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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32889

FusionGeneSummary for SCRG1_TRIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: SCRG1_TRIM5
Fusion gene ID: 32889
HgeneTgene
Gene symbol

SCRG1

TRIM5

Gene ID

11341

85363

Gene namestimulator of chondrogenesis 1tripartite motif containing 5
SynonymsSCRG-1RNF88|TRIM5alpha
Cytomap

4q34.1

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionscrapie-responsive protein 1scrapie responsive gene 1scrapie-responsive gene 1 proteintripartite motif-containing protein 5RING-type E3 ubiquitin transferase TRIM5ring finger protein 88tripartite motif containing 5 transcript variant iotatripartite motif containing 5 transcript variant kappatripartite motif protein TRIM5
Modification date2018051920180519
UniProtAcc

O75711

Q9C035

Ensembl transtripts involved in fusion geneENST00000296506, ENST00000380027, 
ENST00000396855, ENST00000305836, 
ENST00000380034, ENST00000396847, 
ENST00000483835, ENST00000396853, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCRG1 [Title/Abstract] AND TRIM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM5

GO:0002218

activation of innate immune response

21512573

TgeneTRIM5

GO:0006914

autophagy

25127057

TgeneTRIM5

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM5

GO:0045087

innate immune response

18248090

TgeneTRIM5

GO:0046597

negative regulation of viral entry into host cell

18248090

TgeneTRIM5

GO:0070534

protein K63-linked ubiquitination

21512573

TgeneTRIM5

GO:1902187

negative regulation of viral release from host cell

18248090


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ007861SCRG1chr4

174320256

+TRIM5chr11

5719750

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000296506ENST00000380027SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000396855SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000305836SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000380034SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000396847SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000483835SCRG1chr4

174320256

+TRIM5chr11

5719750

+
intron-intronENST00000296506ENST00000396853SCRG1chr4

174320256

+TRIM5chr11

5719750

+

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FusionProtFeatures for SCRG1_TRIM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCRG1

O75711

TRIM5

Q9C035


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCRG1_TRIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCRG1_TRIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCRG1_TRIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCRG1_TRIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRIM5C0019693HIV Infections1CTD_human