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Fusion gene ID: 32838 |
FusionGeneSummary for SCLT1_DNAJB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCLT1_DNAJB1 | Fusion gene ID: 32838 | Hgene | Tgene | Gene symbol | SCLT1 | DNAJB1 | Gene ID | 132320 | 3337 |
| Gene name | sodium channel and clathrin linker 1 | DnaJ heat shock protein family (Hsp40) member B1 | |
| Synonyms | CAP-1A|CAP1A | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1 | |
| Cytomap | 4q28.2 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium channel and clathrin linker 1sodium channel-associated protein 1 | dnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96NL6 | P25685 | |
| Ensembl transtripts involved in fusion gene | ENST00000281142, ENST00000434680, ENST00000439369, ENST00000503215, ENST00000502495, ENST00000506368, ENST00000511426, ENST00000503401, | ENST00000254322, ENST00000396969, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SCLT1 [Title/Abstract] AND DNAJB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DNAJB1 | GO:0032781 | positive regulation of ATPase activity | 23921388 |
| Tgene | DNAJB1 | GO:0051085 | chaperone cofactor-dependent protein refolding | 18620420 |
| Tgene | DNAJB1 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Tgene | DNAJB1 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 9499401 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW380464 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000281142 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000281142 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000434680 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000434680 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000439369 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000439369 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503215 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503215 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000502495 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000502495 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000506368 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000506368 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000511426 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000511426 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503401 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503401 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
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FusionProtFeatures for SCLT1_DNAJB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCLT1 | DNAJB1 |
| Adapter protein that links SCN10A to clathrin. RegulatesSCN10A channel activity, possibly by promoting channelinternalization (By similarity). {ECO:0000250}. | Interacts with HSP70 and can stimulate its ATPaseactivity. Stimulates the association between HSC70 and HIP.Negatively regulates heat shock-induced HSF1 transcriptionalactivity during the attenuation and recovery phase period of theheat shock response (PubMed:9499401). Stimulates ATP hydrolysisand the folding of unfolded proteins mediated by HSPA1A/B (invitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:9499401}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCLT1_DNAJB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCLT1_DNAJB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCLT1_DNAJB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCLT1_DNAJB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DNAJB1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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