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Fusion gene ID: 32819 |
FusionGeneSummary for SCFD2_GSX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCFD2_GSX2 | Fusion gene ID: 32819 | Hgene | Tgene | Gene symbol | SCFD2 | GSX2 | Gene ID | 152579 | 170825 |
| Gene name | sec1 family domain containing 2 | GS homeobox 2 | |
| Synonyms | STXBP1L1 | GSH2 | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | GS homeobox 2genetic-screened homeobox 2homeobox protein GSH-2 | |
| Modification date | 20180519 | 20180429 | |
| UniProtAcc | Q8WU76 | Q9BZM3 | |
| Ensembl transtripts involved in fusion gene | ENST00000401642, ENST00000388940, | ENST00000326902, ENST00000503800, ENST00000548609, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SCFD2 [Title/Abstract] AND GSX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-76-4928-01B | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000401642 | ENST00000326902 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| In-frame | ENST00000401642 | ENST00000503800 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| 5CDS-3UTR | ENST00000401642 | ENST00000548609 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| In-frame | ENST00000388940 | ENST00000326902 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| In-frame | ENST00000388940 | ENST00000503800 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
| 5CDS-3UTR | ENST00000388940 | ENST00000548609 | SCFD2 | chr4 | 54218765 | - | GSX2 | chr4 | 54967749 | + |
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FusionProtFeatures for SCFD2_GSX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCFD2 | GSX2 |
| May be involved in protein transport. | During telencephalic development, causes ventralizationof pallial progenitors and, depending on the developmental stage,specifies different neuronal fates. At early stages, necessary andsufficient to correctly specify the ventral lateral ganglioniceminence (LGE) and its major derivatives, the striatal projectionneurons. At later stages, may specify LGE progenitors towarddorsal LGE fates, including olfactory bulb interneurons (Bysimilarity). Transcription factor that binds 5'-CNAATTAG-3' DNAsequence. {ECO:0000250|UniProtKB:P31316}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SCFD2 | chr4:54218765 | chr4:54967749 | ENST00000388940 | - | 2 | 8 | 120_124 | 335 | 640 | Compositional bias | Note=Poly-Ala |
| Hgene | SCFD2 | chr4:54218765 | chr4:54967749 | ENST00000401642 | - | 2 | 9 | 120_124 | 335 | 685 | Compositional bias | Note=Poly-Ala |
| Tgene | >GSX2 | chr4:54218765 | chr4:54967749 | ENST00000326902 | + | 0 | 2 | 202_261 | 191 | 305 | DNA binding | Homeobox |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GSX2 | chr4:54218765 | chr4:54967749 | ENST00000326902 | + | 0 | 2 | 124_130 | 191 | 305 | Compositional bias | Note=Poly-His |
| Tgene | GSX2 | chr4:54218765 | chr4:54967749 | ENST00000326902 | + | 0 | 2 | 134_139 | 191 | 305 | Compositional bias | Note=Poly-His |
| Tgene | GSX2 | chr4:54218765 | chr4:54967749 | ENST00000326902 | + | 0 | 2 | 147_162 | 191 | 305 | Compositional bias | Note=Poly-Ala |
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FusionGeneSequence for SCFD2_GSX2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_449aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSRRLXRQPGTQWQEDEDGVHXHATPG >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_349aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_449aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV FVDRTLDLTGAVGHHGDNLVEKIISALPQLPGHTNDVMVNMIALTALHTEEENYNVVAPGCLSQSRRLXRQPGTQWQEDEDGVHXHATPG >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_349aa MSASGVLSFTQQGWEQVLAKVKRAVVYLDAACAESLHWGCGSTRLLEAVGGPDCHLREFEPDAIGGGAKQPKAVFVLSCLLKGRTVEILR DIICRSHFQYCVVVTTVSHAVHLTANHVPAAAAAEMEGQQPVFEQLEEKLCEWMGNMNYTAEVFHVPLLLAPVAPHFALTPAFASLFPLL PQDVHLLNSARPDKRKLGSLGDVDSTTLTPELLLQIRCLVSGLSSLCEHLGVREECFAVGSLSQVIAADLANYAPAKNRKKTAAGRASVV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_1348nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAATGGCAAGAGGATGAGGACGGCGTTCACTAGCACGCAACTCCTGGA GCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGGAGGATTGAAATCGCCACTTACCTGAACCTGTCGGAGAAGCAGGT GAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGGAAGGGCACGCAGAGGAACAGTCACGCGGGCTGCAAGTGCGTCGG >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_1049nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_1348nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC TGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAATGGCAAGAGGATGAGGACGGCGTTCACTAGCACGCAACTCCTGGA GCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGGAGGATTGAAATCGCCACTTACCTGAACCTGTCGGAGAAGCAGGT GAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGGAAGGGCACGCAGAGGAACAGTCACGCGGGCTGCAAGTGCGTCGG >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_1049nt ATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCC GCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAG CCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGG GACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCG GCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACG GCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTA CCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCA GAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGT TCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTT TTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTC CCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_2065nt TCAGGGAGCGTGTCAGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAA GAAGTTCCTGCACCGTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGC AGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCC TGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTG TGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAA CCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGC TGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCC ACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGA AGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTC TGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTG CAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATG GAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTG CACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAAT GGCAAGAGGATGAGGACGGCGTTCACTAGCACGCAACTCCTGGAGCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGG AGGATTGAAATCGCCACTTACCTGAACCTGTCGGAGAAGCAGGTGAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGG AAGGGCACGCAGAGGAACAGTCACGCGGGCTGCAAGTGCGTCGGGAGCCAGGTGCACTACGCGCGCTCCGAGGATGAGGACTCCCTGTCG CCGGCCTCAGCCAACGATGACAAGGAGATTTCCCCCTTATGAGGGAGGGCCTCCTCCCTCACATCCCCCGCTCCTGGCAGACCAGGCAAC GCCAAGGCGTGGGGCACCCAGGGGCCAGAATCCTTGCTCATTGCAGTGGTCCCATCTGGAGAAGAAACGAACCTGGAAGTTCTGGAATGG ACAAGCCGGGACCTGACCCTTCGCGTCTCCTTCTTGACCTGTTTATCTAGGACTCCAACTTGAAGTTACAGATTTTTTTAAAAAATGTAA ATAACCTATAATTCAACTCATTCTTGTCGTATAACAGAGGAAAAACAGGGTTGGTTTAAGTTTAACACTGTATGGGGTTTTTGAAAGCAC ATGTCAGTTCCCCATCCCTACTCTCTTTCAGAACTCGATAAGAACACAGGATTTATTGATTATTTTCTGTTGTCGTTTTCAAACAAAAAC ACCCAAGTTGAAAATAATTTAGAAAATTAGACCTTGTAGGTCTTGCTTTCTGAAATTTCGCCTGGGGAGAATTTAAAATCTAAGTCGCTG >In-frame_SCFD2_ENST00000401642_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_1787nt TCAGGGAGCGTGTCAGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAA GAAGTTCCTGCACCGTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGC AGGTGCTGGCCAAAGTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCC TGGAGGCGGTGGGGGGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTG TGCTGAGCTGCCTGCTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAA CCGTGAGCCACGCTGTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGC TGGAGGAGAAGCTGTGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCC ACTTTGCCTTGACTCCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGA AGCTGGGAAGCCTGGGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTC TGTGTGAACATTTAGGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTG CAAAGAACAGGAAGAAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATG GAGACAACTTAGTAGAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTG CACTCCATACTGAGGAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAAT GGCAAGAGGATGAGGACGGCGTTCACTAGCACGCAACTCCTGGAGCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGG AGGATTGAAATCGCCACTTACCTGAACCTGTCGGAGAAGCAGGTGAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGG AAGGGCACGCAGAGGAACAGTCACGCGGGCTGCAAGTGCGTCGGGAGCCAGGTGCACTACGCGCGCTCCGAGGATGAGGACTCCCTGTCG CCGGCCTCAGCCAACGATGACAAGGAGATTTCCCCCTTATGAGGGAGGGCCTCCTCCCTCACATCCCCCGCTCCTGGCAGACCAGGCAAC GCCAAGGCGTGGGGCACCCAGGGGCCAGAATCCTTGCTCATTGCAGTGGTCCCATCTGGAGAAGAAACGAACCTGGAAGTTCTGGAATGG ACAAGCCGGGACCTGACCCTTCGCGTCTCCTTCTTGACCTGTTTATCTAGGACTCCAACTTGAAGTTACAGATTTTTTTAAAAAATGTAA >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000326902_chr4_54967749_+_2051nt AGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAAGAAGTTCCTGCACC GTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAA GTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGG GGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTG CTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCT GTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTG TGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACT CCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTG GGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTA GGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAG AAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTA GAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAG GAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAATGGCAAGAGGATGAG GACGGCGTTCACTAGCACGCAACTCCTGGAGCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGGAGGATTGAAATCGC CACTTACCTGAACCTGTCGGAGAAGCAGGTGAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGGAAGGGCACGCAGAG GAACAGTCACGCGGGCTGCAAGTGCGTCGGGAGCCAGGTGCACTACGCGCGCTCCGAGGATGAGGACTCCCTGTCGCCGGCCTCAGCCAA CGATGACAAGGAGATTTCCCCCTTATGAGGGAGGGCCTCCTCCCTCACATCCCCCGCTCCTGGCAGACCAGGCAACGCCAAGGCGTGGGG CACCCAGGGGCCAGAATCCTTGCTCATTGCAGTGGTCCCATCTGGAGAAGAAACGAACCTGGAAGTTCTGGAATGGACAAGCCGGGACCT GACCCTTCGCGTCTCCTTCTTGACCTGTTTATCTAGGACTCCAACTTGAAGTTACAGATTTTTTTAAAAAATGTAAATAACCTATAATTC AACTCATTCTTGTCGTATAACAGAGGAAAAACAGGGTTGGTTTAAGTTTAACACTGTATGGGGTTTTTGAAAGCACATGTCAGTTCCCCA TCCCTACTCTCTTTCAGAACTCGATAAGAACACAGGATTTATTGATTATTTTCTGTTGTCGTTTTCAAACAAAAACACCCAAGTTGAAAA TAATTTAGAAAATTAGACCTTGTAGGTCTTGCTTTCTGAAATTTCGCCTGGGGAGAATTTAAAATCTAAGTCGCTGGAAGTCCCTTTGTA >In-frame_SCFD2_ENST00000388940_chr4_54218765_-_GSX2_ENST00000503800_chr4_54967749_+_1773nt AGAGGCCGACCACGTGTACTGTGGAGACTGTCAAAGTCTCCCGGAGCCCAATTTCCGGAAGCGGTGAGTTCTGAAAGAAGTTCCTGCACC GTAGTTTCCCAAGTCTGCGAATCCCCAACCATGAGCGCCTCGGGCGTACTGTCCTTTACCCAGCAAGGATGGGAGCAGGTGCTGGCCAAA GTGAAACGGGCTGTGGTTTACCTGGACGCCGCCTGCGCCGAGAGCCTGCACTGGGGCTGCGGATCCACCCGTCTCCTGGAGGCGGTGGGG GGTCCTGACTGTCACCTGCGAGAGTTCGAGCCCGACGCAATTGGTGGTGGAGCCAAGCAGCCCAAGGCAGTGTTTGTGCTGAGCTGCCTG CTGAAAGGCCGGACCGTGGAGATCCTACGGGACATCATCTGCCGCAGTCACTTCCAGTATTGTGTGGTGGTCACAACCGTGAGCCACGCT GTCCACCTCACAGCTAATCATGTCCCAGCGGCGGCAGCGGCCGAGATGGAGGGGCAGCAGCCGGTGTTCGAGCAGCTGGAGGAGAAGCTG TGTGAATGGATGGGCAACATGAACTACACGGCCGAGGTGTTCCATGTCCCGTTATTGCTTGCCCCTGTTGCTCCCCACTTTGCCTTGACT CCAGCTTTTGCATCCCTTTTCCCACTGCTACCCCAGGATGTGCACCTCCTTAATAGCGCCCGACCGGACAAGAGGAAGCTGGGAAGCCTG GGTGATGTGGACTCCACTACGCTAACCCCAGAGCTGCTGCTGCAGATCAGATGCCTAGTGTCAGGCCTCAGTTCTCTGTGTGAACATTTA GGAGTACGGGAGGAGTGTTTTGCTGTAGGTTCCTTAAGTCAGGTCATCGCTGCGGATCTGGCCAATTATGCCCCTGCAAAGAACAGGAAG AAGACTGCTGCAGGCAGGGCATCAGTGGTTTTTGTGGACAGAACCCTGGATCTCACAGGAGCAGTTGGACATCATGGAGACAACTTAGTA GAGAAGATCATTTCAGCACTTCCCCAGCTCCCAGGCCACACAAATGATGTGATGGTTAACATGATAGCGCTCACTGCACTCCATACTGAG GAGGAAAATTATAATGTGGTTGCACCAGGCTGTCTTTCACAATCCAGGAGGCTCTGACGCCAGCCAGGTACCCAATGGCAAGAGGATGAG GACGGCGTTCACTAGCACGCAACTCCTGGAGCTGGAGAGAGAATTCTCTTCCAACATGTACCTGTCTCGACTCCGGAGGATTGAAATCGC CACTTACCTGAACCTGTCGGAGAAGCAGGTGAAAATCTGGTTTCAGAACCGCCGAGTGAAGCACAAGAAGGAGGGGAAGGGCACGCAGAG GAACAGTCACGCGGGCTGCAAGTGCGTCGGGAGCCAGGTGCACTACGCGCGCTCCGAGGATGAGGACTCCCTGTCGCCGGCCTCAGCCAA CGATGACAAGGAGATTTCCCCCTTATGAGGGAGGGCCTCCTCCCTCACATCCCCCGCTCCTGGCAGACCAGGCAACGCCAAGGCGTGGGG CACCCAGGGGCCAGAATCCTTGCTCATTGCAGTGGTCCCATCTGGAGAAGAAACGAACCTGGAAGTTCTGGAATGGACAAGCCGGGACCT GACCCTTCGCGTCTCCTTCTTGACCTGTTTATCTAGGACTCCAACTTGAAGTTACAGATTTTTTTAAAAAATGTAAATAACCTATAATTC |
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FusionGenePPI for SCFD2_GSX2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SCFD2 | USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18 | GSX2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCFD2_GSX2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCFD2_GSX2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GSX2 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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