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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3252

FusionGeneSummary for ATP11A_ADPRHL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11A_ADPRHL1
Fusion gene ID: 3252
HgeneTgene
Gene symbol

ATP11A

ADPRHL1

Gene ID

23250

113622

Gene nameATPase phospholipid transporting 11AADP-ribosylhydrolase like 1
SynonymsATPIH|ATPISARH2
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH[Protein ADP-ribosylarginine] hydrolase-like protein 1ADP-ribosyl-hydrolaseADP-ribosylarginine hydrolase like 1ADP-ribosylhydrolase 2
Modification date2018052320180522
UniProtAcc

P98196

Q8NDY3

Ensembl transtripts involved in fusion geneENST00000283558, ENST00000375630, 
ENST00000487903, ENST00000375645, 
ENST00000419448, 
ENST00000356501, 
ENST00000375418, 
Fusion gene scores* DoF score12 X 9 X 11=11882 X 2 X 2=8
# samples 202
** MAII scorelog2(20/1188*10)=-2.57046293102604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ATP11A [Title/Abstract] AND ADPRHL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-KF-A41W-01AATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000283558ENST00000356501ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000283558ENST00000375418ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000375630ENST00000356501ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000375630ENST00000375418ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000487903ENST00000356501ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000487903ENST00000375418ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000375645ENST00000356501ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
Frame-shiftENST00000375645ENST00000375418ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
intron-3CDSENST00000419448ENST00000356501ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-
intron-3CDSENST00000419448ENST00000375418ATP11Achr13

113439571

+ADPRHL1chr13

114088182

-

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FusionProtFeatures for ATP11A_ADPRHL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11A

P98196

ADPRHL1

Q8NDY3

Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP11A_ADPRHL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP11A_ADPRHL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP11ATMEM30A, NPDC1, PICK1, TRIM25ADPRHL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP11A_ADPRHL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP11A_ADPRHL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET