![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 32923 |
FusionGeneSummary for SDC1_PRRC2B |
![]() |
Fusion gene information | Fusion gene name: SDC1_PRRC2B | Fusion gene ID: 32923 | Hgene | Tgene | Gene symbol | SDC1 | PRRC2B | Gene ID | 6382 | 84726 |
Gene name | syndecan 1 | proline rich coiled-coil 2B | |
Synonyms | CD138|SDC|SYND1|syndecan | BAT2L|BAT2L1|KIAA0515|LQFBS-1 | |
Cytomap | 2p24.1 | 9q34.13 | |
Type of gene | protein-coding | protein-coding | |
Description | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | protein PRRC2BHLA-B associated transcript 2-likeHLA-B-associated transcript 2-like 1proline-rich coiled-coil protein 2Bprotein BAT2-like 1 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P18827 | Q5JSZ5 | |
Ensembl transtripts involved in fusion gene | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | ENST00000405995, ENST00000357304, ENST00000458550, ENST00000372249, ENST00000465931, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 8 X 3=144 |
# samples | 4 | 9 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SDC1 [Title/Abstract] AND PRRC2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA368147 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000254351 | ENST00000405995 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000254351 | ENST00000357304 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000254351 | ENST00000458550 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000254351 | ENST00000372249 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000254351 | ENST00000465931 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000381150 | ENST00000405995 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000381150 | ENST00000357304 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000381150 | ENST00000458550 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000381150 | ENST00000372249 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000381150 | ENST00000465931 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000403076 | ENST00000405995 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000403076 | ENST00000357304 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000403076 | ENST00000458550 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000403076 | ENST00000372249 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000403076 | ENST00000465931 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000482879 | ENST00000405995 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000482879 | ENST00000357304 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000482879 | ENST00000458550 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-intron | ENST00000482879 | ENST00000372249 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
intron-3UTR | ENST00000482879 | ENST00000465931 | SDC1 | chr2 | 20401808 | + | PRRC2B | chr9 | 134374752 | + |
Top |
FusionProtFeatures for SDC1_PRRC2B |
![]() |
Hgene | Tgene |
SDC1 | PRRC2B |
Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SDC1_PRRC2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SDC1_PRRC2B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SDC1_PRRC2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SDC1_PRRC2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |