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Fusion gene ID: 32806 |
FusionGeneSummary for SCD5_ANTXR2 |
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Fusion gene information | Fusion gene name: SCD5_ANTXR2 | Fusion gene ID: 32806 | Hgene | Tgene | Gene symbol | SCD5 | ANTXR2 | Gene ID | 79966 | 118429 |
Gene name | stearoyl-CoA desaturase 5 | ANTXR cell adhesion molecule 2 | |
Synonyms | ACOD4|FADS4|HSCD5|SCD2|SCD4 | CMG-2|CMG2|HFS|ISH|JHF | |
Cytomap | 4q21.22 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4 | anthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86SK9 | P58335 | |
Ensembl transtripts involved in fusion gene | ENST00000319540, ENST00000273908, ENST00000282709, | ENST00000403729, ENST00000482406, ENST00000404191, ENST00000346652, ENST00000307333, ENST00000295465, | |
Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 6 X 7 X 3=126 |
# samples | 5 | 7 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCD5 [Title/Abstract] AND ANTXR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SCD5 | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-YL-A9WL-01A | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000319540 | ENST00000403729 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000319540 | ENST00000482406 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000319540 | ENST00000404191 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000319540 | ENST00000346652 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000319540 | ENST00000307333 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000319540 | ENST00000295465 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
Frame-shift | ENST00000273908 | ENST00000403729 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000273908 | ENST00000482406 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000273908 | ENST00000404191 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000273908 | ENST00000346652 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000273908 | ENST00000307333 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000273908 | ENST00000295465 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
Frame-shift | ENST00000282709 | ENST00000403729 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000282709 | ENST00000482406 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000282709 | ENST00000404191 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000282709 | ENST00000346652 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000282709 | ENST00000307333 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
5CDS-intron | ENST00000282709 | ENST00000295465 | SCD5 | chr4 | 83719459 | - | ANTXR2 | chr4 | 80940130 | - |
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FusionProtFeatures for SCD5_ANTXR2 |
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Hgene | Tgene |
SCD5 | ANTXR2 |
Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. | Necessary for cellular interactions with laminin and theextracellular matrix. {ECO:0000269|PubMed:11683410,ECO:0000269|PubMed:12973667}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCD5_ANTXR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCD5_ANTXR2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SCD5 | CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3 | ANTXR2 | SMAD2, COL4A5, LAMB1, LAMC1, LGR4, TCEB3, HS1BP3, IKBIP, ANKRD13D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCD5_ANTXR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCD5_ANTXR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANTXR2 | C0009917 | Contracture | 2 | CTD_human |
Tgene | ANTXR2 | C0016045 | fibroma | 2 | CTD_human |
Tgene | ANTXR2 | C0017567 | Gingival Hypertrophy | 2 | CTD_human |
Tgene | ANTXR2 | C0038013 | Ankylosing spondylitis | 2 | CTD_human |
Tgene | ANTXR2 | C2745948 | Hyalinosis, Systemic | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | ANTXR2 | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | ANTXR2 | C0221204 | Lytic lesion | 1 | CTD_human |