	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 3292

FusionGeneSummary for ATP1A1_ATP1A1

Fusion gene summary

Fusion gene information	Fusion gene name: ATP1A1_ATP1A1
	Fusion gene ID: 3292
		Hgene	Tgene
	Gene symbol	ATP1A1	ATP1A1
	Gene ID	480	480
	Gene name	ATPase Na+/K+ transporting subunit alpha 4	ATPase Na+/K+ transporting subunit alpha 4
	Synonyms	ATP1A1\|ATP1AL2	ATP1A1\|ATP1AL2
	Cytomap	1q23.2	1q23.2
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
	Modification date	20180523	20180523
	UniProtAcc	P05023	P05023
	Ensembl transtripts involved in fusion gene	ENST00000295598, ENST00000537345, ENST00000369496, ENST00000491156,	ENST00000295598, ENST00000537345, ENST00000369496, ENST00000491156,
Fusion gene scores	* DoF score	15 X 20 X 7=2100	13 X 20 X 3=780
	# samples	25	21
	** MAII score	log2(25/2100*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/780*10)=-1.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP1A1 [Title/Abstract] AND ATP1A1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Hgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599
Tgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Tgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ338264	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
ChiTaRS3.1			BE695741	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
ChiTaRS3.1			BQ312200	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
ChiTaRS3.1			BE837611	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
ChiTaRS3.1			BQ312492	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
ChiTaRS3.1			BQ307354	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
ChiTaRS3.1			CV373603	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
ChiTaRS3.1			CV359423	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000295598	ENST00000295598	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000295598	ENST00000537345	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-5UTR	ENST00000295598	ENST00000369496	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000537345	ENST00000295598	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000537345	ENST00000537345	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-5UTR	ENST00000537345	ENST00000369496	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000369496	ENST00000295598	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000369496	ENST00000537345	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-5UTR	ENST00000369496	ENST00000369496	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
3UTR-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
3UTR-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
3UTR-5UTR	ENST00000491156	ENST00000369496	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
3UTR-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116932165	+	ATP1A1	chr1	116926658	+
In-frame	ENST00000295598	ENST00000295598	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000295598	ENST00000537345	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000295598	ENST00000369496	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000537345	ENST00000295598	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000537345	ENST00000537345	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000537345	ENST00000369496	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000369496	ENST00000295598	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000369496	ENST00000537345	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
In-frame	ENST00000369496	ENST00000369496	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
intron-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116941590	+	ATP1A1	chr1	116941350	-
Frame-shift	ENST00000295598	ENST00000295598	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000295598	ENST00000537345	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000295598	ENST00000369496	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000537345	ENST00000295598	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000537345	ENST00000537345	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000537345	ENST00000369496	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000369496	ENST00000295598	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000369496	ENST00000537345	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000369496	ENST00000369496	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
intron-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116939285	-	ATP1A1	chr1	116935493	+
Frame-shift	ENST00000295598	ENST00000295598	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000295598	ENST00000537345	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000295598	ENST00000369496	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000537345	ENST00000295598	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000537345	ENST00000537345	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000537345	ENST00000369496	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000369496	ENST00000295598	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000369496	ENST00000537345	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000369496	ENST00000369496	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
intron-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116944241	+	ATP1A1	chr1	116936185	+
Frame-shift	ENST00000295598	ENST00000295598	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000295598	ENST00000537345	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000295598	ENST00000369496	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5CDS-3UTR	ENST00000295598	ENST00000491156	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000537345	ENST00000295598	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000537345	ENST00000537345	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000537345	ENST00000369496	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5CDS-3UTR	ENST00000537345	ENST00000491156	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5UTR-3CDS	ENST00000369496	ENST00000295598	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5UTR-3CDS	ENST00000369496	ENST00000537345	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5UTR-3CDS	ENST00000369496	ENST00000369496	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
5UTR-3UTR	ENST00000369496	ENST00000491156	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
intron-3UTR	ENST00000491156	ENST00000491156	ATP1A1	chr1	116926642	-	ATP1A1	chr1	116932144	+
Frame-shift	ENST00000295598	ENST00000295598	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000295598	ENST00000537345	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000295598	ENST00000369496	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
5CDS-3UTR	ENST00000295598	ENST00000491156	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000537345	ENST00000295598	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000537345	ENST00000537345	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000537345	ENST00000369496	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
5CDS-3UTR	ENST00000537345	ENST00000491156	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000369496	ENST00000295598	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000369496	ENST00000537345	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
Frame-shift	ENST00000369496	ENST00000369496	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
5CDS-3UTR	ENST00000369496	ENST00000491156	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
intron-3UTR	ENST00000491156	ENST00000491156	ATP1A1	chr1	116931269	+	ATP1A1	chr1	116932099	-
In-frame	ENST00000295598	ENST00000295598	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000295598	ENST00000537345	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000295598	ENST00000369496	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000537345	ENST00000295598	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000537345	ENST00000537345	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000537345	ENST00000369496	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000369496	ENST00000295598	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000369496	ENST00000537345	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
In-frame	ENST00000369496	ENST00000369496	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
intron-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
intron-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
intron-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
intron-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116943528	+	ATP1A1	chr1	116930050	+
Frame-shift	ENST00000295598	ENST00000295598	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000295598	ENST00000537345	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000295598	ENST00000369496	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
5CDS-intron	ENST00000295598	ENST00000491156	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000537345	ENST00000295598	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000537345	ENST00000537345	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000537345	ENST00000369496	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
5CDS-intron	ENST00000537345	ENST00000491156	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000369496	ENST00000295598	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000369496	ENST00000537345	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
Frame-shift	ENST00000369496	ENST00000369496	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
5CDS-intron	ENST00000369496	ENST00000491156	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
3UTR-3CDS	ENST00000491156	ENST00000295598	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
3UTR-3CDS	ENST00000491156	ENST00000537345	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
3UTR-3CDS	ENST00000491156	ENST00000369496	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+
3UTR-intron	ENST00000491156	ENST00000491156	ATP1A1	chr1	116931577	-	ATP1A1	chr1	116943765	+

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FusionProtFeatures for ATP1A1_ATP1A1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP1A1 P05023	ATP1A1 P05023

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ATP1A1_ATP1A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP1A1_ATP1A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ATP1A1_ATP1A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	ATP1A1	P05023	DB00390	Digoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB00511	Acetyldigitoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB01078	Deslanoside	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB01092	Ouabain	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB01119	Diazoxide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB01430	Almitrine	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Hgene	ATP1A1	P05023	DB00774	Hydroflumethiazide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB00903	Etacrynic acid	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB01188	Ciclopirox	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB01345	Potassium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB01370	Aluminium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB01396	Digitoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Hgene	ATP1A1	P05023	DB01378	Magnesium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|nutraceutical
Hgene	ATP1A1	P05023	DB01021	Trichlormethiazide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|vet_approved
Hgene	ATP1A1	P05023	DB01244	Bepridil	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|withdrawn
Tgene	ATP1A1	P05023	DB00390	Digoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB00511	Acetyldigitoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB01078	Deslanoside	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB01092	Ouabain	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB01119	Diazoxide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB01430	Almitrine	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved
Tgene	ATP1A1	P05023	DB00774	Hydroflumethiazide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB00903	Etacrynic acid	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB01188	Ciclopirox	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB01345	Potassium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB01370	Aluminium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB01396	Digitoxin	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|investigational
Tgene	ATP1A1	P05023	DB01378	Magnesium	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|nutraceutical
Tgene	ATP1A1	P05023	DB01021	Trichlormethiazide	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|vet_approved
Tgene	ATP1A1	P05023	DB01244	Bepridil	Sodium/potassium-transporting ATPase subunit alpha-1	small molecule	approved\|withdrawn

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RelatedDiseases for ATP1A1_ATP1A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ATP1A1	C0001430	Adenoma	2	CTD_human
Hgene	ATP1A1	C0005586	Bipolar Disorder	1	PSYGENET
Hgene	ATP1A1	C0020428	Hyperaldosteronism	1	CTD_human
Hgene	ATP1A1	C0020538	Hypertensive disease	1	CTD_human
Hgene	ATP1A1	C0042594	Vestibular Diseases	1	CTD_human
Hgene	ATP1A1	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	ATP1A1	C0001430	Adenoma	2	CTD_human
Tgene	ATP1A1	C0005586	Bipolar Disorder	1	PSYGENET
Tgene	ATP1A1	C0020428	Hyperaldosteronism	1	CTD_human
Tgene	ATP1A1	C0020538	Hypertensive disease	1	CTD_human
Tgene	ATP1A1	C0042594	Vestibular Diseases	1	CTD_human
Tgene	ATP1A1	C0151744	Myocardial Ischemia	1	CTD_human

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Fusion gene ID: 3292

FusionGeneSummary for ATP1A1_ATP1A1

FusionProtFeatures for ATP1A1_ATP1A1

FusionGeneSequence for ATP1A1_ATP1A1

FusionGenePPI for ATP1A1_ATP1A1

RelatedDrugs for ATP1A1_ATP1A1

RelatedDiseases for ATP1A1_ATP1A1