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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32744

FusionGeneSummary for SCAF8_ATPAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAF8_ATPAF1
Fusion gene ID: 32744
HgeneTgene
Gene symbol

SCAF8

ATPAF1

Gene ID

22828

64756

Gene nameSR-related CTD associated factor 8ATP synthase mitochondrial F1 complex assembly factor 1
SynonymsRBM16ATP11|ATP11p
Cytomap

6q25.2

1p33

Type of geneprotein-codingprotein-coding
Descriptionprotein SCAF8CDC5L complex-associated protein 7RNA-binding motif protein 16SR-like CTD-associated factor 8SR-related and CTD-associated factor 8ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11
Modification date2018052320180523
UniProtAcc

Q9UPN6

Q5TC12

Ensembl transtripts involved in fusion geneENST00000367178, ENST00000461219, 
ENST00000417268, ENST00000367186, 
ENST00000576409, ENST00000574428, 
ENST00000371937, ENST00000542495, 
ENST00000329231, ENST00000532925, 
ENST00000525633, 
Fusion gene scores* DoF score6 X 6 X 4=1443 X 3 X 2=18
# samples 63
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCAF8 [Title/Abstract] AND ATPAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV399120SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000367178ENST00000576409SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000574428SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000371937SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000542495SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000329231SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000532925SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367178ENST00000525633SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000576409SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000574428SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000371937SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000542495SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000329231SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000532925SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000461219ENST00000525633SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000576409SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000574428SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000371937SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000542495SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000329231SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000532925SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000417268ENST00000525633SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000576409SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000574428SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000371937SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000542495SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000329231SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000532925SCAF8chr6

155057705

-ATPAF1chr1

47287388

-
intron-intronENST00000367186ENST00000525633SCAF8chr6

155057705

-ATPAF1chr1

47287388

-

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FusionProtFeatures for SCAF8_ATPAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCAF8

Q9UPN6

ATPAF1

Q5TC12

May play a role in mRNA processing.{ECO:0000269|PubMed:11101529}. May play an essential role for the assembly of themitochondrial F1-F0 complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCAF8_ATPAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCAF8_ATPAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCAF8_ATPAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCAF8_ATPAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATPAF1C0028754Obesity1CTD_human