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Fusion gene ID: 32439 |
FusionGeneSummary for RXRA_LRBA |
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Fusion gene information | Fusion gene name: RXRA_LRBA | Fusion gene ID: 32439 | Hgene | Tgene | Gene symbol | RXRA | LRBA | Gene ID | 6256 | 987 |
Gene name | retinoid X receptor alpha | LPS responsive beige-like anchor protein | |
Synonyms | NR2B1 | BGL|CDC4L|CVID8|LAB300|LBA | |
Cytomap | 9q34.2 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | retinoic acid receptor RXR-alphanuclear receptor subfamily 2 group B member 1retinoid X nuclear receptor alpha | lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P19793 | P50851 | |
Ensembl transtripts involved in fusion gene | ENST00000481739, ENST00000356384, ENST00000540193, | ENST00000535741, ENST00000510413, ENST00000503716, ENST00000357115, ENST00000507224, | |
Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 15 X 15 X 7=1575 |
# samples | 8 | 18 | |
** MAII score | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1575*10)=-3.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RXRA [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RXRA | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17426122 |
Hgene | RXRA | GO:0019048 | modulation by virus of host morphology or physiology | 11915042 |
Hgene | RXRA | GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 10195690 |
Hgene | RXRA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12037571|20219900 |
Hgene | RXRA | GO:0051289 | protein homotetramerization | 7831303 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM978893 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000481739 | ENST00000535741 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000481739 | ENST00000510413 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000481739 | ENST00000503716 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000481739 | ENST00000357115 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000481739 | ENST00000507224 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
3UTR-intron | ENST00000356384 | ENST00000535741 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
3UTR-intron | ENST00000356384 | ENST00000510413 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
3UTR-intron | ENST00000356384 | ENST00000503716 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
3UTR-intron | ENST00000356384 | ENST00000357115 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
3UTR-intron | ENST00000356384 | ENST00000507224 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000540193 | ENST00000535741 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000540193 | ENST00000510413 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000540193 | ENST00000503716 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000540193 | ENST00000357115 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
intron-intron | ENST00000540193 | ENST00000507224 | RXRA | chr9 | 137332343 | - | LRBA | chr4 | 151283588 | + |
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FusionProtFeatures for RXRA_LRBA |
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Hgene | Tgene |
RXRA | LRBA |
Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RAR/RXRheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The highaffinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as acommon heterodimeric partner for a number of nuclear receptors. Inthe absence of ligand, the RXR-RAR heterodimers associate with amultiprotein complex containing transcription corepressors thatinduce histone acetylation, chromatin condensation andtranscriptional suppression. On ligand binding, the corepressorsdissociate from the receptors and associate with the coactivatorsleading to transcriptional activation. The RXRA/PPARA heterodimeris required for PPARA transcriptional activity on fatty acidoxidation genes such as ACOX1 and the P450 system genes.{ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:11162439,ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:20215566}. | May be involved in coupling signal transduction andvesicle trafficking to enable polarized secretion and/or membranedeposition of immune effector molecules. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RXRA_LRBA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RXRA_LRBA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RXRA_LRBA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RXRA | P19793 | DB00210 | Adapalene | Retinoic acid receptor RXR-alpha | small molecule | approved |
Hgene | RXRA | P19793 | DB00459 | Acitretin | Retinoic acid receptor RXR-alpha | small molecule | approved |
Hgene | RXRA | P19793 | DB00307 | Bexarotene | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational |
Hgene | RXRA | P19793 | DB00412 | Rosiglitazone | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational |
Hgene | RXRA | P19793 | DB00523 | Alitretinoin | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational |
Hgene | RXRA | P19793 | DB01393 | Bezafibrate | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational |
Hgene | RXRA | P19793 | DB00755 | Tretinoin | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational|nutraceutical |
Hgene | RXRA | P19793 | DB00749 | Etodolac | Retinoic acid receptor RXR-alpha | small molecule | approved|investigational|vet_approved |
Hgene | RXRA | P19793 | DB01436 | Alfacalcidol | Retinoic acid receptor RXR-alpha | small molecule | approved|nutraceutical |
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RelatedDiseases for RXRA_LRBA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RXRA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | RXRA | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Hgene | RXRA | C0149940 | Sciatic Neuropathy | 1 | CTD_human |
Hgene | RXRA | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | RXRA | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | LRBA | C3553512 | IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY | 1 | ORPHANET;UNIPROT |