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Fusion gene ID: 32820 |
FusionGeneSummary for SCFD2_KDM3B |
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Fusion gene information | Fusion gene name: SCFD2_KDM3B | Fusion gene ID: 32820 | Hgene | Tgene | Gene symbol | SCFD2 | KDM3B | Gene ID | 152579 | 51780 |
Gene name | sec1 family domain containing 2 | lysine demethylase 3B | |
Synonyms | STXBP1L1 | 5qNCA|C5orf7|JMJD1B|NET22 | |
Cytomap | 4q12 | 5q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | lysine-specific demethylase 3BjmjC domain-containing histone demethylation protein 2Bjumonji domain containing 1Bjumonji domain-containing protein 1Blysine (K)-specific demethylase 3Bnuclear protein 5qNCA | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8WU76 | Q7LBC6 | |
Ensembl transtripts involved in fusion gene | ENST00000401642, ENST00000388940, | ENST00000314358, ENST00000394866, ENST00000542866, ENST00000508386, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 6 X 7 X 3=126 |
# samples | 8 | 7 | |
** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCFD2 [Title/Abstract] AND KDM3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF919717 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000401642 | ENST00000314358 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000401642 | ENST00000394866 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000401642 | ENST00000542866 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000401642 | ENST00000508386 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000388940 | ENST00000314358 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000388940 | ENST00000394866 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000388940 | ENST00000542866 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
intron-intron | ENST00000388940 | ENST00000508386 | SCFD2 | chr4 | 54140146 | + | KDM3B | chr5 | 137705815 | - |
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FusionProtFeatures for SCFD2_KDM3B |
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Hgene | Tgene |
SCFD2 | KDM3B |
May be involved in protein transport. | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.Demethylation of Lys residue generates formaldehyde and succinate.May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCFD2_KDM3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCFD2_KDM3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCFD2_KDM3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCFD2_KDM3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KDM3B | C0274869 | Toxic effect of heavy metal | 1 | CTD_human |