FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32820

FusionGeneSummary for SCFD2_KDM3B

check button Fusion gene summary
Fusion gene informationFusion gene name: SCFD2_KDM3B
Fusion gene ID: 32820
HgeneTgene
Gene symbol

SCFD2

KDM3B

Gene ID

152579

51780

Gene namesec1 family domain containing 2lysine demethylase 3B
SynonymsSTXBP1L15qNCA|C5orf7|JMJD1B|NET22
Cytomap

4q12

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionsec1 family domain-containing protein 2syntaxin binding protein 1-like 1lysine-specific demethylase 3BjmjC domain-containing histone demethylation protein 2Bjumonji domain containing 1Bjumonji domain-containing protein 1Blysine (K)-specific demethylase 3Bnuclear protein 5qNCA
Modification date2018051920180523
UniProtAcc

Q8WU76

Q7LBC6

Ensembl transtripts involved in fusion geneENST00000401642, ENST00000388940, 
ENST00000314358, ENST00000394866, 
ENST00000542866, ENST00000508386, 
Fusion gene scores* DoF score7 X 6 X 4=1686 X 7 X 3=126
# samples 87
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCFD2 [Title/Abstract] AND KDM3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF919717SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000401642ENST00000314358SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000401642ENST00000394866SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000401642ENST00000542866SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000401642ENST00000508386SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000388940ENST00000314358SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000388940ENST00000394866SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000388940ENST00000542866SCFD2chr4

54140146

+KDM3Bchr5

137705815

-
intron-intronENST00000388940ENST00000508386SCFD2chr4

54140146

+KDM3Bchr5

137705815

-

Top

FusionProtFeatures for SCFD2_KDM3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCFD2

Q8WU76

KDM3B

Q7LBC6

May be involved in protein transport. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.Demethylation of Lys residue generates formaldehyde and succinate.May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SCFD2_KDM3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SCFD2_KDM3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SCFD2_KDM3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SCFD2_KDM3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKDM3BC0274869Toxic effect of heavy metal1CTD_human