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Fusion gene ID: 32750 |
FusionGeneSummary for SCAI_PPP6C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCAI_PPP6C | Fusion gene ID: 32750 | Hgene | Tgene | Gene symbol | SCAI | PPP6C | Gene ID | 286205 | 5537 |
| Gene name | suppressor of cancer cell invasion | protein phosphatase 6 catalytic subunit | |
| Synonyms | C9orf126|NET40 | PP6|PP6C | |
| Cytomap | 9q33.3 | 9q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein SCAIsuppressor of cancer cell invasion protein | serine/threonine-protein phosphatase 6 catalytic subunitserine/threonine protein phosphatase catalytic subunit | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8N9R8 | O00743 | |
| Ensembl transtripts involved in fusion gene | ENST00000336505, ENST00000373549, ENST00000487795, | ENST00000373547, ENST00000415905, ENST00000451402, ENST00000373546, | |
| Fusion gene scores | * DoF score | 2 X 1 X 1=2 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SCAI [Title/Abstract] AND PPP6C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP6C | GO:0006470 | protein dephosphorylation | 16716191 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0RT-01A | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000336505 | ENST00000373547 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000336505 | ENST00000415905 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000336505 | ENST00000451402 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000336505 | ENST00000373546 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| Frame-shift | ENST00000373549 | ENST00000373547 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000373549 | ENST00000415905 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000373549 | ENST00000451402 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| In-frame | ENST00000373549 | ENST00000373546 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| intron-3CDS | ENST00000487795 | ENST00000373547 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| intron-3CDS | ENST00000487795 | ENST00000415905 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| intron-3CDS | ENST00000487795 | ENST00000451402 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
| intron-3CDS | ENST00000487795 | ENST00000373546 | SCAI | chr9 | 127904912 | - | PPP6C | chr9 | 127912200 | - |
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FusionProtFeatures for SCAI_PPP6C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCAI | PPP6C |
| Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migrationthrough transcriptional regulation of ITGB1.{ECO:0000269|PubMed:19350017}. | Catalytic subunit of protein phosphatase 6 (PP6). PP6 isa component of a signaling pathway regulating cell cycleprogression in response to IL2 receptor stimulation. N-terminaldomain restricts G1 to S phase progression in cancer cells, inpart through control of cyclin D1. Downregulates MAP3K7 kinaseactivation of the IL1 signaling pathway by dephosphorylation ofMAP3K7. Participates also in the innate immune defense againstviruses by desphosphorylating RIG-I/DDX58, an essential step thattriggers RIG-I/DDX58-mediated signaling activation.{ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228,ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:29053956,ECO:0000269|PubMed:9013334}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SCAI_PPP6C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SCAI_PPP6C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SCAI | RANBP17, CBX5, HNRNPA1, CDCA5, NFATC1, NFATC2, APBA3, TNFRSF1A, CACNG5 | PPP6C | TBK1, IGBP1, TIPRL, PPP6R3, PPP6R1, PPP6R2, ANKRD52, ANKRD28, ANKRD44, PRKDC, MYC, MAP3K7, TAB2, PIDD1, ELAVL1, BRCA1, VCP, NOS2, METTL21B, EGFR, FBXO6, MOB1A, MOB1B, ARHGEF2, TUBB6, ACLY, SRRT, USP7, AURKA, AURKB, RNF2, ARAF, ILK, MAST3, ABCE1, CSNK1D, NTRK1, CEP44, CEP19, XPO1, PCGF1, POU5F1, ZNRF2, KRT8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SCAI_PPP6C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SCAI_PPP6C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PPP6C | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Tgene | PPP6C | C0025202 | melanoma | 1 | CTD_human |
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