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Fusion gene ID: 3279 |
FusionGeneSummary for ATP11C_PREX1 |
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Fusion gene information | Fusion gene name: ATP11C_PREX1 | Fusion gene ID: 3279 | Hgene | Tgene | Gene symbol | ATP11C | PREX1 | Gene ID | 286410 | 57580 |
Gene name | ATPase phospholipid transporting 11C | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 | |
Synonyms | ATPIG|ATPIQ | P-REX1 | |
Cytomap | Xq27.1 | 20q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | phospholipid-transporting ATPase IGATPase, class VI, type 11CP4-ATPase flippase complex alpha subunit ATP11Cprobable phospholipid-transporting ATPase IG | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinPIP3 dependent Rac exchange factor 1ptdIns(3,4,5)-dependent Rac exchanger 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NB49 | Q8TCU6 | |
Ensembl transtripts involved in fusion gene | ENST00000370557, ENST00000327569, ENST00000361648, ENST00000460773, ENST00000370543, ENST00000359686, | ENST00000371941, ENST00000396220, ENST00000496915, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 4 X 5 X 2=40 |
# samples | 6 | 6 | |
** MAII score | log2(6/60*10)=0 | log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATP11C [Title/Abstract] AND PREX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A1II-01A | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000370557 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
Frame-shift | ENST00000370557 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
5CDS-intron | ENST00000370557 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000327569 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000327569 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-intron | ENST00000327569 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000361648 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000361648 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-intron | ENST00000361648 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000460773 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000460773 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-intron | ENST00000460773 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000370543 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000370543 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-intron | ENST00000370543 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000359686 | ENST00000371941 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-3CDS | ENST00000359686 | ENST00000396220 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
intron-intron | ENST00000359686 | ENST00000496915 | ATP11C | chrX | 139014175 | - | PREX1 | chr20 | 47309328 | - |
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FusionProtFeatures for ATP11C_PREX1 |
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Hgene | Tgene |
ATP11C | PREX1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP11C_PREX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP11C_PREX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATP11C | TMEM30A, POPDC2, LGALS9, PTH1R, MCAM, LYPD3, TMEM185A, ZACN, SCN2B, HTR3C, CHRNA9, TMEM17, MBLAC2, MTUS2, NRN1, GPR21, P2RY1, MUC1, UPK1A, TMEM63A, SEMA7A, SLC34A2, PTGIR, STS, BCAM, SLC17A2, TMEM107, ATP6V0A2, MARCKSL1, SLC39A12, NMUR2, MFSD4 | PREX1 | BZW1, PPP1CA, ITSN1, MTOR, RPTOR, RICTOR, AKT1, KRAS, NRAS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP11C_PREX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP11C_PREX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |