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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32922

FusionGeneSummary for SDC1_PROS1

check button Fusion gene summary
Fusion gene informationFusion gene name: SDC1_PROS1
Fusion gene ID: 32922
HgeneTgene
Gene symbol

SDC1

PROS1

Gene ID

6382

5627

Gene namesyndecan 1protein S
SynonymsCD138|SDC|SYND1|syndecanPROS|PS21|PS22|PS23|PS24|PS25|PSA|THPH5|THPH6
Cytomap

2p24.1

3q11.1

Type of geneprotein-codingprotein-coding
Descriptionsyndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1vitamin K-dependent protein Sprotein S (alpha)protein Savitamin K-dependent plasma protein S
Modification date2018052720180522
UniProtAcc

P18827

P07225

Ensembl transtripts involved in fusion geneENST00000254351, ENST00000381150, 
ENST00000403076, ENST00000482879, 
ENST00000394236, ENST00000407433, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 2 X 3=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SDC1 [Title/Abstract] AND PROS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE185151SDC1chr2

20402069

+PROS1chr3

93628822

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000254351ENST00000394236SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000254351ENST00000407433SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000381150ENST00000394236SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000381150ENST00000407433SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000403076ENST00000394236SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000403076ENST00000407433SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000482879ENST00000394236SDC1chr2

20402069

+PROS1chr3

93628822

+
intron-intronENST00000482879ENST00000407433SDC1chr2

20402069

+PROS1chr3

93628822

+

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FusionProtFeatures for SDC1_PROS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDC1

P18827

PROS1

P07225

Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. Anticoagulant plasma protein; it is a cofactor toactivated protein C in the degradation of coagulation factors Vaand VIIIa. It helps to prevent coagulation and stimulatingfibrinolysis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDC1_PROS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDC1_PROS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDC1_PROS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePROS1P07225DB00464Sodium Tetradecyl SulfateVitamin K-dependent protein Ssmall moleculeapproved|investigational
TgenePROS1P07225DB00055Drotrecogin alfaVitamin K-dependent protein Sbiotechapproved|investigational|withdrawn
TgenePROS1P07225DB00170MenadioneVitamin K-dependent protein Ssmall moleculeapproved|nutraceutical

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RelatedDiseases for SDC1_PROS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDC1C0345967Malignant mesothelioma1CTD_human
TgenePROS1C3278211THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT26CTD_human;UNIPROT
TgenePROS1C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgenePROS1C0040038Thromboembolism1CTD_human
TgenePROS1C0040053Thrombosis1CTD_human
TgenePROS1C0338575Sagittal Sinus Thrombosis1CTD_human
TgenePROS1C0600433Activated Protein C Resistance1CTD_human
TgenePROS1C3281092THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE1UNIPROT
TgenePROS1C3495559Juvenile arthritis1CTD_human