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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32519

FusionGeneSummary for S100P_BZW2

check button Fusion gene summary
Fusion gene informationFusion gene name: S100P_BZW2
Fusion gene ID: 32519
HgeneTgene
Gene symbol

S100P

BZW2

Gene ID

6286

28969

Gene nameS100 calcium binding protein Pbasic leucine zipper and W2 domains 2
SynonymsMIG9HSPC028|MST017|MSTP017
Cytomap

4p16.1

7p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein S100-Pmigration-inducing gene 9 proteinprotein S100-Ebasic leucine zipper and W2 domain-containing protein 2
Modification date2018052220180523
UniProtAcc

P25815

Q9Y6E2

Ensembl transtripts involved in fusion geneENST00000296370, ENST00000513778, 
ENST00000258761, ENST00000433922, 
ENST00000432311, ENST00000452975, 
ENST00000405202, ENST00000407633, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 3=90
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: S100P [Title/Abstract] AND BZW2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-VS-A9V0-01AS100Pchr4

6695797

+BZW2chr7

16714037

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296370ENST00000258761S100Pchr4

6695797

+BZW2chr7

16714037

+
Frame-shiftENST00000296370ENST00000433922S100Pchr4

6695797

+BZW2chr7

16714037

+
5CDS-3UTRENST00000296370ENST00000432311S100Pchr4

6695797

+BZW2chr7

16714037

+
5CDS-3UTRENST00000296370ENST00000452975S100Pchr4

6695797

+BZW2chr7

16714037

+
5CDS-5UTRENST00000296370ENST00000405202S100Pchr4

6695797

+BZW2chr7

16714037

+
5CDS-intronENST00000296370ENST00000407633S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-3CDSENST00000513778ENST00000258761S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-3CDSENST00000513778ENST00000433922S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-3UTRENST00000513778ENST00000432311S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-3UTRENST00000513778ENST00000452975S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-5UTRENST00000513778ENST00000405202S100Pchr4

6695797

+BZW2chr7

16714037

+
intron-intronENST00000513778ENST00000407633S100Pchr4

6695797

+BZW2chr7

16714037

+

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FusionProtFeatures for S100P_BZW2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
S100P

P25815

BZW2

Q9Y6E2

May function as calcium sensor and contribute tocellular calcium signaling. In a calcium-dependent manner,functions by interacting with other proteins, such as EZR andPPP5C, and indirectly plays a role in physiological processes likethe formation of microvilli in epithelial cells. May stimulatecell proliferation in an autocrine manner via activation of thereceptor for activated glycation end products (RAGE).{ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582,ECO:0000269|PubMed:22399290}. May be involved in neuronal differentiation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for S100P_BZW2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for S100P_BZW2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
S100PS100P, S100A1, AGER, EZR, S100Z, TERF2IP, SUGT1, LRRC45, PPM1G, SNRPF, IGBP1, PSMD4, STUB1, BAG3, S100B, TFIP11, NUSAP1, CDH1, CCDC103, TBC1D22B, ZIC1BZW2BZW1, PSTPIP1, GSK3B, ELAVL1, VCP, FN1, EGFR, ABHD14A, CAPN1, CNBP, DFFA, EIF6, HSPA9, PFAS, CTSA, PPP5C, C11orf58, GINS3, PAFAH1B2, PHKG2, PTPLAD1, EIF2A, EIF2B1, EIF3A, STX12, RAB1B, CD68, GPR183, LYPD3, SCN2B, CYFIP1, EIF5, HSD17B10, STAG2, NTRK1, CDH1, PTPRE, MUL1, EXOG, NT5C3A, CANT1, ENDOD1, TMEM43, TMEM206, ZFPL1, SCCPDH, GYPB, MRS2, MAVS, OMA1, TVP23C, NXT1, RRAS, NRAS, VIPR2, SLC27A2, PTPRN, TPTE, SMDT1, EIF2B2, EIF2B4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for S100P_BZW2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneS100PP25815DB01003Cromoglicic acidProtein S100-Psmall moleculeapproved

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RelatedDiseases for S100P_BZW2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneS100PC0032460Polycystic Ovary Syndrome1CTD_human