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Fusion gene ID: 32791 |
FusionGeneSummary for SCARB2_ESRP2 |
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Fusion gene information | Fusion gene name: SCARB2_ESRP2 | Fusion gene ID: 32791 | Hgene | Tgene | Gene symbol | SCARB2 | ESRP2 | Gene ID | 950 | 80004 |
Gene name | scavenger receptor class B member 2 | epithelial splicing regulatory protein 2 | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | RBM35B | |
Cytomap | 4q21.1 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | epithelial splicing regulatory protein 2RNA binding motif protein 35ARNA-binding motif protein 35BRNA-binding protein 35B | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14108 | Q9H6T0 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000565858, ENST00000473183, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 2 X 2 X 1=4 |
# samples | 11 | 3 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: SCARB2 [Title/Abstract] AND ESRP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ESRP2 | GO:0043484 | regulation of RNA splicing | 19285943 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ308261 | SCARB2 | chr4 | 77096942 | - | ESRP2 | chr16 | 68265554 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264896 | ENST00000565858 | SCARB2 | chr4 | 77096942 | - | ESRP2 | chr16 | 68265554 | + |
Frame-shift | ENST00000264896 | ENST00000473183 | SCARB2 | chr4 | 77096942 | - | ESRP2 | chr16 | 68265554 | + |
Frame-shift | ENST00000452464 | ENST00000565858 | SCARB2 | chr4 | 77096942 | - | ESRP2 | chr16 | 68265554 | + |
Frame-shift | ENST00000452464 | ENST00000473183 | SCARB2 | chr4 | 77096942 | - | ESRP2 | chr16 | 68265554 | + |
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FusionProtFeatures for SCARB2_ESRP2 |
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Hgene | Tgene |
SCARB2 | ESRP2 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. | mRNA splicing factor that regulates the formation ofepithelial cell-specific isoforms. Specifically regulates theexpression of FGFR2-IIIb, an epithelial cell-specific isoform ofFGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3transcripts that undergo changes in splicing during theepithelial-to-mesenchymal transition (EMT). Acts by directlybinding specific sequences in mRNAs. Binds the GU-rich sequencemotifs in the ISE/ISS-3, a cis-element regulatory region presentin the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_ESRP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_ESRP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_ESRP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCARB2_ESRP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |