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Fusion gene ID: 32448 |
FusionGeneSummary for RYBP_FHIT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RYBP_FHIT | Fusion gene ID: 32448 | Hgene | Tgene | Gene symbol | RYBP | FHIT | Gene ID | 23429 | 2272 |
| Gene name | RING1 and YY1 binding protein | fragile histidine triad | |
| Synonyms | AAP1|APAP-1|DEDAF|YEAF1 | AP3Aase|FRA3B | |
| Cytomap | 3p13 | 3p14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING1 and YY1-binding proteinDED-associated factorYY1 and E4TF1 associated factor 1apoptin-associating protein 1death effector domain-associated factorring1 interactor RYBP | bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N488 | P49789 | |
| Ensembl transtripts involved in fusion gene | ENST00000477973, | ENST00000476844, ENST00000492590, ENST00000466788, ENST00000468189, ENST00000341848, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 17 X 7 X 10=1190 |
| # samples | 7 | 20 | |
| ** MAII score | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RYBP [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RYBP | GO:0035518 | histone H2A monoubiquitination | 16943429 |
| Tgene | FHIT | GO:0006163 | purine nucleotide metabolic process | 9323207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IJ-01A | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| TCGA | RV | THYM | TCGA-4V-A9QJ-01A | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000477973 | ENST00000476844 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| In-frame | ENST00000477973 | ENST00000492590 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000466788 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000468189 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000341848 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
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FusionProtFeatures for RYBP_FHIT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RYBP | FHIT |
| Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1-like complex acts viachromatin remodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility (PubMed:25519132).Component of a PRC1-like complex that mediates monoubiquitinationof histone H2A 'Lys-119' on the X chromosome and is required fornormal silencing of one copy of the X chromosome in XX females.May stimulate ubiquitination of histone H2A 'Lys-119' byrecruiting the complex to target sites (By similarity). Inhibitsubiquitination and subsequent degradation of TP53, and therebyplays a role in regulating transcription of TP53 target genes(PubMed:19098711). May also regulate the ubiquitin-mediatedproteasomal degradation of other proteins like FANK1 to regulateapoptosis (PubMed:14765135, PubMed:27060496). May be implicated inthe regulation of the transcription as a repressor of thetranscriptional activity of E4TF1 (PubMed:11953439). May bind toDNA (By similarity). {ECO:0000250|UniProtKB:Q8CCI5,ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135,ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496}. | Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A)to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activitywith ATP. Modulates transcriptional activation by CTNNB1 andthereby contributes to regulate the expression of genes essentialfor cell proliferation and survival, such as CCND1 and BIRC5.Plays a role in the induction of apoptosis via SRC and AKT1signaling pathways. Inhibits MDM2-mediated proteasomal degradationof p53/TP53 and thereby plays a role in p53/TP53-mediatedapoptosis. Induction of apoptosis depends on the ability of FHITto bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or relatedcompounds, but does not require its catalytic activity, it may inpart come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calciumuptake. Functions as tumor suppressor.{ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915,ECO:0000269|PubMed:16407838, ECO:0000269|PubMed:18077326,ECO:0000269|PubMed:19622739, ECO:0000269|PubMed:8794732,ECO:0000269|PubMed:9323207}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RYBP | chr3:72495647 | chr3:59738047 | ENST00000477973 | - | 1 | 4 | 73_76 | 141 | 317 | Compositional bias | Note=Poly-Pro |
| Hgene | RYBP | chr3:72495647 | chr3:59738047 | ENST00000477973 | - | 1 | 4 | 77_119 | 141 | 317 | Compositional bias | Note=Lys-rich |
| Hgene | RYBP | chr3:72495647 | chr3:59738047 | ENST00000477973 | - | 1 | 4 | 21_50 | 141 | 317 | Zinc finger | RanBP2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RYBP | chr3:72495647 | chr3:59738047 | ENST00000477973 | - | 1 | 4 | 179_214 | 141 | 317 | Compositional bias | Note=Ser-rich |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000341848 | - | 3 | 5 | 2_109 | 116 | 148 | Domain | HIT |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000468189 | - | 7 | 9 | 2_109 | 116 | 148 | Domain | HIT |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000476844 | - | 7 | 10 | 2_109 | 116 | 214 | Domain | HIT |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000492590 | - | 7 | 10 | 2_109 | 116 | 205 | Domain | HIT |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000341848 | - | 3 | 5 | 94_98 | 116 | 148 | Motif | Histidine triad motif |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000468189 | - | 7 | 9 | 94_98 | 116 | 148 | Motif | Histidine triad motif |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000476844 | - | 7 | 10 | 94_98 | 116 | 214 | Motif | Histidine triad motif |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000492590 | - | 7 | 10 | 94_98 | 116 | 205 | Motif | Histidine triad motif |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000341848 | - | 3 | 5 | 89_92 | 116 | 148 | Nucleotide binding | Substrate |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000468189 | - | 7 | 9 | 89_92 | 116 | 148 | Nucleotide binding | Substrate |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000476844 | - | 7 | 10 | 89_92 | 116 | 214 | Nucleotide binding | Substrate |
| Tgene | FHIT | chr3:72495647 | chr3:59738047 | ENST00000492590 | - | 7 | 10 | 89_92 | 116 | 205 | Nucleotide binding | Substrate |
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FusionGeneSequence for RYBP_FHIT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_173aa ASCARRGPSRGAAATAWCARLSGPGPGLAGCQWGRPVPFLALSSSPRKGWVGGLPSEVSSTGFLRNYDGSPASVFCCLSPVFLLPASSLP >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_173aa ASCARRGPSRGAAATAWCARLSGPGPGLAGCQWGRPVPFLALSSSPRKGWVGGLPSEVSSTGFLRNYDGSPASVFCCLSPVFLLPASSLP >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_173aa ASCARRGPSRGAAATAWCARLSGPGPGLAGCQWGRPVPFLALSSSPRKGWVGGLPSEVSSTGFLRNYDGSPASVFCCLSPVFLLPASSLP >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_173aa ASCARRGPSRGAAATAWCARLSGPGPGLAGCQWGRPVPFLALSSSPRKGWVGGLPSEVSSTGFLRNYDGSPASVFCCLSPVFLLPASSLP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_519nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_519nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_519nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_519nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_783nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT CCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATCCTGAATTCCAGCA AAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCA CCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGAT >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_794nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT CCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATGTTTTTCAGATCCT GAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTT TCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCA >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000476844_chr3_59738047_-_783nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT CCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATCCTGAATTCCAGCA AAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCA CCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGAT >In-frame_RYBP_ENST00000477973_chr3_72495647_-_FHIT_ENST00000492590_chr3_59738047_-_794nt GCTTCCTGCGCCCGCCGCGGCCCTTCCCGGGGCGCCGCCGCCACCGCCTGGTGTGCGAGGCTATCCGGCCCGGGCCCGGGGCTTGCAGGG TGCCAGTGGGGGCGCCCGGTTCCCTTCCTCGCTCTCTCTTCCAGTCCCCGGAAAGGGTGGGTGGGTGGTCTCCCGAGCGAAGTTTCCAGC ACTGGATTCCTGCGAAATTACGACGGCTCACCCGCGTCTGTGTTTTGCTGTCTCTCCCCCGTTTTCCTGCTCCCTGCCTCTTCCCTCCCT TTTCCCCCACTCTCCACTCCTCGGAAGGCCAAAAAGACAAGCGAAACCTGCCGCAGACGAAGGGTTTTGGGATTGTAGCGTCTGCACCTT CAGAAACAGTGCTGAAGCCTTTAAATGCAGCATCTGCGATGTGAGGAAAGGCACCTCCACCAGCTCCAGAAACATGACAAGGAGGACTTT CCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATGTTTTTCAGATCCT GAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTT TCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCA |
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FusionGenePPI for RYBP_FHIT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RYBP | E2F6, RING1, CBX2, YY1, E2F2, E2F3, E2F4, CASP10, FADD, ABL1, MDM2, TP53, BCOR, PCGF1, RNF2, SOCS2, ZFP42, ELAVL1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, L3MBTL2, CBX3, TFDP1, WDR5, MGA, SKP1, BCORL1, KDM2B, USP7, FBRS, FBRSL1, CSNK2A1, CSNK2A2, CSNK2B, GABPB1, GABPB2, EED, MORC4, ATF7IP, HERC2, AUTS2, HSPB1, CRK, NOS1AP, MAPK8IP2, FANK1, DDX5, CASP8, MLLT1, YAF2, TFDP2, HDAC1, DCAF7, TRIM25 | FHIT | FHIT, UBE2I, CTNNB1, LEF1, TRIM23, RAB40B, MDM2, REL, TP53, ARHGAP19, MTMR6, RABL2A, CHEK1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RYBP | chr3:72495647 | chr3:59738047 | ENST00000477973 | - | 1 | 4 | 143_226 | 141 | 317 | GABPB1 and FANK1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RYBP_FHIT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FHIT | P49789 | DB04173 | Fructose | Bis(5'-adenosyl)-triphosphatase | small molecule | approved|experimental |
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RelatedDiseases for RYBP_FHIT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FHIT | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Tgene | FHIT | C0025500 | Mesothelioma | 2 | CTD_human |
| Tgene | FHIT | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | FHIT | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | FHIT | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | FHIT | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | FHIT | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | FHIT | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| Tgene | FHIT | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | FHIT | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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