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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3279

FusionGeneSummary for ATP11C_PREX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11C_PREX1
Fusion gene ID: 3279
HgeneTgene
Gene symbol

ATP11C

PREX1

Gene ID

286410

57580

Gene nameATPase phospholipid transporting 11Cphosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
SynonymsATPIG|ATPIQP-REX1
Cytomap

Xq27.1

20q13.13

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase IGATPase, class VI, type 11CP4-ATPase flippase complex alpha subunit ATP11Cprobable phospholipid-transporting ATPase IGphosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 proteinPIP3 dependent Rac exchange factor 1ptdIns(3,4,5)-dependent Rac exchanger 1
Modification date2018052320180523
UniProtAcc

Q8NB49

Q8TCU6

Ensembl transtripts involved in fusion geneENST00000370557, ENST00000327569, 
ENST00000361648, ENST00000460773, 
ENST00000370543, ENST00000359686, 
ENST00000371941, ENST00000396220, 
ENST00000496915, 
Fusion gene scores* DoF score5 X 4 X 3=604 X 5 X 2=40
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP11C [Title/Abstract] AND PREX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1II-01AATP11CchrX

139014175

-PREX1chr20

47309328

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370557ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
Frame-shiftENST00000370557ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
5CDS-intronENST00000370557ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000327569ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000327569ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-intronENST00000327569ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000361648ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000361648ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-intronENST00000361648ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000460773ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000460773ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-intronENST00000460773ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000370543ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000370543ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-intronENST00000370543ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000359686ENST00000371941ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-3CDSENST00000359686ENST00000396220ATP11CchrX

139014175

-PREX1chr20

47309328

-
intron-intronENST00000359686ENST00000496915ATP11CchrX

139014175

-PREX1chr20

47309328

-

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FusionProtFeatures for ATP11C_PREX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11C

Q8NB49

PREX1

Q8TCU6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP11C_PREX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP11C_PREX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP11CTMEM30A, POPDC2, LGALS9, PTH1R, MCAM, LYPD3, TMEM185A, ZACN, SCN2B, HTR3C, CHRNA9, TMEM17, MBLAC2, MTUS2, NRN1, GPR21, P2RY1, MUC1, UPK1A, TMEM63A, SEMA7A, SLC34A2, PTGIR, STS, BCAM, SLC17A2, TMEM107, ATP6V0A2, MARCKSL1, SLC39A12, NMUR2, MFSD4PREX1BZW1, PPP1CA, ITSN1, MTOR, RPTOR, RICTOR, AKT1, KRAS, NRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP11C_PREX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP11C_PREX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource