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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32841

FusionGeneSummary for SCLY_UBE2F

check button Fusion gene summary
Fusion gene informationFusion gene name: SCLY_UBE2F
Fusion gene ID: 32841
HgeneTgene
Gene symbol

SCLY

UBE2F

Gene ID

51540

140739

Gene nameselenocysteine lyaseubiquitin conjugating enzyme E2 F (putative)
SynonymsSCL|hSCLNCE2
Cytomap

2q37.3

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionselenocysteine lyaseNEDD8-conjugating enzyme UBE2FNEDD8 carrier protein UBE2FNEDD8 protein ligase UBE2FNEDD8-conjugating enzyme 2RING-type E3 NEDD8 transferase UBE2Fubiquitin-conjugating enzyme E2F (putative)
Modification date2018051920180523
UniProtAcc

Q96I15

Q969M7

Ensembl transtripts involved in fusion geneENST00000254663, ENST00000373332, 
ENST00000555827, ENST00000409736, 
ENST00000422984, ENST00000429612, 
ENST00000480859, 		ENST00000272930, 
ENST00000409633, ENST00000414443, 
ENST00000409953, ENST00000409332, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: SCLY [Title/Abstract] AND UBE2F [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2F

GO:0045116

protein neddylation

19250909


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-VS-A8EC-01ASCLYchr2

238976806

+UBE2Fchr2

238933983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000254663ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000254663ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000254663ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000254663ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000254663ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
5UTR-3CDSENST00000373332ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
5UTR-3CDSENST00000373332ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
5UTR-3CDSENST00000373332ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
5UTR-3CDSENST00000373332ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
5UTR-3CDSENST00000373332ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000555827ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000555827ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000555827ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000555827ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000555827ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000409736ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000409736ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000409736ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000409736ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000409736ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
intron-3CDSENST00000422984ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
intron-3CDSENST00000422984ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
intron-3CDSENST00000422984ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
intron-3CDSENST00000422984ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
intron-3CDSENST00000422984ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000429612ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000429612ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000429612ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000429612ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
In-frameENST00000429612ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+
3UTR-3CDSENST00000480859ENST00000272930SCLYchr2

238976806

+UBE2Fchr2

238933983

+
3UTR-3CDSENST00000480859ENST00000409633SCLYchr2

238976806

+UBE2Fchr2

238933983

+
3UTR-3CDSENST00000480859ENST00000414443SCLYchr2

238976806

+UBE2Fchr2

238933983

+
3UTR-3CDSENST00000480859ENST00000409953SCLYchr2

238976806

+UBE2Fchr2

238933983

+
3UTR-3CDSENST00000480859ENST00000409332SCLYchr2

238976806

+UBE2Fchr2

238933983

+

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FusionProtFeatures for SCLY_UBE2F


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCLY

Q96I15

UBE2F

Q969M7

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCLY_UBE2F


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCLY_UBE2F


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCLYTERF2IP, PAK2, CKB, CNDP2, CSE1L, EIF5, FERMT2, GNS, NPEPPS, SNRPD1, UBFD1, ZNF622, CCBL1, HYI, IDE, NUTF2, GGCT, GMPPB, PAFAH1B1, REXO2, SHMT2, TRIM25, UAP1, WDR1, CREB3, LNX2, TFG, EXOSC5, VPS18UBE2FRNF34, ELAVL1, CUL5, S100A11, RNF7, DCUN1D1, DCUN1D2, DCUN1D3, CUL1, NAE1, UBA3, DCUN1D5, UBE2D2, RC3H1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneUBE2Fchr2:238976806chr2:238933983ENST00000272930+4101_2994186UBA3
TgeneUBE2Fchr2:238976806chr2:238933983ENST00000414443+281_2962154UBA3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCLY_UBE2F


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSCLYQ96I15DB00114Pyridoxal PhosphateSelenocysteine lyasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SCLY_UBE2F


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource