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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32918

FusionGeneSummary for SDAD1_C4orf22

check button Fusion gene summary
Fusion gene informationFusion gene name: SDAD1_C4orf22
Fusion gene ID: 32918
HgeneTgene
Gene symbol

SDAD1

C4orf22

Gene ID

55153

Gene nameSDA1 domain containing 1
Synonyms-
Cytomap

4q21.1

Type of geneprotein-coding
Descriptionprotein SDA1 homologSDA1 domain-containing protein 1nucleolar protein 130
Modification date20180523
UniProtAcc

Q9NVU7

Q6V702

Ensembl transtripts involved in fusion geneENST00000356260, ENST00000395711, 
ENST00000513089, 
ENST00000358105, 
ENST00000508675, ENST00000512931, 
Fusion gene scores* DoF score3 X 2 X 2=125 X 5 X 3=75
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDAD1 [Title/Abstract] AND C4orf22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-A7TA-01ASDAD1chr4

76902525

-C4orf22chr4

81791147

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356260ENST00000358105SDAD1chr4

76902525

-C4orf22chr4

81791147

+
In-frameENST00000356260ENST00000508675SDAD1chr4

76902525

-C4orf22chr4

81791147

+
5CDS-intronENST00000356260ENST00000512931SDAD1chr4

76902525

-C4orf22chr4

81791147

+
In-frameENST00000395711ENST00000358105SDAD1chr4

76902525

-C4orf22chr4

81791147

+
In-frameENST00000395711ENST00000508675SDAD1chr4

76902525

-C4orf22chr4

81791147

+
5CDS-intronENST00000395711ENST00000512931SDAD1chr4

76902525

-C4orf22chr4

81791147

+
intron-3CDSENST00000513089ENST00000358105SDAD1chr4

76902525

-C4orf22chr4

81791147

+
intron-3CDSENST00000513089ENST00000508675SDAD1chr4

76902525

-C4orf22chr4

81791147

+
intron-intronENST00000513089ENST00000512931SDAD1chr4

76902525

-C4orf22chr4

81791147

+

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FusionProtFeatures for SDAD1_C4orf22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDAD1

Q9NVU7

C4orf22

Q6V702

Required for 60S pre-ribosomal subunits export to thecytoplasm. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSDAD1chr4:76902525chr4:81791147ENST00000356260-322253_31598688Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for SDAD1_C4orf22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_221aa
MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHT
VLDPDLRMSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRD

>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_221aa
MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHT
VLDPDLRMSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRD

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_221aa
MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHT
VLDPDLRMSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRD

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_221aa
MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCYPEYLSNFPQEVKDLLSCNHT
VLDPDLRMSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_663nt
ATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATCGAGGAG
TTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAGCTGGTG
ATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAATCATACC
GTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGACTATGCC
CACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTACAACTGG
GACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAAAGAGAC
AGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAAGCTGTC

>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_663nt
ATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATCGAGGAG
TTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAGCTGGTG
ATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAATCATACC
GTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGACTATGCC
CACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTACAACTGG
GACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAAAGAGAC
AGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAAGCTGTC

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_663nt
ATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATCGAGGAG
TTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAGCTGGTG
ATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAATCATACC
GTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGACTATGCC
CACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTACAACTGG
GACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAAAGAGAC
AGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAAGCTGTC

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_663nt
ATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATCGAGGAG
TTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAGCTGGTG
ATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAATCATACC
GTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGACTATGCC
CACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTACAACTGG
GACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAAAGAGAC
AGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAAGCTGTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_926nt
GCGCTATTTCCGGTCATACCCGGAAACACGAGTCCAAGCTGCAGCTGGCAGGGATTGCGGGGTGCCGGCCGTCTGAGTTTTTTTAAAACT
GCTCGCCGCGAAGTCTGTCTGCAGCCAAAATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCA
AGCGAGACCCGCCGGCCTACATCGAGGAGTTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATA
AACCCAGCAAAGAACTAGCAGAGCTGGTGATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGG
TGAAAGATCTTCTCTCCTGCAATCATACCGTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGC
AAGAGATATCAGGATACATCGACTATGCCCACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAA
GGCCTACAGATATAAGCTTTTACAACTGGGACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAG
AAGGCTTACTTTTCAGATACAAAAGAGACAGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTA
TCCTGACAGAACTCTACGTACAAGCTGTCATTTTTGACCACATTTCCAGAAGGAAGACTTAAGTACCAACATGTTAATTTCCTAATAATT
TGCTAAATTTAAATAAATTCCGTAGACAGAGCAAATTAGAATAATAAATGAGCCCTGTAGCTGGAAGGCAAATTAGAACAATAAAGTTAA

>In-frame_SDAD1_ENST00000356260_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_782nt
GCGCTATTTCCGGTCATACCCGGAAACACGAGTCCAAGCTGCAGCTGGCAGGGATTGCGGGGTGCCGGCCGTCTGAGTTTTTTTAAAACT
GCTCGCCGCGAAGTCTGTCTGCAGCCAAAATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCA
AGCGAGACCCGCCGGCCTACATCGAGGAGTTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATA
AACCCAGCAAAGAACTAGCAGAGCTGGTGATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGG
TGAAAGATCTTCTCTCCTGCAATCATACCGTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGC
AAGAGATATCAGGATACATCGACTATGCCCACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAA
GGCCTACAGATATAAGCTTTTACAACTGGGACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAG
AAGGCTTACTTTTCAGATACAAAAGAGACAGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTA

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000358105_chr4_81791147_+_903nt
AAACACGAGTCCAAGCTGCAGCTGGCAGGGATTGCGGGGTGCCGGCCGTCTGAGTTTTTTTAAAACTGCTCGCCGCGAAGTCTGTCTGCA
GCCAAAATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATC
GAGGAGTTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAG
CTGGTGATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAAT
CATACCGTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGAC
TATGCCCACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTAC
AACTGGGACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAA
AGAGACAGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAA
GCTGTCATTTTTGACCACATTTCCAGAAGGAAGACTTAAGTACCAACATGTTAATTTCCTAATAATTTGCTAAATTTAAATAAATTCCGT
AGACAGAGCAAATTAGAATAATAAATGAGCCCTGTAGCTGGAAGGCAAATTAGAACAATAAAGTTAATAAAGAAGTTAGAAAGAAAACTG

>In-frame_SDAD1_ENST00000395711_chr4_76902525_-_C4orf22_ENST00000508675_chr4_81791147_+_759nt
AAACACGAGTCCAAGCTGCAGCTGGCAGGGATTGCGGGGTGCCGGCCGTCTGAGTTTTTTTAAAACTGCTCGCCGCGAAGTCTGTCTGCA
GCCAAAATGTCCAACAGAAACAACAACAAGCTTCCCAGCAACCTGCCGCAGTTACAGAATCTAATCAAGCGAGACCCGCCGGCCTACATC
GAGGAGTTTCTACAGCAGTATAATCACTACAAATCCAATGTGGAGATTTTCAAATTGCAACCAAATAAACCCAGCAAAGAACTAGCAGAG
CTGGTGATGTTTATGGCACAGATTAGTCACTGCTACCCAGAGTACCTAAGTAATTTTCCTCAAGAGGTGAAAGATCTTCTCTCCTGCAAT
CATACCGTATTGGATCCAGATCTGCGAATGTCCGTGATCTTTATTCGTGACAGAAATTCTCATGGGCAAGAGATATCAGGATACATCGAC
TATGCCCACAGGCTAAAGACGGAAGATTTTGAAGTCTACTTTACTGGAAAAAAAAGACTTCTTCCAAGGCCTACAGATATAAGCTTTTAC
AACTGGGACGCTGATATTGCTGTTAGTAATTCAAGTCCCAACTATCAAGTGATTGCCGATAATCCAGAAGGCTTACTTTTCAGATACAAA
AGAGACAGAAAAATTCTTAATGTGGACCCAAAGGCGCAGCCAGGTGACAACTCTACTAGAATCACTATCCTGACAGAACTCTACGTACAA


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FusionGenePPI for SDAD1_C4orf22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDAD1TGIF1, ELAVL1, LAMP1, TARDBP, CSNK2A2, ADARB1, TARBP2, NPM1, ZBTB38, TXNDC15, NAP1L1, FBL, GTPBP4, MRTO4, NMD3, NOC2L, NSA2, RBM28, NTRK1, SCARNA22, CEP19, CDC14B, RBM34, MAGEB10, RPS14, CDX1, RPL18A, FGF8, ZNF512, PLEKHO1, MECP2, TMEM194A, FOXA1C4orf22APP, BAG3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDAD1_C4orf22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDAD1_C4orf22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource