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Fusion gene ID: 32810 |
FusionGeneSummary for SCD5_STAP1 |
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Fusion gene information | Fusion gene name: SCD5_STAP1 | Fusion gene ID: 32810 | Hgene | Tgene | Gene symbol | SCD5 | STAP1 | Gene ID | 79966 | 26228 |
Gene name | stearoyl-CoA desaturase 5 | signal transducing adaptor family member 1 | |
Synonyms | ACOD4|FADS4|HSCD5|SCD2|SCD4 | BRDG1|STAP-1 | |
Cytomap | 4q21.22 | 4q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4 | signal-transducing adaptor protein 1BCR downstream-signaling protein 1docking protein BRDG1stem cell adaptor protein 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q86SK9 | Q9ULZ2 | |
Ensembl transtripts involved in fusion gene | ENST00000319540, ENST00000273908, ENST00000282709, | ENST00000265404, ENST00000396225, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 4 X 4 X 3=48 |
# samples | 5 | 4 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCD5 [Title/Abstract] AND STAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SCD5 | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797 |
Tgene | STAP1 | GO:0050861 | positive regulation of B cell receptor signaling pathway | 10518561 |
Tgene | STAP1 | GO:1903997 | positive regulation of non-membrane spanning protein tyrosine kinase activity | 10518561 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-7212-01A | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000319540 | ENST00000265404 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
In-frame | ENST00000319540 | ENST00000396225 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
intron-3CDS | ENST00000273908 | ENST00000265404 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
intron-3CDS | ENST00000273908 | ENST00000396225 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
intron-3CDS | ENST00000282709 | ENST00000265404 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
intron-3CDS | ENST00000282709 | ENST00000396225 | SCD5 | chr4 | 83557744 | - | STAP1 | chr4 | 68472014 | + |
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FusionProtFeatures for SCD5_STAP1 |
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Hgene | Tgene |
SCD5 | STAP1 |
Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. | In BCR signaling, appears to function as a dockingprotein acting downstream of TEC and participates in a positivefeedback loop by increasing the activity of TEC.{ECO:0000269|PubMed:10518561}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCD5_STAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SCD5_ENST00000319540_chr4_83557744_-_STAP1_ENST00000396225_chr4_68472014_+_288aa MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVT AGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLL ADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGQE |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SCD5_ENST00000319540_chr4_83557744_-_STAP1_ENST00000396225_chr4_68472014_+_864nt ATGCCAGGCCCGGCCACCGACGCGGGGAAGATCCCTTTCTGCGACGCCAAGGAAGAAATCCGTGCCGGGCTCGAAAGCTCTGAGGGCGGC GGCGGCCCGGAGAGGCCAGGCGCGCGCGGGCAGCGGCAGAACATCGTCTGGAGGAATGTCGTCCTGATGAGCTTGCTCCACTTGGGGGCC GTGTACTCCCTGGTGCTCATCCCCAAAGCCAAGCCACTCACTCTGCTCTGGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACA GCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGGCCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTC CAGAATGACATCTTCGAGTGGTCCAGGGACCACCGAGCCCACCACAAGTACTCAGAGACGGATGCTGACCCCCACAATGCCCGCCGGGGC TTCTTCTTCTCCCATATTGGGTGGCTGTTTGTTCGCAAGCATCGAGATGTTATTGAGAAGGGGAGAAAGCTTGACGTCACTGACCTGCTT GCTGATCCTGTGGTCCGGATCCAGAGAAAGTACTATAAGATCTCCGTGGTGCTCATGTGCTTTGTGGTCCCCACGCTGGTGCCCTGGTAC ATCTGGGGAGAGAGTCTGTGGAATTCCTACTTCTTGGCCTCTATTCTCCGCTATACCATCTCACTCAACATCAGCTGGCTGGTCAACAGC GCCGCCCACATGTATGGAAACCGGCCCTATGACAAGCACATCAGCCCTCGGCAGAACCCACTCGTCGCTCTGGGTGCCATTGGTCAAGAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SCD5_ENST00000319540_chr4_83557744_-_STAP1_ENST00000396225_chr4_68472014_+_1360nt ATTTTCACAGCTCCTCCTCCCCGGCCGCGCGCCCCTCCCGCCCCGCGCGCGCCTCCTCTTTCTCGCGGCCGAGTTCAGCCCGGGCAGCCA TATGGGGGATACGCCAGCAACAGACGCCGGCCGCCAAGATCTGCATCCCTAGGCCACGCTAAGACCCTGGGGAAGAGCGCAGGAGCCCGG GAGAAGGGCTGGAAGGAGGGGACTGGACGTGCGGAGAATTCCCCCCTAAAAGGCAGAAGCCCCCGCCCCCACCCTCGAGCTCCGCTCGGG CAGAGCGCCTGCCTGCCTGCCGCTGCTGCGGGCGCCCACCTCGCCCAGCCATGCCAGGCCCGGCCACCGACGCGGGGAAGATCCCTTTCT GCGACGCCAAGGAAGAAATCCGTGCCGGGCTCGAAAGCTCTGAGGGCGGCGGCGGCCCGGAGAGGCCAGGCGCGCGCGGGCAGCGGCAGA ACATCGTCTGGAGGAATGTCGTCCTGATGAGCTTGCTCCACTTGGGGGCCGTGTACTCCCTGGTGCTCATCCCCAAAGCCAAGCCACTCA CTCTGCTCTGGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAGCTGGTGCCCATCGCTTGTGGAGCCACAGGTCCTACCGGG CCAAGCTGCCTCTGAGGATATTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGAATGACATCTTCGAGTGGTCCAGGGACCACCGAGCCC ACCACAAGTACTCAGAGACGGATGCTGACCCCCACAATGCCCGCCGGGGCTTCTTCTTCTCCCATATTGGGTGGCTGTTTGTTCGCAAGC ATCGAGATGTTATTGAGAAGGGGAGAAAGCTTGACGTCACTGACCTGCTTGCTGATCCTGTGGTCCGGATCCAGAGAAAGTACTATAAGA TCTCCGTGGTGCTCATGTGCTTTGTGGTCCCCACGCTGGTGCCCTGGTACATCTGGGGAGAGAGTCTGTGGAATTCCTACTTCTTGGCCT CTATTCTCCGCTATACCATCTCACTCAACATCAGCTGGCTGGTCAACAGCGCCGCCCACATGTATGGAAACCGGCCCTATGACAAGCACA TCAGCCCTCGGCAGAACCCACTCGTCGCTCTGGGTGCCATTGGTCAAGAACCCAGTATGGAAGGGAGAAGTGAAAAGTTGAAGAAAAATC CACACATTGCATGAAATACAATGTGAAAGCTCCTTTGTATATCTTGGGGAAAGACTATGTGAGACAGAGGGAGAAAACAGCCATTGACAA CTCAAGGAGAGAGGCCTCGGGGGGAAAAAAAGATCAACCTGGCCAAAACCTTGAAAATCCGGCTTCTTGACTTGTGAGAAAATAAATTTG |
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FusionGenePPI for SCD5_STAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SCD5 | CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3 | STAP1 | SH3KBP1, FAM134C, CD2AP, SULT1A1, CAPZA2, CAPZB, CCND3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCD5_STAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCD5_STAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |