![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 32706 |
FusionGeneSummary for SBF2_PRMT3 |
![]() |
Fusion gene information | Fusion gene name: SBF2_PRMT3 | Fusion gene ID: 32706 | Hgene | Tgene | Gene symbol | SBF2 | PRMT3 | Gene ID | 81846 | 10196 |
Gene name | SET binding factor 2 | protein arginine methyltransferase 3 | |
Synonyms | CMT4B2|DENND7B|MTMR13 | HRMT1L3 | |
Cytomap | 11p15.4 | 11p15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | myotubularin-related protein 13DENN/MADD domain containing 7B | protein arginine N-methyltransferase 3HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86WG5 | O60678 | |
Ensembl transtripts involved in fusion gene | ENST00000256190, ENST00000527019, | ENST00000331079, ENST00000437750, | |
Fusion gene scores | * DoF score | 16 X 9 X 8=1152 | 3 X 2 X 3=18 |
# samples | 16 | 3 | |
** MAII score | log2(16/1152*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SBF2 [Title/Abstract] AND PRMT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PRMT3 | GO:0031397 | negative regulation of protein ubiquitination | 18573314 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-37-4132-01A | SBF2 | chr11 | 10315562 | - | PRMT3 | chr11 | 20473676 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000256190 | ENST00000331079 | SBF2 | chr11 | 10315562 | - | PRMT3 | chr11 | 20473676 | + |
In-frame | ENST00000256190 | ENST00000437750 | SBF2 | chr11 | 10315562 | - | PRMT3 | chr11 | 20473676 | + |
intron-3CDS | ENST00000527019 | ENST00000331079 | SBF2 | chr11 | 10315562 | - | PRMT3 | chr11 | 20473676 | + |
intron-3CDS | ENST00000527019 | ENST00000437750 | SBF2 | chr11 | 10315562 | - | PRMT3 | chr11 | 20473676 | + |
Top |
FusionProtFeatures for SBF2_PRMT3 |
![]() |
Hgene | Tgene |
SBF2 | PRMT3 |
Methylates (mono and asymmetric dimethylation) theguanidino nitrogens of arginyl residues in some proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 1108_1584 | 18 | 1850 | Domain | Myotubularin phosphatase |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 1743_1847 | 18 | 1850 | Domain | PH |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 191_324 | 18 | 1850 | Domain | cDENN |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 326_427 | 18 | 1850 | Domain | dDENN |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 7_172 | 18 | 1850 | Domain | uDENN |
Hgene | >SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 871_957 | 18 | 1850 | Domain | Note=GRAM |
Tgene | PRMT3 | chr11:10315562 | chr11:20473676 | ENST00000331079 | + | 9 | 16 | 217_531 | 331 | 532 | Domain | SAM-dependent MTase PRMT-type |
Tgene | PRMT3 | chr11:10315562 | chr11:20473676 | ENST00000437750 | + | 7 | 14 | 217_531 | 269 | 470 | Domain | SAM-dependent MTase PRMT-type |
Tgene | PRMT3 | chr11:10315562 | chr11:20473676 | ENST00000331079 | + | 9 | 16 | 48_71 | 331 | 532 | Zinc finger | Note=C2H2-type |
Tgene | PRMT3 | chr11:10315562 | chr11:20473676 | ENST00000437750 | + | 7 | 14 | 48_71 | 269 | 470 | Zinc finger | Note=C2H2-type |
Top |
FusionGeneSequence for SBF2_PRMT3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_219aa MARLADYFIVVGYDHEKPGLFSSVXVYVRFCPLCKEQILGKRRLGLPXHLHYQPCSSEXCEXTCXXNCFLGXCLWLQDVLHEESSYSRSC CGSFRSEDSYFRTLWYXAYRLPYDVYLRFGIFIRFYPENHKDIHVHGNCWLLXYIFXEELPQQGRVLYGPSEHQNTLETNSISTGKTIFS >In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_219aa MARLADYFIVVGYDHEKPGLFSSVXVYVRFCPLCKEQILGKRRLGLPXHLHYQPCSSEXCEXTCXXNCFLGXCLWLQDVLHEESSYSRSC CGSFRSEDSYFRTLWYXAYRLPYDVYLRFGIFIRFYPENHKDIHVHGNCWLLXYIFXEELPQQGRVLYGPSEHQNTLETNSISTGKTIFS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_658nt ATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGACCACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTC TGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGT GAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGT TGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGA ATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTG CCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGT TAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAAGAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAA >In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_658nt ATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGACCACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTC TGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGT GAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGT TGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGA ATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTG CCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGT TAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAAGAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_1636nt GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC ATTTACATTGGCCTATATTTGGAAGAGAGATAGTCTTTTGTTTTTAATAAGTTTCTTACTATAAATTTTAAACAAATTGGTTAGTTATTT GGATATTTTATTAAACTAGTAACACAGGTACTACACATTTTATTATGGACTCCTCTGAGGAGGAGTTTTTAATTGTATTTGCTAGAAAAT CAGGATGTAATAAAGATTTGTATAAAAAAACTAAAATATGGAAAAGAGCTTCAGCCTTCATATACAAATCATATATGCAGACAGCCTAGT TGATTATCTAGCATACTTAGGGTTCTCATTTTGTAGTTTCTTCCCTCTTTGTGACTATTCCTTAGCCTTATAGATTTCTAGTACTGCCCA GGAAATCTAATTTCAATACATTTATCCTAGGTTTCATGAAAGTTTTTAAAGATTGGGATAAATATGTACTTATTTACTAACGTATTATCT TTTTCAAACCAGATTTATGTGCAAAGGTTAAACATGTAACTGTTACTAAGCAGTCTATAAAGTTGTCATTTACAATTACTGATTCAATTT >In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_1091nt GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC |
Top |
FusionGenePPI for SBF2_PRMT3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SBF2 | PMS1, UBC, RBPMS, FBXW11, NTRK1, TP53, XPO1, HNRNPD, SORT1, SYNCRIP, BAG6, MTMR2, MTMR1, SBF1, H2AFY2, BAG5, UBA1, FTO, G6PD, AK2, PMPCB, TXNDC12, DCTPP1 | PRMT3 | RPS2, FBL, VHL, TP53, STAT1, VCP, HNRNPA1, PPARD, RASSF2, HIRIP3, IDE, LIG1, ARFIP1, CTNNA1, EIF4B, FAF1, GFPT1, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, SAMHD1, SEC23A, USP11, XRCC5, YAP1, TROVE2, XPO7, EGFR, STX19, FKBP6, PDCD2L, GMPPB, NTRK1, CNTROB, XPO1, HNRNPD, TSC22D2, KLHL10, TSKS, TSHB, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | SBF2 | chr11:10315562 | chr11:20473676 | ENST00000256190 | - | 1 | 40 | 1630_1683 | 18 | 1850 | MTMR2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SBF2_PRMT3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SBF2_PRMT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |