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Fusion gene ID: 32551 |
FusionGeneSummary for SAFB2_KHSRP |
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Fusion gene information | Fusion gene name: SAFB2_KHSRP | Fusion gene ID: 32551 | Hgene | Tgene | Gene symbol | SAFB2 | KHSRP | Gene ID | 9667 | 8570 |
Gene name | scaffold attachment factor B2 | KH-type splicing regulatory protein | |
Synonyms | - | FBP2|FUBP2|KSRP | |
Cytomap | 19p13.3 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | scaffold attachment factor B2 | far upstream element-binding protein 2FUSE-binding protein 2p75 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q14151 | Q92945 | |
Ensembl transtripts involved in fusion gene | ENST00000252542, ENST00000591310, | ENST00000398148, | |
Fusion gene scores | * DoF score | 6 X 6 X 6=216 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SAFB2 [Title/Abstract] AND KHSRP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KHSRP | GO:0043488 | regulation of mRNA stability | 16126846 |
Tgene | KHSRP | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 16126846 |
Tgene | KHSRP | GO:0061014 | positive regulation of mRNA catabolic process | 16126846 |
Tgene | KHSRP | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 16126846 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5515-01A | SAFB2 | chr19 | 5616143 | - | KHSRP | chr19 | 6418090 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000252542 | ENST00000398148 | SAFB2 | chr19 | 5616143 | - | KHSRP | chr19 | 6418090 | - |
intron-3CDS | ENST00000591310 | ENST00000398148 | SAFB2 | chr19 | 5616143 | - | KHSRP | chr19 | 6418090 | - |
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FusionProtFeatures for SAFB2_KHSRP |
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Hgene | Tgene |
SAFB2 | KHSRP |
Binds to scaffold/matrix attachment region (S/MAR) DNA.Can function as an estrogen receptor corepressor and can alsoinhibit cell proliferation. | Binds to the dendritic targeting element and may play arole in mRNA trafficking (By similarity). Part of a ternarycomplex that binds to the downstream control sequence (DCS) of thepre-mRNA. Mediates exon inclusion in transcripts that are subjectto tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activategene expression. Also involved in degradation of inherentlyunstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644,ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 30_64 | 181 | 954 | Domain | SAP |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 498_612 | 293 | 712 | Compositional bias | Note=Ala/Gly/Pro-rich |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 322_386 | 293 | 712 | Domain | KH 3 |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 424_491 | 293 | 712 | Domain | KH 4 |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 571_684 | 293 | 712 | Region | Note=4 X 12 AA imperfect repeats |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 571_582 | 293 | 712 | Repeat | Note=1 |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 617_628 | 293 | 712 | Repeat | Note=2 |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 643_654 | 293 | 712 | Repeat | Note=3 |
Tgene | >KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 673_684 | 293 | 712 | Repeat | Note=4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 482_545 | 181 | 954 | Compositional bias | Note=Lys-rich |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 619_724 | 181 | 954 | Compositional bias | Note=Glu-rich |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 621_788 | 181 | 954 | Compositional bias | Note=Arg-rich |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 792_926 | 181 | 954 | Compositional bias | Note=Gly-rich |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 407_485 | 181 | 954 | Domain | RRM |
Hgene | >SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 713_730 | 181 | 954 | Motif | Nuclear localization signal |
Tgene | KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 68_496 | 293 | 712 | Compositional bias | Note=Gly-rich |
Tgene | KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 7_67 | 293 | 712 | Compositional bias | Note=Gly/Pro-rich |
Tgene | KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 144_208 | 293 | 712 | Domain | KH 1 |
Tgene | KHSRP | chr19:5616143 | chr19:6418090 | ENST00000398148 | - | 8 | 20 | 233_299 | 293 | 712 | Domain | KH 2 |
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FusionGeneSequence for SAFB2_KHSRP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SAFB2_ENST00000252542_chr19_5616143_-_KHSRP_ENST00000398148_chr19_6418090_-_600aa MAETLPGSGDSGPGTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIELEATSKKSAKRCV KGLKMEEEGTEDNGLEDDSRDGQEDMEASLENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGLLDSFCDSKEYVAAQLRQLPAQPPEH AQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHA ARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNF KLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDP SKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYY |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SAFB2_ENST00000252542_chr19_5616143_-_KHSRP_ENST00000398148_chr19_6418090_-_1800nt ATGGCGGAGACTCTGCCCGGGTCGGGCGACTCGGGCCCTGGCACGGCTTCTCTCGGCCCGGGCGTTGCGGAGACTGGGACGAGGCGGCTC AGCGAGCTGCGGGTGATCGATCTGCGGGCGGAGCTGAAGAAGCGGAACCTGGACACGGGCGGCAACAAGAGCGTCCTGATGGAGCGGCTC AAGAAGGCGGTTAAAGAAGAGGGGCAAGATCCTGATGAAATTGGCATCGAGTTAGAAGCCACCAGCAAGAAGTCAGCCAAGAGATGTGTT AAAGGACTGAAGATGGAGGAGGAAGGCACAGAAGATAATGGCCTGGAAGACGATTCCAGAGACGGGCAGGAGGACATGGAAGCAAGTCTG GAGAACCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATTTTGGGGAGGAT GGCACGGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGCCCCCAGAGCAT GCTCAAGCCTGTGAGATGGTGATGGACATCCTCCGGGAACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGC GGAGGCATCGATGTGCCAGTGCCCAGGCATTCTGTTGGCGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCT GGCGTGCGGATACAGTTCAAGCAAGATGACGGGACAGGGCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCA GCCCGGATCATCAACGACCTCCTCCAGAGCCTCAGGAGTGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGC CGAGGAAGAGGCCAAGGCAATTGGGGTCCCCCTGGCGGGGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGA GGTGGCGAGAATGTGAAAGCCATAAACCAGCAGACGGGAGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTC AAGTTGTTCATCATCCGGGGTTCACCCCAGCAGATTGACCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTT GGACCAGGCCCAGGTGGCCCAGGCCCTGCTGGCCCAATGGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCA CATGCCGGGGGGCCCCCTCCTCACCAGTACCCACCCCAGGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCA AGCAAAGCAGCTGCAGCGGCCGCGGACCCCAACGCCGCGTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCC GGCCCCGCACCGGCCCCTGCGGCCCCACCGGCTCAGGGTGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGG GAAGAGTATTACAAAAAGATCGGCCAGCAGCCCCAGCAGCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTAC AAGAAGCAAGCGCAAGTGGCCACCGGAGGGGGTCCAGGAGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTAC AGACAGCAGGCCGCTTACTACGGACAGACCCCAGGTCCTGGCGGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAGGCTCAATGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SAFB2_ENST00000252542_chr19_5616143_-_KHSRP_ENST00000398148_chr19_6418090_-_2829nt CTCCCGCCGGGAACTGCCGGGACGCATGCGAGCTGCAGATTCAGCGCTTGCGCGTTGTGCCGGGGAACCCGCGGTTGGTGGACGCGCGAG CGTCCTTGCTGCTAAGTACGCTAGTGGGGGCGGTGCGCGTGCGCGTGCGCGGCCGCAAAGCGGGGCGGGAGGAAACGAGTGCGTTTTCCT CTTAGGCGGCGCCATTTTGTGTTCAGAGCCGCTATAGCTGCCGGCGGTGTGCGACTGAGTCGGTGGCGAAGACGGGAACGCGACGATGGC GGAGACTCTGCCCGGGTCGGGCGACTCGGGCCCTGGCACGGCTTCTCTCGGCCCGGGCGTTGCGGAGACTGGGACGAGGCGGCTCAGCGA GCTGCGGGTGATCGATCTGCGGGCGGAGCTGAAGAAGCGGAACCTGGACACGGGCGGCAACAAGAGCGTCCTGATGGAGCGGCTCAAGAA GGCGGTTAAAGAAGAGGGGCAAGATCCTGATGAAATTGGCATCGAGTTAGAAGCCACCAGCAAGAAGTCAGCCAAGAGATGTGTTAAAGG ACTGAAGATGGAGGAGGAAGGCACAGAAGATAATGGCCTGGAAGACGATTCCAGAGACGGGCAGGAGGACATGGAAGCAAGTCTGGAGAA CCTGCAGAATATGGGCATGATGGACATGAGTGTGCTAGACGAAACTGAAGTGGCGAATAGCAGTGCTCCAGATTTTGGGGAGGATGGCAC GGACGGCCTTCTCGATTCCTTTTGTGATAGTAAAGAATACGTGGCTGCACAGCTGAGACAGCTCCCGGCTCAGCCCCCAGAGCATGCTCA AGCCTGTGAGATGGTGATGGACATCCTCCGGGAACGTGACCAAGGCGGCTTTGGGGACCGGAATGAGTACGGATCTCGGATTGGCGGAGG CATCGATGTGCCAGTGCCCAGGCATTCTGTTGGCGTGGTCATTGGCCGGAGTGGAGAGATGATCAAGAAGATCCAGAATGATGCTGGCGT GCGGATACAGTTCAAGCAAGATGACGGGACAGGGCCCGAGAAGATTGCTCATATAATGGGGCCCCCAGACAGGTGCGAGCACGCAGCCCG GATCATCAACGACCTCCTCCAGAGCCTCAGGAGTGGTCCCCCAGGTCCTCCAGGGGGTCCAGGCATGCCCCCGGGGGGCCGAGGCCGAGG AAGAGGCCAAGGCAATTGGGGTCCCCCTGGCGGGGAGATGACCTTCTCCATCCCCACTCACAAGTGTGGGCTGGTCATCGGCCGAGGTGG CGAGAATGTGAAAGCCATAAACCAGCAGACGGGAGCCTTCGTAGAGATCTCCCGGCAGCTGCCACCCAACGGGGACCCCAACTTCAAGTT GTTCATCATCCGGGGTTCACCCCAGCAGATTGACCACGCCAAGCAGCTTATCGAGGAAAAGATCGAGGGTCCTCTCTGCCCAGTTGGACC AGGCCCAGGTGGCCCAGGCCCTGCTGGCCCAATGGGGCCCTTCAATCCTGGGCCCTTCAACCAGGGGCCACCCGGGGCTCCCCCACATGC CGGGGGGCCCCCTCCTCACCAGTACCCACCCCAGGGCTGGGGCAATACCTACCCCCAGTGGCAGCCGCCTGCTCCTCATGACCCAAGCAA AGCAGCTGCAGCGGCCGCGGACCCCAACGCCGCGTGGGCCGCCTACTACTCACACTACTACCAGCAGCCCCCGGGCCCCGTCCCCGGCCC CGCACCGGCCCCTGCGGCCCCACCGGCTCAGGGTGAGCCCCCTCAGCCCCCACCCACCGGCCAGTCGGACTACACTAAGGCCTGGGAAGA GTATTACAAAAAGATCGGCCAGCAGCCCCAGCAGCCCGGAGCACCCCCACAGCAGGACTACACGAAGGCTTGGGAGGAGTACTACAAGAA GCAAGCGCAAGTGGCCACCGGAGGGGGTCCAGGAGCTCCCCCAGGCTCCCAGCCAGACTACAGTGCCGCCTGGGCGGAATATTACAGACA GCAGGCCGCTTACTACGGACAGACCCCAGGTCCTGGCGGCCCCCAGCCGCCGCCCACGCAGCAGGGACAGCAGCAGGCTCAATGAATCGA ATGAATGTGAACTTCTTCATCTGTGAAAAATCTTTTTTTTTTCCATTTTGTTCTGTTTGGGGGCTTCTGTTTTGTTTGGCGAGAGAGCGA TGGCTGCCGTGGGGAGTACTGGGGAGCCCTCGCGGCAAGCAGGGTGGGGGGGACTTGGGGGCATGCCGGGCCCTCACTCTCTCGCCTGTT CTGTGTCTCACATGCTTTTTCTTTCAAAATTGGGATCCTTCCATGTTGAGCCAGCCAGAGAAGATAGCGAGATCTAAATCTCTGCCAAAA AAAAAAAAAAACTTAAAAATTAAAAACACAAAGAGCAAAGCAGAACTTATAAAATTATATATATATATATTAAAAAGTCTCTATTCTTCA CCCCCCAGCCTTCCTGAACCTGCCTCTCTGAGGATAAAGCAATTCATTTTCTCCCACCCTCGGCCCTCTTGTTTTTAAAATAAACTTTTA AAAAGGAAAAAAAAAAGTCACTCTTGCTATTTCTTTTTTTTAGTTAGAGGTGGAACATTCCTTGGACCAGGTGTTGTATTGCAGGACCCC TTCCCCCAGCAGCCAAGCCCCCTCTTCTCTCCCTCCCGCCCTGGCTCAGCTCCCGCGGCCCCGCCCGTCCCCCCTCCCAGGACTGGTCTG TTGTCTTTTCATCTGTTCAAGAGGAGATTGAAACTGAAAACAAAATGAGAACAACAAAAAAAATTGTATGGCAGTTTTTACTTTTTATCG |
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FusionGenePPI for SAFB2_KHSRP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SAFB2 | SAFB, ESR1, SORBS3, CHGB, MAP1LC3A, RB1CC1, NCOR1, HDAC3, TOPORS, CUL3, COPS5, CAND1, SRCAP, IK, APOA1, FNTA, FUS, GIT2, ZSCAN18, MOV10, CUL7, OBSL1, EZH2, SUZ12, EED, BMI1, TP53, RSPH9, RBMX, FNDC4, ZFP41, HNRNPUL1, CCAR1, SSB, HNRNPA1, MYO1C, PPP1CB, PPP1CC, EMC2, MATR3, MPHOSPH8, CAMKK1, MEX3C, ELAVL2, DHPS, TRIP6, APOBEC3D, CAPN13, CIZ1, CLK3, COX15, VDAC1, G3BP1 | KHSRP | PUF60, EXOSC2, PARN, PTBP2, HNRNPA1, HNRNPH1, A1CF, PSMA3, GSK3B, STK3, GADD45A, ELAVL1, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, RAE1, CPLX1, CIRBP, ASF1B, STRIP1, FN1, VCAM1, UBL4A, ITGA4, MPG, CD81, TARDBP, APBB1, GARS, GFPT1, HNRNPD, ALDH16A1, NAP1L4, WWOX, LGR4, UBC, STAU1, HUWE1, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, MAEL, CHCHD2, CPSF6, CPSF7, FUBP3, HTRA2, EIF4B, RAD54L2, SMARCA2, KYNU, NUP50, PRDX2, PRDX5, SIN3A, SMARCC1, SMARCC2, SYMPK, NTRK1, SCARNA22, MKNK2, FOS, JUN, FOXF1, CRY2, MCM2, NANOG, U2AF2, KLHL12, BRCA1, UBE2I, DROSHA, DGCR8, MIRLET7A1, MIRLET7A3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | SAFB2 | chr19:5616143 | chr19:6418090 | ENST00000252542 | - | 4 | 21 | 600_953 | 181 | 954 | SAFB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SAFB2_KHSRP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | KHSRP | Q92945 | DB11638 | Artenimol | Far upstream element-binding protein 2 | small molecule | approved|investigational |
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RelatedDiseases for SAFB2_KHSRP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KHSRP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |