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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32861

FusionGeneSummary for SCML4_TUSC3

check button Fusion gene summary
Fusion gene informationFusion gene name: SCML4_TUSC3
Fusion gene ID: 32861
HgeneTgene
Gene symbol

SCML4

TUSC3

Gene ID

256380

7991

Gene nameScm polycomb group protein like 4tumor suppressor candidate 3
SynonymsdJ47M23.1D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A
Cytomap

6q21

8p22

Type of geneprotein-codingprotein-coding
Descriptionsex comb on midleg-like protein 4sex comb on midleg like 4tumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressor
Modification date2018051920180523
UniProtAcc

Q8N228

Q13454

Ensembl transtripts involved in fusion geneENST00000369022, ENST00000369020, 
ENST00000369025, ENST00000369021, 
ENST00000479803, 		ENST00000503191, 
ENST00000382020, ENST00000506802, 
ENST00000509380, ENST00000503731, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCML4 [Title/Abstract] AND TUSC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1FE-01ASCML4chr6

108093376

-TUSC3chr8

15480589

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000369022ENST00000503191SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369022ENST00000382020SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369022ENST00000506802SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369022ENST00000509380SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369022ENST00000503731SCML4chr6

108093376

-TUSC3chr8

15480589

+
5CDS-3UTRENST00000369020ENST00000503191SCML4chr6

108093376

-TUSC3chr8

15480589

+
5CDS-3UTRENST00000369020ENST00000382020SCML4chr6

108093376

-TUSC3chr8

15480589

+
5CDS-3UTRENST00000369020ENST00000506802SCML4chr6

108093376

-TUSC3chr8

15480589

+
5CDS-3UTRENST00000369020ENST00000509380SCML4chr6

108093376

-TUSC3chr8

15480589

+
5CDS-3UTRENST00000369020ENST00000503731SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369025ENST00000503191SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369025ENST00000382020SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369025ENST00000506802SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369025ENST00000509380SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369025ENST00000503731SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369021ENST00000503191SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369021ENST00000382020SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369021ENST00000506802SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369021ENST00000509380SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000369021ENST00000503731SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000479803ENST00000503191SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000479803ENST00000382020SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000479803ENST00000506802SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000479803ENST00000509380SCML4chr6

108093376

-TUSC3chr8

15480589

+
intron-3UTRENST00000479803ENST00000503731SCML4chr6

108093376

-TUSC3chr8

15480589

+

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FusionProtFeatures for SCML4_TUSC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCML4

Q8N228

TUSC3

Q13454

Putative Polycomb group (PcG) protein. PcG proteins actby forming multiprotein complexes, which are required to maintainthe transcriptionally repressive state of homeotic genesthroughout development (By similarity). {ECO:0000250}. Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCML4_TUSC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCML4_TUSC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCML4UBR1, FBXO11, KDM5CTUSC3BMI1, PPP1CA, FBXO6, PEX19, MCOLN3, SYNE4, HTR3C, RPN2, FAM122B, UPK1A, HTR3A, STXBP2, LIN54, SCN3B, STXBP1, NDRG3, GGT7, GABRA3, GABRD, SLC9A3R2, RNF185, CHRND, CHEK1, MAP2K1, TUBA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCML4_TUSC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCML4_TUSC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human