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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32520

FusionGeneSummary for S100P_CHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: S100P_CHD1
Fusion gene ID: 32520
HgeneTgene
Gene symbol

S100P

CHD1

Gene ID

6286

1105

Gene nameS100 calcium binding protein Pchromodomain helicase DNA binding protein 1
SynonymsMIG9PILBOS
Cytomap

4p16.1

5q15-q21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-Pmigration-inducing gene 9 proteinprotein S100-Echromodomain-helicase-DNA-binding protein 1ATP-dependent helicase CHD1CHD-1
Modification date2018052220180522
UniProtAcc

P25815

O14646

Ensembl transtripts involved in fusion geneENST00000296370, ENST00000513778, 
ENST00000284049, ENST00000511067, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 1 X 6=48
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/48*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: S100P [Title/Abstract] AND CHD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AK-01AS100Pchr4

6698896

+CHD1chr5

98219587

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296370ENST00000284049S100Pchr4

6698896

+CHD1chr5

98219587

-
5CDS-intronENST00000296370ENST00000511067S100Pchr4

6698896

+CHD1chr5

98219587

-
5CDS-intronENST00000513778ENST00000284049S100Pchr4

6698896

+CHD1chr5

98219587

-
5CDS-intronENST00000513778ENST00000511067S100Pchr4

6698896

+CHD1chr5

98219587

-

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FusionProtFeatures for S100P_CHD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100P

P25815

CHD1

O14646

May function as calcium sensor and contribute tocellular calcium signaling. In a calcium-dependent manner,functions by interacting with other proteins, such as EZR andPPP5C, and indirectly plays a role in physiological processes likethe formation of microvilli in epithelial cells. May stimulatecell proliferation in an autocrine manner via activation of thereceptor for activated glycation end products (RAGE).{ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582,ECO:0000269|PubMed:22399290}. ATP-dependent chromatin-remodeling factor whichfunctions as substrate recognition component of the transcriptionregulatory histone acetylation (HAT) complex SAGA. Regulatespolymerase II transcription. Also required for efficienttranscription by RNA polymerase I, and more specifically thepolymerase I transcription termination step. Regulates negativelyDNA replication. Not only involved in transcription-relatedchromatin-remodeling, but also required to maintain a specificchromatin configuration across the genome. Is also associated withhistone deacetylase (HDAC) activity (By similarity). Required forthe bridging of SNF2, the FACT complex, the PAF complex as well asthe U2 snRNP complex to H3K4me3. Functions to modulate theefficiency of pre-mRNA splicing in part through physical bridgingof spliceosomal components to H3K4me3 (PubMed:18042460,PubMed:28866611). Required for maintaining open chromatin andpluripotency in embryonic stem cells (By similarity).{ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460,ECO:0000269|PubMed:28866611}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for S100P_CHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for S100P_CHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
S100PS100P, S100A1, AGER, EZR, S100Z, TERF2IP, SUGT1, LRRC45, PPM1G, SNRPF, IGBP1, PSMD4, STUB1, BAG3, S100B, TFIP11, NUSAP1, CDH1, CCDC103, TBC1D22B, ZIC1CHD1ARRB1, HDAC1, BCLAF1, SRSF3, NCOR1, SAFB, SSRP1, CEBPA, HMGA1, HIST1H3A, MLLT1, PAF1, ELAVL1, SIRT7, ISG15, SPP1, FBXW11, HIST3H3, CUL7, OBSL1, NTRK1, CTR9, RTF1, HNRNPU, NPM1, RPL10, TMPO, BTRC, INO80B, RNF157


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for S100P_CHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100PP25815DB01003Cromoglicic acidProtein S100-Psmall moleculeapproved
TgeneCHD1O14646DB00445EpirubicinChromodomain-helicase-DNA-binding protein 1small moleculeapproved

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RelatedDiseases for S100P_CHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneS100PC0032460Polycystic Ovary Syndrome1CTD_human