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Fusion gene ID: 32460 |
FusionGeneSummary for RYR2_GPR137B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RYR2_GPR137B | Fusion gene ID: 32460 | Hgene | Tgene | Gene symbol | RYR2 | GPR137B | Gene ID | 6262 | 7107 |
| Gene name | ryanodine receptor 2 | G protein-coupled receptor 137B | |
| Synonyms | ARVC2|ARVD2|RYR-2|RyR|VTSIP | TM7SF1 | |
| Cytomap | 1q43 | 1q42.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ryanodine receptor 2cardiac muscle ryanodine receptor-calcium release channelcardiac-type ryanodine receptorislet-type ryanodine receptorkidney-type ryanodine receptorryanodine receptor 2 (cardiac)type 2 ryanodine receptor | integral membrane protein GPR137Btransmembrane 7 superfamily member 1 (upregulated in kidney)transmembrane 7 superfamily member 1 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q92736 | O60478 | |
| Ensembl transtripts involved in fusion gene | ENST00000366574, ENST00000360064, ENST00000542537, ENST00000609119, | ENST00000366592, ENST00000366591, ENST00000477559, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RYR2 [Title/Abstract] AND GPR137B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RYR2 | GO:0005513 | detection of calcium ion | 10830164 |
| Hgene | RYR2 | GO:0006816 | calcium ion transport | 17921453 |
| Hgene | RYR2 | GO:0031000 | response to caffeine | 17921453 |
| Hgene | RYR2 | GO:0035584 | calcium-mediated signaling using intracellular calcium source | 17921453 |
| Hgene | RYR2 | GO:0051209 | release of sequestered calcium ion into cytosol | 12443530|17921453 |
| Hgene | RYR2 | GO:0051284 | positive regulation of sequestering of calcium ion | 12443530|12919952 |
| Hgene | RYR2 | GO:0051775 | response to redox state | 19226252 |
| Hgene | RYR2 | GO:0060402 | calcium ion transport into cytosol | 17921453 |
| Hgene | RYR2 | GO:0071313 | cellular response to caffeine | 12919952 |
| Hgene | RYR2 | GO:0072599 | establishment of protein localization to endoplasmic reticulum | 12443530 |
| Hgene | RYR2 | GO:1901896 | positive regulation of calcium-transporting ATPase activity | 12443530 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A07C-01A | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000366574 | ENST00000366592 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-intron | ENST00000366574 | ENST00000366591 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-3UTR | ENST00000366574 | ENST00000477559 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| In-frame | ENST00000360064 | ENST00000366592 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-intron | ENST00000360064 | ENST00000366591 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-3UTR | ENST00000360064 | ENST00000477559 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| In-frame | ENST00000542537 | ENST00000366592 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-intron | ENST00000542537 | ENST00000366591 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| 5CDS-3UTR | ENST00000542537 | ENST00000477559 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| intron-3CDS | ENST00000609119 | ENST00000366592 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| intron-intron | ENST00000609119 | ENST00000366591 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
| intron-3UTR | ENST00000609119 | ENST00000477559 | RYR2 | chr1 | 237780786 | + | GPR137B | chr1 | 236368426 | + |
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FusionProtFeatures for RYR2_GPR137B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RYR2 | GPR137B |
| Calcium channel that mediates the release of Ca(2+) fromthe sarcoplasmic reticulum into the cytoplasm and thereby plays akey role in triggering cardiac muscle contraction. Aberrantchannel activation can lead to cardiac arrhythmia. In cardiacmyocytes, calcium release is triggered by increased Ca(2+) levelsdue to activation of the L-type calcium channel CACNA1C. Thecalcium channel activity is modulated by formation ofheterotetramers with RYR3. Required for cellular calcium ionhomeostasis. Required for embryonic heart development.{ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:20056922,ECO:0000269|PubMed:27733687}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 1025_1222 | 1972 | 4968 | Domain | B30.2/SPRY 2 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 110_165 | 1972 | 4968 | Domain | MIR 1 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 1337_1562 | 1972 | 4968 | Domain | B30.2/SPRY 3 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 172_217 | 1972 | 4968 | Domain | MIR 2 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 225_280 | 1972 | 4968 | Domain | MIR 3 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 286_343 | 1972 | 4968 | Domain | MIR 4 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 351_408 | 1972 | 4968 | Domain | MIR 5 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 599_809 | 1972 | 4968 | Domain | B30.2/SPRY 1 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 853_966 | 1972 | 4968 | Repeat | Note=1 |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 967_1080 | 1972 | 4968 | Repeat | Note=2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4412_4445 | 1972 | 4968 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4414_4455 | 1972 | 4968 | Compositional bias | Note=Glu-rich (acidic) |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4820_4829 | 1972 | 4968 | Intramembrane | Pore-forming |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 853_2925 | 1972 | 4968 | Region | Note=4 X approximate repeats |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 2692_2810 | 1972 | 4968 | Repeat | Note=3 |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 2812_2925 | 1972 | 4968 | Repeat | Note=4 |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 1_4281 | 1972 | 4968 | Topological domain | Cytoplasmic |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4871_4967 | 1972 | 4968 | Topological domain | Cytoplasmic |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4282_4302 | 1972 | 4968 | Transmembrane | Helical |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4504_4524 | 1972 | 4968 | Transmembrane | Helical |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4580_4600 | 1972 | 4968 | Transmembrane | Helical |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4730_4750 | 1972 | 4968 | Transmembrane | Helical |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4769_4789 | 1972 | 4968 | Transmembrane | Helical |
| Hgene | >RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 4850_4870 | 1972 | 4968 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 101_111 | 322 | 400 | Topological domain | Extracellular |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 133_159 | 322 | 400 | Topological domain | Cytoplasmic |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 181_188 | 322 | 400 | Topological domain | Extracellular |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 1_46 | 322 | 400 | Topological domain | Extracellular |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 210_237 | 322 | 400 | Topological domain | Cytoplasmic |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 259_292 | 322 | 400 | Topological domain | Extracellular |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 314_399 | 322 | 400 | Topological domain | Cytoplasmic |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 68_79 | 322 | 400 | Topological domain | Cytoplasmic |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 112_132 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 160_180 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 189_209 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 238_258 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 293_313 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 47_67 | 322 | 400 | Transmembrane | Helical |
| Tgene | GPR137B | chr1:237780786 | chr1:236368426 | ENST00000366592 | + | 4 | 7 | 80_100 | 322 | 400 | Transmembrane | Helical |
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FusionGeneSequence for RYR2_GPR137B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RYR2_ENST00000366574_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_2050aa MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSE GQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVH ARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIE SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQH LICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGE FKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTP SQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNE HTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTA HGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTY YQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIH LSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPK EGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQTNPGMVPS >In-frame_RYR2_ENST00000360064_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_2048aa LGPRSSSNKLSNKKMMKWFCSAPQPSTKNNRSYAWQQKDLATDFVSWSPLPIPRMCPQTSPSAPLCWSSPSLSGRCRRCWLTPWRNQKGQ LDIIKWSFGLKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLI LVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHAR SLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCY IQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESV SLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIR GNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLI CDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDL FSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFK FLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGW QYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQ EAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTG ERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHT MMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVP SNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHG HLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVW VGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQ VEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCL DPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLS SYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEG SLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEG LLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQTNPGMVPSHG >In-frame_RYR2_ENST00000542537_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_2034aa DDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQ GGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSY GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSG SHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQS VDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPP DEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLD WLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQT RLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGC IARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAV LPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHP CLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNV WARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAV KAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDS GSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGT IDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEAT KPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTG FDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQ ATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEEN RSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYI VPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEF LFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQM CLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQTNPGMVPSHGFSPRSYFFDNPRRY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RYR2_ENST00000366574_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_6150nt ATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGCGAACTGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAA GAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCA GACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAA GGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTG CTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAA GAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGAC CTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACT CTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACAC ATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCAT GCACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTC ACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACC TTCCGGTCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTA TGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAG GCTATTATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGG AGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTCAGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAG TCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGA GCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAACCTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGT GCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTA ATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGC ATTCTGGAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTT TTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCAT CTCATCTGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTT CTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCA ACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGAT GATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGA ACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAG AATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAA TTCAAATTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTAC AAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGC CAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTT GGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAAT TACAACTTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAG GTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATACAAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCA TCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATC CAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTC CGCGAGGCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGC ACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCT GGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTC AAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAA CACACCATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGA TTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGT GGCTTACAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAA GTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTT GGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGA GGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCT CATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAG CCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTT GCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAAT GTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGA GATGAAAAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGC AACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATAC TATCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATA AAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTC CTGTCACACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAG TGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTG CTGAAATTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTG GATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCAC CTGAGCTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCT GATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGC ATTAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAA GAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATC ATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAG AGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAG GAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCAC CGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCC TTAAACATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGATCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGC CATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGA CTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACT >In-frame_RYR2_ENST00000360064_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_6144nt CTGGGCCCTAGATCCTCATCTAACAAGCTCTCAAATAAAAAGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAAC AGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCT CCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAA CTAGATATCATTAAATGGTCATTTGGTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGC CATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGAC ACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATC TTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGG AGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGAC GAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGT TCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACA GGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGG TCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTAT ATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGCTATT ATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACA GTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTCAGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTA AGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTG AAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAACCTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCA CACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTAATTAGA GGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTG GAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGAC AAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATC TGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTTCTGGGC GTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCAC CTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTC TTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGAT GATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTC AACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAA TTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAA GAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGATC GTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGG CAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAAC TTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAA AAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATACAAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAA GAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAG GACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAG GCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGG GAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGAC ATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGCC CAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACC ATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGATTCATA CCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTA CAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCA TCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCT CAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTC CCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGC CATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCT CGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGAT GATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGG GTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAA AAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAAT AATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAG GTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGAAT GTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCA CACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTG GATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAA TTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAA CCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGC TCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAG AACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGT AATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGC AGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGC ATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGAC ACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGC CTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATA GAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAAC ATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGATCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGCCATGGA TTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAG GGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGAT >In-frame_RYR2_ENST00000542537_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_6102nt GATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTT TGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGG GCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTGCTCAA GGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCC CGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCT AAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTAT GGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGG TATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAG CGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGAGTGGA AGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTC ATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTA GATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCT GTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGCTATTATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCG AGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTC AGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCA GATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAAC CTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGG AAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTAATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGAC TGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTA AATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCA CTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACA CGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTTCTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAA TTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTAC CCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGT ATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATC TCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCA GGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTT CTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCC CTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCA GAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCA TGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGGCATTA GGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATAC AAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTG TGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACT CTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCA CCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTG AAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAG GAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGG CAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCA GGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGATTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAAC TTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGAT ATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACC ATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATG CCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGAT TATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACT AAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGAT TACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGTAC TATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGC TTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACTGCTAT ATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGG CTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAA GCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAG AACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTA GATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAAC AGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCT CTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGT TTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATT GTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCC CTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATC CTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTC CTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATT GAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAA GGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGATG TGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTC CAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGA TCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATAT GACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RYR2_ENST00000366574_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_7215nt CCGAGCGGACCGCCGGCTGCAGGCAGCGAGCGCGGCTGGGCTGCGGGGCTGCTTCCCCGCGTCCTCCGGGCCCGGGCCGCCCTCCTCCCG CACAGTGCGGAGCAGGGAGGCCCCGCGCCTCGACCACCCGCGCCCGAGCGTCCGCGCCTCCTCCTCCGCTCTGCAGGCGGGGACCGCCCG GCGCTCGGCACCCGGCAGCGCGGCCCCCTCCAGCCCCCGGCTCCCGGCAGCAGAAGCAGAAGGCAGCGCCAGGGGCCGCCGCCGCCGCCG AGCTCCGCGGGGCTCGGGAGCCGGCCCCGGCGAGGAGGCGCGGAACCATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGC GAACTGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACA GACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTG TCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTG CTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCA CCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTG CCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGT CTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCC AAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAG AGCAGCGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGA GTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTC TACTCATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAG AAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACC AGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGCTATTATGCATCATGAAGGCCACATGGATGATGGCATAAGTT TGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATG CTCTCAGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACC CCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGA TCAACCTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGT CTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTAATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCC TCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAG CTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGT GCTCACTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGC AGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTTCTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACT ATGAATTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTC CCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAG GTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAA GCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCT CTGCAGGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAG CTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAG TTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAAC TGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAAC ACCCATGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGG CATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTG GATACAAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATA ATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCT ACACTCTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGG AAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATG CAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGG ATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCT CTTGGCAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAAATCCTTCTTGATG ATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGATTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGA TGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCCGTTAATACAAACA GGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACG GCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGA GCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGG AAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAG CTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGC CAGATTACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCA CGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACA CAGGCTTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACT GCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCA GCGGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTG CACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGC ACAAGAACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGA AGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGG AAAACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCT GTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGC CTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGT ACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCA CCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGG ACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTG AATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGT TGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGC TGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGC AGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTA AGCTCCAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAAT TTAGATCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAA GATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAAC AAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAG TTTTATGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTG ATTTTTATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGC CTTGCTATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAATGCT AAAGTATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAAAAT ATAGAATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGA TTCTGAGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAA AGCAGCAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACT GGTACTTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATTAAAAATGTAGCTGACTTATCCTATTAAACCTC >In-frame_RYR2_ENST00000360064_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_6892nt CTGGGCCCTAGATCCTCATCTAACAAGCTCTCAAATAAAAAGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAAC AGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCT CCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAA CTAGATATCATTAAATGGTCATTTGGTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGC CATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGAC ACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATC TTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGG AGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGAC GAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGT TCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACA GGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGG TCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTAT ATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGCTATT ATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACA GTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTCAGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTA AGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTG AAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAACCTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCA CACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTAATTAGA GGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTG GAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGAC AAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATC TGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTTCTGGGC GTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCAC CTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTC TTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGTATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGAT GATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTC AACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAA TTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAA GAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGATC GTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGG CAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAAC TTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAA AAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATACAAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAA GAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAG GACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAG GCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGG GAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGAC ATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGCC CAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACC ATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGATTCATA CCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTA CAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCA TCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACCATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCT CAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTC CCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGC CATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCT CGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGAT GATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGG GTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAA AAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAAT AATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAG GTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGAAT GTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCA CACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTG GATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAA TTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAA CCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGC TCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAG AACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGT AATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGC AGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGC ATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGAC ACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGC CTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATA GAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAAC ATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGATCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGCCATGGA TTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATATGACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAG GGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACTAACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGAT CCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTATGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTG AATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTTTATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTA GACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGCTATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTT ATAAAGATGTATTTTGTATAACTTAAATAATAATGCTAAAGTATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAG TTTGCACAGACTTTTATGCATAATTCACTTTAAAAATATAGAATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCAC AAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTGAGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAAT TGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAGCAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAG GTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTACTTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATA >In-frame_RYR2_ENST00000542537_chr1_237780786_+_GPR137B_ENST00000366592_chr1_236368426_+_6850nt GATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTT TGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGG GCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTGCTCAA GGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCC CGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCT AAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTAT GGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGG TATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAG CGGAGAACTGTTCATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTAAGAGTTGCGTGGAGTGGA AGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTCACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTC ATGGACAAAGAGAAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGAAAAATTGGATGTAGGGGTGAGAAAAGAAGTA GATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTATGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCT GTGGACGTGAAATCCGTGAGAATGGGATCTATACAACGTAAGGCTATTATGCATCATGAAGGCCACATGGATGATGGCATAAGTTTGTCG AGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGGAGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTC AGCAAGAAAGCGAAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATTGGCTACTTCCACCCCCCA GATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGAGCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAAC CTCGTGCTTGAGTGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGAGAAGCAGGAGAGTCTTGG AAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTAATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGAC TGGTTGATCAGCAGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTAGAAAGTCCAGAAGCTCTA AATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTTTTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCA CTCTGTGTTTGCCACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGAGACTTGTTATTGCAGACA CGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTTCTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAA TTGATGGTGGACCACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACTGAAGGATATTCTCCCTAC CCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGATGATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGT ATTGCTCGTACTGTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGATCTGAGTGCCCCAAGCATC TCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAGAATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCA GGAATAAAAGTACGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCTCCTTGTTATGAAGCTGTT CTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTACAAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCC CTGACGCAAGCTGCCTTCACACCCATCCCTGTGGATACCAGCCAGATCGTGTTGCCTCCTCATCTAGAAAGAATAAGAGAAAAACTGGCA GAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTTGGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCA TGCCTGGTGGAGTTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTGAAGACTTTGTTGGCATTA GGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAGGTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATAC AAGCCTGCCCCTATGGACCTGAGCTTTATCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCAGAAAATGCACATAATGTG TGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATCCAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACT CTTCTGGATGACCGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTACGGCTACAACTTGGAAGCA CCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGCACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTG AAGGCCGGACGGTGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCTGGTTGTCAACCGGATCAG GAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTCAAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGG CAAGCAGGCGATGTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAAATCCTTCTTGATGATTCA GGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGATTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAAC TTTGGAAAGGATGTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCCGTTAATACAAACAGGGAT ATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAAGTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACC ATAGACAGTTCCCCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATGTTTTATCGCCTGAGCATG CCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGAGGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGAT TATGATGCTGATTCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGACAAAGACAAAGAAGCTACT AAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAGCCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGAT TACAGCACAAGCCATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTGATGCAAACGTCCACGTAC TATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAATGTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGC TTTGACTTGGACAGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGCATCAAACGCAGCAACTGCTAT ATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGCAACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGG CTGCTCACATTCATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTGGAACCGAGTACAAAATTATTTCCTGCGGTTTTTGCACAA GCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATAAAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAG AACCCCGTGCCGCAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCCAACCAGTTTTTGAAGGTA GATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAGTGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAAC AGATCTGTTGACATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTCTACTCAGCCGTCTGTGCT CTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTGGATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGT TTGCTGCGTGCTGGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATGATGAACAACGAGTACATT GTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCTGATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCC CTCAGGCCACGGATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCAGAGTTCCCACTGGACATC CTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAAGAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTC CTCTTTGTACCTCTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAGCACATCTTGCAGTTGATT GAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAGAGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAA GGAGCTGGTGAGGAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAGCCAGTTAAATTGCAGATG TGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCACCGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTC CAAGACAATCAACGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGGAAGACAAAGGAATTTAGA TCACCACCTCAAGAACAGACCAACCCTGGAATGGTCCCCAGCCATGGATTCAGTCCCAGATCTTATTTCTTTGACAACCCTCGAAGATAT GACAGTGATGATGACCTTGCCTGGAACATTGCCCCTCAGGGACTTCAGGGAGGTTTTGCTCCAGATTACTATGATTGGGGACAACAAACT AACAGCTTCCTGGCACAAGCAGGAACTTTGCAAGACTCAACTTTGGATCCTGACAAACCAAGCCTTGGGTAGCATCAGTTAACAGTTTTA TGGACGATTCCTCAGATGAAAAGCTTCAGAAAAGCATAGTGACAGCTGAATTTTTAGGGCACTTTTCCTTAAGAAATAGAACTTGATTTT TATTTGTTACAGGTTTCCAATGGCCCCATAGGAATAAGCAATAATGTAGACTGATAAACCCTTATTTTAGTACTAAAGAGGGAGCCTTGC TATTTCAGTGGGTATAATTTAAACTTTTTAAAGAAAATCTGTACTTTTATAAAGATGTATTTTGTATAACTTAAATAATAATGCTAAAGT ATACTAGGGTTTTTTTTTCTTGAGAATGTTACTGCAATCATGTTGTAGTTTGCACAGACTTTTATGCATAATTCACTTTAAAAATATAGA ATATATGGTCTAATAGTTTTTTAAAGCTTTTGGACTAAAGTATTCCACAAATCTTACCTCTTTAGGTCACTGATGGTCACTCCGATTCTG AGTGCCACATTGGTAGACTCCTAAAATACAGTTGACAACTTAGCCAATTGCAACTCCAGTGTTGATAATTAAAATGAAATGGTAAAGCAG CAGACTGTAAGGTCTTTAGAGATTTTTTTTTTAAGGTTCAGGCCGTAGGTTCCTCAAGGAATCTCTTAAGTTTTGCCCAAAGACTGGTAC TTCCTTTCAGTAGGGCGCTAATGTATACACATTAATGATAAGTTGATAACATTAAAAATGTAGCTGACTTATCCTATTAAACCTCCTCTG |
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FusionGenePPI for RYR2_GPR137B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RYR2 | HOMER1, PRKACA, PRKACG, PRKACB, RYR2, PRKAR2A, PRKAR2B, PPP1CA, PPP1CB, PPP1CC, AKAP6, RYR3, RYR1, SRI, CACNA1C, FKBP1B, TERF1, TERF2, ALB, SMAD5, CFTR, CALM1, SNTA1, MDM2, HSPB2, PSEN1, TRIM25 | GPR137B | NCAPD2, SMC2, ZYG11B, NCAPH, DOC2A, NCAPG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RYR2 | chr1:237780786 | chr1:236368426 | ENST00000366574 | + | 38 | 105 | 3581_3610 | 1972 | 4968 | CALM |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RYR2_GPR137B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RYR2 | Q92736 | DB09085 | Tetracaine | Ryanodine receptor 2 | small molecule | approved|vet_approved |
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RelatedDiseases for RYR2_GPR137B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RYR2 | C1631597 | VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) | 12 | CTD_human;ORPHANET;UNIPROT |
| Hgene | RYR2 | C0042514 | Tachycardia, Ventricular | 2 | CTD_human;HPO |
| Hgene | RYR2 | C1832931 | ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2 | 2 | CTD_human;UNIPROT |
| Hgene | RYR2 | C0039231 | Tachycardia | 1 | CTD_human |
| Hgene | RYR2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | RYR2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | RYR2 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
| Hgene | RYR2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
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