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Fusion gene ID: 32822 |
FusionGeneSummary for SCFD2_NARS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCFD2_NARS2 | Fusion gene ID: 32822 | Hgene | Tgene | Gene symbol | SCFD2 | NARS2 | Gene ID | 152579 | 79731 |
| Gene name | sec1 family domain containing 2 | asparaginyl-tRNA synthetase 2, mitochondrial | |
| Synonyms | STXBP1L1 | DFNB94|SLM5|asnRS | |
| Cytomap | 4q12 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WU76 | Q96I59 | |
| Ensembl transtripts involved in fusion gene | ENST00000401642, ENST00000388940, | ENST00000281038, ENST00000528850, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 20 X 8 X 9=1440 |
| # samples | 8 | 20 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SCFD2 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-8074-01A | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000401642 | ENST00000281038 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000401642 | ENST00000528850 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000388940 | ENST00000281038 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000388940 | ENST00000528850 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
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FusionProtFeatures for SCFD2_NARS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCFD2 | NARS2 |
| May be involved in protein transport. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SCFD2 | chr4:54218765 | chr11:78180359 | ENST00000388940 | - | 2 | 8 | 120_124 | 335 | 640 | Compositional bias | Note=Poly-Ala |
| Hgene | SCFD2 | chr4:54218765 | chr11:78180359 | ENST00000401642 | - | 2 | 9 | 120_124 | 335 | 685 | Compositional bias | Note=Poly-Ala |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCFD2_NARS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_494aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSSISYTEAVEILKQASQNFTFTPEWG ADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDL >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_494aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSSISYTEAVEILKQASQNFTFTPEWG ADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDL >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_494aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSSISYTEAVEILKQASQNFTFTPEWG ADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDL >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_494aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSSISYTEAVEILKQASQNFTFTPEWG ADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_1482nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGT GCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAG CCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGA GGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTT CGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGAT >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_1482nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGT GCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAG CCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGA GGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTT CGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGAT >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_1482nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGT GCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAG CCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGA GGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTT CGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGAT >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_1482nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGT GCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAG CCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGA GGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTT CGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_2325nt TCAGGGAGCGTGTCAGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAA GAAGTTCCTGCACCGTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGC AGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCC TGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTG TGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAA CCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGC TGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCC ACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGA AGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTC TGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTG CAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATG GAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTG CACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCT TAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTG GCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTG CTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAG CCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTG AACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGG AAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGC AGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACG TAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGT CTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGA GAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTAC TTCATTAAACATTGCAGAAAAAAATATTCCTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAA CTGGATGAAAAAATCATGTTTAATAACTGTTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCAC >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_2063nt TCAGGGAGCGTGTCAGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAA GAAGTTCCTGCACCGTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGC AGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCC TGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTG TGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAA CCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGC TGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCC ACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGA AGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTC TGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTG CAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATG GAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTG CACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCT TAAAGCAAGCATCCCAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTG GCAACATACCTGTCTTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTG CTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAG CCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTG AACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGG AAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGC AGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACG TAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGT CTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGA >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000281038_chr11_78180359_-_2311nt AGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAAGAAGTTCCTGCACC GTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAA GTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGG GGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTG CTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCT GTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTG TGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACT CCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTG GGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTA GGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAG AAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTA GAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAG GAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCC CAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTC TTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTT CTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTT ACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAG TGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGG AAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGT AATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCC CGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTT TAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAG CTCGAAATAAAATAATGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTACTTCATTAAACATTG CAGAAAAAAATATTCCTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAACTGGATGAAAAAAT CATGTTTAATAACTGTTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCACTGTTGTTATAATTT >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_NARS2_ENST00000528850_chr11_78180359_-_2049nt AGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAAGAAGTTCCTGCACC GTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAA GTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGG GGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTG CTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCT GTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTG TGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACT CCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTG GGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTA GGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAG AAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTA GAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAG GAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGCATTTCTTATACTGAAGCAGTGGAGATCTTAAAGCAAGCATCC CAGAACTTCACCTTTACCCCAGAGTGGGGTGCTGACCTACGGACTGAACATGAAAAGTACCTGGTGAAGCACTGTGGCAACATACCTGTC TTCGTTATTAATTATCCATTAACACTCAAGCCTTTCTACATGAGGGATAATGAAGATGGCCCTCAGCACACGGTTGCTGCTGTTGATCTT CTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTT ACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAG TGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGG AAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGT AATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCC CGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTT TAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAG |
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FusionGenePPI for SCFD2_NARS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SCFD2 | USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18 | NARS2 | SLC25A41, OXLD1, DARS2, ADRBK1, CHCHD2, RAB8B, PDK4, LAMP3, NDUFS7, HSPD1, ACSM5, TRNT1, CD70, YBEY, TMEM70, NIT1, GATC, CLEC2D, FOXRED1, OTC, BPNT1, CHRM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCFD2_NARS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCFD2_NARS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NARS2 | C0023264 | Leigh Disease | 1 | UNIPROT |
| Tgene | NARS2 | C4015643 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 24 | 1 | ORPHANET;UNIPROT |
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