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Fusion gene ID: 3275 |
FusionGeneSummary for ATP11B_TPRG1 |
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Fusion gene information | Fusion gene name: ATP11B_TPRG1 | Fusion gene ID: 3275 | Hgene | Tgene | Gene symbol | ATP11B | TPRG1 | Gene ID | 23200 | 285386 |
Gene name | ATPase phospholipid transporting 11B (putative) | tumor protein p63 regulated 1 | |
Synonyms | ATPIF|ATPIR | FAM79B | |
Cytomap | 3q26.33 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | probable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180523 | 20180403 | |
UniProtAcc | Q9Y2G3 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000323116, ENST00000493826, ENST00000482794, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 12 X 11 X 8=1056 | 12 X 6 X 6=432 |
# samples | 12 | 13 | |
** MAII score | log2(12/1056*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATP11B [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-63-A5MV-01A | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000323116 | ENST00000433971 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
5CDS-intron | ENST00000323116 | ENST00000345063 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
5CDS-intron | ENST00000323116 | ENST00000488841 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
intron-5UTR | ENST00000493826 | ENST00000433971 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
intron-intron | ENST00000493826 | ENST00000345063 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
intron-intron | ENST00000493826 | ENST00000488841 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
5CDS-5UTR | ENST00000482794 | ENST00000433971 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
5CDS-intron | ENST00000482794 | ENST00000345063 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
5CDS-intron | ENST00000482794 | ENST00000488841 | ATP11B | chr3 | 182566345 | + | TPRG1 | chr3 | 188741539 | + |
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FusionProtFeatures for ATP11B_TPRG1 |
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Hgene | Tgene |
ATP11B | TPRG1 |
Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). Involved in regulation of sensitivity tocisplatin; may contribute to secretory vesicle transport ofcisplatin from Golgi to plasma membrane.{ECO:0000269|PubMed:23585472, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP11B_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP11B_TPRG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATP11B | TMEM30A, IFNA21 | TPRG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP11B_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP11B_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |