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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32706

FusionGeneSummary for SBF2_PRMT3

check button Fusion gene summary
Fusion gene informationFusion gene name: SBF2_PRMT3
Fusion gene ID: 32706
HgeneTgene
Gene symbol

SBF2

PRMT3

Gene ID

81846

10196

Gene nameSET binding factor 2protein arginine methyltransferase 3
SynonymsCMT4B2|DENND7B|MTMR13HRMT1L3
Cytomap

11p15.4

11p15.1

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 13DENN/MADD domain containing 7Bprotein arginine N-methyltransferase 3HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Modification date2018051920180523
UniProtAcc

Q86WG5

O60678

Ensembl transtripts involved in fusion geneENST00000256190, ENST00000527019, 
ENST00000331079, ENST00000437750, 
Fusion gene scores* DoF score16 X 9 X 8=11523 X 2 X 3=18
# samples 163
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SBF2 [Title/Abstract] AND PRMT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRMT3

GO:0031397

negative regulation of protein ubiquitination

18573314


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-37-4132-01ASBF2chr11

10315562

-PRMT3chr11

20473676

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000256190ENST00000331079SBF2chr11

10315562

-PRMT3chr11

20473676

+
In-frameENST00000256190ENST00000437750SBF2chr11

10315562

-PRMT3chr11

20473676

+
intron-3CDSENST00000527019ENST00000331079SBF2chr11

10315562

-PRMT3chr11

20473676

+
intron-3CDSENST00000527019ENST00000437750SBF2chr11

10315562

-PRMT3chr11

20473676

+

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FusionProtFeatures for SBF2_PRMT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SBF2

Q86WG5

PRMT3

O60678

Methylates (mono and asymmetric dimethylation) theguanidino nitrogens of arginyl residues in some proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1401108_1584181850DomainMyotubularin phosphatase
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1401743_1847181850DomainPH
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140191_324181850DomaincDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140326_427181850DomaindDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1407_172181850DomainuDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140871_957181850DomainNote=GRAM
TgenePRMT3chr11:10315562chr11:20473676ENST00000331079+916217_531331532DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315562chr11:20473676ENST00000437750+714217_531269470DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315562chr11:20473676ENST00000331079+91648_71331532Zinc fingerNote=C2H2-type
TgenePRMT3chr11:10315562chr11:20473676ENST00000437750+71448_71269470Zinc fingerNote=C2H2-type


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FusionGeneSequence for SBF2_PRMT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_219aa
MARLADYFIVVGYDHEKPGLFSSVXVYVRFCPLCKEQILGKRRLGLPXHLHYQPCSSEXCEXTCXXNCFLGXCLWLQDVLHEESSYSRSC
CGSFRSEDSYFRTLWYXAYRLPYDVYLRFGIFIRFYPENHKDIHVHGNCWLLXYIFXEELPQQGRVLYGPSEHQNTLETNSISTGKTIFS

>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_219aa
MARLADYFIVVGYDHEKPGLFSSVXVYVRFCPLCKEQILGKRRLGLPXHLHYQPCSSEXCEXTCXXNCFLGXCLWLQDVLHEESSYSRSC
CGSFRSEDSYFRTLWYXAYRLPYDVYLRFGIFIRFYPENHKDIHVHGNCWLLXYIFXEELPQQGRVLYGPSEHQNTLETNSISTGKTIFS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_658nt
ATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGACCACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTC
TGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGT
GAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGT
TGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGA
ATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTG
CCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGT
TAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAAGAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAA

>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_658nt
ATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGACCACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTC
TGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTCGGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGT
GAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTATGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGT
TGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTGTGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGA
ATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCATGTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTG
CCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAAAACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGT
TAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAAGAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000331079_chr11_20473676_+_1636nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC
ATTTACATTGGCCTATATTTGGAAGAGAGATAGTCTTTTGTTTTTAATAAGTTTCTTACTATAAATTTTAAACAAATTGGTTAGTTATTT
GGATATTTTATTAAACTAGTAACACAGGTACTACACATTTTATTATGGACTCCTCTGAGGAGGAGTTTTTAATTGTATTTGCTAGAAAAT
CAGGATGTAATAAAGATTTGTATAAAAAAACTAAAATATGGAAAAGAGCTTCAGCCTTCATATACAAATCATATATGCAGACAGCCTAGT
TGATTATCTAGCATACTTAGGGTTCTCATTTTGTAGTTTCTTCCCTCTTTGTGACTATTCCTTAGCCTTATAGATTTCTAGTACTGCCCA
GGAAATCTAATTTCAATACATTTATCCTAGGTTTCATGAAAGTTTTTAAAGATTGGGATAAATATGTACTTATTTACTAACGTATTATCT
TTTTCAAACCAGATTTATGTGCAAAGGTTAAACATGTAACTGTTACTAAGCAGTCTATAAAGTTGTCATTTACAATTACTGATTCAATTT

>In-frame_SBF2_ENST00000256190_chr11_10315562_-_PRMT3_ENST00000437750_chr11_20473676_+_1091nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC


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FusionGenePPI for SBF2_PRMT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SBF2PMS1, UBC, RBPMS, FBXW11, NTRK1, TP53, XPO1, HNRNPD, SORT1, SYNCRIP, BAG6, MTMR2, MTMR1, SBF1, H2AFY2, BAG5, UBA1, FTO, G6PD, AK2, PMPCB, TXNDC12, DCTPP1PRMT3RPS2, FBL, VHL, TP53, STAT1, VCP, HNRNPA1, PPARD, RASSF2, HIRIP3, IDE, LIG1, ARFIP1, CTNNA1, EIF4B, FAF1, GFPT1, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, SAMHD1, SEC23A, USP11, XRCC5, YAP1, TROVE2, XPO7, EGFR, STX19, FKBP6, PDCD2L, GMPPB, NTRK1, CNTROB, XPO1, HNRNPD, TSC22D2, KLHL10, TSKS, TSHB, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1401630_1683181850MTMR2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SBF2_PRMT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SBF2_PRMT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource