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Fusion gene ID: 32922 |
FusionGeneSummary for SDC1_PROS1 |
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Fusion gene information | Fusion gene name: SDC1_PROS1 | Fusion gene ID: 32922 | Hgene | Tgene | Gene symbol | SDC1 | PROS1 | Gene ID | 6382 | 5627 |
Gene name | syndecan 1 | protein S | |
Synonyms | CD138|SDC|SYND1|syndecan | PROS|PS21|PS22|PS23|PS24|PS25|PSA|THPH5|THPH6 | |
Cytomap | 2p24.1 | 3q11.1 | |
Type of gene | protein-coding | protein-coding | |
Description | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | vitamin K-dependent protein Sprotein S (alpha)protein Savitamin K-dependent plasma protein S | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | P18827 | P07225 | |
Ensembl transtripts involved in fusion gene | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | ENST00000394236, ENST00000407433, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 2 X 3=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SDC1 [Title/Abstract] AND PROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE185151 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000254351 | ENST00000394236 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000254351 | ENST00000407433 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000381150 | ENST00000394236 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000381150 | ENST00000407433 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000403076 | ENST00000394236 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000403076 | ENST00000407433 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000482879 | ENST00000394236 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
intron-intron | ENST00000482879 | ENST00000407433 | SDC1 | chr2 | 20402069 | + | PROS1 | chr3 | 93628822 | + |
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FusionProtFeatures for SDC1_PROS1 |
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Hgene | Tgene |
SDC1 | PROS1 |
Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. | Anticoagulant plasma protein; it is a cofactor toactivated protein C in the degradation of coagulation factors Vaand VIIIa. It helps to prevent coagulation and stimulatingfibrinolysis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SDC1_PROS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SDC1_PROS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SDC1_PROS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PROS1 | P07225 | DB00464 | Sodium Tetradecyl Sulfate | Vitamin K-dependent protein S | small molecule | approved|investigational |
Tgene | PROS1 | P07225 | DB00055 | Drotrecogin alfa | Vitamin K-dependent protein S | biotech | approved|investigational|withdrawn |
Tgene | PROS1 | P07225 | DB00170 | Menadione | Vitamin K-dependent protein S | small molecule | approved|nutraceutical |
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RelatedDiseases for SDC1_PROS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | PROS1 | C3278211 | THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT | 26 | CTD_human;UNIPROT |
Tgene | PROS1 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Tgene | PROS1 | C0040038 | Thromboembolism | 1 | CTD_human |
Tgene | PROS1 | C0040053 | Thrombosis | 1 | CTD_human |
Tgene | PROS1 | C0338575 | Sagittal Sinus Thrombosis | 1 | CTD_human |
Tgene | PROS1 | C0600433 | Activated Protein C Resistance | 1 | CTD_human |
Tgene | PROS1 | C3281092 | THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE | 1 | UNIPROT |
Tgene | PROS1 | C3495559 | Juvenile arthritis | 1 | CTD_human |