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Fusion gene ID: 32543 |
FusionGeneSummary for SAE1_GRIN2D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAE1_GRIN2D | Fusion gene ID: 32543 | Hgene | Tgene | Gene symbol | SAE1 | GRIN2D | Gene ID | 10055 | 2906 |
| Gene name | SUMO1 activating enzyme subunit 1 | glutamate ionotropic receptor NMDA type subunit 2D | |
| Synonyms | AOS1|HSPC140|SUA1|UBLE1A | EB11|EIEE46|GluN2D|NMDAR2D|NR2D | |
| Cytomap | 19q13.32 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SUMO-activating enzyme subunit 1SUMO-1 activating enzyme E1 N subunitSUMO-1 activating enzyme subunit 1activator of SUMO1sentrin/SUMO-activating protein AOS1ubiquitin-like 1-activating enzyme E1Aubiquitin-like protein SUMO-1 activating enzyme | glutamate receptor ionotropic, NMDA 2DN-methyl D-aspartate receptor subtype 2DN-methyl-d-aspartate receptor subunit 2Destrogen receptor binding CpG islandglutamate [NMDA] receptor subunit epsilon-4glutamate receptor, ionotropic, N-methyl D-aspartate | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBE0 | O15399 | |
| Ensembl transtripts involved in fusion gene | ENST00000413379, ENST00000540850, ENST00000598840, ENST00000270225, ENST00000392776, | ENST00000263269, | |
| Fusion gene scores | * DoF score | 9 X 3 X 8=216 | 4 X 4 X 4=64 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SAE1 [Title/Abstract] AND GRIN2D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SAE1 | GO:0016925 | protein sumoylation | 15660128|20164921 |
| Tgene | GRIN2D | GO:0097553 | calcium ion transmembrane import into cytosol | 26875626 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-AG-3731-01A | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000413379 | ENST00000263269 | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
| intron-3CDS | ENST00000540850 | ENST00000263269 | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
| In-frame | ENST00000598840 | ENST00000263269 | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
| In-frame | ENST00000270225 | ENST00000263269 | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
| In-frame | ENST00000392776 | ENST00000263269 | SAE1 | chr19 | 47634285 | + | GRIN2D | chr19 | 48945026 | + |
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FusionProtFeatures for SAE1_GRIN2D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAE1 | GRIN2D |
| The heterodimer acts as an E1 ligase for SUMO1, SUMO2,SUMO3, and probably SUMO4. It mediates ATP-dependent activation ofSUMO proteins followed by formation of a thioester bond between aSUMO protein and a conserved active site cysteine residue onUBA2/SAE2. {ECO:0000269|PubMed:10187858,ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128,ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}. | Component of NMDA receptor complexes that function asheterotetrameric, ligand-gated ion channels with high calciumpermeability and voltage-dependent sensitivity to magnesium.Channel activation requires binding of the neurotransmitterglutamate to the epsilon subunit, glycine binding to the zetasubunit, plus membrane depolarization to eliminate channelinhibition by Mg(2+) (PubMed:9489750, PubMed:27616483,PubMed:26875626, PubMed:28126851). Sensitivity to glutamate andchannel kinetics depend on the subunit composition(PubMed:9489750). {ECO:0000269|PubMed:26875626,ECO:0000269|PubMed:27616483, ECO:0000269|PubMed:28095420,ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:9489750}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 1035_1040 | 750 | 1337 | Compositional bias | Note=Poly-Ala |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 1209_1213 | 750 | 1337 | Compositional bias | Note=Poly-Pro |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 1244_1247 | 750 | 1337 | Compositional bias | Note=Poly-Ala |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 908_916 | 750 | 1337 | Compositional bias | Note=Poly-Pro |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 1334_1336 | 750 | 1337 | Motif | PDZ-binding |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 865_1336 | 750 | 1337 | Topological domain | Cytoplasmic |
| Tgene | >GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 845_864 | 750 | 1337 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 281_286 | 750 | 1337 | Compositional bias | Note=Poly-Gly |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 539_541 | 750 | 1337 | Region | Glutamate binding |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 631_650 | 750 | 1337 | Region | Pore-forming |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 717_718 | 750 | 1337 | Region | Glutamate binding |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 28_584 | 750 | 1337 | Topological domain | Extracellular |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 604_630 | 750 | 1337 | Topological domain | Cytoplasmic |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 651_657 | 750 | 1337 | Topological domain | Cytoplasmic |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 674_844 | 750 | 1337 | Topological domain | Extracellular |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 585_603 | 750 | 1337 | Transmembrane | Helical |
| Tgene | GRIN2D | chr19:47634285 | chr19:48945026 | ENST00000263269 | + | 9 | 13 | 658_673 | 750 | 1337 | Transmembrane | Helical |
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FusionGeneSequence for SAE1_GRIN2D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SAE1_ENST00000413379_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_619aa MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCS AEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAA GRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGG AGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDY LPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAG >In-frame_SAE1_ENST00000598840_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_619aa MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCS AEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAA GRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGG AGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDY LPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAG >In-frame_SAE1_ENST00000270225_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_619aa MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCS AEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAA GRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGG AGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDY LPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAG >In-frame_SAE1_ENST00000392776_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_619aa MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCS AEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAPRGAA GRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGG AGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDY LPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SAE1_ENST00000413379_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_1857nt ATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCC CAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATC GGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTG CAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGCAGC AAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTG GTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGC GCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGG CCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCC GACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCC GGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAG CCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTG GCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGC GCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTC GAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCT TACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTAC CTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCG CACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGC CCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGG GGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACC GGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGG >In-frame_SAE1_ENST00000598840_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_1857nt ATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCC CAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATC GGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTG CAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGCAGC AAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTG GTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGC GCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGG CCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCC GACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCC GGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAG CCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTG GCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGC GCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTC GAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCT TACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTAC CTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCG CACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGC CCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGG GGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACC GGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGG >In-frame_SAE1_ENST00000270225_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_1857nt ATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCC CAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATC GGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTG CAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGCAGC AAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTG GTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGC GCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGG CCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCC GACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCC GGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAG CCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTG GCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGC GCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTC GAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCT TACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTAC CTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCG CACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGC CCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGG GGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACC GGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGG >In-frame_SAE1_ENST00000392776_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_1857nt ATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCC CAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATC GGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTG CAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGCAGC AAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTG GTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGC GCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGG CCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCC GACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCC GGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAG CCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTG GCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGC GCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTC GAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCT TACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTAC CTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCG CACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGC CCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGG GGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACC GGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SAE1_ENST00000413379_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_2953nt AGAAGCACTCCGGGCGTGCTGCCGGCGGCGGTAGGTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGA AGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGG GGACTGGAGGCCCAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAG CTTGTCACCATCGGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGAC CTGGCGTTGCTGCAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAG GTGATGAGCAGCAAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCC TGGGAGCACCTGGTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTAC AGCTGCTGCAGCGCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGG CCGGCTCCCGGGCCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGC GCGGGCCTGGCCGACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCG CGGGGCGCAGCCGGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAG GAGCCAGCCGAGCCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCA CTCTGCCGCTTGGCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCA GGCGCGGGCGGCGCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCT TACCTCGATCTCGAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTC GCCGACTTCCCTTACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGG AGCTGGGACTACCTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCAT CTCAGCTGCTCGCACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCC CGCTGCGGGTGCCCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGG CGCGCCGCTGGGGGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCG CGCAGGCTTACCGGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGA CACCGGGGCGGGGACCTGGGCACCCGCAGGGGCTCGGCGCACTTCTCTAGCCTCGAGTCCGAGGTATGACGCGGCCCCGGGGGCCCCACC GCCCCCTTGGTCAGCGCAGGCCACGGCCCGAGGGGGCGCCCGCAGTGGACAGGACCCGCGTGGGTTGGGAAGGAAAGCAGTGGAACTGGC CGGACCCCGCCTGGAGCAGCGTCCTGCGCCCCCTGGTTCTGGAGGAACCGCAAGCCGGAGAGGATTTGGTCCCTCAACTATCACCCAGCC TGAGAACGAGGGGGCGGGGGCCTTGGAGCCCACCGGACTTTTTTTTAAACCCGACAAGGGCTTTTTAACGTCACCAGATGGGGCGGGAGG TGGGGGGTTCACGCCACTCCCGCGTCCCACCTCCACGCCCGGGGCCGTGGCCCCCACATCACTGTGCAGCTCCCCGGCCCCAGCCGCGCC TCCGGGGAAGCCCGTTTTTAACCTTTCATCCATTGGGACTCAAAACTGTGAGACGCGTTCGCCAAACTGTGACCCCAGACCTTGGCCCCG CCACACAGAAACCCCTGACCCAGACTGTGACATCCGACTCCTAAAATGGTCATCCGACTCCAGACTGTGACCCCTGACCCCAAACTGTGA CCCGAACCCCAGACTGTGCCCCGACCAGACTGTGACCCTTGACATCAAACCGTGACACCCCCTCCTCCTCTTCCACCCTCGGTCGCTTTT CCCTACTCTGACCTAGGACACGTCCCCAACGGAAGCCCCGCCTTCCCTTGCACCGCGATGAACCCAACCTCCCTGAAGCCAAAACTTCCC ACCCTGCCGCACCTCCGGACCACCCCACTTGCCACCAAGCACATCCTCTCCAAATCCAACCCTTATTTGCGACCCTTCAGTGATGACCCA GCAGACCTCCAAAAAGCCTCCTCTGCCCAGATCTCCAGCCGGGTCTGGGGCTGGGTTGCGGAGGGGAGGGTCTGGGAGTCCACACTTCTC >In-frame_SAE1_ENST00000598840_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_2944nt CCGGGCGTGCTGCCGGCGGCGGTAGGTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGC GCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAG GCCCAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACC ATCGGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTG CTGCAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGC AGCAAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCAC CTGGTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGC AGCGCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCC GGGCCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTG GCCGACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCA GCCGGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCC GAGCCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGC TTGGCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGC GGCGCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGAT CTCGAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTC CCTTACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGAC TACCTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGC TCGCACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGG TGCCCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCT GGGGGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTT ACCGGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGC GGGGACCTGGGCACCCGCAGGGGCTCGGCGCACTTCTCTAGCCTCGAGTCCGAGGTATGACGCGGCCCCGGGGGCCCCACCGCCCCCTTG GTCAGCGCAGGCCACGGCCCGAGGGGGCGCCCGCAGTGGACAGGACCCGCGTGGGTTGGGAAGGAAAGCAGTGGAACTGGCCGGACCCCG CCTGGAGCAGCGTCCTGCGCCCCCTGGTTCTGGAGGAACCGCAAGCCGGAGAGGATTTGGTCCCTCAACTATCACCCAGCCTGAGAACGA GGGGGCGGGGGCCTTGGAGCCCACCGGACTTTTTTTTAAACCCGACAAGGGCTTTTTAACGTCACCAGATGGGGCGGGAGGTGGGGGGTT CACGCCACTCCCGCGTCCCACCTCCACGCCCGGGGCCGTGGCCCCCACATCACTGTGCAGCTCCCCGGCCCCAGCCGCGCCTCCGGGGAA GCCCGTTTTTAACCTTTCATCCATTGGGACTCAAAACTGTGAGACGCGTTCGCCAAACTGTGACCCCAGACCTTGGCCCCGCCACACAGA AACCCCTGACCCAGACTGTGACATCCGACTCCTAAAATGGTCATCCGACTCCAGACTGTGACCCCTGACCCCAAACTGTGACCCGAACCC CAGACTGTGCCCCGACCAGACTGTGACCCTTGACATCAAACCGTGACACCCCCTCCTCCTCTTCCACCCTCGGTCGCTTTTCCCTACTCT GACCTAGGACACGTCCCCAACGGAAGCCCCGCCTTCCCTTGCACCGCGATGAACCCAACCTCCCTGAAGCCAAAACTTCCCACCCTGCCG CACCTCCGGACCACCCCACTTGCCACCAAGCACATCCTCTCCAAATCCAACCCTTATTTGCGACCCTTCAGTGATGACCCAGCAGACCTC CAAAAAGCCTCCTCTGCCCAGATCTCCAGCCGGGTCTGGGGCTGGGTTGCGGAGGGGAGGGTCTGGGAGTCCACACTTCTCCACCAACTT >In-frame_SAE1_ENST00000270225_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_2919nt GTGGCGCGCGGGTCCGGCGGGCGGTTGGCTTGAGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTG GCGGCGGCATTAGCGAGGAGGAGGCGGCACAGTATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCCCAGAAACGGAAGCTGGACGCCT TCATCTACGATGCTGCAGTGCTCAATTACATGGCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATCGGCTCCGGCAAGGTCTTCGCCA CGACAGGCTATGGCATCGCCCTGCACAAGGGCTCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTGCAGTTCCTGGGGGATGATGAGA TCGAGATGCTGGAGCGGCTGTGGCTCTCTGGGATCTGCCACAATGACAAAATCGAGGTGATGAGCAGCAAGCTGGACATCGACAACATGG CGGGCGTCTTCTACATGCTCCTGGTGGCCATGGGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTGGTGTACTGGCGCCTGCGGCACT GCCTGGGGCCCACCCACCGCATGGACTTCCTGCTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGCGCTGAGGCCGCCCCACCGCCCG CCAAGCCCCCGCCGCCGCCACAGCCCCTGCCCAGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGGCCCGCACCTTTCGTGCCCCGCG AGCGCGCCTCAGTGGACCGCTGGCGCCGGACCAAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCCGACGGCTTCCACCGCTACTACG GCCCCATCGAGCCGCAGGGCCTAGGCCTCGGCCTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCCGGGCGCCCGCTGTCCCCGCCGG CCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCCTATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAGCCCCCCGCCGGCGCCTTCCCCG GCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCCGCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTGGCCTTCGAGGACGAGAGCCCGC CGGCGCCCGCGCGGTGGCCGCGCTCGGACCCCGAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGCGCGGGGGGCACGGGGGGCGCAG GCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGCCGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTCGAGCCGTCGCCGTCGGACTCGG AGGACTCGGAGAGCCTGGGCGGCGCGTCGCTGGGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCTTACCCGTATGCCGAGCGCCTCG GGCCGCCGCCCGGCCGCTACTGGTCGGTCGACAAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTACCTGCCCCCGCGCAGCGGTCCGG CCGCCTGGCACTGTCGGCACTGCGCCAGCCTGGAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCGCACGATGGCCTGGACGGCGGCT GGTGGGCGCCACCGCCTCCACCCTGGGCCGCCGGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGCCCGCGGTCGCACCCGCACCGCC CGCGGGCCTCGCACCGCACGCCCGCCGCCGCCGCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGGGGCTGGGACCTCCCGCCGCCCG CGCCCACCTCGCGCTCGCTCGAGGACCTCAGCTCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACCGGGCCCTCCCGCCACGCTCGCA GGTGTCCGCACGCCGCGCACTGGGGGCCGCCGCTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGGGACCTGGGCACCCGCAGGGGCT CGGCGCACTTCTCTAGCCTCGAGTCCGAGGTATGACGCGGCCCCGGGGGCCCCACCGCCCCCTTGGTCAGCGCAGGCCACGGCCCGAGGG GGCGCCCGCAGTGGACAGGACCCGCGTGGGTTGGGAAGGAAAGCAGTGGAACTGGCCGGACCCCGCCTGGAGCAGCGTCCTGCGCCCCCT GGTTCTGGAGGAACCGCAAGCCGGAGAGGATTTGGTCCCTCAACTATCACCCAGCCTGAGAACGAGGGGGCGGGGGCCTTGGAGCCCACC GGACTTTTTTTTAAACCCGACAAGGGCTTTTTAACGTCACCAGATGGGGCGGGAGGTGGGGGGTTCACGCCACTCCCGCGTCCCACCTCC ACGCCCGGGGCCGTGGCCCCCACATCACTGTGCAGCTCCCCGGCCCCAGCCGCGCCTCCGGGGAAGCCCGTTTTTAACCTTTCATCCATT GGGACTCAAAACTGTGAGACGCGTTCGCCAAACTGTGACCCCAGACCTTGGCCCCGCCACACAGAAACCCCTGACCCAGACTGTGACATC CGACTCCTAAAATGGTCATCCGACTCCAGACTGTGACCCCTGACCCCAAACTGTGACCCGAACCCCAGACTGTGCCCCGACCAGACTGTG ACCCTTGACATCAAACCGTGACACCCCCTCCTCCTCTTCCACCCTCGGTCGCTTTTCCCTACTCTGACCTAGGACACGTCCCCAACGGAA GCCCCGCCTTCCCTTGCACCGCGATGAACCCAACCTCCCTGAAGCCAAAACTTCCCACCCTGCCGCACCTCCGGACCACCCCACTTGCCA CCAAGCACATCCTCTCCAAATCCAACCCTTATTTGCGACCCTTCAGTGATGACCCAGCAGACCTCCAAAAAGCCTCCTCTGCCCAGATCT CCAGCCGGGTCTGGGGCTGGGTTGCGGAGGGGAGGGTCTGGGAGTCCACACTTCTCCACCAACTTCCCTTCCCACTCTCTTATTCCACAT >In-frame_SAE1_ENST00000392776_chr19_47634285_+_GRIN2D_ENST00000263269_chr19_48945026_+_2887nt AGCGGGACCGGAGCTGAGGCAGGAAGAGCCGGCGCCATGGTGGAGAAGGAGGAGGCTGGCGGCGGCATTAGCGAGGAGGAGGCGGCACAG TATGACCGGCAGATCCGCCTGTGGGGACTGGAGGCCCAGAAACGGAAGCTGGACGCCTTCATCTACGATGCTGCAGTGCTCAATTACATG GCCCGCAAGGACGAGGGCTGCAAGCTTGTCACCATCGGCTCCGGCAAGGTCTTCGCCACGACAGGCTATGGCATCGCCCTGCACAAGGGC TCCCGCTGGAAGCGGCCCATCGACCTGGCGTTGCTGCAGTTCCTGGGGGATGATGAGATCGAGATGCTGGAGCGGCTGTGGCTCTCTGGG ATCTGCCACAATGACAAAATCGAGGTGATGAGCAGCAAGCTGGACATCGACAACATGGCGGGCGTCTTCTACATGCTCCTGGTGGCCATG GGCCTGTCCCTGCTGGTCTTCGCCTGGGAGCACCTGGTGTACTGGCGCCTGCGGCACTGCCTGGGGCCCACCCACCGCATGGACTTCCTG CTGGCCTTCTCCAGGGGCATGTACAGCTGCTGCAGCGCTGAGGCCGCCCCACCGCCCGCCAAGCCCCCGCCGCCGCCACAGCCCCTGCCC AGCCCCGCGTACCCCGCGCCGCGGCCGGCTCCCGGGCCCGCACCTTTCGTGCCCCGCGAGCGCGCCTCAGTGGACCGCTGGCGCCGGACC AAGGGCGCGGGGCCGCCGGGGGGCGCGGGCCTGGCCGACGGCTTCCACCGCTACTACGGCCCCATCGAGCCGCAGGGCCTAGGCCTCGGC CTGGGCGAAGCGCGCGCGGCACCGCGGGGCGCAGCCGGGCGCCCGCTGTCCCCGCCGGCCGCTCAGCCCCCGCAGAAGCCGCCGCCCTCC TATTTCGCCATCGTACGCGACAAGGAGCCAGCCGAGCCCCCCGCCGGCGCCTTCCCCGGCTTCCCGTCGCCGCCCGCGCCCCCCGCCGCC GCGGCCACCGCCGTCGGGCCGCCACTCTGCCGCTTGGCCTTCGAGGACGAGAGCCCGCCGGCGCCCGCGCGGTGGCCGCGCTCGGACCCC GAGAGCCAACCCCTGCTGGGGCCAGGCGCGGGCGGCGCGGGGGGCACGGGGGGCGCAGGCGGAGGAGCCCCGGCCGCTCCGCCCCCGTGC CGCGCCGCGCCGCCCCCGTGCCCTTACCTCGATCTCGAGCCGTCGCCGTCGGACTCGGAGGACTCGGAGAGCCTGGGCGGCGCGTCGCTG GGCGGCCTGGAGCCCTGGTGGTTCGCCGACTTCCCTTACCCGTATGCCGAGCGCCTCGGGCCGCCGCCCGGCCGCTACTGGTCGGTCGAC AAGCTCGGGGGCTGGCGCGCCGGGAGCTGGGACTACCTGCCCCCGCGCAGCGGTCCGGCCGCCTGGCACTGTCGGCACTGCGCCAGCCTG GAGCTGCTGCCGCCGCCGCGCCATCTCAGCTGCTCGCACGATGGCCTGGACGGCGGCTGGTGGGCGCCACCGCCTCCACCCTGGGCCGCC GGGCCCCTGCCCCGACGCCGGGCCCGCTGCGGGTGCCCGCGGTCGCACCCGCACCGCCCGCGGGCCTCGCACCGCACGCCCGCCGCCGCC GCGCCCCACCACCACAGGCACCGGCGCGCCGCTGGGGGCTGGGACCTCCCGCCGCCCGCGCCCACCTCGCGCTCGCTCGAGGACCTCAGC TCGTGCCCTCGCGCCGCCCCTGCGCGCAGGCTTACCGGGCCCTCCCGCCACGCTCGCAGGTGTCCGCACGCCGCGCACTGGGGGCCGCCG CTGCCCACAGCTTCCCACCGGAGACACCGGGGCGGGGACCTGGGCACCCGCAGGGGCTCGGCGCACTTCTCTAGCCTCGAGTCCGAGGTA TGACGCGGCCCCGGGGGCCCCACCGCCCCCTTGGTCAGCGCAGGCCACGGCCCGAGGGGGCGCCCGCAGTGGACAGGACCCGCGTGGGTT GGGAAGGAAAGCAGTGGAACTGGCCGGACCCCGCCTGGAGCAGCGTCCTGCGCCCCCTGGTTCTGGAGGAACCGCAAGCCGGAGAGGATT TGGTCCCTCAACTATCACCCAGCCTGAGAACGAGGGGGCGGGGGCCTTGGAGCCCACCGGACTTTTTTTTAAACCCGACAAGGGCTTTTT AACGTCACCAGATGGGGCGGGAGGTGGGGGGTTCACGCCACTCCCGCGTCCCACCTCCACGCCCGGGGCCGTGGCCCCCACATCACTGTG CAGCTCCCCGGCCCCAGCCGCGCCTCCGGGGAAGCCCGTTTTTAACCTTTCATCCATTGGGACTCAAAACTGTGAGACGCGTTCGCCAAA CTGTGACCCCAGACCTTGGCCCCGCCACACAGAAACCCCTGACCCAGACTGTGACATCCGACTCCTAAAATGGTCATCCGACTCCAGACT GTGACCCCTGACCCCAAACTGTGACCCGAACCCCAGACTGTGCCCCGACCAGACTGTGACCCTTGACATCAAACCGTGACACCCCCTCCT CCTCTTCCACCCTCGGTCGCTTTTCCCTACTCTGACCTAGGACACGTCCCCAACGGAAGCCCCGCCTTCCCTTGCACCGCGATGAACCCA ACCTCCCTGAAGCCAAAACTTCCCACCCTGCCGCACCTCCGGACCACCCCACTTGCCACCAAGCACATCCTCTCCAAATCCAACCCTTAT TTGCGACCCTTCAGTGATGACCCAGCAGACCTCCAAAAAGCCTCCTCTGCCCAGATCTCCAGCCGGGTCTGGGGCTGGGTTGCGGAGGGG AGGGTCTGGGAGTCCACACTTCTCCACCAACTTCCCTTCCCACTCTCTTATTCCACATTGCAGTGTTTGGAATAAACCATGTTTTTATGC |
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FusionGenePPI for SAE1_GRIN2D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SAE1 | UBA2, UBE2I, FKBP4, SUMO3, UNC79, CYP1B1, SUMO1, SUMO2, BCL6, ETV4, APP, BAG3, IL3RA, PTK2, AARS, ADSL, DHPS, LPP, PDE12, RANGAP1, CALU, CUL5, DPP9, MCM3, NPLOC4, OSGEP, PANK4, PPP2R5E, TRMT10A, RPRD1B, SRP14, TP53RK, TPD52L2, WDR4, USP39, HSPA1A, HSPA2, FUS, FAF2, ABCE1, FRG1B, PSMB6, UBE2M, TYMS, NTRK1, KRAS, MYC, EWSR1, OFD1, CTSC, GDF15, PQBP1, WAS, DNM1L, SOD1, EDEM3 | GRIN2D | NEDD4, VCP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SAE1_GRIN2D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GRIN2D | O15399 | DB00454 | Pethidine | Glutamate receptor ionotropic, NMDA 2D | small molecule | approved |
| Tgene | GRIN2D | O15399 | DB01173 | Orphenadrine | Glutamate receptor ionotropic, NMDA 2D | small molecule | approved |
| Tgene | GRIN2D | O15399 | DB06151 | Acetylcysteine | Glutamate receptor ionotropic, NMDA 2D | small molecule | approved|investigational |
| Tgene | GRIN2D | O15399 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, NMDA 2D | small molecule | approved|nutraceutical |
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RelatedDiseases for SAE1_GRIN2D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GRIN2D | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | GRIN2D | C0036341 | Schizophrenia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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