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Fusion gene ID: 32841 |
FusionGeneSummary for SCLY_UBE2F |
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Fusion gene information | Fusion gene name: SCLY_UBE2F | Fusion gene ID: 32841 | Hgene | Tgene | Gene symbol | SCLY | UBE2F | Gene ID | 51540 | 140739 |
Gene name | selenocysteine lyase | ubiquitin conjugating enzyme E2 F (putative) | |
Synonyms | SCL|hSCL | NCE2 | |
Cytomap | 2q37.3 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | selenocysteine lyase | NEDD8-conjugating enzyme UBE2FNEDD8 carrier protein UBE2FNEDD8 protein ligase UBE2FNEDD8-conjugating enzyme 2RING-type E3 NEDD8 transferase UBE2Fubiquitin-conjugating enzyme E2F (putative) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96I15 | Q969M7 | |
Ensembl transtripts involved in fusion gene | ENST00000254663, ENST00000373332, ENST00000555827, ENST00000409736, ENST00000422984, ENST00000429612, ENST00000480859, | ENST00000272930, ENST00000409633, ENST00000414443, ENST00000409953, ENST00000409332, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SCLY [Title/Abstract] AND UBE2F [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2F | GO:0045116 | protein neddylation | 19250909 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-VS-A8EC-01A | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000254663 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000254663 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000254663 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000254663 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000254663 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
5UTR-3CDS | ENST00000373332 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
5UTR-3CDS | ENST00000373332 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
5UTR-3CDS | ENST00000373332 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
5UTR-3CDS | ENST00000373332 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
5UTR-3CDS | ENST00000373332 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000555827 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000555827 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000555827 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000555827 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000555827 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000409736 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000409736 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000409736 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000409736 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000409736 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
intron-3CDS | ENST00000422984 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
intron-3CDS | ENST00000422984 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
intron-3CDS | ENST00000422984 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
intron-3CDS | ENST00000422984 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
intron-3CDS | ENST00000422984 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000429612 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000429612 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000429612 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000429612 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
In-frame | ENST00000429612 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
3UTR-3CDS | ENST00000480859 | ENST00000272930 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
3UTR-3CDS | ENST00000480859 | ENST00000409633 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
3UTR-3CDS | ENST00000480859 | ENST00000414443 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
3UTR-3CDS | ENST00000480859 | ENST00000409953 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
3UTR-3CDS | ENST00000480859 | ENST00000409332 | SCLY | chr2 | 238976806 | + | UBE2F | chr2 | 238933983 | + |
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FusionProtFeatures for SCLY_UBE2F |
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Hgene | Tgene |
SCLY | UBE2F |
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCLY_UBE2F |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCLY_UBE2F |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SCLY | TERF2IP, PAK2, CKB, CNDP2, CSE1L, EIF5, FERMT2, GNS, NPEPPS, SNRPD1, UBFD1, ZNF622, CCBL1, HYI, IDE, NUTF2, GGCT, GMPPB, PAFAH1B1, REXO2, SHMT2, TRIM25, UAP1, WDR1, CREB3, LNX2, TFG, EXOSC5, VPS18 | UBE2F | RNF34, ELAVL1, CUL5, S100A11, RNF7, DCUN1D1, DCUN1D2, DCUN1D3, CUL1, NAE1, UBA3, DCUN1D5, UBE2D2, RC3H1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | UBE2F | chr2:238976806 | chr2:238933983 | ENST00000272930 | + | 4 | 10 | 1_29 | 94 | 186 | UBA3 |
Tgene | UBE2F | chr2:238976806 | chr2:238933983 | ENST00000414443 | + | 2 | 8 | 1_29 | 62 | 154 | UBA3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCLY_UBE2F |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SCLY | Q96I15 | DB00114 | Pyridoxal Phosphate | Selenocysteine lyase | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for SCLY_UBE2F |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |