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Fusion gene ID: 32797 |
FusionGeneSummary for SCARB2_SERPINE1 |
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Fusion gene information | Fusion gene name: SCARB2_SERPINE1 | Fusion gene ID: 32797 | Hgene | Tgene | Gene symbol | SCARB2 | SERPINE1 | Gene ID | 950 | 5054 |
Gene name | scavenger receptor class B member 2 | serpin family E member 1 | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | PAI|PAI-1|PAI1|PLANH1 | |
Cytomap | 4q21.1 | 7q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | plasminogen activator inhibitor 1endothelial plasminogen activator inhibitorserine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1serpin E1serpin peptidase inhibitor, clade E (nexin, plasminogen ac | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q14108 | P05121 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000223095, ENST00000445463, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 6 X 6 X 1=36 |
# samples | 11 | 6 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SCARB2 [Title/Abstract] AND SERPINE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SERPINE1 | GO:0010469 | regulation of signaling receptor activity | 8837777 |
Tgene | SERPINE1 | GO:0010757 | negative regulation of plasminogen activation | 8508955 |
Tgene | SERPINE1 | GO:0010951 | negative regulation of endopeptidase activity | 1695900 |
Tgene | SERPINE1 | GO:0014912 | negative regulation of smooth muscle cell migration | 8837777 |
Tgene | SERPINE1 | GO:0030336 | negative regulation of cell migration | 10902815 |
Tgene | SERPINE1 | GO:0033629 | negative regulation of cell adhesion mediated by integrin | 8837777 |
Tgene | SERPINE1 | GO:0048260 | positive regulation of receptor-mediated endocytosis | 8626514 |
Tgene | SERPINE1 | GO:0051918 | negative regulation of fibrinolysis | 2503541 |
Tgene | SERPINE1 | GO:0097187 | dentinogenesis | 27046084 |
Tgene | SERPINE1 | GO:1901331 | positive regulation of odontoblast differentiation | 27046084 |
Tgene | SERPINE1 | GO:2000098 | negative regulation of smooth muscle cell-matrix adhesion | 8837777 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ650179 | SCARB2 | chr4 | 77091105 | - | SERPINE1 | chr7 | 100777064 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000264896 | ENST00000223095 | SCARB2 | chr4 | 77091105 | - | SERPINE1 | chr7 | 100777064 | + |
intron-3CDS | ENST00000264896 | ENST00000445463 | SCARB2 | chr4 | 77091105 | - | SERPINE1 | chr7 | 100777064 | + |
intron-3CDS | ENST00000452464 | ENST00000223095 | SCARB2 | chr4 | 77091105 | - | SERPINE1 | chr7 | 100777064 | + |
intron-3CDS | ENST00000452464 | ENST00000445463 | SCARB2 | chr4 | 77091105 | - | SERPINE1 | chr7 | 100777064 | + |
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FusionProtFeatures for SCARB2_SERPINE1 |
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Hgene | Tgene |
SCARB2 | SERPINE1 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. | Serine protease inhibitor. Inhibits TMPRSS7(PubMed:15853774). Is a primary inhibitor of tissue-typeplasminogen activator (PLAT) and urokinase-type plasminogenactivator (PLAU). As PLAT inhibitor, it is required forfibrinolysis down-regulation and is responsible for the controlleddegradation of blood clots (PubMed:8481516, PubMed:9207454,PubMed:17912461). As PLAU inhibitor, it is involved in theregulation of cell adhesion and spreading (PubMed:9175705). Actsas a regulator of cell migration, independently of its role asprotease inhibitor (PubMed:15001579, PubMed:9168821). It isrequired for stimulation of keratinocyte migration duringcutaneous injury repair (PubMed:18386027). It is involved incellular and replicative senescence (PubMed:16862142). Plays arole in alveolar type 2 cells senescence in the lung (Bysimilarity). Is involved in the regulation of cementogenicdifferentiation of periodontal ligament stem cells, and regulatesodontoblast differentiation and dentin formation duringodontogenesis (PubMed:25808697, PubMed:27046084).{ECO:0000250|UniProtKB:P22777, ECO:0000269|PubMed:15001579,ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:16862142,ECO:0000269|PubMed:17912461, ECO:0000269|PubMed:18386027,ECO:0000269|PubMed:25808697, ECO:0000269|PubMed:27046084,ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9168821,ECO:0000269|PubMed:9175705, ECO:0000269|PubMed:9207454}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_SERPINE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_SERPINE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_SERPINE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SERPINE1 | P05121 | DB00009 | Alteplase | Plasminogen activator inhibitor 1 | biotech | approved |
Tgene | SERPINE1 | P05121 | DB00029 | Anistreplase | Plasminogen activator inhibitor 1 | biotech | approved |
Tgene | SERPINE1 | P05121 | DB00031 | Tenecteplase | Plasminogen activator inhibitor 1 | biotech | approved |
Tgene | SERPINE1 | P05121 | DB00015 | Reteplase | Plasminogen activator inhibitor 1 | biotech | approved|investigational |
Tgene | SERPINE1 | P05121 | DB00013 | Urokinase | Plasminogen activator inhibitor 1 | biotech | approved|investigational|withdrawn |
Tgene | SERPINE1 | P05121 | DB00055 | Drotrecogin alfa | Plasminogen activator inhibitor 1 | biotech | approved|investigational|withdrawn |
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RelatedDiseases for SCARB2_SERPINE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | SERPINE1 | C0020538 | Hypertensive disease | 2 | CTD_human |
Tgene | SERPINE1 | C0040053 | Thrombosis | 2 | CTD_human |
Tgene | SERPINE1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | SERPINE1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SERPINE1 | C0004943 | Behcet Syndrome | 1 | CTD_human |
Tgene | SERPINE1 | C0008370 | Cholestasis | 1 | CTD_human |
Tgene | SERPINE1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Tgene | SERPINE1 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Tgene | SERPINE1 | C0015695 | Fatty Liver | 1 | CTD_human |
Tgene | SERPINE1 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Tgene | SERPINE1 | C0018801 | Heart failure | 1 | CTD_human |
Tgene | SERPINE1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | SERPINE1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | SERPINE1 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Tgene | SERPINE1 | C0027765 | nervous system disorder | 1 | CTD_human |
Tgene | SERPINE1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | SERPINE1 | C0032914 | Pre-Eclampsia | 1 | CTD_human |
Tgene | SERPINE1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | SERPINE1 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Tgene | SERPINE1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | SERPINE1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | SERPINE1 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Tgene | SERPINE1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |