FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32920

FusionGeneSummary for SDAD1_PARM1

check button Fusion gene summary
Fusion gene informationFusion gene name: SDAD1_PARM1
Fusion gene ID: 32920
HgeneTgene
Gene symbol

SDAD1

PARM1

Gene ID

55153

25849

Gene nameSDA1 domain containing 1prostate androgen-regulated mucin-like protein 1
Synonyms-Cipar1|DKFZP564O0823|PARM-1|WSC4
Cytomap

4q21.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SDA1 homologSDA1 domain-containing protein 1nucleolar protein 130prostate androgen-regulated mucin-like protein 1WSC4, cell wall integrity and stress response component 4 homologcastration-induced prostatic apoptosis-related protein 1prostatic androgen-regulated mucin-like protein 1prostatic androgen-repressed mess
Modification date2018052320180329
UniProtAcc

Q9NVU7

Q6UWI2

Ensembl transtripts involved in fusion geneENST00000356260, ENST00000395711, 
ENST00000513089, 
ENST00000513238, 
ENST00000307428, 
Fusion gene scores* DoF score3 X 2 X 2=124 X 4 X 2=32
# samples 37
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/32*10)=1.12928301694497
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SDAD1 [Title/Abstract] AND PARM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-C5-A8XH-01ASDAD1chr4

76911905

-PARM1chr4

75937635

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356260ENST00000513238SDAD1chr4

76911905

-PARM1chr4

75937635

+
5CDS-intronENST00000356260ENST00000307428SDAD1chr4

76911905

-PARM1chr4

75937635

+
5CDS-intronENST00000395711ENST00000513238SDAD1chr4

76911905

-PARM1chr4

75937635

+
5CDS-intronENST00000395711ENST00000307428SDAD1chr4

76911905

-PARM1chr4

75937635

+
intron-intronENST00000513089ENST00000513238SDAD1chr4

76911905

-PARM1chr4

75937635

+
intron-intronENST00000513089ENST00000307428SDAD1chr4

76911905

-PARM1chr4

75937635

+

Top

FusionProtFeatures for SDAD1_PARM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDAD1

Q9NVU7

PARM1

Q6UWI2

Required for 60S pre-ribosomal subunits export to thecytoplasm. {ECO:0000250}. May regulate TLP1 expression and telomerase activity,thus enabling certain prostatic cells to resist apoptosis.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SDAD1_PARM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SDAD1_PARM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDAD1TGIF1, ELAVL1, LAMP1, TARDBP, CSNK2A2, ADARB1, TARBP2, NPM1, ZBTB38, TXNDC15, NAP1L1, FBL, GTPBP4, MRTO4, NMD3, NOC2L, NSA2, RBM28, NTRK1, SCARNA22, CEP19, CDC14B, RBM34, MAGEB10, RPS14, CDX1, RPL18A, FGF8, ZNF512, PLEKHO1, MECP2, TMEM194A, FOXA1PARM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SDAD1_PARM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SDAD1_PARM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource