FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32901

FusionGeneSummary for SCUBE2_SCUBE2

check button Fusion gene summary
Fusion gene informationFusion gene name: SCUBE2_SCUBE2
Fusion gene ID: 32901
HgeneTgene
Gene symbol

SCUBE2

SCUBE2

Gene ID

57758

57758

Gene namesignal peptide, CUB domain and EGF like domain containing 2signal peptide, CUB domain and EGF like domain containing 2
SynonymsCEGB1|CEGF1|CEGP1CEGB1|CEGF1|CEGP1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsignal peptide, CUB and EGF-like domain-containing protein 2scube/Yousignal peptide, CUB domain, EGF-like 2signal peptide, CUB and EGF-like domain-containing protein 2scube/Yousignal peptide, CUB domain, EGF-like 2
Modification date2018052320180523
UniProtAcc

Q9NQ36

Q9NQ36

Ensembl transtripts involved in fusion geneENST00000457346, ENST00000309263, 
ENST00000450649, ENST00000520467, 
ENST00000534295, 		ENST00000457346, 
ENST00000309263, ENST00000450649, 
ENST00000520467, ENST00000534295, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 3 X 3=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCUBE2 [Title/Abstract] AND SCUBE2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA557990SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000457346ENST00000457346SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000457346ENST00000309263SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000457346ENST00000450649SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000457346ENST00000520467SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
5CDS-intronENST00000457346ENST00000534295SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000309263ENST00000457346SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000309263ENST00000309263SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000309263ENST00000450649SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000309263ENST00000520467SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
5CDS-intronENST00000309263ENST00000534295SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000450649ENST00000457346SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000450649ENST00000309263SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000450649ENST00000450649SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000450649ENST00000520467SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
5CDS-intronENST00000450649ENST00000534295SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000520467ENST00000457346SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000520467ENST00000309263SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000520467ENST00000450649SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
In-frameENST00000520467ENST00000520467SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
5CDS-intronENST00000520467ENST00000534295SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
intron-3CDSENST00000534295ENST00000457346SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
intron-3CDSENST00000534295ENST00000309263SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
intron-3CDSENST00000534295ENST00000450649SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
intron-3CDSENST00000534295ENST00000520467SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+
intron-intronENST00000534295ENST00000534295SCUBE2chr11

9090917

-SCUBE2chr11

9088267

+

Top

FusionProtFeatures for SCUBE2_SCUBE2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCUBE2

Q9NQ36

SCUBE2

Q9NQ36

Lipid-binding protein required for SHH long-rangesignaling by binding to the dually lipid-modified SHH (ShhNp) andby promoting ShhNp mobilization, solubilization and release fromthe cell membrane (PubMed:22902404, PubMed:22677548). Acts byenhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface(PubMed:24522195). Synergizes with DISP1 to increase SHH secretion(PubMed:22902404). Probable cell surface coreceptor for VEGFR2involved in VEGFR2-mediated angiogenesis (PubMed:27834687).{ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404,ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687,ECO:0000303|PubMed:26875496}. Lipid-binding protein required for SHH long-rangesignaling by binding to the dually lipid-modified SHH (ShhNp) andby promoting ShhNp mobilization, solubilization and release fromthe cell membrane (PubMed:22902404, PubMed:22677548). Acts byenhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface(PubMed:24522195). Synergizes with DISP1 to increase SHH secretion(PubMed:22902404). Probable cell surface coreceptor for VEGFR2involved in VEGFR2-mediated angiogenesis (PubMed:27834687).{ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404,ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687,ECO:0000303|PubMed:26875496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522128_1682141000DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522177_2132141000DomainEGF-like 4
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-52245_852141000DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-52286_1272141000DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518128_168214808DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518177_213214808DomainEGF-like 4
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-51845_85214808DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-51886_127214808DomainEGF-like 2%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522128_168214972DomainEGF-like 3%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522177_213214972DomainEGF-like 4
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-52245_85214972DomainEGF-like 1%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-52286_127214972DomainEGF-like 2%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022128_168-251000DomainEGF-like 3%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022177_213-251000DomainEGF-like 4
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022217_252-251000DomainEGF-like 5
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022286_321-251000DomainEGF-like 6
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022323_363-251000DomainEGF-like 7%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022364_402-251000DomainEGF-like 8%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022403_443-251000DomainEGF-like 9%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-02245_85-251000DomainEGF-like 1%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022809_921-251000DomainCUB
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-02286_127-251000DomainEGF-like 2%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018128_168-6808DomainEGF-like 3%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018177_213-6808DomainEGF-like 4
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018217_252-6808DomainEGF-like 5
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018286_321-6808DomainEGF-like 6
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018323_363-6808DomainEGF-like 7%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018364_402-6808DomainEGF-like 8%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018403_443-6808DomainEGF-like 9%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-01845_85-6808DomainEGF-like 1%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018809_921-6808DomainCUB
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-01886_127-6808DomainEGF-like 2%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022128_168-24972DomainEGF-like 3%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022177_213-24972DomainEGF-like 4
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022217_252-24972DomainEGF-like 5
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022286_321-24972DomainEGF-like 6
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022323_363-24972DomainEGF-like 7%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022364_402-24972DomainEGF-like 8%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022403_443-24972DomainEGF-like 9%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-02245_85-24972DomainEGF-like 1%3B calcium-binding
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022809_921-24972DomainCUB
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-02286_127-24972DomainEGF-like 2%3B calcium-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522217_2522141000DomainEGF-like 5
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522286_3212141000DomainEGF-like 6
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522323_3632141000DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522364_4022141000DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522403_4432141000DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522809_9212141000DomainCUB
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518217_252214808DomainEGF-like 5
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518286_321214808DomainEGF-like 6
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518323_363214808DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518364_402214808DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518403_443214808DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518809_921214808DomainCUB
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522217_252214972DomainEGF-like 5
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522286_321214972DomainEGF-like 6
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522323_363214972DomainEGF-like 7%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522364_402214972DomainEGF-like 8%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522403_443214972DomainEGF-like 9%3B calcium-binding
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522809_921214972DomainCUB


Top

FusionGeneSequence for SCUBE2_SCUBE2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SCUBE2_SCUBE2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCUBE2SCUBE2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-022847_856-251000the cholesterol-anchor of SHH
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-018847_856-6808the cholesterol-anchor of SHH
TgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-022847_856-24972the cholesterol-anchor of SHH


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000309263-522847_8562141000the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000450649-518847_856214808the cholesterol-anchor of SHH
HgeneSCUBE2chr11:9090917chr11:9088267ENST00000520467-522847_856214972the cholesterol-anchor of SHH


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SCUBE2_SCUBE2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SCUBE2_SCUBE2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource