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Fusion gene ID: 32564 |
FusionGeneSummary for SAMD11_PROZ |
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Fusion gene information | Fusion gene name: SAMD11_PROZ | Fusion gene ID: 32564 | Hgene | Tgene | Gene symbol | SAMD11 | PROZ | Gene ID | 148398 | 8858 |
Gene name | sterile alpha motif domain containing 11 | protein Z, vitamin K dependent plasma glycoprotein | |
Synonyms | MRS | PZ | |
Cytomap | 1p36.33 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | sterile alpha motif domain-containing protein 11SAM domain-containing protein 11 | vitamin K-dependent protein Zvitamin K-dependent protein Z precursor variant 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96NU1 | P22891 | |
Ensembl transtripts involved in fusion gene | ENST00000342066, ENST00000478729, | ENST00000342783, ENST00000375547, ENST00000493630, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SAMD11 [Title/Abstract] AND PROZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-KF-A41W-01A | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000342066 | ENST00000342783 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
In-frame | ENST00000342066 | ENST00000375547 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
5CDS-3UTR | ENST00000342066 | ENST00000493630 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
intron-3CDS | ENST00000478729 | ENST00000342783 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
intron-3CDS | ENST00000478729 | ENST00000375547 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
intron-3UTR | ENST00000478729 | ENST00000493630 | SAMD11 | chr1 | 861393 | + | PROZ | chr13 | 113824727 | + |
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FusionProtFeatures for SAMD11_PROZ |
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Hgene | Tgene |
SAMD11 | PROZ |
Appears to assist hemostasis by binding thrombin andpromoting its association with phospholipid vesicles. Inhibitsactivity of the coagulation protease factor Xa in the presence ofSERPINA10, calcium and phospholipids. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SAMD11 | chr1:861393 | chr13:113824727 | ENST00000342066 | + | 2 | 14 | 543_608 | 24 | 682 | Domain | SAM |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 125_166 | 213 | 423 | Domain | EGF-like 2 |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 175_400 | 213 | 423 | Domain | Peptidase S1 |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 41_86 | 213 | 423 | Domain | Gla |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000342783 | + | 6 | 9 | 87_123 | 213 | 423 | Domain | EGF-like 1 |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 125_166 | 191 | 401 | Domain | EGF-like 2 |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 175_400 | 191 | 401 | Domain | Peptidase S1 |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 41_86 | 191 | 401 | Domain | Gla |
Tgene | PROZ | chr1:861393 | chr13:113824727 | ENST00000375547 | + | 5 | 8 | 87_123 | 191 | 401 | Domain | EGF-like 1 |
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FusionGeneSequence for SAMD11_PROZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_234aa MSKGILQVHPPICDCPGCRISSPVVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADA GENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVA >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_234aa MSKGILQVHPPICDCPGCRISSPVVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADA GENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_702nt ATGTCCAAGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCC GAAGGAAAAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACT GTAAAAACATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCG GGGGAGAATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTC GCTGAGCACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGG CCTGTCACACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCG GCCATGCACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGA >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_702nt ATGTCCAAGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCC GAAGGAAAAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACT GTAAAAACATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCG GGGGAGAATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTC GCTGAGCACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGG CCTGTCACACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCG GCCATGCACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000342783_chr13_113824727_+_1060nt CCAGCAGATCCCTGCGGCGTTCGCGAGGGTGGGACGGGAAGCGGGCTGGGAAGTCGGGCCGAGGGAAAAGTCTGAAGACGCTTATGTCCA AGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCCGAAGGAA AAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACTGTAAAAA CATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCGGGGGAGA ATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTCGCTGAGC ACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGGCCTGTCA CACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCGGCCATGC ACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGAGGGCAGG CTCACATGGTCCTTGTCACCAAGGTCTCCAGGTACTCACTCTGGTTTAAACAGATCATGAACTAACTGAAACTCAGCTAGCCAGAATGAA CAACACAACCGGAAGCGGGATTCCAAGCTGGCACTGCCACTGTGGAGGGCGCTGAAACTTCATCACACACTGAGAGGCCGTCACAGCCCC AGACCACCCGCTTGGCCCACGCAGCAGCAGAGCCGCCGTTTGCTGGGTTGTTTACCGAGCACTGTGACCTTTCTTTCCCTGGAACTCTTT >In-frame_SAMD11_ENST00000342066_chr1_861393_+_PROZ_ENST00000375547_chr13_113824727_+_1060nt CCAGCAGATCCCTGCGGCGTTCGCGAGGGTGGGACGGGAAGCGGGCTGGGAAGTCGGGCCGAGGGAAAAGTCTGAAGACGCTTATGTCCA AGGGGATCCTGCAGGTGCATCCTCCGATCTGCGACTGCCCGGGCTGCCGAATATCCTCCCCGGTGGTAAAGTTAACAAATTCCGAAGGAA AAGACTTCTGTGGTGGTGTTATAATACGGGAAAATTTTGTACTGACAACAGCAAAATGTTCACTGTTACACAGGAATATTACTGTAAAAA CATATTTTAACAGAACGAGCCAAGACCCGCTGATGATCAAGATAACGCACGTCCATGTGCACATGCGGTATGACGCGGACGCGGGGGAGA ATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGGTGCGGGGCTCCCCGTGTGCACCCCTGAGAAAGACTTCGCTGAGC ACCTCCTCATCCCACGCACCAGGGGCCTCCTCAGCGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCGGCCTGTCA CACTTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACTGTCACCACCAGGACCTACTGTGAGAGAAGCAGCGTGGCGGCCATGC ACTGGATGGATGGAAGTGTGGTCACCAGAGAACACAGAGGCTCCTGGTTTCTCACGGGGGTCCTGGGCTCGCAGCCAGTAGGAGGGCAGG CTCACATGGTCCTTGTCACCAAGGTCTCCAGGTACTCACTCTGGTTTAAACAGATCATGAACTAACTGAAACTCAGCTAGCCAGAATGAA CAACACAACCGGAAGCGGGATTCCAAGCTGGCACTGCCACTGTGGAGGGCGCTGAAACTTCATCACACACTGAGAGGCCGTCACAGCCCC AGACCACCCGCTTGGCCCACGCAGCAGCAGAGCCGCCGTTTGCTGGGTTGTTTACCGAGCACTGTGACCTTTCTTTCCCTGGAACTCTTT |
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FusionGenePPI for SAMD11_PROZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SAMD11 | SAMD7, PRR20E, L3MBTL1, HNRNPLL, NCAPH2, ASB3, SIRT6, TRIM25 | PROZ | FOXG1, INTS6, IP6K3, XRCC6BP1, FOXF2, OR52W1, SIPA1L2, SDF2L1, SIK2, MAP2K7, CDC6, SENP1, RICTOR, TUBA4A, TYW3, MELK, EGFL7, TUBB8, SEPN1, KANK2, GNL3L, MLF1, ACOT9, ETV3, HSPA5, DNAJB9, HIGD1A, TUBB3, N4BP2L2, ZNHIT6, ARVCF |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SAMD11_PROZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PROZ | P22891 | DB00170 | Menadione | Vitamin K-dependent protein Z | small molecule | approved|nutraceutical |
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RelatedDiseases for SAMD11_PROZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SAMD11 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |