|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32564 |
FusionGeneSummary for SAMD11_PROZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAMD11_PROZ | Fusion gene ID: 32564 | Hgene | Tgene | Gene symbol | SAMD11 | PROZ | Gene ID | 148398 | 8858 |
| Gene name | sterile alpha motif domain containing 11 | protein Z, vitamin K dependent plasma glycoprotein | |
| Synonyms | MRS | PZ | |
| Cytomap | 1p36.33 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sterile alpha motif domain-containing protein 11SAM domain-containing protein 11 | vitamin K-dependent protein Zvitamin K-dependent protein Z precursor variant 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96NU1 | P22891 | |
| Ensembl transtripts involved in fusion gene | ENST00000342066, ENST00000478729, | ENST00000342783, ENST00000375547, ENST00000493630, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SAMD11 [Title/Abstract] AND PROZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-KF-A41W-01A | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000342066 | ENST00000342783 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| In-frame | ENST00000342066 | ENST00000375547 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| 5CDS-3UTR | ENST00000342066 | ENST00000493630 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| intron-3CDS | ENST00000478729 | ENST00000342783 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| intron-3CDS | ENST00000478729 | ENST00000375547 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
| intron-3UTR | ENST00000478729 | ENST00000493630 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
Top |
FusionProtFeatures for SAMD11_PROZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAMD11 | PROZ |
| Appears to assist hemostasis by binding thrombin andpromoting its association with phospholipid vesicles. Inhibitsactivity of the coagulation protease factor Xa in the presence ofSERPINA10, calcium and phospholipids. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SAMD11 | chr1:861393 | chr13:113824727 | ENST00000342066 | + | 2 | 14 | 543_608 | 24 | 682 | Domain | SAM |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 125_166 | 213 | 423 | Domain | EGF-like 2 |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 175_400 | 213 | 423 | Domain | Peptidase S1 |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 41_86 | 213 | 423 | Domain | Gla |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 87_123 | 213 | 423 | Domain | EGF-like 1 |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 125_166 | 191 | 401 | Domain | EGF-like 2 |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 175_400 | 191 | 401 | Domain | Peptidase S1 |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 41_86 | 191 | 401 | Domain | Gla |
| Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 87_123 | 191 | 401 | Domain | EGF-like 1 |
Top |
FusionGeneSequence for SAMD11_PROZ |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_234aa MSKGILQVHPPICDCPGCRISSPVVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTTFNRTSQDPLMIKITHVHVHMRTDADA GENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVA >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_234aa MSKGILQVHPPICDCPGCRISSPVVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTTFNRTSQDPLMIKITHVHVHMRTDADA GENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_702nt ATGTCCAAGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCC GAAGGAAAAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACT GTAAAAACATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCG GGGGAGAATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTC GCTGAGCACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGG CCTGTCACACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCG GCCATGCACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGA >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_702nt ATGTCCAAGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCC GAAGGAAAAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACT GTAAAAACATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCG GGGGAGAATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTC GCTGAGCACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGG CCTGTCACACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCG GCCATGCACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_1060nt CCAGCAGATCCCTGCGGCGTTCGCGAGGGTGGGACGGGAAGCGGGCTGGGAAGTCGGGCCGAGGGAAAAGTCTGAAGACGCTTATGTCCA AGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCCGAAGGAA AAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACTGTAAAAA CATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCGGGGGAGA ATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTCGCTGAGC ACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGGCCTGTCA CACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCGGCCATGC ACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGAGGGCAGG CTCACATGGTCCTTGTCACCAAGGTCTCCAGGTACTCACTCTGGTTTAAACAGATCATGAACTAACTGAAACTCAGCTAGCCAGAATGAA CAACACAACCGGAAGCGGGATTCCAAGCTGGCACTGCCACTGTGGAGGGCGCTGAAACTTCATCACACACTGAGAGGCCGTCACAGCCCC AGACCACCCGCTTGGCCCACGCAGCAGCAGAGCCGCCGTTTGCTGGGTTGTTTACCGAGCACTGTGACCTTTCTTTCCCTGGAACTCTTT >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_1060nt CCAGCAGATCCCTGCGGCGTTCGCGAGGGTGGGACGGGAAGCGGGCTGGGAAGTCGGGCCGAGGGAAAAGTCTGAAGACGCTTATGTCCA AGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCCGAAGGAA AAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACTGTAAAAA CATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCGGGGGAGA ATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTCGCTGAGC ACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGGCCTGTCA CACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCGGCCATGC ACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGAGGGCAGG CTCACATGGTCCTTGTCACCAAGGTCTCCAGGTACTCACTCTGGTTTAAACAGATCATGAACTAACTGAAACTCAGCTAGCCAGAATGAA CAACACAACCGGAAGCGGGATTCCAAGCTGGCACTGCCACTGTGGAGGGCGCTGAAACTTCATCACACACTGAGAGGCCGTCACAGCCCC AGACCACCCGCTTGGCCCACGCAGCAGCAGAGCCGCCGTTTGCTGGGTTGTTTACCGAGCACTGTGACCTTTCTTTCCCTGGAACTCTTT |
Top |
FusionGenePPI for SAMD11_PROZ |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SAMD11 | SAMD7, PRR20E, L3MBTL1, HNRNPLL, NCAPH2, ASB3, SIRT6, TRIM25 | PROZ | FOXG1, INTS6, IP6K3, XRCC6BP1, FOXF2, OR52W1, SIPA1L2, SDF2L1, SIK2, MAP2K7, CDC6, SENP1, RICTOR, TUBA4A, TYW3, MELK, EGFL7, TUBB8, SEPN1, KANK2, GNL3L, MLF1, ACOT9, ETV3, HSPA5, DNAJB9, HIGD1A, TUBB3, N4BP2L2, ZNHIT6, ARVCF |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SAMD11_PROZ |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PROZ | P22891 | DB00170 | Menadione | Vitamin K-dependent protein Z | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for SAMD11_PROZ |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SAMD11 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|