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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 32700

FusionGeneSummary for SBF2_MDM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SBF2_MDM2
Fusion gene ID: 32700
HgeneTgene
Gene symbol

SBF2

MDM2

Gene ID

81846

4193

Gene nameSET binding factor 2MDM2 proto-oncogene
SynonymsCMT4B2|DENND7B|MTMR13ACTFS|HDMX|hdm2
Cytomap

11p15.4

12q15

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 13DENN/MADD domain containing 7BE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
Modification date2018051920180527
UniProtAcc

Q86WG5

Q00987

Ensembl transtripts involved in fusion geneENST00000256190, ENST00000527019, 
ENST00000462284, ENST00000356290, 
ENST00000540827, ENST00000258149, 
ENST00000428863, ENST00000393412, 
ENST00000258148, ENST00000544561, 
ENST00000393410, ENST00000393413, 
ENST00000517852, ENST00000545204, 
ENST00000350057, ENST00000360430, 
ENST00000299252, ENST00000348801, 
ENST00000478070, ENST00000544125, 
Fusion gene scores* DoF score16 X 9 X 8=115210 X 7 X 6=420
# samples 169
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/420*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SBF2 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

TgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

TgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

TgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

TgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

TgeneMDM2

GO:0034504

protein localization to nucleus

10360174

TgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

TgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

TgeneMDM2

GO:0045184

establishment of protein localization

10360174

TgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

TgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

TgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

TgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

TgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

TgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A06U-01ASBF2chr11

9983504

-MDM2chr12

69210592

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000256190ENST00000462284SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000356290SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000540827SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000258149SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000428863SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000393412SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000258148SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000544561SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000393410SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000393413SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000517852SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000545204SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000350057SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000360430SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000299252SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000348801SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000478070SBF2chr11

9983504

-MDM2chr12

69210592

+
5CDS-intronENST00000256190ENST00000544125SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-3CDSENST00000527019ENST00000462284SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000356290SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000540827SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000258149SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000428863SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000393412SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000258148SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000544561SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000393410SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000393413SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000517852SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000545204SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000350057SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000360430SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000299252SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000348801SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000478070SBF2chr11

9983504

-MDM2chr12

69210592

+
intron-intronENST00000527019ENST00000544125SBF2chr11

9983504

-MDM2chr12

69210592

+

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FusionProtFeatures for SBF2_MDM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SBF2

Q86WG5

MDM2

Q00987


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-1640191_3246201850DomaincDENN
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-1640326_4276201850DomaindDENN
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-16407_1726201850DomainuDENN
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29210_21552437Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29243_30152437Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05210_2150322Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05243_3010322Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03210_2150266Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03243_3010266Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06210_215-102322Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06243_301-102322Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04210_2150297Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04243_3010297Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03210_215-92219Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03243_301-92219Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02210_2150219Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02243_3010219Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04210_215-102271Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04243_301-102271Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211210_21558498Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211243_30158498Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05210_215-102297Compositional biasNote=Poly-Ser
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05243_301-102297Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+0527_1070322DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+0327_1070266DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+0627_107-102322DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+0427_1070297DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+0327_107-92219DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+0227_1070219DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+0427_107-102271DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+0527_107-102297DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29179_18552437MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29190_20252437MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29466_47352437MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05179_1850322MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05190_2020322MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05466_4730322MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03179_1850266MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03190_2020266MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03466_4730266MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06179_185-102322MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06190_202-102322MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06466_473-102322MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04179_1850297MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04190_2020297MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04466_4730297MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03179_185-92219MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03190_202-92219MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03466_473-92219MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02179_1850219MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02190_2020219MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02466_4730219MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04179_185-102271MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04190_202-102271MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04466_473-102271MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211179_18558498MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211190_20258498MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211466_47358498MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05179_185-102297MotifNuclear localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05190_202-102297MotifNote=Nuclear export signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05466_473-102297MotifNucleolar localization signal
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29210_30452437RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29242_33152437RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05210_3040322RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05242_3310322RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03210_3040266RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03242_3310266RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06210_304-102322RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06242_331-102322RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04210_3040297RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04242_3310297RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03210_304-92219RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03242_331-92219RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02210_3040219RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02242_3310219RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04210_304-102271RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04242_331-102271RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211210_30458498RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211242_33158498RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05210_304-102297RegionNote=ARF-binding
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05242_331-102297RegionNote=Region II
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29299_32852437Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29438_47952437Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05299_3280322Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05438_4790322Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03299_3280266Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03438_4790266Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06299_328-102322Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06438_479-102322Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04299_3280297Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04438_4790297Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03299_328-92219Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03438_479-92219Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02299_3280219Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02438_4790219Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04299_328-102271Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04438_479-102271Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211299_32858498Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211438_47958498Zinc fingerRING-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05299_328-102297Zinc fingerRanBP2-type
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05438_479-102297Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-16401108_15846201850DomainMyotubularin phosphatase
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-16401743_18476201850DomainPH
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-1640871_9576201850DomainNote=GRAM
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+2927_10752437DomainNote=SWIB
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+21127_10758498DomainNote=SWIB


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FusionGeneSequence for SBF2_MDM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SBF2_ENST00000256190_chr11_9983504_-_MDM2_ENST00000462284_chr12_69210592_+_1060aa
MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEI
NLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGD
RQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPT
PFIIGVHSVFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL
RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVK
MIKHVRELAEQLFKNENPNPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKV
TTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQVLFYLGQYIM
TKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHL
VSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVS
DQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPE
DKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SBF2_ENST00000256190_chr11_9983504_-_MDM2_ENST00000462284_chr12_69210592_+_3180nt
ATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGACCACGAGAAGCCAGGATCAGGAGAAGGTCTGGGGAAAATAATCCAGAGA
TTTCCACAGAAGGACTGGGATGATACACCTTTTCCACAGGGAATTGAGTTGTTTTGTCAGCCTGGCGGGTGGCAGCTGTCCAGAGAGAGG
AAGCAGCCAACGTTCTTTGTGGTTGTCCTGACAGACATTGACTCAGATCGACATTACTGCTCATGCCTAACCTTCTATGAGGCAGAGATC
AATCTTCAGGGAACAAAGAAGGAAGAGATTGAAGGTGAAGCAAAAGTGTCTGGTTTAATTCAGCCTGCAGAAGTGTTTGCTCCCAAAAGC
CTGGTGTTGGTATCCAGATTATATTATCCAGAAATTTTTAGGGCTTGCCTGGGTTTGATCTATACCGTGTATGTGGACAGCCTGAATGTC
TCCTTGGAAAGTCTAATTGCAAACCTTTGTGCCTGCCTTGTCCCAGCGGCTGGAGGGTCTCAGAAGCTGTTTTCTTTGGGTGCAGGAGAT
AGACAGTTGATCCAGACTCCTTTACATGATAGTCTTCCTATCACGGGCACTAGTGTGGCTCTCCTGTTCCAGCAATTGGGAATTCAAAAT
GTCCTCAGCCTCTTTTGTGCAGTCCTCACAGAAAATAAGGTTCTCTTCCATTCTGCAAGTTTCCAGAGACTTAGTGATGCTTGTAGAGCC
CTGGAATCTTTAATGTTTCCTCTTAAATATAGTTATCCTTATATCCCTATTCTCCCGGCTCAGCTACTGGAAGTTCTAAGTTCCCCAACG
CCTTTCATTATTGGAGTACATTCTGTCTTTAAAACTGATGTCCATGAACTTTTAGATGTAATCATAGCAGATTTGGATGGAGGCACTATT
AAAATTCCCGAATGTATTCACCTCTCTTCCCTCCCAGAACCACTTCTACATCAGACTCAATCAGCTCTTTCTTTGATTTTACACCCAGAT
TTGGAAGTAGCAGATCATGCTTTTCCTCCTCCACGAACAGCTTTATCCCACTCAAAAATGCTGGATAAAGAGGTGCGAGCCGTTTTCCTT
AGATTATTTGCACAACTCTTCCAAGGATATAGATCCTGCCTGCAACTTATAAGAATTCATGCAGAGCCAGTAATACATTTCCACAAGACA
GCATTCTTGGGGCAGCGTGGTTTGGTCGAGAATGATTTCCTCACTAAAGTACTCAGTGGAATGGCATTTGCAGGTTTTGTTTCAGAAAGA
GGTCCTCCTTATAGATCTTGTGATCTCTTTGATGAGTTGGTAGCCTTTGAAGTAGAGAGAATTAAAGTTGAAGAAAATAACCCAGTGAAG
ATGATAAAGCATGTCAGGGAACTTGCTGAGCAACTATTCAAAAATGAGAATCCAAATCCTCATATGGCATTCCAGAAAGTTCCACGGCCA
ACAGAAGGATCCCATTTGCGAGTTCATATTCTTCCTTTCCCAGAGATTAATGAAGCCCGGGTTCAGGAATTAATACAGGAAAATGTTGCT
AAGAACCAGAATGCACCTCCTGCCACACGAATAGAAAAGAAATGTGTTGTGCCAGCAGGTCCACCTGTTGTTTCGATAATGGACAAGGTG
ACGACAGTTTTCAACAGTGCACAAAGACTAGAAGTTGTCAGAAACTGTATCTCATTCATATTTGAAAATAAAATTTTGGAAACTGAAAAG
ACCCTTCCTGCTGCACTCAGAGCCCTTAAAGGAAAGGCAGCAAGACAGTGTCTCACTGATGAATTGGGTTTGCATGTCCAGCAAAACCGG
GCAATATTAGACCATCAACAGTTTGACTACATAATAAGGATGATGAATTGTACTCTACAGGTTCTTTTTTATCTTGGCCAGTATATTATG
ACTAAACGATTATATGATGAGAAGCAACAACATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCT
GTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTG
AGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTG
GTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAA
CGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGC
AGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCA
GATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGAT
GATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGACTAT
TGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCACATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAA
GATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGGAAAACTCAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGT
AAAAAAACTATAGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAAATGATGATAAAATTACACAAGCTTCACAATCACAAGAAAGTGAA
GACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGCAGCCAAGAAGATGTGAAAGAGTTTGAAAGGGAAGAAACCCAAGACAAA
GAAGAGAGTGTGGAATCTAGTTTGCCCCTTAATGCCATTGAACCTTGTGTGATTTGTCAAGGTCGACCTAAAAATGGTTGCATTGTCCAT
GGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAGAAGCTAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGACAACCAATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SBF2_ENST00000256190_chr11_9983504_-_MDM2_ENST00000462284_chr12_69210592_+_8903nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGATCAGGAGAAGGTCTGGGGAAAATAATCCAGAGATTTCCACAGAAGGACTGGGATGATACACCTTTTCCACAGGGA
ATTGAGTTGTTTTGTCAGCCTGGCGGGTGGCAGCTGTCCAGAGAGAGGAAGCAGCCAACGTTCTTTGTGGTTGTCCTGACAGACATTGAC
TCAGATCGACATTACTGCTCATGCCTAACCTTCTATGAGGCAGAGATCAATCTTCAGGGAACAAAGAAGGAAGAGATTGAAGGTGAAGCA
AAAGTGTCTGGTTTAATTCAGCCTGCAGAAGTGTTTGCTCCCAAAAGCCTGGTGTTGGTATCCAGATTATATTATCCAGAAATTTTTAGG
GCTTGCCTGGGTTTGATCTATACCGTGTATGTGGACAGCCTGAATGTCTCCTTGGAAAGTCTAATTGCAAACCTTTGTGCCTGCCTTGTC
CCAGCGGCTGGAGGGTCTCAGAAGCTGTTTTCTTTGGGTGCAGGAGATAGACAGTTGATCCAGACTCCTTTACATGATAGTCTTCCTATC
ACGGGCACTAGTGTGGCTCTCCTGTTCCAGCAATTGGGAATTCAAAATGTCCTCAGCCTCTTTTGTGCAGTCCTCACAGAAAATAAGGTT
CTCTTCCATTCTGCAAGTTTCCAGAGACTTAGTGATGCTTGTAGAGCCCTGGAATCTTTAATGTTTCCTCTTAAATATAGTTATCCTTAT
ATCCCTATTCTCCCGGCTCAGCTACTGGAAGTTCTAAGTTCCCCAACGCCTTTCATTATTGGAGTACATTCTGTCTTTAAAACTGATGTC
CATGAACTTTTAGATGTAATCATAGCAGATTTGGATGGAGGCACTATTAAAATTCCCGAATGTATTCACCTCTCTTCCCTCCCAGAACCA
CTTCTACATCAGACTCAATCAGCTCTTTCTTTGATTTTACACCCAGATTTGGAAGTAGCAGATCATGCTTTTCCTCCTCCACGAACAGCT
TTATCCCACTCAAAAATGCTGGATAAAGAGGTGCGAGCCGTTTTCCTTAGATTATTTGCACAACTCTTCCAAGGATATAGATCCTGCCTG
CAACTTATAAGAATTCATGCAGAGCCAGTAATACATTTCCACAAGACAGCATTCTTGGGGCAGCGTGGTTTGGTCGAGAATGATTTCCTC
ACTAAAGTACTCAGTGGAATGGCATTTGCAGGTTTTGTTTCAGAAAGAGGTCCTCCTTATAGATCTTGTGATCTCTTTGATGAGTTGGTA
GCCTTTGAAGTAGAGAGAATTAAAGTTGAAGAAAATAACCCAGTGAAGATGATAAAGCATGTCAGGGAACTTGCTGAGCAACTATTCAAA
AATGAGAATCCAAATCCTCATATGGCATTCCAGAAAGTTCCACGGCCAACAGAAGGATCCCATTTGCGAGTTCATATTCTTCCTTTCCCA
GAGATTAATGAAGCCCGGGTTCAGGAATTAATACAGGAAAATGTTGCTAAGAACCAGAATGCACCTCCTGCCACACGAATAGAAAAGAAA
TGTGTTGTGCCAGCAGGTCCACCTGTTGTTTCGATAATGGACAAGGTGACGACAGTTTTCAACAGTGCACAAAGACTAGAAGTTGTCAGA
AACTGTATCTCATTCATATTTGAAAATAAAATTTTGGAAACTGAAAAGACCCTTCCTGCTGCACTCAGAGCCCTTAAAGGAAAGGCAGCA
AGACAGTGTCTCACTGATGAATTGGGTTTGCATGTCCAGCAAAACCGGGCAATATTAGACCATCAACAGTTTGACTACATAATAAGGATG
ATGAATTGTACTCTACAGGTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTGTATAT
TGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAAC
TTGGTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAG
GACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGT
GAGACAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGC
CTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCT
GGTGTAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCA
GAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGT
GATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGACTATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCA
TCACATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAAGATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAA
CTGGAAAACTCAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTATAGTGAATGATTCCAGAGAGTCATGTGTTGAG
GAAAATGATGATAAAATTACACAAGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGC
AGCCAAGAAGATGTGAAAGAGTTTGAAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGCCCCTTAATGCCATTGAA
CCTTGTGTGATTTGTCAAGGTCGACCTAAAAATGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAG
AAGCTAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTA
TAAGAGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCA
ATTCACATAGATTTCTTCTCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGC
TCATCCTTTACACCAACTCCTAATTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTTTTTTTTTTTCTTAAATATGTATA
TGACATTTAAATGTAACTTATTATTTTTTTTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACT
GCAAGCTCTGCCTCCCGGGTTCGCACCATTCTCCTGCCTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGGCTAA
TTTTTTGTACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTC
CCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGTCCGGCCTAAATGTCACTTAGTACCTTTGATATAAAGAGAAAATGTGTGAAAGAT
TTAGTTTTTTGTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGATGAGTCTCTCTGTCGCCCAGGCTGGAGTGCAGTGTCATGATCT
AGCAGTCTCCGCTTCCCGGGTTCAAGCCATTCTCCTGGCTCAGCCTCTGGAGCAGCTGGGATTACAGGCATGCACCACCATGCCCAGCTA
ATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGAGGTCACCCGCCTCGGC
CTCCCGAAGTGCTGGGATTGCAGATGTGAGCCACCATGTCCAGCCAAGAATTAGTATTTAAATTTTAGATACTCTTTTTTTTTTTTTTTT
TTTTTTTTTTTGAGACAGAGTCTTGCTCCATCACCCATGCTAGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTCCGCCTTCTGGGT
TCAAGCTATTCTCCTGCCTCAGCCTTCCAAGTAACTGGGATTACAGGCATGTACCACCATACCAGCTGATTTTTTTGTATTTTTAGTAAA
GACAGGGTTTCACCATGTTAGCCAGGCTGATCTTGAACTCCTAAACTCAAGTGATCTACTCACCTCAGCCTCCCAAAATGCTGGGATTAC
AGATGTGAGGCACCTGGCCTCAGATTTTTGATACTCTTAAACCTTCTGATCCTTAGTTTCTCTCTCCAAAATACTCTTTCTAGGTTAAAA
AAAAAAAGGCTCTTATATTTGGTGCTATGTAAATGAAAATGTTTTTTAGGTTTTCTTGATTTAACAATAGAGACAGGGTCTCCCTGTGTT
GCCCAGGCTGGTCTCGAACTCCTGGGCTCAAGAGATCCTCCTGTCTTGGCCTCGCAAAGTGCTAAGTAGGATTACAGGCGTTAGCCACCA
CACCCGGCTGTAAAAATGTACTTATTCTCCAGCCTCTTTTGTATAAACCATAGTAAGGGATGGGAGTAATGATGTTATCTGTGAAAATAG
CCACCATTTACCCGTAAGACAAAACTTGTTAAAGCCTCCTGAGTCTAACCTAGATTACATCAGGCCCTTTTTCACACACAAAAAAATCCT
TTATGGGATTTAATGGAATCTGTTGTTTCCCCCTAAGTTGAAAAACAACTCTAAGACACTTTAAAGTACCTTCTTGGCCTGGGTTACATG
GTTCCCAGCCTAGGTTTCAGACTTTTGCTTAAGGCCAGTTTTAGAAACCCGTGAATTCAGAAAAGTTAATTCAGAAATTTGATAAACAGA
ATTGTTATTTAAAAACTAACTGGAAAGATTGTTAAGTTCTTTCTGAATTATTCAGAAATTATGCATCATTTTCCTTCAAGAATGACAGGG
TCAGCATGTGGAATTCCAAGATACCTCTTGACTTCCTCTCAAGCTCCGTGTTTGGTCAGTGGAGGCCCATCCGAGCTCAGCACTGAGAAG
TGTTAGTTTCTTTGGGACCCATCTACCCTGACCACATCATGATGTTCATCTGCAGCTGTTGCAAGGTGTTCAGATTGTATAAACATAAAT
GTCACAAAAACTTTAAAAGAAGTGCAATTCTCAAAAGGTTAGGTGGACTAAAGCATTCTGTAAAGCAACTGCTAATAATGAGCTTACAGT
GGATTTGAATTTGAAAAATATAGTAACAAGCCTGTCAAATATCTGCAAGAACTATGGAATAAAACTACTGATGCAGTGAAGACAGTTGAA
AAGATCAAACAAATGCCAAGCTATATTTATAATGAACAAATTCAAGAAAAAGGACTACGGAAAGTTCAGGACATCAAAGAAGTCAGGCAA
AACTCATCTTGACCCCTGTTGCAGGCAAAGGAACGCAGCTGGAAGAAAAGATGATATAACAGTTAACAGGATGCAGACATGGCAGAGGTT
TCCTAAAAATCTCATTATCTATAACCATTTCTATATTTACATTTGAAAATCTCCTTTGGAGACTTAGAACCTCTAAATTATTGACTTATT
TTTTATATAAGGTCACTCCGATGAAAGGTGATTACAAAATCATCTACATTGCTGTCTACAAAACAGATAATATGGATGTTTGATCGCATC
TCATTGTTAACTCTTTACTGATATGTTTGTAAATACAGAAGTGAAATGTGGACATAAAATAGTTACGCTATTTGGTTAATGGTACTAGAC
AACATGTAATTAATGACATTCAAAAATTTATGGCTAGTGATATATATAAAGTAAAATTTTCTTTGCAGTAAAATATGCCCTTTATTATAG
AAGGGAGGATATAAGGAACCAACAGTTTGTATGAAAATAGCTCAAATAATATCTTTTATTTTGATTTTAATATTTCTTATTTTGGTTTAT
TAGTGTCTTAGAACAAAATGGCCTTATATAATGAAGCCTAGTTATGCTGGACTGTTTTGATCTCTTTTAATTGTTCTGACAGATAGTTGG
GGATGAGAGCCGAATAAGGTTTGCCTGAAATAACTGACACTATATAATTTCTGCTTTGGCAAATACTAAGTTCTAACTTGTCATTCCTGG
TAGAACAAGCTTTATTTTTCGAGCCTAGCAATGATCTAGAAGCAGATGTTATCTCAGTGCCTTTTGCAATTTGTTGTGTGGGTTTTTTTT
TTTTTAAAGCCACACAATAATTTTGGAAAACAATGTATGGGTAGAACATGTGTCTGTTAATTGCACACAAAACCACTTTTAATGGGTACA
GAGTTAAATTTGAAGGAATAAGTTCTAGCTGAAGTATTATGAACTCCAAATAATGCTTTGAGGACCTCCAAAGGTAAAAGTACTAATCCC
TTTGGCCATTTATTGAGAGAGAGAGAGAGAGAGAGTAGGGTGACTATAGTTAATGTATTGAATGTTCTTGCTACAAATAAATGATATTTG
AGCTGATGGGTGTGCTAATTACACTGATTTGATCAATACCCATTGTATGTGAAACAGTACATACACCATATTTACAATTATGTATTTAAC
ATTTAAAATTTCTAATATAAGTATCTCTCAAACTGTGGATTAACTTCTTGATTTATATTTAAATATGAATCTTAAGCAAAACAGTGAAAA
TAACCATCTTGATTTAGTGTTTTTCTCCCATATGTGAATTGTATATACTTAGGTGAAGACAATAAAATCAACTGAACTGTAAGCTTAGAA
TAGGACTGAGGTAATTCTGCACAGCAACTTTACTAATGGTACATTGTTGCTTCAAAACTCTCTCTCTCTCTCTCTGTCTGTCTCAATAAA
TGGCCAAAGGGATTAGTAGTTTACCTGTGGAGGTCCTCCAAGCATTATTTGGAGTTGATAATACTTCAGCTACAACCAAGCAGAATCTCT
TTTTTTTGGAGGTCCTCGAAGCATTATTTGGAGTTGATAATACTTCAGCTTCAATTTGGAGTTGATAATATTTCAGCTAGAACCTAGTAG
AATCTGTTTTTTTCCTTTGGAGGTCCTCAAAGCATTATTGGAGTTCATAATACTGAAGCTAGAACCAAGCAGAATCTGTTTTTTTCTGAG
GAGTATCGGTAGCATAAATGTGATTATAAACATAGTACACTTGATATATGGAGGCAGTGACAGCTATTTTTACAAAATTTAAATCTGCAA
ATGGATTCAACATGTTTATGGGTTATTAAAATTGTCTGATTTCTTAGGTTCTTTATAGTACACGTGTTGAAAATAAATGATTAAGAATTG
TTTCAAGAATGCAATTATTTGATCTTAAATTTTTATGAGTTGTTAAAATAGAAATTATTTGAATATCATATATTTGGGTAACAAAAGGCA
CAAGTCTGAATGTGTTTCTTTTTCTGGAATGGCCATGCCTGCCCACTTTAGAAATACAAATATCACTGGGCAGCTTGAAGCAGTTGGGAG
CCTCCAATGAGAGCAACTTGAGAGAATGATGTTGCAAGTTAGTAGGAGTAAGAAATGCTGTGTTCTCCCTGTCTTCTCTTAGGTCACATG
GCAGCCTGGCCTAAGTGATCGTGAATGGTCTATAAGGGAGGTAGCTGGGACAGGGAGGGGAGTTTGGGCTAGCCACCGTACCACTTGTCA
GCGTGAAAAGTAAGATTGTAATTGCCTGTTTAGTTTTCTGCCTCATCTTTGAAAGTTCCACCAAGCTGGGAACCTCTTGATTGTGAGGCA
CAAATGTAAGTACATCAGAAAAAAACAAAAAAACTGGCTTTAAAGCAGGAGCTTGTGGGCCCCTAAGCCAGACGGGGACTAGCTTTTGGC
ATTATATAATTAAGATTTTTTAAATCCTTAATAAGGGTTTTATTTTATTTTTATTTATTTTTTGAGACGGAGTCTTGCTCTGTGGCTCAG
GCTGGAGTACAGTGGTGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGCTGTGTTCAAGTGGTTCTGCTTCAGCCTCCCAAGTAGCTG
GGGTTAGAGCACCCTGTCACCACGCCCCGCTAATTTTTGTATTTCTAGCAGAGATGAAGTTTCACTATGTTGGCCAGGCTGGGCTCAAAC
TCCTGACCTCAAGTGATCTGCCCGCCTTGGCCCCCCAAAGTGCTGTGATTACAGGCGTGAGCCGCCACGCCCAGCCTAATAAGGGTTTTA
AAGATAATTAGTGTGTAGGTCTGTAGGCTTATGATGGTAACCACAAGTTGTTAATGGCATTGTGAAAAGTTTTTAGTTGCGCTTTATGGG
TGGATGCTGAATTACATTTTGATTTGATACTTATAAAAAGAAAAAGTATTTCTTCAGCTTAAAAAATTGTTTAAAAGTTTGTGATCATAT
TGTCTACCATGTAGCCAGCTTTCAATTATATGTAAGAGGGACTTTTTGACATTTACAAATAATACTTTGAGGTAGATATCTGAAAGCACC


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FusionGenePPI for SBF2_MDM2


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SBF2PMS1, UBC, RBPMS, FBXW11, NTRK1, TP53, XPO1, HNRNPD, SORT1, SYNCRIP, BAG6, MTMR2, MTMR1, SBF1, H2AFY2, BAG5, UBA1, FTO, G6PD, AK2, PMPCB, TXNDC12, DCTPP1MDM2TP53, MDC1, CTBP1, CTBP2, TP73, PML, RPL11, RPL5, CDKN2A, NUMB, UBE2A, HIF1A, KAT5, HDAC1, EID1, MDM4, KAT2B, EP300, TBP, TAF1, MDM2, ESR1, ARRB2, ABL1, CCNG1, ARRB1, TSG101, RB1, MTBP, FKBP3, RYBP, RRM2B, RPL26, GNAS, FOXO4, IGF1R, DAXX, DHFR, GNL3, CCAR1, PSMD10, PSME3, PTK2, AR, PPM1D, USP7, COPS5, SFN, RBBP6, CDH1, CHEK2, YWHAQ, NCL, UBE2G2, UBE2U, UBE2Z, PYHIN1, BANP, DDX17, E2F1, TRIM28, UBC, GATA3, ATF3, HIST2H2BE, RPL23, YY1, AKT1, RAD23A, CDKN1A, NR3C1, UBE2I, HIST3H3, EHMT1, SUV39H1, RPS27L, RPS27, ADRB2, SIVA1, MTA1, RCHY1, UBE2D1, CASP2, RPS27A, RPS7, G3BP2, PSMD2, PAK1IP1, RPS6KB1, ZNF668, TP63, PCNA, USP10, PSMC1, PSMD4, PSMC3, PSMC5, PSMC6, PSMA7, PSMD1, RUNX3, GNL3L, TERT, APEX1, UIMC1, CREBBP, SOX4, UBE4B, TBRG1, BAIAP2L1, RFWD3, ERBB3, PA2G4, HEXIM1, CDK9, DYRK2, HSP90AA1, HSPA4, HSPA8, LAMP2, RPS3, USP2, TRIM13, XRCC6, GORAB, FOXO1, FOXO3, UCHL1, S100A1, S100A2, S100A4, S100A6, S100B, USP42, CUL1, BTRC, FBXW11, CSNK1D, RFWD2, SMURF1, NOTCH4, CSNK1A1, PDLIM7, SENP3, RN5S1@, PDE4D, NOTCH1, SNAI1, RASSF1, TRIM27, RFFL, RPS14, PPP2R4, TTF1, PSMB6, PSMA8, RASSF3, NR0B2, UBE2B, PIAS1, RANBP1, LATS1, RAD50, NBN, MRE11A, CUL4A, DTL, PIM1, GSK3B, PSMA3, ESR2, ADRBK1, AATF, HNRNPK, BUB1B, SUMO1, RASSF5, UBE2D2, POLH, NPM1, TCAP, CDK5RAP3, ARIH2, IRF2, RPS25, TPT1, ANG, RHOA, PDCD5, CDKN2AIP, LATS2, WWOX, MED1, ERCC6, ERCC8, DDB1, CUL4B, HIPK2, DHRS2, CASP3, ITCH, EEF1A1, DCD, TUBB, TUBB2A, KRT14, RPS20, GAPDH, TUBA1C, GSN, ERBB4, XIAP, HNF4A, PLK1, NME2, NEDD4, DAPK1, DAPK3, ATM, PBX1, UBE2D3, UBE3A, UBE2L3, UBE2E2, UBE2E3, RNF2, EGR1, PAK6, DLG4, IRF1, VCP, STRA13, GADD45A, RABL6, RPS26, RPL37, RPS15, RNF8, TRIM4, TRIM23, TRAF5, TRIM9, MKRN3, PHF7, RNF10, RNF126, UBE2K, LMO7, HLA-DMB, SETDB1, YY1AP1, NACA, ATF4, MYD88, RELA, SDHC, WT1, SORBS2, HRSP12, DNAJB4, GCAT, SHPK, POT1, ANKRD17, GLTSCR2, SESN2, RASSF6, JUND, EZR, RYR2, JUN, CLSTN1, APP, CLU, SREK1, SET, HSP90B1, CWC25, ZNF133, PKM, TAB1, RPL6, AURKA, NOC2L, JAK1, XPC, PGAM1, PGAM2, DNAJB1, ANAPC2, NLK, SNAI2, RBM38, FHIT, AGPS, ALDH16A1, DDX5, DHX9, DLAT, EDC4, EIF2AK1, ESYT1, GTF2I, HMHA1, HNRNPM, HNRNPU, HRNR, HSP90AB1, IARS, IFI16, IGF2BP3, ILF3, KARS, CCAR2, NEK9, OGDH, OGDHL, RARS, RBBP8, RECQL, SF3B1, SFPQ, TOP1, ZNF318, PER2, SIRT6, TSC22D3, RPS6, UBE2M, RAD54B, SMARCA2, ACACA, PTBP1, IYD, ACTB, HNRNPD, U2AF2, FUBP1, TFRC, EEF2, XPO1, KRT2, EIF3B, SND1, DCAF8, USO1, EFTUD2, EXOSC6, IPO7, SF3B3, DET1, UBE2N, RPL10A, DIRAS3, SURF2, RFPL2, CMSS1, PPARD, RPL22L1, IER2, MAGEA2, ZNF420, ELF4, ABL2, SRC, HCK, GTF2E2, ATP2A2, BRINP1, C19orf10, CANX, MS4A1, PDIA3, PPIB, RAB8A, RPS23, RUVBL2, SMARCA4, SMARCE1, SRSF11, TPR, UBTF, PPARG, VDR, FBXO31, TFIP11, SETD7, PPP1CA, RARA, DDX24, NAT10, CCND1, RLIM, IER3, FHL2, RPL23A, SUZ12, EZH2, EED, RRM1, RPL4, NOLC1, DDX42, MAP2, NUCKS1, RRP1, PDS5A, RPL36A, TP53RK, RPL15, NPIPB3, HMGN1, MAP1LC3A, PRDM2, KIAA1551, PBXIP1, SP1, SHARPIN, MAPKAPK2, USP15, USP26, FKBP1A, NGFR, SMG7, RSL1D1, SIRT1, SIRT7, SIRT2, SIRT3, KPNA1, KPNA6, MSI2, PHLDB3, CLPB, XAGE1B, ZNF550, YAF2, PDGFB, ARNTL2, RPS11, TSPYL6, HIST1H2BJ, ZNF764, MAK16, ZNF274, PPAN, RPL37A, CRTC2, CRTC3, TRIM25, CSNK2A1, CSNK2B, CSNK2A2, HEY1, RANBP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29170_30652437MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05170_3060322MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03170_3060266MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06170_306-102322MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04170_3060297MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03170_306-92219MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02170_3060219MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04170_306-102271MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211170_30658498MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05170_306-102297MTBP
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29150_23052437PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05150_2300322PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03150_2300266PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06150_230-102322PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04150_2300297PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03150_230-92219PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02150_2300219PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04150_230-102271PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211150_23058498PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05150_230-102297PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr11:9983504chr12:69210592ENST00000258149+29223_23252437USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000299252+05223_2320322USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000348801+03223_2320266USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000356290+06223_232-102322USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000360430+04223_2320297USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000393412+03223_232-92219USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000393413+02223_2320219USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000428863+04223_232-102271USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000462284+211223_23258498USP7
TgeneMDM2chr11:9983504chr12:69210592ENST00000540827+05223_232-102297USP7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSBF2chr11:9983504chr12:69210592ENST00000256190-16401630_16836201850MTMR2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SBF2_MDM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMDM2Q00987DB01593ZincE3 ubiquitin-protein ligase Mdm2small moleculeapproved|investigational

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RelatedDiseases for SBF2_MDM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMDM2C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneMDM2C0007621Neoplastic Cell Transformation1CTD_human
TgeneMDM2C0019693HIV Infections1CTD_human
TgeneMDM2C0021364Male infertility1CTD_human
TgeneMDM2C0025202melanoma1CTD_human
TgeneMDM2C0032927Precancerous Conditions1CTD_human
TgeneMDM2C0033578Prostatic Neoplasms1CTD_human
TgeneMDM2C1458155Mammary Neoplasms1CTD_human