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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 32467

FusionGeneSummary for RYR3_LRRC57

check button Fusion gene summary
Fusion gene informationFusion gene name: RYR3_LRRC57
Fusion gene ID: 32467
HgeneTgene
Gene symbol

RYR3

LRRC57

Gene ID

6263

255252

Gene nameryanodine receptor 3leucine rich repeat containing 57
SynonymsRYR-3-
Cytomap

15q13.3-q14

15q15.2

Type of geneprotein-codingprotein-coding
Descriptionryanodine receptor 3brain ryanodine receptor-calcium release channelbrain-type ryanodine receptortype 3 ryanodine receptorleucine-rich repeat-containing protein 57
Modification date2018052320180523
UniProtAcc

Q15413

Q8N9N7

Ensembl transtripts involved in fusion geneENST00000415757, ENST00000389232, 
ENST00000559917, 		ENST00000397130, 
ENST00000323443, ENST00000563454, 
Fusion gene scores* DoF score4 X 4 X 4=645 X 5 X 2=50
# samples 45
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: RYR3 [Title/Abstract] AND LRRC57 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A2IZ-01ARYR3chr15

33603297

+LRRC57chr15

42837460

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000415757ENST00000397130RYR3chr15

33603297

+LRRC57chr15

42837460

-
In-frameENST00000415757ENST00000323443RYR3chr15

33603297

+LRRC57chr15

42837460

-
In-frameENST00000415757ENST00000563454RYR3chr15

33603297

+LRRC57chr15

42837460

-
In-frameENST00000389232ENST00000397130RYR3chr15

33603297

+LRRC57chr15

42837460

-
In-frameENST00000389232ENST00000323443RYR3chr15

33603297

+LRRC57chr15

42837460

-
In-frameENST00000389232ENST00000563454RYR3chr15

33603297

+LRRC57chr15

42837460

-
intron-3CDSENST00000559917ENST00000397130RYR3chr15

33603297

+LRRC57chr15

42837460

-
intron-3CDSENST00000559917ENST00000323443RYR3chr15

33603297

+LRRC57chr15

42837460

-
intron-3CDSENST00000559917ENST00000563454RYR3chr15

33603297

+LRRC57chr15

42837460

-

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FusionProtFeatures for RYR3_LRRC57


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RYR3

Q15413

LRRC57

Q8N9N7

Calcium channel that mediates the release of Ca(2+) fromthe sarcoplasmic reticulum into the cytoplasm in muscle andthereby plays a role in triggering muscle contraction. Mayregulate Ca(2+) release by other calcium channels. Calcium channelthat mediates Ca(2+)-induced Ca(2+) release from the endoplasmicreticulum in non-muscle cells. Contributes to cellular calcium ionhomeostasis (By similarity). Plays a role in cellular calciumsignaling. {ECO:0000250, ECO:0000269|PubMed:12354756}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-25177_197164240RepeatNote=LRR 7
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-25202_222164240RepeatNote=LRR 8
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-36177_197164240RepeatNote=LRR 7
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-36202_222164240RepeatNote=LRR 8
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-36177_197164240RepeatNote=LRR 7
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-36202_222164240RepeatNote=LRR 8

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104100_155174871DomainMIR 1
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11041012_1208174871DomainB30.2/SPRY 2
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11041254_1466174871DomainB30.2/SPRY 3
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104162_207174871DomainMIR 2
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104215_269174871DomainMIR 3
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104275_333174871DomainMIR 4
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104343_400174871DomainMIR 5
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104585_796174871DomainB30.2/SPRY 1
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103100_155174866DomainMIR 1
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11031012_1208174866DomainB30.2/SPRY 2
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11031254_1466174866DomainB30.2/SPRY 3
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103162_207174866DomainMIR 2
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103215_269174866DomainMIR 3
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103275_333174866DomainMIR 4
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103343_400174866DomainMIR 5
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103585_796174866DomainB30.2/SPRY 1
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044723_4732174871IntramembranePore-forming
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034723_4732174866IntramembranePore-forming
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104840_2820174871RegionNote=4 X approximate repeats
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103840_2820174866RegionNote=4 X approximate repeats
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11042589_2707174871RepeatNote=3
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11042708_2820174871RepeatNote=4
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104840_953174871RepeatNote=1
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+1104954_1068174871RepeatNote=2
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11032589_2707174866RepeatNote=3
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11032708_2820174866RepeatNote=4
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103840_953174866RepeatNote=1
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+1103954_1068174866RepeatNote=2
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11041_4186174871Topological domainCytoplasmic
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044774_4870174871Topological domainCytoplasmic
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11031_4186174866Topological domainCytoplasmic
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034774_4870174866Topological domainCytoplasmic
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044187_4207174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044410_4430174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044485_4505174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044610_4630174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044633_4653174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044672_4692174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11044753_4773174871TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034187_4207174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034410_4430174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034485_4505174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034610_4630174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034633_4653174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034672_4692174866TransmembraneHelical
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11034753_4773174866TransmembraneHelical
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-25109_131164240RepeatNote=LRR 4
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-25132_153164240RepeatNote=LRR 5
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-25154_175164240RepeatNote=LRR 6
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-2539_60164240RepeatNote=LRR 1
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-2563_84164240RepeatNote=LRR 2
TgeneLRRC57chr15:33603297chr15:42837460ENST00000323443-2586_107164240RepeatNote=LRR 3
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-36109_131164240RepeatNote=LRR 4
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-36132_153164240RepeatNote=LRR 5
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-36154_175164240RepeatNote=LRR 6
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-3639_60164240RepeatNote=LRR 1
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-3663_84164240RepeatNote=LRR 2
TgeneLRRC57chr15:33603297chr15:42837460ENST00000397130-3686_107164240RepeatNote=LRR 3
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-36109_131164240RepeatNote=LRR 4
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-36132_153164240RepeatNote=LRR 5
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-36154_175164240RepeatNote=LRR 6
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-3639_60164240RepeatNote=LRR 1
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-3663_84164240RepeatNote=LRR 2
TgeneLRRC57chr15:33603297chr15:42837460ENST00000563454-3686_107164240RepeatNote=LRR 3


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FusionGeneSequence for RYR3_LRRC57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_93aa
MAEGGEGGEDEIQFLRTISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_279nt
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGC
CTTAAAATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCT
GTGGAAGGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_1924nt
GCAGCAGCAGTCAGCGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCC
GAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAA
ATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAA
GGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCG
TGAAGTTCTCCAGGACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTT
AGGGGTATCTACAGTAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCT
AAAAGAAAAAGGATCAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAG
TTTGGCTTTAAGAAACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGA
TTTTGTTTAGTTTCACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATA
ATTTGTGAGAGGCTGGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGA
TGTACATAAATGTGTGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGA
GGCCAAGGCGGGTGGCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAAT
TAGCTGGGTGTGTTGGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCA
GTGAGCCGAGATTATGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTT
TTAAAGTACGCTTTGTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGG
AGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATC
CCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGAC
TCTGGGCAACAGAGCAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGC
TCTCTAAGGCTGCGGTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTT
GTAAGATAAAAGGGACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTAT
TTATAACTCTACTAACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTG

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_1924nt
GCAGCAGCAGTCAGCGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCC
GAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAA
ATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAA
GGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCG
TGAAGTTCTCCAGGACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTT
AGGGGTATCTACAGTAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCT
AAAAGAAAAAGGATCAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAG
TTTGGCTTTAAGAAACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGA
TTTTGTTTAGTTTCACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATA
ATTTGTGAGAGGCTGGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGA
TGTACATAAATGTGTGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGA
GGCCAAGGCGGGTGGCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAAT
TAGCTGGGTGTGTTGGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCA
GTGAGCCGAGATTATGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTT
TTAAAGTACGCTTTGTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGG
AGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATC
CCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGAC
TCTGGGCAACAGAGCAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGC
TCTCTAAGGCTGCGGTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTT
GTAAGATAAAAGGGACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTAT
TTATAACTCTACTAACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTG

>In-frame_RYR3_ENST00000415757_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_1922nt
GCAGCAGCAGTCAGCGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCC
GAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAA
ATTCTTCGCCTGGAAGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAA
GGCAATCTTTTTGAAATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCG
TGAAGTTCTCCAGGACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTT
AGGGGTATCTACAGTAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCT
AAAAGAAAAAGGATCAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAG
TTTGGCTTTAAGAAACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGA
TTTTGTTTAGTTTCACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATA
ATTTGTGAGAGGCTGGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGA
TGTACATAAATGTGTGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGA
GGCCAAGGCGGGTGGCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAAT
TAGCTGGGTGTGTTGGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCA
GTGAGCCGAGATTATGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTT
TTAAAGTACGCTTTGTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGG
AGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATC
CCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGAC
TCTGGGCAACAGAGCAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGC
TCTCTAAGGCTGCGGTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTT
GTAAGATAAAAGGGACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTAT
TTATAACTCTACTAACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTG

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000397130_chr15_42837460_-_1910nt
CGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCCGAAGGGGGAGAAGG
AGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAAATTCTTCGCCTGGA
AGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAAGGCAATCTTTTTGA
AATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCGTGAAGTTCTCCAGG
ACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTTAGGGGTATCTACAG
TAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCTAAAAGAAAAAGGAT
CAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAGTTTGGCTTTAAGAA
ACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGATTTTGTTTAGTTTC
ACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATAATTTGTGAGAGGCT
GGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGATGTACATAAATGTG
TGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCGGGTG
GCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGTT
GGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATTA
TGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTTTTAAAGTACGCTTT
GTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGGAGTTCGAGACCAGC
CTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGACTCTGGGCAACAGAG
CAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGCTCTCTAAGGCTGCG
GTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTTGTAAGATAAAAGGG
ACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTATTTATAACTCTACTA
ACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTGACAGAATATACTAA

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000323443_chr15_42837460_-_1910nt
CGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCCGAAGGGGGAGAAGG
AGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAAATTCTTCGCCTGGA
AGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAAGGCAATCTTTTTGA
AATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCGTGAAGTTCTCCAGG
ACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTTAGGGGTATCTACAG
TAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCTAAAAGAAAAAGGAT
CAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAGTTTGGCTTTAAGAA
ACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGATTTTGTTTAGTTTC
ACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATAATTTGTGAGAGGCT
GGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGATGTACATAAATGTG
TGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCGGGTG
GCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGTT
GGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATTA
TGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTTTTAAAGTACGCTTT
GTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGGAGTTCGAGACCAGC
CTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGACTCTGGGCAACAGAG
CAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGCTCTCTAAGGCTGCG
GTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTTGTAAGATAAAAGGG
ACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTATTTATAACTCTACTA
ACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTGACAGAATATACTAA

>In-frame_RYR3_ENST00000389232_chr15_33603297_+_LRRC57_ENST00000563454_chr15_42837460_-_1908nt
CGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGGCTGGGGCACCGCCGACGCCTCGGGAGCCATGGCCGAAGGGGGAGAAGG
AGGCGAGGACGAGATCCAGTTTCTGAGGACTATATCTCAGATCTCAGTGAAGATATCTTGCTGTCCACGCCTTAAAATTCTTCGCCTGGA
AGAGAATTGTCTTGAGCTCAGCATGCTTCCCCAGAGCATCCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAAGGCAATCTTTTTGA
AATAAAGAAACTTCGAGAACTGGAAGGCTATGATAAGTACATGGAGAGGTTCACAGCCACCAAGAAGAAGTTTGCGTGAAGTTCTCCAGG
ACTATGGAAACCTTACAGGATACTGACTTAGAACCTCTGTTGGAATGTGGCTGAGTCAAAGCCTCCTGTTGTTGTTAGGGGTATCTACAG
TAAGGAGATGATACTTCAGGAGATTATATTTCACTCAATGATCTTTTCTCATTTCAGGGCTCTTCTCAAATAAGCTAAAAGAAAAAGGAT
CAGGAGACAGGAAAAGTCTTCCGTTTTGAGTCATGAGTAGGGCAATAGACAAGGTTCTCTTCAAAACCATCATTAGTTTGGCTTTAAGAA
ACCAGTAGCTAGCTGCTATTTATATGGTGAGGGGGTGCTGCCTGGTAACAGAATAGCTCCACACCACAGCTTGAGATTTTGTTTAGTTTC
ACTGTGTGAGCTTTCATAAAGTCTGTTGCCATTCCATCTCTGTGTTAACACTTCATATTTTTATGAAATTCAGATAATTTGTGAGAGGCT
GGCATGGATCTAAGGATTTATTATTTTTATTCTAGTCCATCAGTTCAGTCGCAGTTTTTATACTAGGACTTTAGGATGTACATAAATGTG
TGACTGTTTGTCTTGATTAAAAGTGCACTTTGGCCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCGGGTG
GCTCACTTGAGGCTAGGAGTTCAAGACTAGCGTGGCCAACATGAGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGTT
GGTGCATGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATTA
TGCCACTGTACTCCAGCGTGGGTGACAGAGTGAGACTCTGTCTCAAATTAAAAAAATAAAAAATAATTTTTTTTTTTTAAAGTACGCTTT
GTTGGCTGGGCACGGCGACTCACGCCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGGCAGATCACGAGGTTAGGAGTTCGAGACCAGC
CTGGCCAACATGGTGAAACCCTGTCTCTACTGAAAATACAAAAATTAGCTGGGCGTGGTGGTGGGTACCTGTAATCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCACTCCGACTCTGGGCAACAGAG
CAAGACTCTGTCTCGGGGGAAACAAAAAAAAAGTGTGCTTTGTCAAGAGAAGCACCAGCAGACCTCTAAGAACTGCTCTCTAAGGCTGCG
GTAGCAAATTATCTACTATTGCAGGTGCCTTATTGGTAGAGGGCTCTGAAGAGCCAAAACTGTATATGCAACACTTGTAAGATAAAAGGG
ACTTTAATAATCAAGATTTTCTTGAAGATTTGTTAGAAATAATGTCTTATTTCTGGTAACCTTTCCCTTTTTGTATTTATAACTCTACTA
ACCAAATTACCTATCAATAAACCATTACTATAATATTTTAAAACAACCTATGTTTATCAAGCTTACTCTCTGAGTGACAGAATATACTAA


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FusionGenePPI for RYR3_LRRC57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RYR3RYR2, FKBP1A, CUL1, CFTR, HNF1A, BMI1, FKBP1BLRRC57COL7A1, XPO1, CDH1, C5orf30, LRRC40, SUGT1, CSGALNACT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11043469_3498174871CALM
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11033469_3498174866CALM
HgeneRYR3chr15:33603297chr15:42837460ENST00000389232+11042322_2335174871FKBP1A
HgeneRYR3chr15:33603297chr15:42837460ENST00000415757+11032322_2335174866FKBP1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RYR3_LRRC57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RYR3_LRRC57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource