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Fusion gene ID: 32473 |
FusionGeneSummary for S100A13_MAT2B |
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Fusion gene information | Fusion gene name: S100A13_MAT2B | Fusion gene ID: 32473 | Hgene | Tgene | Gene symbol | S100A13 | MAT2B | Gene ID | 6284 | 27430 |
Gene name | S100 calcium binding protein A13 | methionine adenosyltransferase 2B | |
Synonyms | - | MAT-II|MATIIbeta|Nbla02999|SDR23E1|TGR | |
Cytomap | 1q21.3 | 5q34 | |
Type of gene | protein-coding | protein-coding | |
Description | protein S100-A13 | methionine adenosyltransferase 2 subunit betaMAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase II, betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputati | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q99584 | Q9NZL9 | |
Ensembl transtripts involved in fusion gene | ENST00000339556, ENST00000392622, ENST00000392623, ENST00000440685, ENST00000368699, ENST00000491177, | ENST00000280969, ENST00000321757, ENST00000518095, ENST00000521838, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/50*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: S100A13 [Title/Abstract] AND MAT2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | S100A13 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 15033494 |
Hgene | S100A13 | GO:0050703 | interleukin-1 alpha secretion | 12746488 |
Tgene | MAT2B | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686|25075345 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP259408 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000339556 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000339556 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000339556 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000339556 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392622 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392622 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392622 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000392622 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392623 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392623 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000392623 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000392623 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000440685 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000440685 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000440685 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000440685 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000368699 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000368699 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000368699 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000368699 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000491177 | ENST00000280969 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000491177 | ENST00000321757 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-3CDS | ENST00000491177 | ENST00000518095 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
intron-intron | ENST00000491177 | ENST00000521838 | S100A13 | chr1 | 153604262 | + | MAT2B | chr5 | 162939116 | + |
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FusionProtFeatures for S100A13_MAT2B |
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Hgene | Tgene |
S100A13 | MAT2B |
Plays a role in the export of proteins that lack asignal peptide and are secreted by an alternative pathway. Bindstwo calcium ions per subunit. Binds one copper ion. Binding of onecopper ion does not interfere with calcium binding. Required forthe copper-dependent stress-induced export of IL1A and FGF1. Thecalcium-free protein binds to lipid vesicles containingphosphatidylserine, but not to vesicles containingphosphatidylcholine (By similarity). {ECO:0000250,ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for S100A13_MAT2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for S100A13_MAT2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for S100A13_MAT2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | S100A13 | Q99584 | DB00768 | Olopatadine | Protein S100-A13 | small molecule | approved |
Hgene | S100A13 | Q99584 | DB01164 | Calcium Chloride | Protein S100-A13 | small molecule | approved |
Hgene | S100A13 | Q99584 | DB11093 | Calcium Citrate | Protein S100-A13 | small molecule | approved |
Hgene | S100A13 | Q99584 | DB11348 | Calcium Phosphate | Protein S100-A13 | small molecule | approved |
Hgene | S100A13 | Q99584 | DB01025 | Amlexanox | Protein S100-A13 | small molecule | approved|investigational |
Hgene | S100A13 | Q99584 | DB01373 | Calcium | Protein S100-A13 | small molecule | approved|nutraceutical |
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RelatedDiseases for S100A13_MAT2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |