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Fusion gene ID: 32799 |
FusionGeneSummary for SCARB2_STAU2 |
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Fusion gene information | Fusion gene name: SCARB2_STAU2 | Fusion gene ID: 32799 | Hgene | Tgene | Gene symbol | SCARB2 | STAU2 | Gene ID | 950 | 27067 |
Gene name | scavenger receptor class B member 2 | staufen double-stranded RNA binding protein 2 | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | 39K2|39K3 | |
Cytomap | 4q21.1 | 8q21.11 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | double-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14108 | Q9NUL3 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000522695, ENST00000524300, ENST00000523558, ENST00000521210, ENST00000355780, ENST00000519961, ENST00000521727, ENST00000521451, ENST00000522509, ENST00000517542, ENST00000524104, ENST00000522962, ENST00000521419, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 10 X 9 X 5=450 |
# samples | 11 | 12 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCARB2 [Title/Abstract] AND STAU2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0D0-01A | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264896 | ENST00000522695 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000524300 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000523558 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000521210 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000355780 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000519961 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000521727 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000521451 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000522509 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000264896 | ENST00000517542 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000264896 | ENST00000524104 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000264896 | ENST00000522962 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000264896 | ENST00000521419 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000522695 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000524300 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000523558 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000521210 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000355780 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000519961 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000521727 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000521451 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000522509 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
Frame-shift | ENST00000452464 | ENST00000517542 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000452464 | ENST00000524104 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000452464 | ENST00000522962 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
5CDS-intron | ENST00000452464 | ENST00000521419 | SCARB2 | chr4 | 77116860 | - | STAU2 | chr8 | 74495065 | - |
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FusionProtFeatures for SCARB2_STAU2 |
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Hgene | Tgene |
SCARB2 | STAU2 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_STAU2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_STAU2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SCARB2 | THBS1, ATP6V1B1, NONO, DDX1, HSPD1, TAF15, ATP4A, GEM, LGALS8, NAALADL2, PTPRK, WISP3, NTRK1, SMC6, EIF2AK2, PRPF8, PNKD, MYOF, RHCG, VAMP3, SPAG9, GLMN, RAB27B, SCGB1D1, LMNA | STAU2 | KIAA1377, DHX58, EIF2AK2, ELAVL1, COPS5, DICER1, PRKRA, UPF1, ZNF346, ADAR, SHMT2, MOV10, NXF1, BMI1, HIST1H1A, RPL14, RPL8, RPL6, NIFK, RPS2, PRR11, RBM4B, ILF2, PAIP1, HNRNPU, MATR3, STRBP, STAU1, GLTSCR2, WDR46, ELAVL2, PPAN, ZCRB1, ZC3HAV1, E4F1, DGCR8, ZNF324B, NXF2, CDX1, RPL37A, ZNF169, HIST1H1E, RPF1, ZNF2, GPATCH4, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_STAU2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCARB2_STAU2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | STAU2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |