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Fusion gene ID: 32790 |
FusionGeneSummary for SCARB2_CYP19A1 |
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Fusion gene information | Fusion gene name: SCARB2_CYP19A1 | Fusion gene ID: 32790 | Hgene | Tgene | Gene symbol | SCARB2 | CYP19A1 | Gene ID | 950 | 1588 |
Gene name | scavenger receptor class B member 2 | cytochrome P450 family 19 subfamily A member 1 | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | ARO|ARO1|CPV1|CYAR|CYP19|CYPXIX|P-450AROM | |
Cytomap | 4q21.1 | 15q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | aromatasecytochrome P-450AROMcytochrome P450 19A1cytochrome P450, family 19, subfamily A, polypeptide 1cytochrome P450, subfamily XIX (aromatization of androgens)estrogen synthaseestrogen synthetaseflavoprotein-linked monooxygenasemicrosomal monoo | |
Modification date | 20180519 | 20180520 | |
UniProtAcc | Q14108 | P11511 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000396402, ENST00000260433, ENST00000396404, ENST00000559878, ENST00000405913, ENST00000557858, ENST00000492852, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 9 X 9 X 3=243 |
# samples | 11 | 11 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/243*10)=-1.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SCARB2 [Title/Abstract] AND CYP19A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CYP19A1 | GO:0006710 | androgen catabolic process | 26482249 |
Tgene | CYP19A1 | GO:2000866 | positive regulation of estradiol secretion | 26482249 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF989796 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000264896 | ENST00000396402 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000264896 | ENST00000260433 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000264896 | ENST00000396404 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000264896 | ENST00000559878 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000264896 | ENST00000405913 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000264896 | ENST00000557858 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-intron | ENST00000264896 | ENST00000492852 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000396402 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000260433 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000396404 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000559878 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000405913 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-3CDS | ENST00000452464 | ENST00000557858 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
intron-intron | ENST00000452464 | ENST00000492852 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
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FusionProtFeatures for SCARB2_CYP19A1 |
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Hgene | Tgene |
SCARB2 | CYP19A1 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. | Catalyzes the formation of aromatic C18 estrogens fromC19 androgens. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_CYP19A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_CYP19A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_CYP19A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CYP19A1 | P11511 | DB00184 | Nicotine | Aromatase | small molecule | approved |
Tgene | CYP19A1 | P11511 | DB00655 | Estrone | Aromatase | small molecule | approved |
Tgene | CYP19A1 | P11511 | DB00357 | Aminoglutethimide | Aromatase | small molecule | approved|investigational |
Tgene | CYP19A1 | P11511 | DB00990 | Exemestane | Aromatase | small molecule | approved|investigational |
Tgene | CYP19A1 | P11511 | DB01006 | Letrozole | Aromatase | small molecule | approved|investigational |
Tgene | CYP19A1 | P11511 | DB01026 | Ketoconazole | Aromatase | small molecule | approved|investigational |
Tgene | CYP19A1 | P11511 | DB01217 | Anastrozole | Aromatase | small molecule | approved|investigational |
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RelatedDiseases for SCARB2_CYP19A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | CYP19A1 | C1960539 | Aromatase deficiency | 6 | CTD_human;ORPHANET;UNIPROT |
Tgene | CYP19A1 | C0032460 | Polycystic Ovary Syndrome | 4 | CTD_human |
Tgene | CYP19A1 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
Tgene | CYP19A1 | C0014175 | Endometriosis | 2 | CTD_human |
Tgene | CYP19A1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Tgene | CYP19A1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | CYP19A1 | C0002453 | Amenorrhea | 1 | CTD_human |
Tgene | CYP19A1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | CYP19A1 | C0005974 | Bone Resorption | 1 | CTD_human |
Tgene | CYP19A1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | CYP19A1 | C0015695 | Fatty Liver | 1 | CTD_human |
Tgene | CYP19A1 | C0016059 | Fibrosis | 1 | CTD_human |
Tgene | CYP19A1 | C0020619 | Hypogonadism | 1 | CTD_human |
Tgene | CYP19A1 | C0020635 | Hypopituitarism | 1 | CTD_human |
Tgene | CYP19A1 | C0021361 | Female infertility | 1 | CTD_human;HPO |
Tgene | CYP19A1 | C0029456 | Osteoporosis | 1 | CTD_human;HPO |
Tgene | CYP19A1 | C0029928 | Ovarian Diseases | 1 | CTD_human |
Tgene | CYP19A1 | C0085207 | Gestational Diabetes | 1 | CTD_human |
Tgene | CYP19A1 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Tgene | CYP19A1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Tgene | CYP19A1 | C0242341 | Sexual Infantilism | 1 | CTD_human |