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Fusion gene ID: 32921 |
FusionGeneSummary for SDC1_PLAT |
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Fusion gene information | Fusion gene name: SDC1_PLAT | Fusion gene ID: 32921 | Hgene | Tgene | Gene symbol | SDC1 | PLAT | Gene ID | 6382 | 5327 |
Gene name | syndecan 1 | plasminogen activator, tissue type | |
Synonyms | CD138|SDC|SYND1|syndecan | T-PA|TPA | |
Cytomap | 2p24.1 | 8p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | tissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P18827 | P00750 | |
Ensembl transtripts involved in fusion gene | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | ENST00000270189, ENST00000429089, ENST00000220809, ENST00000352041, ENST00000519510, ENST00000429710, ENST00000524009, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 27 X 5 X 11=1485 |
# samples | 4 | 26 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/1485*10)=-2.51387940265967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SDC1 [Title/Abstract] AND PLAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLAT | GO:0031639 | plasminogen activation | 12694198|17849409|24196407 |
Tgene | PLAT | GO:0045861 | negative regulation of proteolysis | 1695900 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-IR-A3LC-01A | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000254351 | ENST00000270189 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000429089 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000220809 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000352041 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000519510 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000429710 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000254351 | ENST00000524009 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000270189 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000429089 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000220809 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000352041 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000519510 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000429710 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000381150 | ENST00000524009 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000270189 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000429089 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000220809 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000352041 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000519510 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000429710 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000403076 | ENST00000524009 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000270189 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000429089 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000220809 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000352041 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000519510 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000429710 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000482879 | ENST00000524009 | SDC1 | chr2 | 20400560 | - | PLAT | chr8 | 42051245 | - |
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FusionProtFeatures for SDC1_PLAT |
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Hgene | Tgene |
SDC1 | PLAT |
Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SDC1_PLAT |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SDC1_PLAT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SDC1 | LACRT, FGF2, CCL5, CXCL8, HGF, CASK, SDCBP, CTSG, APP, AHCY, ZNF593, BAG3, CD63, PTEN, EP300, FARP1, DHRS2, GMEB2, PRDM10, CYHR1, EPHA2, CSNK1G3, OCLN, HMGCS1, CCNY, EFR3A, PTPRG, ARVCF, AMPD2, RAP2A, RFTN1, PARP2, EEPD1, GNAZ, VANGL1, RRAS, GNB4, GMEB1, FBXO46, FTO, CSNK1G2, AHNAK, PRRC1, CTH, HRAS, NCAM1 | PLAT | CLEC3B, CALR, PLAU, KRT8, ANXA2, SERPINI1, SERPINA5, F2, SERPINE1, FGA, LRP1, HMGB1, F10, FN1, LAMA1, TERF2, POT1, PDGFC, FGL1, DCN, TMEM25, PTPRK, IFNA14, LAMA3, SERPINB2, SERPING1, SERPINA10, PLA2G10, SERPINB6, SERPINE2, IGFBP1, DEFA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SDC1_PLAT |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PLAT | P00750 | DB01050 | Ibuprofen | Tissue-type plasminogen activator | small molecule | approved |
Tgene | PLAT | P00750 | DB06404 | Human C1-esterase inhibitor | Tissue-type plasminogen activator | biotech | approved |
Tgene | PLAT | P00750 | DB00513 | Aminocaproic Acid | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB01088 | Iloprost | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB09213 | Dexibuprofen | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB09228 | Conestat alfa | Tissue-type plasminogen activator | biotech | approved|investigational |
Tgene | PLAT | P00750 | DB00013 | Urokinase | Tissue-type plasminogen activator | biotech | approved|investigational|withdrawn |
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RelatedDiseases for SDC1_PLAT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | PLAT | C0038454 | Cerebrovascular accident | 59 | CTD_human |
Tgene | PLAT | C0027051 | Myocardial Infarction | 35 | CTD_human |
Tgene | PLAT | C0007786 | Brain Ischemia | 25 | CTD_human |
Tgene | PLAT | C2937358 | Cerebral Hemorrhage | 21 | CTD_human |
Tgene | PLAT | C0151699 | Intracranial Hemorrhages | 14 | CTD_human |
Tgene | PLAT | C0034065 | Pulmonary Embolism | 9 | CTD_human |
Tgene | PLAT | C0019080 | Hemorrhage | 8 | CTD_human |
Tgene | PLAT | C0007785 | Cerebral Infarction | 6 | CTD_human |
Tgene | PLAT | C0040053 | Thrombosis | 4 | CTD_human |
Tgene | PLAT | C0740392 | Infarction, Middle Cerebral Artery | 4 | CTD_human |
Tgene | PLAT | C0002994 | Angioedema | 3 | CTD_human |
Tgene | PLAT | C0010072 | Coronary Thrombosis | 3 | CTD_human |
Tgene | PLAT | C0042487 | Venous Thrombosis | 3 | CTD_human |
Tgene | PLAT | C0007781 | Intracranial Embolism and Thrombosis | 2 | CTD_human |
Tgene | PLAT | C0877172 | Hematoma, Epidural, Spinal | 2 | CTD_human |
Tgene | PLAT | C0001125 | Acidosis, Lactic | 1 | CTD_human |
Tgene | PLAT | C0001883 | Airway Obstruction | 1 | CTD_human |
Tgene | PLAT | C0003537 | Aphasia | 1 | CTD_human |
Tgene | PLAT | C0003838 | Arterial Occlusive Diseases | 1 | CTD_human |
Tgene | PLAT | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | PLAT | C0004604 | Back Pain | 1 | CTD_human |
Tgene | PLAT | C0004610 | Bacteremia | 1 | CTD_human |
Tgene | PLAT | C0007177 | Cardiac Tamponade | 1 | CTD_human |
Tgene | PLAT | C0013922 | Embolism | 1 | CTD_human |
Tgene | PLAT | C0018801 | Heart failure | 1 | CTD_human |
Tgene | PLAT | C0018946 | Hematoma, Subdural | 1 | CTD_human |
Tgene | PLAT | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | PLAT | C0020649 | Hypotension | 1 | CTD_human |
Tgene | PLAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PLAT | C0024031 | Low Back Pain | 1 | CTD_human |
Tgene | PLAT | C0025309 | Meningoencephalitis | 1 | CTD_human |
Tgene | PLAT | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | PLAT | C0030552 | Paresis | 1 | CTD_human |
Tgene | PLAT | C0031039 | Pericardial effusion | 1 | CTD_human |
Tgene | PLAT | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | PLAT | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | PLAT | C0035229 | Respiratory Insufficiency | 1 | CTD_human |
Tgene | PLAT | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PLAT | C0036980 | Shock, Cardiogenic | 1 | CTD_human |
Tgene | PLAT | C0037926 | Compression of spinal cord | 1 | CTD_human |
Tgene | PLAT | C0040038 | Thromboembolism | 1 | CTD_human |
Tgene | PLAT | C0085307 | Embolism and Thrombosis | 1 | CTD_human |
Tgene | PLAT | C0149649 | Cholesterol Embolism | 1 | CTD_human |
Tgene | PLAT | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Tgene | PLAT | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Tgene | PLAT | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | PLAT | C0242184 | Hypoxia | 1 | CTD_human |
Tgene | PLAT | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Tgene | PLAT | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | PLAT | C0740858 | Substance abuse problem | 1 | PSYGENET |
Tgene | PLAT | C0751895 | Vasospasm, Intracranial | 1 | CTD_human |
Tgene | PLAT | C0751955 | Brain Infarction | 1 | CTD_human |
Tgene | PLAT | C0752143 | Intracranial Thrombosis | 1 | CTD_human |
Tgene | PLAT | C1861172 | Venous Thromboembolism | 1 | CTD_human |
Tgene | PLAT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |