAGGTTAAACATGAGGACCAGCAGCAAGGAGAGGTAATTTGTTAATGATAAGTATATGTT
TAAAATTATTATAAAGTATAATACATACAAAAATATTTATAATGTGTATGTTGATTCTAAAGAATGATAATAAAATAAATGCCATATACC
CACCAACCACTTTAAAAATTAAACATTGATAAAGTCAATATATTTTCTAGGATATGCATGCATTTTTAAACTCATAATTAATTTCTAGAA
TACAGACTAAATACATAATGATATTACTAATGGTATATCTGTTTTCAACAAGTACACATTGGTGGGAACATTTCCAGGTTGGGAACTATG
ATCCTCTTATTTCCAAGGTGGATATGGTAATGAAAAGGTGTATACGGCTGGTAAAAAAACCTATGTAAAATTTGTCCCATATTGCCTTTA
TTCCCATATGGACAACACAAAATCCTGTATTTCATTAAATTACATTTATGGTGATATGTTTACCCAATTATAATTTTCAATTGCTTTGTG
TACCAATGAATTGTTTGGAGTCACATAAAATATTTCTAAAATCAAATTTAAACAAAAAAATTGATGTCTCTTGAAAGACTCAAGAGACTA
TCTTCTCCCAAGGGAAGGAATGTAAGAATTTGGCCGGTGTTAAATTACTTCCTGAGATTAGCCACAAATTAAGACTGATTTTCTTTTTCA
TCAAACCAAAACAAAACAAAAATAAACCTTGGAATTGTCCCTCTAAGTCTTTTTAAACTGATCTCTTTTCACTGTATGAAAACAATTTGG
TCTACTATTGGCACAACTGTGTTGAAAAGTAAATTCTCTCTGAAGACCAAAGTGTACAGCTACAGCTATCCAGGCAATTCAGGAAAATGT
TAAAAAAAGTGTTTCTGAAATATCCAAACATTGATTTCACTTTGGCCTGTGGAGTTACCCATGAAGTGAGTGGATTAAAATTTTTCAACA
AACAGTTTACTCATTTTTCTTCGCATGACTCAAGATACTTTCTTAACCAAAATAAGTGAAATATTTTCTCCTCTCTTTTTACTCATTTAT
CATTGTCTAAAAGAGAGAAATGAATTCATTATGAATGGCAATTATAGCTTAATCAAGGACTCAAAGATTCTTTTTCCTTCTTTCCAGGAT
GAACACCAGGATAAAATCTACCCCTCTTTCCAGCCACAGCCTCTGATCTATCCATTCGTTGAACCTATCCCCTATGGTTTTCTTCCACAA


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FusionGenePPI for ATP1A1_CSN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP1A1PRKCA, MAPK1, MAPK3, FXYD1, EZH2, HGS, HDAC5, NDRG1, CDK9, NELFB, NELFCD, NELFA, SIRT7, FBXO25, CUL3, CDK2, AKT1, A2M, PKD1, PKD2, ATF2, IQCB1, MMS19, CLN3, ADRB2, ATP4A, DYRK4, HIPK4, MAPK4, CDK20, EGFR, FBXO6, LGR4, UBC, STAU1, SPRTN, HUWE1, AP2A2, CUL7, CCDC8, ZNRF1, ZNRF2, ILK, IRAK1, LIMK2, PPT1, RPS6KB2, LGALS3, ACADM, AFG3L2, ATP1B1, ATP1B2, ATP1B3, ATP2B1, ATP2B4, ATP6V0D1, CCT6A, CCT8, CLTC, CLTCL1, HADHB, HSD17B12, LMAN1, MTCH1, MTCH2, NDUFS1, PPP2R1A, RAB1A, RAB1B, RAB2A, TPM3, ATP5C1, ATP5L, ATP6V1A, CAD, CCT7, CYB5B, CYC1, DDOST, EIF3B, IPO5, ITGA5, MRPL40, NDUFB8, NDUFS4, NDUFV1, PC, PHB, RPN1, SLC25A3, SSR2, TECR, TMCO1, TMED2, TPM4, UQCRC2, UQCRQ, VDAC1, VDAC2, VDAC3, NTRK1, TCTN3, TMEM17, AHSA1, ERBB2, NCSTN, GOLT1B, TMEM63B, YIPF5, TUBA1C, MBOAT1, KIAA0368, SKI, CRY2, ESRRB, C3orf17, ZNF746, CYLD, NCDN, COX15, PDHA1, SDHA, SOD1CSN2CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP1A1_CSN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATP1A1P05023DB00390DigoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB00511AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01078DeslanosideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01119DiazoxideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01430AlmitrineSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB00774HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01345PotassiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01370AluminiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01396DigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01378MagnesiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|nutraceutical
HgeneATP1A1P05023DB01021TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|vet_approved
HgeneATP1A1P05023DB01244BepridilSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|withdrawn

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RelatedDiseases for ATP1A1_CSN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP1A1C0001430Adenoma2CTD_human
HgeneATP1A1C0005586Bipolar Disorder1PSYGENET
HgeneATP1A1C0020428Hyperaldosteronism1CTD_human
HgeneATP1A1C0020538Hypertensive disease1CTD_human
HgeneATP1A1C0042594Vestibular Diseases1CTD_human
HgeneATP1A1C0151744Myocardial Ischemia1CTD_human
TgeneCSN2C0024667Animal Mammary Neoplasms2CTD_human
TgeneCSN2C0024668Mammary Neoplasms, Experimental2CTD_human