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Fusion gene ID: 32792 |
FusionGeneSummary for SCARB2_JAK1 |
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Fusion gene information | Fusion gene name: SCARB2_JAK1 | Fusion gene ID: 32792 | Hgene | Tgene | Gene symbol | SCARB2 | JAK1 | Gene ID | 950 | 3716 |
Gene name | scavenger receptor class B member 2 | Janus kinase 1 | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | JAK1A|JAK1B|JTK3 | |
Cytomap | 4q21.1 | 1p31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | tyrosine-protein kinase JAK1 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q14108 | P23458 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000342505, ENST00000465376, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 9 X 8 X 4=288 |
# samples | 11 | 10 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCARB2 [Title/Abstract] AND JAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
Tgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ361764 | SCARB2 | chr4 | 77082602 | - | JAK1 | chr1 | 65300040 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000264896 | ENST00000342505 | SCARB2 | chr4 | 77082602 | - | JAK1 | chr1 | 65300040 | - |
intron-intron | ENST00000264896 | ENST00000465376 | SCARB2 | chr4 | 77082602 | - | JAK1 | chr1 | 65300040 | - |
intron-3UTR | ENST00000452464 | ENST00000342505 | SCARB2 | chr4 | 77082602 | - | JAK1 | chr1 | 65300040 | - |
intron-intron | ENST00000452464 | ENST00000465376 | SCARB2 | chr4 | 77082602 | - | JAK1 | chr1 | 65300040 | - |
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FusionProtFeatures for SCARB2_JAK1 |
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Hgene | Tgene |
SCARB2 | JAK1 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. | Tyrosine kinase of the non-receptor type, involved inthe IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinasepartner for the interleukin (IL)-2 receptor (PubMed:11909529).{ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:7615558}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_JAK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_JAK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_JAK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | JAK1 | P23458 | DB08877 | Ruxolitinib | Tyrosine-protein kinase JAK1 | small molecule | approved |
Tgene | JAK1 | P23458 | DB08895 | Tofacitinib | Tyrosine-protein kinase JAK1 | small molecule | approved|investigational |
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RelatedDiseases for SCARB2_JAK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |