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Fusion gene ID: 32755 |
FusionGeneSummary for SCAMP2_DBN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCAMP2_DBN1 | Fusion gene ID: 32755 | Hgene | Tgene | Gene symbol | SCAMP2 | DBN1 | Gene ID | 10066 | 1627 |
| Gene name | secretory carrier membrane protein 2 | drebrin 1 | |
| Synonyms | - | D0S117E | |
| Cytomap | 15q24.1 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | secretory carrier-associated membrane protein 2testis secretory sperm-binding protein Li 219p | drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2 | |
| Modification date | 20180523 | 20180525 | |
| UniProtAcc | O15127 | Q16643 | |
| Ensembl transtripts involved in fusion gene | ENST00000268099, | ENST00000309007, ENST00000292385, ENST00000393565, ENST00000393563, ENST00000512501, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 8 X 7 X 6=336 |
| # samples | 8 | 9 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SCAMP2 [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SCAMP2 | GO:0015031 | protein transport | 15840657 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-CS-6186-01A | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000268099 | ENST00000309007 | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
| In-frame | ENST00000268099 | ENST00000292385 | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
| In-frame | ENST00000268099 | ENST00000393565 | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
| 5CDS-5UTR | ENST00000268099 | ENST00000393563 | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
| 5CDS-5UTR | ENST00000268099 | ENST00000512501 | SCAMP2 | chr15 | 75165540 | - | DBN1 | chr5 | 176887704 | - |
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FusionProtFeatures for SCAMP2_DBN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCAMP2 | DBN1 |
| Functions in post-Golgi recycling pathways. Acts as arecycling carrier to the cell surface. | Drebrins might play some role in cell migration,extension of neuronal processes and plasticity of dendrites.Required for actin polymerization at immunological synapses (IS)and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 175_181 | 19 | 330 | Topological domain | Lumenal |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 1_153 | 19 | 330 | Topological domain | Cytoplasmic |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 240_262 | 19 | 330 | Topological domain | Lumenal |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 284_329 | 19 | 330 | Topological domain | Cytoplasmic |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 154_174 | 19 | 330 | Transmembrane | Helical |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 182_202 | 19 | 330 | Transmembrane | Helical |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 219_239 | 19 | 330 | Transmembrane | Helical |
| Hgene | >SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 263_283 | 19 | 330 | Transmembrane | Helical |
| Tgene | DBN1 | chr15:75165540 | chr5:176887704 | ENST00000292385 | - | 8 | 15 | 3_134 | 259 | 652 | Domain | ADF-H |
| Tgene | DBN1 | chr15:75165540 | chr5:176887704 | ENST00000309007 | - | 7 | 14 | 3_134 | 257 | 650 | Domain | ADF-H |
| Tgene | DBN1 | chr15:75165540 | chr5:176887704 | ENST00000393565 | - | 7 | 15 | 3_134 | 257 | 696 | Domain | ADF-H |
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FusionGeneSequence for SCAMP2_DBN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000309007_chr5_176887704_-_412aa MSAFDTNPFADPVDVNPFQGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000292385_chr5_176887704_-_412aa MSAFDTNPFADPVDVNPFQGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRM APTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPA EDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAE VPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYF >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000393565_chr5_176887704_-_458aa MSAFDTNPFADPVDVNPFQGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKA SDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPP PAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADT TVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGE SLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000309007_chr5_176887704_-_1236nt ATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATG GCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAG GTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAG ACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCA GAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGAT GCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTA TGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAG GTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAG CCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAG CTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTC AGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATC >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000292385_chr5_176887704_-_1236nt ATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATG GCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAG GTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAG ACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCA GAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGAT GCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTA TGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAG GTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAG CCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAG CTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTC AGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATC >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000393565_chr5_176887704_-_1374nt ATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGGATGAGGAGGAAGAGACCCAC ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGGAGTTCTTCAAGCAGCAGGAA AGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGTCGTCCGTACTGCCCTTTCATAAAGGCA TCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCCTCCTCCCCTCCACGGACTCCCTTTCCCTATATCACCTGCCACCGCACCCCAAAC CTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGC ACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCA CCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAG GAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTG GCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACC ACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAG CCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCA GCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAG TCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAAT GGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTC TGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000309007_chr5_176887704_-_2171nt AGAACCGCTGCCTCGCTCCCGGAAGTGGAGGGTCTACACGAAGCGCCGCTGGGTCTGGGTGCCCGGAGGCAGCAGCGTTCGCGGAGTTCG CCCGCTGGCCCCCGATCACCATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGG ATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGG AGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACC TGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGA TAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCC CCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCC GGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTG ACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCG CCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTA CTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCA ACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTC TGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCC AGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCT ACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGT GGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTC CGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTT TTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCC TGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTG GTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTT GCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGGCTCTGGCTCCCTGGGACCCCCTCCCCGCCCTTCTTTTGACCCCTTCCTGTCT GGCCCAAAGGAAGTAGCAGGCCCAGCTGGGGCCCCTCGGCTACCCCCCGTCTCCTGCCGGGCAGGTCCCAGGTTGGAGGCCCTAGGCGCG GTTCAGGTCAGGGCTATGGATGGGGCCCAGGGGCTTTGGTGGCCCCTCCCCAACTCCTTCCTCTTTGCTTGGGTTCCTTTTTCACGTTTA GTAACTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGAAAGCACAAACTTCTGTAACGGGTCGTGCTCATGTCTGTTAATAAAGAAATCC >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000292385_chr5_176887704_-_1852nt AGAACCGCTGCCTCGCTCCCGGAAGTGGAGGGTCTACACGAAGCGCCGCTGGGTCTGGGTGCCCGGAGGCAGCAGCGTTCGCGGAGTTCG CCCGCTGGCCCCCGATCACCATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGG ATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGG AGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACC TGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGA TAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCC CCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCC GGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTG ACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCG CCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTA CTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCA ACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTC TGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCC AGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCT ACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGT GGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTC CGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTT TTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCC TGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTG GTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTT >In-frame_SCAMP2_ENST00000268099_chr15_75165540_-_DBN1_ENST00000393565_chr5_176887704_-_1981nt AGAACCGCTGCCTCGCTCCCGGAAGTGGAGGGTCTACACGAAGCGCCGCTGGGTCTGGGTGCCCGGAGGCAGCAGCGTTCGCGGAGTTCG CCCGCTGGCCCCCGATCACCATGTCGGCTTTCGACACCAACCCCTTCGCGGACCCAGTGGATGTAAACCCCTTCCAGGGTGACCATCGGG ATGAGGAGGAAGAGACCCACATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGACAACCCAAGGG AGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGTGATGTACCCTCGCCCTTCAACCATCGACCAGGTCGTCCGT ACTGCCCTTTCATAAAGGCATCGGACAGTGGGCCTTCCTCCTCCTCCTCTTCCTCCTCCTCCCCTCCACGGACTCCCTTTCCCTATATCA CCTGCCACCGCACCCCAAACCTCTCTTCCTCCCTCCCATGCAGCCACCTGGACAGCCACCGGAGGATGGCGCCCACTCCCATCCCCACGC GGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTCGCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCAC CACTGCCACCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAGACCAGAGCAGCAGCCCCTCAGG CCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAGGCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGT CTGCAGAGCAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGATCCACGATGCAGCTGACACCATTGAAACTG ACACTGCCACTGCTGACACCACTGTTGCCAACAACGTACCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGG CCTCCACACTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAGGTGCCCCTGCTGGATGAGGTGG CTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCCACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACC CAGAGGAAGTGGAAGGGGAGTCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAGCTGGAGCAAGAGCAGGAGCCGG AGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAGGAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGT TTGCCCAATCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATCGACATCACATGCTGGGATGCAG ACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGTGATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGC ATCAGCCTCTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGATTCCGGCCCTGGCTGGGGACTT GGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCTTTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTC CTCTCGTTGGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTTAGTCCTCCCTGCTCAGCTGGCC GGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGGGGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTC TTGGGAAAATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGGCAATAAATGGCTCGTGGGCTCT |
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FusionGenePPI for SCAMP2_DBN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SCAMP2 | ST3GAL3, ARIH2, SNAP23, SCAMP1, ATP4A, TSPAN5, GPM6A, ASGR2, DLK1, ART3, RTN4, BSCL2, LPAR1, BCAP31, JAGN1, PHB, RPN1, ATP5L, TCTN3, TMEM17, REEP5, NCAPH | DBN1 | DNMBP, SNUPN, BAK1, NUDT21, MEST, NUDT3, DUSP23, MAPK6, FHL1, BTRC, TPT1, MAP1LC3B, UBE2D3, TAB1, CDK2AP2, ARRB2, SP1, UBE2Q2, FBXO25, TERF1, TINF2, ACD, POT1, LRRK2, TPM1, CALU, ZC3H4, TPM4, RPLP0, TXNDC5, FLNA, MTHFD1, NUP133, JUP, ECE1, CDH2, SPTBN1, SPTAN1, HNRNPUL1, MARCKS, ESR1, MAGOH, BTK, FN1, PHB, PAN2, PIK3C3, FBXO6, LRCH3, TP53, MOV10, EZH2, SUZ12, BMI1, USP7, NTRK1, GRB2, RABGAP1L, PTEN, HIST1H3E, ACTG1, ACTN4, ACTN1, AP2A1, AP2A2, AP2B1, ANXA2, ATP6V1A, ATP6AP1, DST, CALM1, CAMK2G, CAPZA2, CAPZB, CAV1, CD44, CD59, CDC42, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, CDK2, GAK, MYH9, MYO1C, PPP1CB, IQGAP1, ACTR2, SYNPO, MAPRE1, LIMA1, ANLN, MYO19, MYO18A, DSG2, CTTN, STOM, EPS15, FLII, FLNB, FLOT2, GART, GNAS, GNB2, GSN, HSP90AB1, IARS, ITPKA, LGALS1, ABLIM1, LMO7, MYO1B, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, NAP1L1, NAP1L4, NF2, PALM, PIK3C2A, PPP1CA, PPP1CC, TWF1, RAB1A, SDC4, SIPA1, FSCN1, SSFA2, SVIL, TMOD1, CORO2A, YES1, LUZP1, CLTCL1, PICALM, SORBS2, NUMB, GPRC5A, LRRFIP1, LRRFIP2, XPR1, ABCG2, HOMER3, HOMER1, CLINT1, ARHGAP11A, SEC16A, WDR1, ARPC5, ARPC4, ARPC3, ARPC1B, ACTR3, ARPC2, FLOT1, BASP1, DCTN2, ARPC1A, ERLIN1, AKAP2, RRAS2, CEP162, TAB2, MPRIP, COBL, SPECC1L, CORO1C, ZDHHC5, PLEKHG3, RAI14, TIMM13, UHRF1, PACSIN3, TMOD3, CARD10, GTSE1, C14orf166, PALMD, BMP2K, PPP1R9A, ERBB2IP, MYO5C, CGN, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, KCTD10, DCTN5, PPP1R9B, STON2, DIXDC1, SSH2, NEXN, SPECC1, FCHO2, MISP, CHMP4B, PPP1R18, PTRF, TPRN, MCM5, CDH1, HOMER2, ACTA2, ACTB, ACTBL2, TMOD2, COX15, DLST, DNM1L, PARK7, PDHA1, RNF168, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SCAMP2 | chr15:75165540 | chr5:176887704 | ENST00000268099 | - | 1 | 9 | 203_218 | 19 | 330 | SLC9A7 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCAMP2_DBN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCAMP2_DBN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DBN1 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | DBN1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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