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Fusion gene ID: 32519 |
FusionGeneSummary for S100P_BZW2 |
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Fusion gene information | Fusion gene name: S100P_BZW2 | Fusion gene ID: 32519 | Hgene | Tgene | Gene symbol | S100P | BZW2 | Gene ID | 6286 | 28969 |
Gene name | S100 calcium binding protein P | basic leucine zipper and W2 domains 2 | |
Synonyms | MIG9 | HSPC028|MST017|MSTP017 | |
Cytomap | 4p16.1 | 7p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein S100-Pmigration-inducing gene 9 proteinprotein S100-E | basic leucine zipper and W2 domain-containing protein 2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P25815 | Q9Y6E2 | |
Ensembl transtripts involved in fusion gene | ENST00000296370, ENST00000513778, | ENST00000258761, ENST00000433922, ENST00000432311, ENST00000452975, ENST00000405202, ENST00000407633, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 3=90 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: S100P [Title/Abstract] AND BZW2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-VS-A9V0-01A | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000296370 | ENST00000258761 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
Frame-shift | ENST00000296370 | ENST00000433922 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
5CDS-3UTR | ENST00000296370 | ENST00000432311 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
5CDS-3UTR | ENST00000296370 | ENST00000452975 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
5CDS-5UTR | ENST00000296370 | ENST00000405202 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
5CDS-intron | ENST00000296370 | ENST00000407633 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-3CDS | ENST00000513778 | ENST00000258761 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-3CDS | ENST00000513778 | ENST00000433922 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-3UTR | ENST00000513778 | ENST00000432311 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-3UTR | ENST00000513778 | ENST00000452975 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-5UTR | ENST00000513778 | ENST00000405202 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
intron-intron | ENST00000513778 | ENST00000407633 | S100P | chr4 | 6695797 | + | BZW2 | chr7 | 16714037 | + |
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FusionProtFeatures for S100P_BZW2 |
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Hgene | Tgene |
S100P | BZW2 |
May function as calcium sensor and contribute tocellular calcium signaling. In a calcium-dependent manner,functions by interacting with other proteins, such as EZR andPPP5C, and indirectly plays a role in physiological processes likethe formation of microvilli in epithelial cells. May stimulatecell proliferation in an autocrine manner via activation of thereceptor for activated glycation end products (RAGE).{ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582,ECO:0000269|PubMed:22399290}. | May be involved in neuronal differentiation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for S100P_BZW2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for S100P_BZW2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
S100P | S100P, S100A1, AGER, EZR, S100Z, TERF2IP, SUGT1, LRRC45, PPM1G, SNRPF, IGBP1, PSMD4, STUB1, BAG3, S100B, TFIP11, NUSAP1, CDH1, CCDC103, TBC1D22B, ZIC1 | BZW2 | BZW1, PSTPIP1, GSK3B, ELAVL1, VCP, FN1, EGFR, ABHD14A, CAPN1, CNBP, DFFA, EIF6, HSPA9, PFAS, CTSA, PPP5C, C11orf58, GINS3, PAFAH1B2, PHKG2, PTPLAD1, EIF2A, EIF2B1, EIF3A, STX12, RAB1B, CD68, GPR183, LYPD3, SCN2B, CYFIP1, EIF5, HSD17B10, STAG2, NTRK1, CDH1, PTPRE, MUL1, EXOG, NT5C3A, CANT1, ENDOD1, TMEM43, TMEM206, ZFPL1, SCCPDH, GYPB, MRS2, MAVS, OMA1, TVP23C, NXT1, RRAS, NRAS, VIPR2, SLC27A2, PTPRN, TPTE, SMDT1, EIF2B2, EIF2B4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for S100P_BZW2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | S100P | P25815 | DB01003 | Cromoglicic acid | Protein S100-P | small molecule | approved |
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RelatedDiseases for S100P_BZW2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | S100P | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |