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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32892

FusionGeneSummary for SCRIB_NRBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SCRIB_NRBP2
Fusion gene ID: 32892
HgeneTgene
Gene symbol

SCRIB

NRBP2

Gene ID

23513

340371

Gene namescribbled planar cell polarity proteinnuclear receptor binding protein 2
SynonymsCRIB1|SCRB1|SCRIB1|VartulTRG16|pp9320
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein scribble homologscribbled homolognuclear receptor-binding protein 2transformation-related protein 16
Modification date2018052320180523
UniProtAcc

Q14160

Q9NSY0

Ensembl transtripts involved in fusion geneENST00000320476, ENST00000356994, 
ENST00000377533, ENST00000546337, 
ENST00000442628, ENST00000327830, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCRIB [Title/Abstract] AND NRBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCRIB

GO:0008283

cell proliferation

16965391

HgeneSCRIB

GO:0045930

negative regulation of mitotic cell cycle

16965391


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-HT-A5RC-01ASCRIBchr8

144897384

-NRBP2chr8

144922401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000320476ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
5CDS-5UTRENST00000320476ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
In-frameENST00000356994ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
5CDS-5UTRENST00000356994ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-3CDSENST00000377533ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-5UTRENST00000377533ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-3CDSENST00000546337ENST00000442628SCRIBchr8

144897384

-NRBP2chr8

144922401

-
intron-5UTRENST00000546337ENST00000327830SCRIBchr8

144897384

-NRBP2chr8

144922401

-

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FusionProtFeatures for SCRIB_NRBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCRIB

Q14160

NRBP2

Q9NSY0

Scaffold protein involved in different aspects ofpolarized cells differentiation regulating epithelial and neuronalmorphogenesis. Most probably functions in the establishment ofapico-basal cell polarity. May function in cell proliferationregulating progression from G1 to S phase and as a positiveregulator of apoptosis for instance during acinar morphogenesis ofthe mammary epithelium. May also function in cell migration andadhesion and hence regulate cell invasion through MAPK signaling.May play a role in exocytosis and in the targeting synapticvesicles to synapses. Functions as an activator of Rac GTPaseactivity. {ECO:0000269|PubMed:15182672,ECO:0000269|PubMed:15775968, ECO:0000269|PubMed:16344308,ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685,ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. May regulate apoptosis of neural progenitor cells duringtheir differentiation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361379_1419531631Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136458_474531631Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136656_701531631Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371379_1419531656Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137458_474531656Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137656_701531656Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361379_1419-741550Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136458_474-741550Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136656_701-741550Coiled coilOntology_term=ECO:0000255
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361296_1349531631Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136660_695531631Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371296_1349531656Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137660_695531656Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361296_1349-741550Compositional biasNote=Pro-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136660_695-741550Compositional biasNote=Glu-rich
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361004_1093531631DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361100_1194531631DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136728_815531631DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136862_950531631DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371004_1093531656DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371100_1194531656DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137728_815531656DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137862_950531656DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361004_1093-741550DomainPDZ 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361100_1194-741550DomainPDZ 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136728_815-741550DomainPDZ 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136862_950-741550DomainPDZ 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361_818531631RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371_818531656RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361_818-741550RegionNote=Sufficient for targeting to adherens junction and to inhibit cell proliferation
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136106_127531631RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136129_150531631RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136152_174531631RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136175_197531631RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136198_219531631RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136221_243531631RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136244_265531631RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136267_288531631RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136290_312531631RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136313_334531631RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136336_357531631RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136359_381531631RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13637_58531631RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136382_402531631RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13660_81531631RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-13683_104531631RepeatNote=LRR 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137106_127531656RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137129_150531656RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137152_174531656RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137175_197531656RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137198_219531656RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137221_243531656RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137244_265531656RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137267_288531656RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137290_312531656RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137313_334531656RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137336_357531656RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137359_381531656RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13737_58531656RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137382_402531656RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13760_81531656RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-13783_104531656RepeatNote=LRR 3
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136106_127-741550RepeatNote=LRR 4
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136129_150-741550RepeatNote=LRR 5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136152_174-741550RepeatNote=LRR 6
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136175_197-741550RepeatNote=LRR 7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136198_219-741550RepeatNote=LRR 8
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136221_243-741550RepeatNote=LRR 9
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136244_265-741550RepeatNote=LRR 10
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136267_288-741550RepeatNote=LRR 11
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136290_312-741550RepeatNote=LRR 12
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136313_334-741550RepeatNote=LRR 13
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136336_357-741550RepeatNote=LRR 14
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136359_381-741550RepeatNote=LRR 15
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13637_58-741550RepeatNote=LRR 1
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136382_402-741550RepeatNote=LRR 16
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13660_81-741550RepeatNote=LRR 2
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-13683_104-741550RepeatNote=LRR 3
TgeneNRBP2chr8:144897384chr8:144922401ENST00000442628-01838_30643502DomainProtein kinase


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FusionGeneSequence for SCRIB_NRBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCRIB_NRBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCRIBPHLPP1, DMWD, UBE3A, SSTR3, APC, DCUN1D1, TSHR, MAPK3, PRKCA, HSP90AA1, FN1, VCAM1, ITGA4, EXOSC10, CLK3, LGR4, LRRC6, SHMT2, MOV10, NXF1, OBSL1, CCDC8, CNPY3, PPP1CC, PPP1CA, CLEC18A, RBM23, ZBTB44, PPP1R3A, NTRK1, MED4, FBF1, CEP19, TMEM17, VPS11, TGS1, FOXB1, FOXE1, FOXG1, FOXH1, FOXK1, FOXL1, CDC5L, CDH1, ARHGEF7, GUCY1A2, PKP4, MAPK12, PPP1CB, IL1R2, LRRC27, ZNF263, LRIG1, P4HA3NRBP2TSC22D4, PDK1, RAP1B, NEDD1, PHF19, IL16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-136717_1229531631ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-137717_1229531656ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-136717_1229-741550ARHGEF7
HgeneSCRIBchr8:144897384chr8:144922401ENST00000320476-1361105_1117531631tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000356994-1371105_1117531656tick-borne encephalitis virus RNA-directed RNA polymerase NS5
HgeneSCRIBchr8:144897384chr8:144922401ENST00000377533-1361105_1117-741550tick-borne encephalitis virus RNA-directed RNA polymerase NS5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCRIB_NRBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCRIB_NRBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSCRIBC3891448NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO1UNIPROT