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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32806

FusionGeneSummary for SCD5_ANTXR2

check button Fusion gene summary
Fusion gene informationFusion gene name: SCD5_ANTXR2
Fusion gene ID: 32806
HgeneTgene
Gene symbol

SCD5

ANTXR2

Gene ID

79966

118429

Gene namestearoyl-CoA desaturase 5ANTXR cell adhesion molecule 2
SynonymsACOD4|FADS4|HSCD5|SCD2|SCD4CMG-2|CMG2|HFS|ISH|JHF
Cytomap

4q21.22

4q21.21

Type of geneprotein-codingprotein-coding
Descriptionstearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2
Modification date2018052320180523
UniProtAcc

Q86SK9

P58335

Ensembl transtripts involved in fusion geneENST00000319540, ENST00000273908, 
ENST00000282709, 
ENST00000403729, 
ENST00000482406, ENST00000404191, 
ENST00000346652, ENST00000307333, 
ENST00000295465, 
Fusion gene scores* DoF score5 X 2 X 4=406 X 7 X 3=126
# samples 57
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCD5 [Title/Abstract] AND ANTXR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCD5

GO:0006636

unsaturated fatty acid biosynthetic process

15907797


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-YL-A9WL-01ASCD5chr4

83719459

-ANTXR2chr4

80940130

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000319540ENST00000403729SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000319540ENST00000482406SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000319540ENST00000404191SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000319540ENST00000346652SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000319540ENST00000307333SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000319540ENST00000295465SCD5chr4

83719459

-ANTXR2chr4

80940130

-
Frame-shiftENST00000273908ENST00000403729SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000273908ENST00000482406SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000273908ENST00000404191SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000273908ENST00000346652SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000273908ENST00000307333SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000273908ENST00000295465SCD5chr4

83719459

-ANTXR2chr4

80940130

-
Frame-shiftENST00000282709ENST00000403729SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000282709ENST00000482406SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000282709ENST00000404191SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000282709ENST00000346652SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000282709ENST00000307333SCD5chr4

83719459

-ANTXR2chr4

80940130

-
5CDS-intronENST00000282709ENST00000295465SCD5chr4

83719459

-ANTXR2chr4

80940130

-

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FusionProtFeatures for SCD5_ANTXR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCD5

Q86SK9

ANTXR2

P58335

Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCD5_ANTXR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCD5_ANTXR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCD5CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3ANTXR2SMAD2, COL4A5, LAMB1, LAMC1, LGR4, TCEB3, HS1BP3, IKBIP, ANKRD13D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCD5_ANTXR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCD5_ANTXR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneANTXR2C0009917Contracture2CTD_human
TgeneANTXR2C0016045fibroma2CTD_human
TgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
TgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
TgeneANTXR2C2745948Hyalinosis, Systemic2CTD_human;ORPHANET;UNIPROT
TgeneANTXR2C0029456Osteoporosis1CTD_human
TgeneANTXR2C0221204Lytic lesion1CTD_human