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Fusion gene ID: 32862 |
FusionGeneSummary for SCN11A_ZCCHC14 |
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Fusion gene information | Fusion gene name: SCN11A_ZCCHC14 | Fusion gene ID: 32862 | Hgene | Tgene | Gene symbol | SCN11A | ZCCHC14 | Gene ID | 11280 | 23174 |
Gene name | sodium voltage-gated channel alpha subunit 11 | zinc finger CCHC-type containing 14 | |
Synonyms | FEPS3|HSAN7|NAV1.9|NaN|PN5|SCN12A|SNS-2 | BDG-29|BDG29 | |
Cytomap | 3p22.2 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium channel protein type 11 subunit alphaperipheral nerve sodium channel 5sensory neuron sodium channel 2sodium channel protein type XI subunit alphasodium channel, voltage-gated, type XI, alpha polypeptidesodium channel, voltage-gated, type XI, a | zinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UI33 | Q8WYQ9 | |
Ensembl transtripts involved in fusion gene | ENST00000302328, ENST00000450244, ENST00000456224, ENST00000444237, | ENST00000268616, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 2 | 3 | |
** MAII score | log2(2/1*10)=4.32192809488736 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: SCN11A [Title/Abstract] AND ZCCHC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF433084 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + | ||
ChiTaRS3.1 | BF591663 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000302328 | ENST00000268616 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + |
intron-intron | ENST00000450244 | ENST00000268616 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + |
intron-intron | ENST00000456224 | ENST00000268616 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + |
intron-intron | ENST00000444237 | ENST00000268616 | SCN11A | chr3 | 38887632 | + | ZCCHC14 | chr16 | 87517137 | + |
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FusionProtFeatures for SCN11A_ZCCHC14 |
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Hgene | Tgene |
SCN11A | ZCCHC14 |
This protein mediates the voltage-dependent sodium ionpermeability of excitable membranes. Assuming opened or closedconformations in response to the voltage difference across themembrane, the protein forms a sodium-selective channel throughwhich sodium ions may pass in accordance with theirelectrochemical gradient. It is a tetrodotoxin-resistant sodiumchannel isoform. Also involved, with the contribution of thereceptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronaldepolarization. {ECO:0000269|PubMed:10580103,ECO:0000269|PubMed:12384689}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCN11A_ZCCHC14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCN11A_ZCCHC14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCN11A_ZCCHC14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SCN11A | Q9UI33 | DB00907 | Cocaine | Sodium channel protein type 11 subunit alpha | small molecule | approved|illicit |
Hgene | SCN11A | Q9UI33 | DB00909 | Zonisamide | Sodium channel protein type 11 subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for SCN11A_ZCCHC14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCN11A | C3809899 | EPISODIC PAIN SYNDROME, FAMILIAL, 3 | 4 | ORPHANET;UNIPROT |
Hgene | SCN11A | C3809882 | NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE VII | 2 | ORPHANET;UNIPROT |
Hgene | SCN11A | C0002768 | Congenital Pain Insensitivity | 1 | CTD_human;ORPHANET |
Hgene | SCN11A | C0020429 | Hyperalgesia | 1 | CTD_human |
Tgene | ZCCHC14 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |