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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3256

FusionGeneSummary for ATP11A_COL14A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11A_COL14A1
Fusion gene ID: 3256
HgeneTgene
Gene symbol

ATP11A

COL14A1

Gene ID

23250

7373

Gene nameATPase phospholipid transporting 11Acollagen type XIV alpha 1 chain
SynonymsATPIH|ATPISUND
Cytomap

13q34

8q24.12

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IHcollagen alpha-1(XIV) chaincollagen, type XIV, alpha 1undulin (fibronectin-tenascin-related)
Modification date2018052320180523
UniProtAcc

P98196

Q05707

Ensembl transtripts involved in fusion geneENST00000283558, ENST00000375630, 
ENST00000487903, ENST00000375645, 
ENST00000419448, 
ENST00000537875, 
ENST00000309791, ENST00000297848, 
ENST00000247781, ENST00000432943, 
Fusion gene scores* DoF score12 X 9 X 11=11888 X 7 X 6=336
# samples 207
** MAII scorelog2(20/1188*10)=-2.57046293102604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/336*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP11A [Title/Abstract] AND COL14A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-3U-A98D-01AATP11Achr13

113344769

+COL14A1chr8

121160045

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283558ENST00000537875ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000283558ENST00000309791ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000283558ENST00000297848ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000283558ENST00000247781ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-3UTRENST00000283558ENST00000432943ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375630ENST00000537875ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375630ENST00000309791ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375630ENST00000297848ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375630ENST00000247781ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-3UTRENST00000375630ENST00000432943ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000487903ENST00000537875ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000487903ENST00000309791ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000487903ENST00000297848ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000487903ENST00000247781ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-3UTRENST00000487903ENST00000432943ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375645ENST00000537875ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375645ENST00000309791ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375645ENST00000297848ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-5UTRENST00000375645ENST00000247781ATP11Achr13

113344769

+COL14A1chr8

121160045

+
5CDS-3UTRENST00000375645ENST00000432943ATP11Achr13

113344769

+COL14A1chr8

121160045

+
intron-5UTRENST00000419448ENST00000537875ATP11Achr13

113344769

+COL14A1chr8

121160045

+
intron-5UTRENST00000419448ENST00000309791ATP11Achr13

113344769

+COL14A1chr8

121160045

+
intron-5UTRENST00000419448ENST00000297848ATP11Achr13

113344769

+COL14A1chr8

121160045

+
intron-5UTRENST00000419448ENST00000247781ATP11Achr13

113344769

+COL14A1chr8

121160045

+
intron-3UTRENST00000419448ENST00000432943ATP11Achr13

113344769

+COL14A1chr8

121160045

+

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FusionProtFeatures for ATP11A_COL14A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11A

P98196

COL14A1

Q05707

Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP11A_COL14A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP11A_COL14A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP11ATMEM30A, NPDC1, PICK1, TRIM25COL14A1DCN, CD44, APP, HLA-DQB2, C1QTNF2, CNPY3, OGN, FGL1, C1QTNF9, PVRL3, TMEM25, PRELP, GCNT2, COL8A2, RNASE13, MMP9, MMP2, PLOD1, COL20A1, SCGB2A2, DEFA1, GIP, OS9, C1QL4, SCGB1D2, LYZL2, IL12A, PSG1, SIL1, INSL5, PRDX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP11A_COL14A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP11A_COL14A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
TgeneCOL14A1C4277682Chemical and Drug Induced Liver Injury1CTD_human