	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
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Fusion gene ID: 32847

FusionGeneSummary for SCMH1_CUL3

Fusion gene summary

Fusion gene information	Fusion gene name: SCMH1_CUL3
	Fusion gene ID: 32847
		Hgene	Tgene
	Gene symbol	SCMH1	CUL3
	Gene ID	22955	8452
	Gene name	Scm polycomb group protein homolog 1	cullin 3
	Synonyms	Scml3	CUL-3\|PHA2E
	Cytomap	1p34.2	2q36.2
	Type of gene	protein-coding	protein-coding
	Description	polycomb protein SCMH1sex comb on midleg homolog 1	cullin-3
	Modification date	20180519	20180523
	UniProtAcc	Q96GD3	Q13618
	Ensembl transtripts involved in fusion gene	ENST00000456518, ENST00000397174, ENST00000402904, ENST00000361191, ENST00000397171, ENST00000361705, ENST00000326197, ENST00000372595, ENST00000337495, ENST00000372596, ENST00000372597, ENST00000472037,	ENST00000264414, ENST00000344951, ENST00000409096, ENST00000409777, ENST00000432260,
Fusion gene scores	* DoF score	16 X 9 X 10=1440	5 X 5 X 4=100
	# samples	16	5
	** MAII score	log2(16/1440*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SCMH1 [Title/Abstract] AND CUL3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CUL3	GO:0000209	protein polyubiquitination	19261606
Tgene	CUL3	GO:0006511	ubiquitin-dependent protein catabolic process	25401743\|27561354
Tgene	CUL3	GO:0006513	protein monoubiquitination	22358839
Tgene	CUL3	GO:0006888	ER to Golgi vesicle-mediated transport	22358839
Tgene	CUL3	GO:0016567	protein ubiquitination	17543862\|19782033\|19995937\|20389280
Tgene	CUL3	GO:0031145	anaphase-promoting complex-dependent catabolic process	10500095
Tgene	CUL3	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	19261606\|19782033\|20389280
Tgene	CUL3	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	27561354

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-44-7670-01A	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
TCGA	LD	LUAD	TCGA-44-7670-01A	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000456518	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000456518	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397174	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397174	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000402904	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000402904	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361191	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361191	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000397171	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000397171	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000361705	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000361705	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000326197	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000326197	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000372595	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000372595	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000337495	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000337495	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372596	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372596	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-3CDS	ENST00000372597	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
5UTR-intron	ENST00000372597	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000472037	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-intron	ENST00000472037	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225346795	-
intron-3CDS	ENST00000456518	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000456518	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000456518	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397174	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000397174	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000402904	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000402904	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361191	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000361191	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000397171	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000397171	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000361705	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000361705	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000326197	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000326197	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000372595	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000372595	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000337495	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000337495	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372596	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000372596	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-3CDS	ENST00000372597	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
5UTR-intron	ENST00000372597	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000264414	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000344951	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000409096	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-3CDS	ENST00000472037	ENST00000409777	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-
intron-intron	ENST00000472037	ENST00000432260	SCMH1	chr1	41707731	-	CUL3	chr2	225343062	-

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FusionProtFeatures for SCMH1_CUL3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SCMH1 Q96GD3	CUL3 Q13618
Associates with Polycomb group (PcG) multiproteincomplexes; the complex class is required to maintain thetranscriptionally repressive state of some genes. {ECO:0000250}.	Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of targetproteins. BCR complexes and ARIH1 collaborate in tandem to mediateubiquitination of target proteins (PubMed:27565346). As a scaffoldprotein may contribute to catalysis through positioning of thesubstrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on theneddylation of the cullin subunit and is inhibited by theassociation of the deneddylated cullin subunit with TIP120A/CAND1.The functional specificity of the BCR complex depends on the BTBdomain-containing protein as the substrate recognition component.BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) isinvolved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX,GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimericSPOPL or the heterodimer formed by SPOP and SPOPL; these complexeshave lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controlsthe dynamic behavior of AURKB on mitotic chromosomes and therebycoordinates faithful mitotic progression and completion ofcytokinesis. BCR(KLHL12) is involved in ER-Golgi transport byregulating the size of COPII coats, thereby playing a key role incollagen export, which is required for embryonic stem (ES) cellsdivision: BCR(KLHL12) acts by mediating monoubiquitination ofSEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508).BCR(KLHL3) acts as a regulator of ion transport in the distalnephron; by mediating ubiquitination of WNK4 (PubMed:23387299,PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitinligase complex is involved in interferon response and anterogradeGolgi to endosome transport: it mediates both ubiquitinationleading to degradation and 'Lys-33'-linked ubiquitination(PubMed:20389280, PubMed:21840486, PubMed:21670212,PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complexregulates localization of the chromosomal passenger complex (CPC)from chromosomes to the spindle midzone in anaphase and mediatesthe ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22)ubiquitin ligase complex mediates monoubiquitination of PLK1,leading to PLK1 dissociation from phosphoreceptor proteins andsubsequent removal from kinetochores, allowing silencing of thespindle assembly checkpoint (SAC) and chromosome segregation(PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex isalso responsible for the amino acid-stimulated 'Lys-48'polyubiquitination and proteasomal degradation of DEPDC5. Throughthe degradation of DEPDC5, releases the GATOR1 complex-mediatedinhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25)ubiquitin ligase complex is involved in translational homeostasisby mediating ubiquitination and subsequent degradation ofhypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). TheBCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1and TCOF1, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in ubiquitination of cyclin E and ofcyclin D1 (in vitro) thus involved in regulation of G1/Stransition. Involved in the ubiquitination of KEAP1, ENC1 andKLHL41. In concert with ATF2 and RBX1, promotes degradation ofKAT5 thereby attenuating its ability to acetylate and activateATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediatesubiquitination and degradation of TCHP, a down-regulator of ciliumassembly, thereby inducing ciliogenesis (PubMed:25270598). TheBCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination ofKRT14, controls KRT14 levels during keratinocytes differentiation,and is essential for skin integrity (PubMed:27798626).{ECO:0000269\|PubMed:10500095, ECO:0000269\|PubMed:11311237,ECO:0000269\|PubMed:15897469, ECO:0000269\|PubMed:15983046,ECO:0000269\|PubMed:16524876, ECO:0000269\|PubMed:17543862,ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:19261606,ECO:0000269\|PubMed:19995937, ECO:0000269\|PubMed:20389280,ECO:0000269\|PubMed:21670212, ECO:0000269\|PubMed:21840486,ECO:0000269\|PubMed:22085717, ECO:0000269\|PubMed:22358839,ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:22632832,ECO:0000269\|PubMed:23387299, ECO:0000269\|PubMed:23453970,ECO:0000269\|PubMed:23455478, ECO:0000269\|PubMed:23576762,ECO:0000269\|PubMed:24768539, ECO:0000269\|PubMed:25270598,ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:27565346,ECO:0000269\|PubMed:27716508, ECO:0000269\|PubMed:27798626,ECO:0000269\|PubMed:29769719}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SCMH1_CUL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCMH1_CUL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SCMH1	POLR2M, LYPLA2, SCMH1, TOB1, MOB4, PHC2, EWSR1, PCBD1, LZTR1, MAML3, PCGF2, BMI1, RNF2, PHC1, PHC3, CBX4, UBQLN4, MAGEA12, UBQLN1, CDC42, ZWINT, ACTBL2, ACTA2, PGK2, GNB2	CUL3	CCNE1, CAND1, RBX1, DCUN1D1, KCTD5, ABTB2, DNTT, KEAP1, KLHL12, COPS5, COPS6, CUL3, PMS1, PGAM5, KCTD11, GABARAPL1, GABARAPL2, KBTBD7, COPS3, GAN, ENC1, KLHL41, NFE2L2, BMI1, H2AFY, KLHL20, DAPK1, ARHGEF12, COMMD1, DNMT3B, SPOP, IKBKB, KLHL42, PDIA2, KATNA1, RHOA, KLHL21, KLHL9, KLHL13, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, HSF2, SQSTM1, NCOA3, KBTBD13, KAT5, ATF2, GLMN, KLHL25, NACC1, PSMA7, COPS2, NEDD8, HTR7, TNFAIP1, RHOBTB2, HSPA4, HSPD1, KCTD7, AURKB, KLHL22, BTBD2, BTBD1, KLHL7, IPP, KBTBD2, IBTK, KCTD9, KLHL17, DYNC1I2, KLHL5, ZSWIM8, RHOBTB3, KLHL36, KLHL11, BTBD10, CDKN2AIP, DYNLRB1, KCTD2, KCTD20, KLHL28, KLHL4, LRRC42, RPAP3, KLHL26, KBTBD4, KBTBD6, DYNC1I1, GMCL1, KIAA0020, KLHL2, KPNA5, MLLT6, OFCC1, PGM3, KBTBD8, NISCH, KCTD18, KCTD6, ARMC5, CSDE1, DHX38, SLC1A3, CPOX, TEFM, NUDCD3, KLHL18, KLHL23, SHKBP1, PLEC, COPS4, ABCA13, AKAP11, CAPRIN1, HOOK3, PIK3R2, ANKRD39, PHF6, PLRG1, ELAVL2, KCTD3, KLHL24, HNRNPU, ALDH2, BCKDHA, DNAJC13, GPS1, KRT84, LARP4B, KLHL15, HCFC1, RHOBTB1, ATXN2L, FBXL17, GLUD1, IMPDH2, KDELC1, MRPL19, MRPS11, RPL10, SF3A1, COPS7A, PRRC2A, DLG4, PAIP1, RPS27, DYNC1H1, ARF4, EMC1, PRPF40A, RPA3, RPS28, ATXN2, ITCH, KCTD10, LAS1L, SUPT5H, KLHL8, MLLT11, COPS7B, AGO3, FUBP1, GEMIN5, GPATCH4, SEC16A, MRPS31, DUT, PYCR2, WDR6, NUP62, BTBD9, CTTN, KPNA1, PRKAR1A, SAFB, COPS8, LLGL1, SART1, DCTN1, NDUFS2, RPSAP55, SRPX, SEC31A, AKAP8L, SART3, NUP88, CTNND1, DCTN2, DYNC1LI1, IGHV3OR15-7, SDF4, SRPRB, TTN, USP15, HOOK2, NDUFA5, PDE12, VCP, CLTA, MAP1B, TUBA1A, SRRM2, CUL1, QDPR, SEC24B, TNRC6C, PRPF8, GPSM1, PLD2, DROSHA, KRT4, C17orf85, DNAJB1, FANCI, MRPS18B, RRS1, PSMC2, RFC2, CUL4B, KPNA3, RBM10, PSMC1, CPSF1, DNAJB6, SMC3, G3BP2, SHMT2, G3BP1, HSP90B1, P4HA1, SF3B2, TCEB1, WDR5, ZC3HAV1, ZCCHC3, FLNA, SND1, YWHAB, HAT1, SNRNP200, ABTB1, AIM1, ATP6V1A, BCDIN3D, BCL7A, BTBD7, FAM208B, C11orf57, RHNO1, VIPAS39, C20orf196, NYAP1, RPP25L, CCDC39, CKMT1B, CKMT1A, CTNNB1, DGCR8, DLG5, DPAGT1, DYNC1LI2, MTFR2, CMTR1, IPO5, IPO8, KCTD17, KCTD21, KEL, KNDC1, LOC646377, KCTD9P3, LPL, LZTR1, METTL15, MIPEP, MRPL2, MRPL21, MTMR3, MTMR9, N4BP1, NAALADL2, NVL, OR2T35, PCDHA6, PDPR, PIK3R1, POLR1C, PON2, PPIG, PSMC5, PTPRT, PXDNL, RBMS2, RNF219, SCO2, SEPHS1, SEPT10, SLC25A23, TAF5, TMTC2, UST, WBSCR22, WDR81, XAB2, ZBTB10, ZFP36L2, RNPS1, RPS3A, SEC13, SPTBN1, EFTUD2, POP1, SUCLG2, TFAM, CCAR2, POLR2B, RCN2, RPL7, TOE1, CD2BP2, PYCRL, RPP30, SDF2L1, ACLY, AKAP8, BTBD8, GRB2, KIF13B, MRPS35, SEC23B, SMARCB1, TFG, YTHDC2, DDB1, MSH6, RPSAP12, SKP1, ZMYM4, BSG, CPSF2, FAM103A1, GRSF1, PELO, SF1, SRRM1, ACIN1, AP2M1, ARHGDIA, ASPM, BBS4, CBWD2, CCDC110, CD84, CNNM4, CPN2, DDX28, ERC1, FAR1, FTSJ1, FUCA2, GCLM, GVINP1, HTATSF1, LARP1B, EIF2D, MASP1, MRPL28, MSI2, MTA2, NLE1, NOSIP, NUDT16L1, NUP50, PCID2, PKP2, PRKAR1B, RBM22, RTEL1, THADA, TIPRL, TTC7B, UGGT1, ZC3H18, ZRANB2, AGL, DARS, KCTD13, PDXK, RBM4, RPSAP15, ALDH3A2, EXOSC10, KCTD12, MRPS23, PDCD11, PRMT5, TNRC6A, BRIX1, DIS3, EIF4G1, MRPL1, MRPL45, MRPS22, MRPS26, PHAX, SNRPA, TNRC6B, UBR5, ARID1A, CANX, FUCA1, HUWE1, IRS4, MCCC2, USP25, AMOT, AP1B1, ARMC8, ASPH, ATP1A1, ATP1A4, ATXN10, BCKDHB, BCLAF1, C11orf70, DDX41, DDX6, DHX36, DICER1, GPT2, HBS1L, HMGB3P1, METTL13, MRPL11, MRPS9, PJA2, POLD1, PRKDC, PURB, RBM4B, RPN1, SNRPA1, SS18L1, SUPV3L1, TMEM165, TXNDC5, UBAP2, UPF1, XPNPEP3, YARS2, ATAD3B, DNAJB11, FARSA, PRPF39, PUF60, RBM45, TRMT10C, RNMT, SF3B1, SRPK1, TTC5, TRMT6, YWHAE, ACBD3, CAD, CAMK2G, CLCC1, DDX24, DYNLT1, EIF3G, ERAL1, H2AFV, P3H1, MACF1, MAGED1, MRPL14, MRPL24, MRPL37, MRPL44, NACA, NDUFS1, NSUN2, NUP153, PWP2, RBM17, RCBTB1, RRBP1, SAV1, SF3A2, SRPK2, SSR1, TRIM33, TTC37, USP32, AGO2, EIF4A1, EXOSC9, FBXO3, FECH, FTSJ3, HSD17B10, NXF1, RBM7, RPA2, CLPB, EBNA1BP2, FN3KRP, GNB2L1, HSPA8, NCAPG, NSF, NUP160, OPA1, PDHA2, PDHB, PRKACA, RCN1, SLC25A22, SMARCE1, SPATA5L1, SRP72, TARBP2, TARDBP, TFB2M, TPM3, MCMBP, CSTF3, CUL5, DPF2, AGO1, FARS2, GCAT, HNRNPM, IGF2BP3, KRT33B, MRPL12, MRPL50, MYEOV2, NCBP1, NCL, PFKM, PPP4C, RAE1, RPS11, RPS26P54, SNW1, U2SURP, TIMM50, UBA1, UBAP2L, WDR77, AURKAIP1, ALDH18A1, ATP1A2, ATP5B, PBDC1, DDX1, DDX3X, DDX46, FAM98B, FLNC, FUS, GTF3C5, HNRNPH1, IKBKAP, MEPCE, MOV10, MRPS21, MRPS27, MYBBP1A, NOP2, PEF1, PSPC1, RUVBL1, SARS2, SRSF4, SKIV2L2, SMARCD2, SNRPF, SNX9, TKT, TUBB4B, USP9X, YLPM1, YTHDF1, ADSS, BAG5, AAR2, CALM1, CALM2, CALM3, CAPZA1, CKAP4, CLINT1, CLTC, DHX30, DHX8, DHX9, EIF1AY, EIF3I, FAM120B, FAM98A, HLA-H, HNRNPA2B1, HNRNPUL1, HSPA9, IPO4, LDHB, MCM7, MRPL39, MRPL4, MRPS34, MTDH, NKRF, NOP56, NPEPPS, NUP214, PABPC1, PCBP2, PHB, PPP1CA, PRPF31, PSMD2, PURA, SAFB2, SMN2, SMN1, SRP68, TUBB6, ABCD3, ACTR2, ANKFY1, ATP2A2, ATP5C1, BOP1, RTCB, CARM1, CDC45, CPNE7, CPSF6, EIF3CL, EIF3C, EMD, EXOSC6, FAM120A, GBAS, GFPT2, GMPPA, GPRASP2, HSPA5, KPNA2, KRT1, KRT31, KRT36, KRT85, LARP1, SLC3A2, MAGED2, NIFK, NUDT21, NUP93, PFKP, PPIH, PPP1CB, PRDX4, PRPF4, PSMD1, RBM28, RBM3, RBM39, RPL35, RPS19, RRP15, SF3B3, SRSF2, SMNDC1, SNRPD2, SUPT16H, TARS2, TCP1, TUBA4A, U2AF2, VIM, VPS4B, ABCE1, AIFM1, BAG4, BOLA2, BOLA2B, C14orf166, C1orf35, DLGAP3, DNAJC10, DNAJC9, EIF4A3, EIF6, EWSR1, FXR2, GPN1, HNRNPA3, HNRNPL, HNRNPUL2, KRT9, LUC7L2, MAD2L1, MAPKAPK2, NAP1L1, PABPC4, PES1, PHGDH, PLOD1, PRMT1, PRPF19, RBM14, RBFOX2, RPN2, RPS5, RUVBL2, SRSF5, SMARCA4, SMARCC1, SNRPB, STAU1, TBL2, TCEB2, TIAL1, ZCCHC8, ACADM, ACTR1B, AHSA1, FBF1, AP2B1, ARL1, CCT2, CCT3, YBX3, DDX21, DNAJA2, DNAJC7, EIF4B, ENO1, EPPK1, GALK1, HNRNPH3, HNRNPK, HSP90AB2P, IGF2BP1, ILF3, ILVBL, IRAK1, KHSRP, KRR1, LANCL1, MARS, MATR3, MRPL49, MRPS15, NAT10, NONO, NT5DC2, PCNA, PDCD6IP, PDHA1, PLOD3, POLR2C, POLR2E, POLRMT, PPP1R15A, RARS, RBMX, RPL10P16, RPL37A, RPL5, RPL7L1, RPS17, RRP1B, SRSF3, SLC25A3, SMC1A, SMU1, SNRNP70, SPTAN1, SSR4, TAF15, TROVE2, TUBA4B, TUBB2A, UMPS, USP7, VARS, WDR18, XRN2, YTHDF2, YWHAH, YWHAQ, AGK, AHCY, ATP2A1, ATP5A1, CCDC47, CCT5, CDC5L, CIRBP, DAZAP1, DDX5, EXOSC5, FKBP8, GMPS, GTPBP1, HNRNPC, HNRNPF, KPNA4, KRT16, KRT6B, LARP4, LARS, LGALS3BP, MAT2A, MMS19, MRPS7, MRTO4, MTHFD2, NPM1, NUP155, NUP205, PPP2CA, PSMC4, PTBP1, PYCR1, RPL10A, RPL17, RPL26L1, RPL36AP37, HNRNPH2, RPS3, RPS7, RSL1D1, SAMHD1, SDHA, SEC23A, SEC24C, SSBP1, STRBP, TARS, TIA1, TRIM28, TUBA1C, TUBA3D, TUBA3C, TUBB1, TUBB4A, TUFM, YBX1, ZFR, AK2, BAG2, C1QBP, NTPCR, YAE1D1, C8orf33, DDX17, DDX50, DHX15, DSP, EEF1G, EPRS, FASN, FBL, GART, GTF2I, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, HNRNPA0, HNRNPR, HP1BP3, HSPA1A, HSPA1B, HSPA1L, KRT10, MCM6, MRPS5, MTHFD1L, NDUFS3, NUP107, PABPN1, PGRMC1, PPP2R2A, PTCD3, PTPLAD1, QARS, RFC5, RPL3, RPL6, RPLP0, RPS10, RPS12, RPS14, RPS21, SEP15, SF3B4, SRSF1, SRSF9, SLC16A1, SLC1A5, SNRPD1, SNRPE, SS18, SYNCRIP, TRA2B, TRIP13, TUBB, TUBB3, YWHAZ, ACAT1, ACTB, ADAR, ALDOA, BUB3, CDK4, CKB, CLTCL1, CTPS1, DDX4, DNAJA1, DNAJA3, EEF1A2, EEF1B2, EIF2AK2, FXR1, TECR, GRWD1, HAX1, HNRNPA1, HNRNPDL, HPRT1, HSP90AA1, HSPB1, HSPH1, IARS, ILF2, ILK, CCT4, KHDRBS1, KPNA6, KRT2, LSM12, MTHFD1, NDUFA4, NDUFA4P1, P4HB, PCMT1, PKM, POLDIP2, PRDX3, PSMA5, RPL23, RPL35A, RPL9, RPLP2, RPS13, RPS15, RPS2, RPS25, RPS7P4, RRP12, SRSF11, SNRPG, SRRT, SSB, ALYREF, TIMM13, U2AF1, YWHAG, ZNF326, ACTBL2, ACTL6A, ACTR1A, ALDH1B1, ATAD3A, CCT6A, CSTB, DCD, DDX18, LDHD, EEF1A1, ELAVL1, GAPDH, GNL3, HNRNPAB, HNRNPD, HSP90AA2P, IGF2BP2, KPNB1, KRT5, KRT78, LDHA, LYAR, PAICS, PFN1, PPP2R1A, PRPH, RPL22, RPL23A, RPL36, RPL4, RPL8, RPS20, RPS8, SEC24A, SNRPC, SRP14, TOP1, TRA2A, TUBB2B, UBC, AMPD1, CCT7, EEF2, EIF5A2, ENO2, FAU, GSTP1, HIST1H1C, HIST2H2BE, HSP90AB1, KRT13, KRT14, KRT71, KRT76, MCM3, NAP1L4, PCBD1, PRDX1, PWP1, QPCT, RBMXL2, RPL11, RPL12, RPL13P12, RPL14, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL24, RPL27, RPL30, RPL31, RPL38, RPL7A, RPLP1, RPS15A, RPS16, RPS18, RPS24, RPS4X, RPS6, RPS9, SDHB, SERBP1, SLC25A5, SLC25A6, SMARCC2, SNRPB2, TRAP1, XRCC5, ACTA2, CCT8, HNRNPCL1, KRT24, KRT75, NFKB1, PDIA6, PPIA, RPL13, RPL13A, RPL7AP27, SNRPD3, CUL4A, ANK1, ESR1, UBE2E3, UBE2E1, UBE2E2, CDC34, UBE2D2, RCBTB2, UBE2M, RFWD2, CASP8, APP, PPP2R2B, TNFRSF10B, TNFRSF10A, FADD, DDIT3, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, KLHL3, WNK4, CCDC22, COMMD8, DAXX, CAMK1D, EFNB1, WNT7B, HLA-DMB, CDC25A, FOLR1, DYRK4, OLIG2, DLC1, GORASP2, ME1, TBCD, OIP5, BCL6, GMCL1P1, MYNN, NLRP1, FMOD, CIITA, LRRC8B, RTN4RL1, PRAMEF8, ERBB2IP, LRRK1, LRFN2, LRRC7, PAK1IP1, HIRA, DMWD, COPB2, TRIM3, TRIM32, UTP15, BRWD1, FBXW5, WDR91, WDTC1, PHIP, WDR35, WDR48, POC1B, WDR76, DPH7, WDR90, WDR1, WDFY4, LRR1, UBE2D1, ZMAT4, BRMS1, RNF7, DRD4, ARIH1, CUL2, TXLNA, RPUSD2, SBDS, TBC1D24, NTRK1, MEMO1, MAP1LC3B, GABARAP, MAP1LC3C, HIST1H2BG, CLK1, ERG, UBASH3B, ZNF711, FAM193B, PALB2, SENP3, ARRB2, ARRB1, GLI2, DVL2, USP21, AURKA, EGLN2, ZNF444, KLHL10, TCEB3, MTNR1A, MTNR1B, RBBP8, NOTCH1, PHLPP2, BRD4

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SCMH1_CUL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SCMH1_CUL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CUL3	C0025202	melanoma	1	CTD_human
Tgene	CUL3	C3469606	PSEUDOHYPOALDOSTERONISM, TYPE IIE	1	ORPHANET;UNIPROT

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Fusion gene ID: 32847

FusionGeneSummary for SCMH1_CUL3

FusionProtFeatures for SCMH1_CUL3

FusionGeneSequence for SCMH1_CUL3

FusionGenePPI for SCMH1_CUL3

RelatedDrugs for SCMH1_CUL3

RelatedDiseases for SCMH1_CUL3