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Fusion gene ID: 32789 |
FusionGeneSummary for SCARB2_AREG |
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Fusion gene information | Fusion gene name: SCARB2_AREG | Fusion gene ID: 32789 | Hgene | Tgene | Gene symbol | SCARB2 | AREG | Gene ID | 950 | 374 |
Gene name | scavenger receptor class B member 2 | amphiregulin | |
Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | AR|AREGB|CRDGF|SDGF | |
Cytomap | 4q21.1 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | amphiregulinamphiregulin Bcolorectum cell-derived growth factorschwannoma-derived growth factor | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14108 | P15514 | |
Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000395748, ENST00000264487, ENST00000502307, ENST00000511560, | |
Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SCARB2 [Title/Abstract] AND AREG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | AREG | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
Tgene | AREG | GO:0007186 | G-protein coupled receptor signaling pathway | 12743035 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-69-8255-01A | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264896 | ENST00000395748 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
Frame-shift | ENST00000264896 | ENST00000264487 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
Frame-shift | ENST00000264896 | ENST00000502307 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
5CDS-intron | ENST00000264896 | ENST00000511560 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
Frame-shift | ENST00000452464 | ENST00000395748 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
Frame-shift | ENST00000452464 | ENST00000264487 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
Frame-shift | ENST00000452464 | ENST00000502307 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
5CDS-intron | ENST00000452464 | ENST00000511560 | SCARB2 | chr4 | 77134580 | - | AREG | chr4 | 75312251 | + |
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FusionProtFeatures for SCARB2_AREG |
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Hgene | Tgene |
SCARB2 | AREG |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. | Ligand of the EGF receptor/EGFR. Autocrine growth factoras well as a mitogen for a broad range of target cells includingastrocytes, Schwann cells and fibroblasts. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCARB2_AREG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCARB2_AREG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SCARB2 | THBS1, ATP6V1B1, NONO, DDX1, HSPD1, TAF15, ATP4A, GEM, LGALS8, NAALADL2, PTPRK, WISP3, NTRK1, SMC6, EIF2AK2, PRPF8, PNKD, MYOF, RHCG, VAMP3, SPAG9, GLMN, RAB27B, SCGB1D1, LMNA | AREG | EGFR, UBQLN4, APP, WDR92, KRTAP10-3, ADCY9, ICAM1, AREG, NEURL4, CCND3, SNX11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCARB2_AREG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCARB2_AREG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | AREG | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Tgene | AREG | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Tgene | AREG | C0004096 | Asthma | 1 | CTD_human |
Tgene | AREG | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | AREG | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | AREG | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Tgene | AREG | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Tgene | AREG | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | AREG | C0162568 | Erythropoietic Protoporphyria | 1 | CTD_human |
Tgene | AREG | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | AREG | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | AREG | C3495559 | Juvenile arthritis | 1 | CTD_human |