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Fusion gene ID: 32603 |
FusionGeneSummary for SAMHD1_HCK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAMHD1_HCK | Fusion gene ID: 32603 | Hgene | Tgene | Gene symbol | SAMHD1 | HCK | Gene ID | 25939 | 3055 |
| Gene name | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | HCK proto-oncogene, Src family tyrosine kinase | |
| Synonyms | CHBL2|DCIP|HDDC1|MOP-5|SBBI88 | JTK9|p59Hck|p61Hck | |
| Cytomap | 20q11.23 | 20q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | deoxynucleoside triphosphate triphosphohydrolase SAMHD1SAM domain and HD domain 1SAM domain and HD domain-containing protein 1dNTPasedendritic cell-derived IFNG-induced proteinmonocyte protein 5 | tyrosine-protein kinase HCKhematopoietic cell kinasehemopoietic cell kinasep59-HCK/p60-HCK | |
| Modification date | 20180528 | 20180523 | |
| UniProtAcc | Q9Y3Z3 | P08631 | |
| Ensembl transtripts involved in fusion gene | ENST00000262878, ENST00000373694, | ENST00000534862, ENST00000538448, ENST00000375862, ENST00000520553, ENST00000518730, ENST00000375852, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 6 X 4 X 5=120 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SAMHD1 [Title/Abstract] AND HCK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SAMHD1 | GO:0006203 | dGTP catabolic process | 24217394 |
| Hgene | SAMHD1 | GO:0046061 | dATP catabolic process | 24141705 |
| Hgene | SAMHD1 | GO:0051289 | protein homotetramerization | 24217394 |
| Tgene | HCK | GO:0071801 | regulation of podosome assembly | 15998323 |
| Tgene | HCK | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 15998323 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4443-01A | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262878 | ENST00000534862 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5CDS-5UTR | ENST00000262878 | ENST00000538448 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5CDS-5UTR | ENST00000262878 | ENST00000375862 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5CDS-5UTR | ENST00000262878 | ENST00000520553 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5CDS-5UTR | ENST00000262878 | ENST00000518730 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5CDS-5UTR | ENST00000262878 | ENST00000375852 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-3CDS | ENST00000373694 | ENST00000534862 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-5UTR | ENST00000373694 | ENST00000538448 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-5UTR | ENST00000373694 | ENST00000375862 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-5UTR | ENST00000373694 | ENST00000520553 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-5UTR | ENST00000373694 | ENST00000518730 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
| 5UTR-5UTR | ENST00000373694 | ENST00000375852 | SAMHD1 | chr20 | 35563432 | - | HCK | chr20 | 30659465 | + |
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FusionProtFeatures for SAMHD1_HCK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAMHD1 | HCK |
| Protein that acts both as a host restriction factorinvolved in defense response to virus and as a regulator of DNAend resection at stalled replication forks (PubMed:19525956,PubMed:21613998, PubMed:21720370, PubMed:23602554,PubMed:23601106, PubMed:22056990, PubMed:24336198,PubMed:26294762, PubMed:26431200, PubMed:28229507,PubMed:28834754, PubMed:29670289). Has deoxynucleosidetriphosphate (dNTPase) activity, which is required to restrictinfection by viruses, such as HIV-1: dNTPase activity reducescellular dNTP levels to levels too low for retroviral reversetranscription to occur, blocking early-stage virus replication indendritic and other myeloid cells (PubMed:19525956,PubMed:21613998, PubMed:21720370, PubMed:23602554,PubMed:23601106, PubMed:23364794, PubMed:25038827,PubMed:26101257, PubMed:22056990, PubMed:24336198,PubMed:28229507, PubMed:26294762, PubMed:26431200). Likewise,suppresses LINE-1 retrotransposon activity (PubMed:24035396,PubMed:29610582, PubMed:24217394). Not able to restrict infectionby HIV-2 virus; because restriction activity is counteracted byHIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). Inaddition to virus restriction, dNTPase activity acts as aregulator of DNA precursor pools by regulating dNTP pools(PubMed:23858451). Phosphorylation at Thr-592 acts as a switch tocontrol dNTPase-dependent and -independent functions: it inhibitsdNTPase activity and ability to restrict infection by viruses,while it promotes DNA end resection at stalled replication forks(PubMed:23602554, PubMed:23601106, PubMed:29610582,PubMed:29670289). Functions during S phase at stalled DNAreplication forks to promote the resection of gapped or reversedforks: acts by stimulating the exonuclease activity of MRE11,activating the ATR-CHK1 pathway and allowing the forks to restartreplication (PubMed:29670289). Its ability to promote degradationof nascent DNA at stalled replication forks is required to preventinduction of type I interferons, thereby preventing chronicinflammation (PubMed:27477283, PubMed:29670289). Ability topromote DNA end resection at stalled replication forks isindependent of dNTPase activity (PubMed:29670289). Enhancesimmunoglobulin hypermutation in B-lymphocytes by promotingtransversion mutation (By similarity).{ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956,ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370,ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794,ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554,ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396,ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198,ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257,ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200,ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507,ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582,ECO:0000269|PubMed:29670289}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 45_110 | 169 | 627 | Domain | SAM |
| Hgene | SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 137_145 | 169 | 627 | Nucleotide binding | GTP |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000518730 | + | 0 | 13 | 144_241 | -1 | 505 | Domain | SH2 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000518730 | + | 0 | 13 | 262_515 | -1 | 505 | Domain | Protein kinase |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000518730 | + | 0 | 13 | 78_138 | -1 | 505 | Domain | SH3 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000520553 | + | 0 | 13 | 144_241 | -1 | 506 | Domain | SH2 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000520553 | + | 0 | 13 | 262_515 | -1 | 506 | Domain | Protein kinase |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000520553 | + | 0 | 13 | 78_138 | -1 | 506 | Domain | SH3 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000538448 | + | 1 | 14 | 144_241 | -1 | 506 | Domain | SH2 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000538448 | + | 1 | 14 | 262_515 | -1 | 506 | Domain | Protein kinase |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000538448 | + | 1 | 14 | 78_138 | -1 | 506 | Domain | SH3 |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000518730 | + | 0 | 13 | 268_276 | -1 | 505 | Nucleotide binding | Note=ATP |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000520553 | + | 0 | 13 | 268_276 | -1 | 506 | Nucleotide binding | Note=ATP |
| Tgene | >HCK | chr20:35563432 | chr20:30659465 | ENST00000538448 | + | 1 | 14 | 268_276 | -1 | 506 | Nucleotide binding | Note=ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 164_316 | 169 | 627 | Domain | HD |
| Hgene | >SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 352_354 | 169 | 627 | Nucleotide binding | dNTP |
| Hgene | >SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 309_315 | 169 | 627 | Region | Substrate binding |
| Hgene | >SAMHD1 | chr20:35563432 | chr20:30659465 | ENST00000262878 | - | 4 | 16 | 370_375 | 169 | 627 | Region | Substrate binding |
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FusionGeneSequence for SAMHD1_HCK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SAMHD1_ENST00000262878_chr20_35563432_-_HCK_ENST00000534862_chr20_30659465_+_676aa MQRADSEQPSKRPRCDDSPRTPSNTPSAEADWSPGLELHPDYKTWGPEQVCSFLRRGGFEEPVLLKNIRENEITGALLPCLDESRFENLG VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGMGCMKSKFLQ VGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLA TRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYIS PRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA FLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA SLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SAMHD1_ENST00000262878_chr20_35563432_-_HCK_ENST00000534862_chr20_30659465_+_2028nt ATGCAGCGAGCCGATTCCGAGCAGCCCTCCAAGCGTCCCCGTTGCGATGACAGCCCGAGAACCCCCTCAAACACCCCTTCCGCAGAGGCA GACTGGTCCCCGGGCCTGGAACTCCATCCCGACTACAAGACATGGGGTCCGGAGCAGGTGTGCTCCTTCCTCAGGCGCGGTGGCTTTGAA GAGCCGGTGCTGCTGAAGAACATCCGAGAAAATGAAATCACAGGCGCATTACTGCCTTGTCTTGATGAGTCTCGTTTTGAAAATCTTGGA GTAAGTTCCTTGGGGGAGAGGAAGAAGCTGCTTAGTTATATCCAGCGATTGGTTCAAATCCACGTTGATACAATGAAGGTAATTAATGAT CCTATCCATGGCCACATTGAGCTCCACCCTCTCCTCGTCCGAATCATTGATACACCTCAATTTCAACGTCTTCGATACATCAAACAGCTG GGAGGTGGTTACTATGTTTTTCCAGGAGCTTCACACAATCGATTTGAGCATAGTCTAGGGATGGGGTGCATGAAGTCCAAGTTCCTCCAG GTCGGAGGCAATACATTCTCAAAAACTGAAACCAGCGCCAGCCCACACTGTCCTGTGTACGTGCCGGATCCCACATCCACCATCAAGCCG GGGCCTAATAGCCACAACAGCAACACACCAGGAATCAGGGAGGCAGGCTCTGAGGACATCATCGTGGTTGCCCTGTATGATTACGAGGCC ATTCACCACGAAGACCTCAGCTTCCAGAAGGGGGACCAGATGGTGGTCCTAGAGGAATCCGGGGAGTGGTGGAAGGCTCGATCCCTGGCC ACCCGGAAGGAGGGCTACATCCCAAGCAACTATGTCGCCCGCGTTGACTCTCTGGAGACAGAGGAGTGGTTTTTCAAGGGCATCAGCCGG AAGGACGCAGAGCGCCAACTGCTGGCTCCCGGCAACATGCTGGGCTCCTTCATGATCCGGGATAGCGAGACCACTAAAGGAAGCTACTCT TTGTCCGTGCGAGACTACGACCCTCGGCAGGGAGATACCGTGAAACATTACAAGATCCGGACCCTGGACAACGGGGGCTTCTACATATCC CCCCGAAGCACCTTCAGCACTCTGCAGGAGCTGGTGGACCACTACAAGAAGGGGAACGACGGGCTCTGCCAGAAACTGTCGGTGCCCTGC ATGTCTTCCAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCGGGAATCCCTCAAGCTGGAGAAGAAACTTGGAGCTGGG CAGTTTGGGGAAGTCTGGATGGCCACCTACAACAAGCACACCAAGGTGGCAGTGAAGACGATGAAGCCAGGGAGCATGTCGGTGGAGGCC TTCCTGGCAGAGGCCAACGTGATGAAAACTCTGCAGCATGACAAGCTGGTCAAACTTCATGCGGTGGTCACCAAGGAGCCCATCTACATC ATCACGGAGTTCATGGCCAAAGGAAGCTTGCTGGACTTTCTGAAAAGTGATGAGGGCAGCAAGCAGCCATTGCCAAAACTCATTGACTTC TCAGCCCAGATTGCAGAAGGCATGGCCTTCATCGAGCAGAGGAACTACATCCACCGAGACCTCCGAGCTGCCAACATCTTGGTCTCTGCA TCCCTGGTGTGTAAGATTGCTGACTTTGGCCTGGCCCGGGTCATTGAGGACAACGAGTACACGGCTCGGGAAGGGGCCAAGTTCCCCATC AAGTGGACAGCTCCTGAAGCCATCAACTTTGGCTCCTTCACCATCAAGTCAGACGTCTGGTCCTTTGGTATCCTGCTGATGGAGATCGTC ACCTACGGCCGGATCCCTTACCCAGGGATGTCAAACCCTGAAGTGATCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCCCAGAGAAC TGCCCAGAGGAGCTCTACAACATCATGATGCGCTGCTGGAAAAACCGTCCGGAGGAGCGGCCGACCTTCGAATACATCCAGAGTGTGCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SAMHD1_ENST00000262878_chr20_35563432_-_HCK_ENST00000534862_chr20_30659465_+_2561nt ATTGCGCCTGCGCAGGGAGCCCAAGGCAAGAGCCGCTAGGCTGCCCTGCCCGAAGGGCTCAACTGTCAGTGAGCCTGCGCAGGAGGCCAA TAGGCTGCCAATACTCCTTGGACTCCCCGCCAGGGCCCTGCTGTCAGTGCGCCTGCGCGCGGGTCCGGCGCCGAGGTTCTTGACTGCTGT GCCGGACGCCAGGTGTAGCCATGCAGCGAGCCGATTCCGAGCAGCCCTCCAAGCGTCCCCGTTGCGATGACAGCCCGAGAACCCCCTCAA ACACCCCTTCCGCAGAGGCAGACTGGTCCCCGGGCCTGGAACTCCATCCCGACTACAAGACATGGGGTCCGGAGCAGGTGTGCTCCTTCC TCAGGCGCGGTGGCTTTGAAGAGCCGGTGCTGCTGAAGAACATCCGAGAAAATGAAATCACAGGCGCATTACTGCCTTGTCTTGATGAGT CTCGTTTTGAAAATCTTGGAGTAAGTTCCTTGGGGGAGAGGAAGAAGCTGCTTAGTTATATCCAGCGATTGGTTCAAATCCACGTTGATA CAATGAAGGTAATTAATGATCCTATCCATGGCCACATTGAGCTCCACCCTCTCCTCGTCCGAATCATTGATACACCTCAATTTCAACGTC TTCGATACATCAAACAGCTGGGAGGTGGTTACTATGTTTTTCCAGGAGCTTCACACAATCGATTTGAGCATAGTCTAGGGATGGGGTGCA TGAAGTCCAAGTTCCTCCAGGTCGGAGGCAATACATTCTCAAAAACTGAAACCAGCGCCAGCCCACACTGTCCTGTGTACGTGCCGGATC CCACATCCACCATCAAGCCGGGGCCTAATAGCCACAACAGCAACACACCAGGAATCAGGGAGGCAGGCTCTGAGGACATCATCGTGGTTG CCCTGTATGATTACGAGGCCATTCACCACGAAGACCTCAGCTTCCAGAAGGGGGACCAGATGGTGGTCCTAGAGGAATCCGGGGAGTGGT GGAAGGCTCGATCCCTGGCCACCCGGAAGGAGGGCTACATCCCAAGCAACTATGTCGCCCGCGTTGACTCTCTGGAGACAGAGGAGTGGT TTTTCAAGGGCATCAGCCGGAAGGACGCAGAGCGCCAACTGCTGGCTCCCGGCAACATGCTGGGCTCCTTCATGATCCGGGATAGCGAGA CCACTAAAGGAAGCTACTCTTTGTCCGTGCGAGACTACGACCCTCGGCAGGGAGATACCGTGAAACATTACAAGATCCGGACCCTGGACA ACGGGGGCTTCTACATATCCCCCCGAAGCACCTTCAGCACTCTGCAGGAGCTGGTGGACCACTACAAGAAGGGGAACGACGGGCTCTGCC AGAAACTGTCGGTGCCCTGCATGTCTTCCAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCGGGAATCCCTCAAGCTGG AGAAGAAACTTGGAGCTGGGCAGTTTGGGGAAGTCTGGATGGCCACCTACAACAAGCACACCAAGGTGGCAGTGAAGACGATGAAGCCAG GGAGCATGTCGGTGGAGGCCTTCCTGGCAGAGGCCAACGTGATGAAAACTCTGCAGCATGACAAGCTGGTCAAACTTCATGCGGTGGTCA CCAAGGAGCCCATCTACATCATCACGGAGTTCATGGCCAAAGGAAGCTTGCTGGACTTTCTGAAAAGTGATGAGGGCAGCAAGCAGCCAT TGCCAAAACTCATTGACTTCTCAGCCCAGATTGCAGAAGGCATGGCCTTCATCGAGCAGAGGAACTACATCCACCGAGACCTCCGAGCTG CCAACATCTTGGTCTCTGCATCCCTGGTGTGTAAGATTGCTGACTTTGGCCTGGCCCGGGTCATTGAGGACAACGAGTACACGGCTCGGG AAGGGGCCAAGTTCCCCATCAAGTGGACAGCTCCTGAAGCCATCAACTTTGGCTCCTTCACCATCAAGTCAGACGTCTGGTCCTTTGGTA TCCTGCTGATGGAGATCGTCACCTACGGCCGGATCCCTTACCCAGGGATGTCAAACCCTGAAGTGATCCGAGCTCTGGAGCGTGGATACC GGATGCCTCGCCCAGAGAACTGCCCAGAGGAGCTCTACAACATCATGATGCGCTGCTGGAAAAACCGTCCGGAGGAGCGGCCGACCTTCG AATACATCCAGAGTGTGCTGGATGACTTCTACACGGCCACAGAGAGCCAGTACCAACAGCAGCCATGATAGGGAGGACCAGGGCAGGGCC AGGGGGTGCCCAGGTGGTGGCTGCAAGGTGGCTCCAGCACCATCCGCCAGGGCCCACACCCCCTTCCTACTCCCAGACACCCACCCTCGC TTCAGCCACAGTTTCCTCATCTGTCCAGTGGGTAGGTTGGACTGGAAAATCTCTTTTTGACTCTTGCAATCCACAATCTGACATTCTCAG GAAGCCCCCAAGTTGATATTTCTATTTCCTGGAATGGTTGGATTTTAGTTACAGCTGTGATTTGGAAGGGAAACTTTCAAAATAGTGAAA |
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FusionGenePPI for SAMHD1_HCK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SAMHD1 | TIRAP, VPRBP, DDB1, CUL3, CUL5, CUL2, COPS6, APP, BARD1, CD81, KPNB1, FBXO25, EIF4B, GANAB, GART, HSPH1, JUP, PLOD2, PRMT3, RANBP3, RPL24, ATP6V1E1, FAF1, MSH6, NARS, OSBP, SEC23A, TUBG1, XRCC5, XRCC6, SF1, SUPT5H, TRMT1, XPO7, HSF5, CCNA2, CDK2, SKP2, CDK1, RNF2, EGFR, FAM13B, SAMHD1, EEF1A1, ACTB, RBX1, CUL4A, NTRK1, CCNL2, SPICE1, PPP2R1A, PPP2R5E, SMARCD2, STX3, AKAP12, MTCL1, RACGAP1, GPATCH4, KANSL3, ZMAT3, LCOR, SOGA1, RSBN1L, U2AF2, GSK3A, GSK3B, NAA10, TRIM25, KPNA2 | HCK | BCR, CBL, RAPGEF1, UNC119, DOK1, ELMO1, WIPF1, WAS, BCAR1, ABL1, SKAP2, BTK, PECAM1, CCR3, CSF3R, CHST15, ADAM15, IL6ST, RPL10, TRPV4, RASA3, RASA1, FCGR1A, MAP4K5, SRC, MYC, KHDRBS1, SH3KBP1, CREBBP, FASLG, TNK2, PAK2, APP, MED28, ACTB, RUFY1, HSP90AA1, ERBB3, STAT3, ABL2, WNT2, SPRR2A, MTUS2, GOPC, KRT40, KRTAP10-9, NOTCH2NL, EGFR, MDM2, KRAS, NGEF, PIK3R3, FRS3, LETMD1, OLIG1, PTK2, GRB14, FHL2, PIK3CB, CDC37, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SAMHD1_HCK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HCK | P08631 | DB06616 | Bosutinib | Tyrosine-protein kinase HCK | small molecule | approved |
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RelatedDiseases for SAMHD1_HCK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SAMHD1 | C2749659 | AICARDI-GOUTIERES SYNDROME 5 (disorder) | 3 | CTD_human;UNIPROT |
| Hgene | SAMHD1 | C0024145 | Chilblain lupus 1 | 1 | CTD_human;ORPHANET |
| Hgene | SAMHD1 | C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | CTD_human |
| Hgene | SAMHD1 | C3711385 | Deoxyguanosine Kinase Deficiency | 1 | CTD_human |
| Tgene | HCK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | HCK | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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